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Synthesis and Self-assembly of [60]Fullerene Containing Sulfobetaine Polymer in Aqueous Solution

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dc.contributor.author Ravi, P.
dc.contributor.author Dai, S.
dc.contributor.author Tam, K. C.
dc.date.accessioned 2005-12-16T15:04:22Z
dc.date.available 2005-12-16T15:04:22Z
dc.date.issued 2006-01
dc.identifier.uri http://hdl.handle.net/1721.1/30393
dc.description.abstract A series of well-defined stimuli responsive water soluble [60]fullerene (C₆₀) containing polymers such as polyelectrolytes (polyacids and polybases), polyampholyte and polyzwitterionic polymers were synthesized using atom transfer radical polymerization. The aqueous solution properties of these polymers with respective external stimuli such as pH, temperature and salt were studied using potentiometric and conductivity titration, light transmittance, laser light scattering and transmission electron microscopic techniques. The influence of polymer concentration, temperature, pH and electrolyte on the hydrodynamic radius (Rh), radius of gyration (Rg) and aggregation number (Nagg) of the particles were investigated in detail to elucidate the morphology of the particles. The morphology of the aggregates was further confirmed by the TEM micrographs. The cytotoxicity of the pH responsive C₆₀ containing well-defined polymers (PAA-b-C₆₀, C₆₀-b-PAA-b-C₆₀ and PEO-b-PAA-b-C₆₀) was studied to confirm the suitability of these particles as potential drug delivery vehicles. The binding interaction between the anti-cancer drug (doxorubicin) and C₆₀ containing pH responsive polymers was studied using isothermal titration calorimetry, and the implication of the results will be discussed. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 296315 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Molecular Engineering of Biological and Chemical Systems (MEBCS) en
dc.subject ATRP en
dc.subject Fullerene en
dc.subject stimuli-responsive en
dc.subject UCST en
dc.title Synthesis and Self-assembly of [60]Fullerene Containing Sulfobetaine Polymer in Aqueous Solution en
dc.type Article en


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