| dc.contributor.author |
Tian, Y. |
|
| dc.contributor.author |
Tam, Michael K. C. |
|
| dc.contributor.author |
Hatton, T. Alan |
|
| dc.contributor.author |
Bromberg, Lev |
|
| dc.date.accessioned |
2007-02-06 |
|
| dc.date.available |
2007-02-06 |
|
| dc.date.issued |
2007-01 |
|
| dc.identifier.uri |
http://hdl.handle.net/1721.1/35873 |
|
| dc.description.abstract |
Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). The P85PAA-DOX complex formation and drug loading were strongly dependent on the PAA segment and pH, where the protonation of the carboxyl groups in the PAA segment at pH<7.2 reduced the binding sites of DOX onto P85PAA chains, resulting less DOX uptake at low pH. The composition of the copolymer-DOX complexes that at pH 7.2 was close to the stoichiometric (1:1 mol Dox:carboxyl ratio), indicating the dominance of the electrostatic interactions between cationic DOX molecules and carboxyl groups. DOX loading at pH 5.0 reduced to 0.6:1 molar ratio of DOX:carboxyl indicated that protonation of the carboxyl reduced the DOX binding to the P85PAA block copolymer. DOX release from the complex is highly pH-responsive process, where 57% of encapsulated DOX was released in 30h at pH7.2, and the cumulative release fraction was accelerated to 95% by decreasing the pH to 5.0. Thus, complexation of DOX with P85PAA yielded a drug delivery system affording a pH-triggered release of DOX in acidic environment pH5.0. |
en |
| dc.description.provenance |
Submitted by Matthew Mahoney (mahoney1@mit.edu) on 2007-02-01T16:27:42Z
No. of bitstreams: 1
CPE011.pdf: 10958 bytes, checksum: 440ffb19bbe14b00d6f3f99ae3aa52e1 (MD5) |
en |
| dc.description.provenance |
Approved for entry into archive by Robert Wolfe(rwolfe@mit.edu) on 2007-02-06 (GMT) No. of bitstreams: 1
CPE011.pdf: 10958 bytes, checksum: 440ffb19bbe14b00d6f3f99ae3aa52e1 (MD5) |
en |
| dc.description.provenance |
Made available in DSpace on 2007-02-06 (GMT). No. of bitstreams: 1
CPE011.pdf: 10958 bytes, checksum: 440ffb19bbe14b00d6f3f99ae3aa52e1 (MD5)
Previous issue date: 2007-01 |
en |
| dc.description.sponsorship |
Singapore-MIT Alliance (SMA) |
en |
| dc.language.iso |
en |
en |
| dc.relation.ispartofseries |
Chemical and Pharmaceutical Engineering (CPE) |
en |
| dc.subject |
Doxorubicin |
en |
| dc.subject |
Atom Transfer Radical Polymerization |
en |
| dc.subject |
Pluronic P85 |
en |
| dc.title |
Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
en |
| dc.type |
Article |
en |
