Advanced Search
DSpace@MIT

Micro-porous Paclitaxel-Loaded PLGA Foams -- a New Implant Material for Controlled Release of Chemotherapeutic Agents

Research and Teaching Output of the MIT Community

Show simple item record

dc.contributor.author Lee, Lai Yeng
dc.contributor.author Wang, Chi Hwa
dc.contributor.author Smith, Kenneth A.
dc.date.accessioned 2007-02-06T12:00:00Z en_US
dc.date.available 2007-02-06T12:00:00Z en_US
dc.date.issued 2007-01
dc.identifier.uri http://hdl.handle.net/1721.1/35874
dc.description.abstract Supercritical gas foaming using CO₂ was used to fabricate blank poly DL lactide-co-glycolide (PLGA) micro-porous foams. Paclitaxel-loaded PLGA foams were also produced for the first time using a modification of the supercritical gas foaming technique whereby pacltitaxel-loaded PLGA microparticle powders obtained from spray drying was foamed. In this study, it was found that using polymer powders, more compact foams and smaller pores foams may be achieved with lower saturation pressures and time which is due to the much higher surface area to volume ratio of the microparticle powders. Experiments were carried out with varying lactide to glycolide ratio of the copolymer PLGA and it was shown that the pore size, in vitro swelling behavior and drug release profiles may be altered by changing the copolymer composition used. The foams fabricated also have good mechanical strength which makes it suitable to be applied as an implantation material for the post-surgical controlled delivery of chemotherapeutic drugs. The residual organic solvent content of the paclitaxel-foams were well below the allowable limit set by the US Pharmacopeia as shown in the present study. The in vitro release profiles over a period of 5 weeks showed close to linear release. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.language.iso en en
dc.relation.ispartofseries Chemical and Pharmaceutical Engineering (CPE) en
dc.subject Supercritical Gas Foaming Technique en
dc.subject Poly DL Lactide-Co-Glycolide (PLGA) en
dc.subject Micro-porous Foams en
dc.subject Controlled Release en
dc.subject Paclitaxel en
dc.title Micro-porous Paclitaxel-Loaded PLGA Foams -- a New Implant Material for Controlled Release of Chemotherapeutic Agents en
dc.type Article en


Files in this item

Name Size Format Description
CPE004.pdf 496.6Kb PDF

This item appears in the following Collection(s)

Show simple item record

MIT-Mirage