| dc.contributor.author |
Sinaga, Akasta |
|
| dc.contributor.author |
Ravi, P. |
|
| dc.contributor.author |
Hatton, T. Alan |
|
| dc.contributor.author |
Tam, Michael K. C. |
|
| dc.date.accessioned |
2007-02-06T01:00:46Z |
|
| dc.date.available |
2007-02-06T01:00:46Z |
|
| dc.date.issued |
2007-01 |
|
| dc.identifier.uri |
http://hdl.handle.net/1721.1/35877 |
|
| dc.description.abstract |
The talk will present the synthesis and characterization of a new class of hybrid amphiphilic system between an electrolyte polyacrylic acid (PAA) synthetic segment, and a hydrophobic beta-sheet forming peptide segment, poly(L-valine) (PLVAL). The synthesis of monodispersed copolymers (Mw/Mn < 1.3) was achieved through a combination of atom transfer radical polymerization, click chemistry, and nickel-catalyzed ring opening of N-carboxy anhydrides. The click chemistry is demonstrated to be an excellent method for the intermediate -amino functionalization step to afford macroinitiators that are free from deactivating or interfering molecules with degree of functionality about 90%. Light scattering and circular dichroism characterization of PAAx-block-PLVALy (x-y of 80-100, 80-80, 80-60, and 40-100) show a correlation of the formation of spherical core-shell micelles to the ability of the peptide segment to form ordered beta-sheet structures. Generally, the beta sheet formation is stabilized by a low pH condition (low charge on PAA), higher Val/PAA ratio (less interference from PAA-Val hydrogen bondings), and degree of core shielding by PAA in the presence of disrupting agents, e.g. urea. At higher pH, the beta-sheet structure was also found to counteract the charge repulsions of PAA units, which allows the micelles to retain their overall size and shape. |
en |
| dc.description.provenance |
Submitted by Matthew Mahoney (mahoney1@mit.edu) on 2007-02-01T17:35:09Z
No. of bitstreams: 1
CPE012.pdf: 22426 bytes, checksum: 6d7ec5260d5166921dc8ced975c027d2 (MD5) |
en |
| dc.description.provenance |
Approved for entry into archive by Robert Wolfe(rwolfe@mit.edu) on 2007-02-06T01:00:45Z (GMT) No. of bitstreams: 1
CPE012.pdf: 22426 bytes, checksum: 6d7ec5260d5166921dc8ced975c027d2 (MD5) |
en |
| dc.description.provenance |
Made available in DSpace on 2007-02-06T01:00:46Z (GMT). No. of bitstreams: 1
CPE012.pdf: 22426 bytes, checksum: 6d7ec5260d5166921dc8ced975c027d2 (MD5)
Previous issue date: 2007-01 |
en |
| dc.description.sponsorship |
Singapore-MIT Alliance (SMA) |
en |
| dc.language.iso |
en |
en |
| dc.relation.ispartofseries |
Chemical and Pharmaceutical Engineering (CPE) |
en |
| dc.subject |
Peptide Hybrid Block Copolymers |
en |
| dc.subject |
Atom Transfer Radical Polymerization (ATRP) |
en |
| dc.subject |
Ring Opening Polymerization |
en |
| dc.subject |
Self-Assembly |
en |
| dc.title |
Synthesis and Self-Assembly Behavior of Poly(acrylic Acid)-b-Poly(l-Amino Acid) System |
en |
| dc.type |
Article |
en |
