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Development of and proposed applications for tetrodes in functional mapping of rodent sensorimotor striatum

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dc.contributor.advisor Earl Miller. en_US
dc.contributor.author Iyengar, Deepa Radhakrishna, 1972- en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.date.accessioned 2005-09-26T20:00:16Z
dc.date.available 2005-09-26T20:00:16Z
dc.date.copyright 2004 en_US
dc.date.issued 2004 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/28355
dc.description Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2004. en_US
dc.description Includes bibliographical references (leaves 60-66). en_US
dc.description.abstract The Wilson-McNaughton tetrode preparation for awake, behaving rodents was adapted by a group of investigators for use in dorsolateral striatum. Measures were taken to improve the reliability of reaching the target area in the brain and the stability of the implanted tetrode drive over several weeks of recording. Novel methods were developed to confirm the dorsoventral level of tetrodes at intermediate stages of advancement during recording, and to reconstruct estimated directions and distances of recorded sources from tetrodes by post-hoc analysis. Alternative methods of source separation and data visualization were implemented. Additional refinements to improve unit separation within and across recording sessions are proposed. The resulting recording technique is expected to have considerable potential in clarifying behavioral and other functional correlates of systems of striatal anatomical compartmentalization. A set of experiments is proposed to investigate how dorsolateral striatal neuronal activity changes in correlation with learning of three stimulus-response tasks relative to three control tasks with similar sensory, motor and motivational aspects but different learning and memory requirements, and to localize task-responsive units with respect to striosomes and body part areas identified by neuronal responses to cutaneous stimulation/passive manipulation and anterograde anatomical tracers from primary motor cortex. Neuronal activity in the globus pallidus and substantia nigra pars reticulata, output areas of the basal ganglia, is also to be examined over the course of acquisition of the three stimulus-response tasks. en_US
dc.description.abstract (cont.) The proposed investigations will begin to empirically anchor learning and memory functions of the striatum and basal ganglia to patterns of neuronal activity in the context of the intricate anatomical organization of these areas. en_US
dc.description.statementofresponsibility by Deepa Radhakrishna Iyengar. en_US
dc.format.extent 66 leaves en_US
dc.format.extent 4569916 bytes
dc.format.extent 4569721 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582
dc.subject Brain and Cognitive Sciences. en_US
dc.title Development of and proposed applications for tetrodes in functional mapping of rodent sensorimotor striatum en_US
dc.type Thesis en_US
dc.description.degree S.M. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.identifier.oclc 56051582 en_US


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