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Inhibition of Hsp90 in Streptomyces coelicolor

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dc.contributor.advisor Sarah E. O'Connor. en_US Wu, Katherine A. (Katherine Ann) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Chemistry. en_US 2007-02-21T13:20:56Z 2007-02-21T13:20:56Z 2005 en_US 2005 en_US
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005. en_US
dc.description Includes bibliographical references (leaves 20-21). en_US
dc.description.abstract Inhibition of the chaperone protein Hsp90 in plants and insects has been found to result in drastic changes in phenotype. We investigated the effect of Hsp90 inhibition on the bacteria Streptomyces coelicolor. These changes were studied by growing S. coelicolor in the presence of Hsp90 inhibitors, extracting the growth media, and subjecting the extractions to HPLC and MS analysis. It has been found that reproducibility is difficult to achieve. Since the genome of S. coelicolor has been sequenced, attention was turned to studying changes in mRNA expression levels, which gave more reproducible results, as well as insight to the specific genes being affected. en_US
dc.description.statementofresponsibility by Katherine A. Wu. en_US
dc.format.extent 21 leaves en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Chemistry. en_US
dc.title Inhibition of Hsp90 in Streptomyces coelicolor en_US
dc.title.alternative Inhibition of Hsp90 in S. coelicolor en_US
dc.type Thesis en_US S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Chemistry. en_US
dc.identifier.oclc 77529661 en_US

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