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The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price

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dc.contributor.advisor Frank Douglas. en_US
dc.contributor.author Subramaniam, Sundar en_US
dc.contributor.other Sloan School of Management. en_US
dc.date.accessioned 2007-01-10T16:37:53Z
dc.date.available 2007-01-10T16:37:53Z
dc.date.copyright 2006 en_US
dc.date.issued 2006 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/35555
dc.description Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology; and, (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2006. en_US
dc.description Includes bibliographical references (leaves 47-48). en_US
dc.description.abstract For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and tuberculosis, combination therapies are now the standard of care. With the emergence of drug-device combinations, genetic testing, and individualized medicine, this trend towards combination therapies is likely to continue to grow. In this context the pricing of combination therapies is a critical component that needs to be understood by medical practitioners, payors and policy makers. There are three factors to consider in the pricing of combination therapies: the characteristics and structure of the market in which the combined product is sold, the absence or presence of market exclusivity, and the prices of the components of the combined product, when sold individually. When one or more of the components of the combined product has market exclusivity, additional factors such as exclusionary bundling, tying, and double marginalization may come into play. en_US
dc.description.abstract (cont.) In this thesis I discuss combination therapies, describe the factors that can affect the pricing of combination therapies, and then attempt to identify the relationships among component pricing, market forces, market exclusivity and the pricing of combination therapies. To illustrate these relationships empirically, I will analyze data from a sample of unified combined drugs, a subset of combination therapies. The results of this analysis are consistent with a hypothesis that, for combination drugs with a patented ingredient, the elimination of double marginalization by efficient transfer pricing and economic and exclusionary bundling, lowers the price of the unified combination drug relative to the price of its constituents. en_US
dc.description.statementofresponsibility b y Sundar Subramaniam. en_US
dc.format.extent 48 leaves en_US
dc.format.extent 2474316 bytes
dc.format.extent 2474664 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582
dc.subject Harvard University--MIT Division of Health Sciences and Technology. en_US
dc.subject Sloan School of Management. en_US
dc.title The pharmaco-economics of combination therapies : a study of the effects of component and market factors on combined therapy price en_US
dc.type Thesis en_US
dc.description.degree M.B.A. en_US
dc.description.degree S.M. en_US
dc.contributor.department Harvard University--MIT Division of Health Sciences and Technology. en_US
dc.contributor.department Sloan School of Management. en_US
dc.identifier.oclc 73806146 en_US


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