Characterizing Protein Conformation Space
| dc.contributor.author | Nigham, Anshul | |
| dc.contributor.author | Hsu, David | |
| dc.contributor.author | Latombe, Jean-Claude | |
| dc.date.accessioned | 2007-01-23T19:20:19Z | |
| dc.date.available | 2007-01-23T19:20:19Z | |
| dc.date.issued | 2007-01 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/35776 | |
| dc.description.abstract | In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in self-collision. Unlike energy based methods, this approach allows efficient exploration and remains general -- the benefits of characterization of the space apply to all proteins. We hypothesize that this conformation space branches into many small funnels as we sample compact conformations. We develop a compact representation the conformation space, and give experimental results that support our hypothesis. Potential applications of our method include protein folding as well as observing structural relationships between proteins. | en |
| dc.description.provenance | Submitted by Matthew Mahoney (mahoney1@mit.edu) on 2007-01-22T16:59:14Z No. of bitstreams: 1 CS002.pdf: 844455 bytes, checksum: 002ac17e3c1b96cd90caab2f9d7b1b1a (MD5) | en |
| dc.description.provenance | Approved for entry into archive by Robert Wolfe(rwolfe@mit.edu) on 2007-01-23T19:20:18Z (GMT) No. of bitstreams: 1 CS002.pdf: 844455 bytes, checksum: 002ac17e3c1b96cd90caab2f9d7b1b1a (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2007-01-23T19:20:19Z (GMT). No. of bitstreams: 1 CS002.pdf: 844455 bytes, checksum: 002ac17e3c1b96cd90caab2f9d7b1b1a (MD5) Previous issue date: 2007-01 | en |
| dc.description.sponsorship | Singapore-MIT Alliance (SMA) | en |
| dc.format.extent | 844455 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Computer Science (CS) | en |
| dc.subject | Protein Structure | en |
| dc.subject | Protein Conformation Space | en |
| dc.subject | Protein Folding | en |
| dc.title | Characterizing Protein Conformation Space | en |
| dc.type | Article | en |
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| Files | Size | Format |
|---|---|---|
| CS002.pdf | 844.4Kb | application/pdf |
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