Lamination of a biodegradable polymeric microchip
Citable URI:
http://hdl.handle.net/1721.1/35137
| Title: | Lamination of a biodegradable polymeric microchip |
| Author: | Kim, Jina, 1984- |
| Other Contributors: | Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. |
| Advisor: | Michael J. Cima. |
| Department: | Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. |
| Publisher: | Massachusetts Institute of Technology |
| Issue Date: | 2006 |
| Abstract: | This work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that are fabricated via lamination, and a final design was proposed based on the results. Design 1 sought to replace the sealant directly with a PLA backing layer, but the laminated backing layer was found to leak in 14C-dextran release experiments. Design 2 used a laminated film instead of the original injected membrane. The laminated film was optimized to a 200- [mu]m thick poly(D,L-lactic-co-glycolic acid) 2A membrane, and the film-laminated microchip was shown to release 14C-dextran within a 40-day period. The final proposed design was based on Design 2, which demonstrated more potential as a future means of drug delivery. |
| Description: |
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. Includes bibliographical references (leaf 22). |
| URI: | http://hdl.handle.net/1721.1/35137 |
| Keywords: | Materials Science and Engineering. |
Files in this item
| Files | Size | Format |
|---|---|---|
| Preview, non-printable (open to all) | 1.010Mb | application/pdf |
| Full printable version (MIT only) | 1.008Mb | application/pdf |
This item appears in the following Collection(s)
All Items in DSpace@MIT are protected by original copyright, with all rights reserved, unless otherwise indicated.
|
|
Contact
MIT Libraries
|