Search
Now showing items 1-3 of 3
Stabilization of Therapeutic Proteins
(2003-01)
We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation ...
Stabilization of Proteins against Aggregation
(2004-01)
Proteins degrade in vitro by a variety of routes, the most common of which is aggregation. In order to develop protein formulations that will limit aggregation, researchers use heuristic, experimental screening procedures. ...
Molecular Computations for the Stabilization of Therapeutic Proteins
(2004-01)
Molecular computations based on quantum mechanics and statistical mechanics have been applied to the understanding and quantification of processes leading to the degradation of therapeutic proteins. In particular, we focus ...