Advanced Search
DSpace@MIT

Characterizing Protein Conformation Space

Research and Teaching Output of the MIT Community

Show simple item record

dc.contributor.author Nigham, Anshul
dc.contributor.author Hsu, David
dc.contributor.author Latombe, Jean-Claude
dc.date.accessioned 2007-01-23T19:20:19Z
dc.date.available 2007-01-23T19:20:19Z
dc.date.issued 2007-01
dc.identifier.uri http://hdl.handle.net/1721.1/35776
dc.description.abstract In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in self-collision. Unlike energy based methods, this approach allows efficient exploration and remains general -- the benefits of characterization of the space apply to all proteins. We hypothesize that this conformation space branches into many small funnels as we sample compact conformations. We develop a compact representation the conformation space, and give experimental results that support our hypothesis. Potential applications of our method include protein folding as well as observing structural relationships between proteins. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 844455 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Computer Science (CS) en
dc.subject Protein Structure en
dc.subject Protein Conformation Space en
dc.subject Protein Folding en
dc.title Characterizing Protein Conformation Space en
dc.type Article en


Files in this item

Name Size Format Description
CS002.pdf 824.6Kb PDF

This item appears in the following Collection(s)

Show simple item record

MIT-Mirage