Advanced Search
DSpace@MIT

Fabrication of Micro and Nanoparticles of Paclitaxel-loaded Poly L Lactide for Controlled Release using Supercritical Antisolvent Method: Effects of Thermodynamics and Hydrodynamics

Research and Teaching Output of the MIT Community

Show simple item record

dc.contributor.author Lee, Lai Yeng
dc.contributor.author Smith, Kenneth A.
dc.contributor.author Wang, Chi-Hwa
dc.date.accessioned 2005-12-16T14:51:09Z
dc.date.available 2005-12-16T14:51:09Z
dc.date.issued 2006-01
dc.identifier.uri http://hdl.handle.net/1721.1/30387
dc.description.abstract This paper presents the fabrication of controlled release devices for anticancer drug paclitaxel using supercritical antisolvent method. The thermodynamic and hydrodynamic effects during supercritical antisolvent process on the particle properties obtained were investigated. Scanning electron microscopy was employed to study particle sizes and morphologies achieved. It was observed that increasing supercritical pressure improves the surface morphology of particles obtained, and increasing the flow rate of the organic solution jet reduces the particle sizes obtained. A modified Supercritical Antisolvent with Enhanced Mass transfer setup was developed to produce monodispersed nanoparticles with high recovery yield. High performance liquid chromatography was used to determine the encapsulation efficiency and in vitro release profiles of paclitaxel loaded particles obtained. The encapsulation efficiencies of particles obtained using the modified SASEM process were high and up to 83.5%, and sustained release of paclitaxel from the polymer matrix was observed over 36 days release. The thermogram properties of the particles were also analyzed using differential scanning calorimetry to determine the crystalline state of polymer and drug. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 597919 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Molecular Engineering of Biological and Chemical Systems (MEBCS) en
dc.subject Supercritical antisolvent en
dc.subject controlled release devices en
dc.subject paclitaxel en
dc.subject Poly L lactide en
dc.subject ultrasonication en
dc.title Fabrication of Micro and Nanoparticles of Paclitaxel-loaded Poly L Lactide for Controlled Release using Supercritical Antisolvent Method: Effects of Thermodynamics and Hydrodynamics en
dc.type Article en


Files in this item

Name Size Format Description
MEBCS009.pdf 583.9Kb PDF

This item appears in the following Collection(s)

Show simple item record

MIT-Mirage