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Characterizing Protein Conformation Space

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Show simple item record Nigham, Anshul Hsu, David Latombe, Jean-Claude 2007-01-23T19:20:19Z 2007-01-23T19:20:19Z 2007-01
dc.description.abstract In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in self-collision. Unlike energy based methods, this approach allows efficient exploration and remains general -- the benefits of characterization of the space apply to all proteins. We hypothesize that this conformation space branches into many small funnels as we sample compact conformations. We develop a compact representation the conformation space, and give experimental results that support our hypothesis. Potential applications of our method include protein folding as well as observing structural relationships between proteins. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 844455 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Computer Science (CS) en
dc.subject Protein Structure en
dc.subject Protein Conformation Space en
dc.subject Protein Folding en
dc.title Characterizing Protein Conformation Space en
dc.type Article en

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