dc.contributor.author | Seong, Jiehyun | |
dc.contributor.author | Lee, Seok-Won | |
dc.contributor.author | Jun, Shinae | |
dc.contributor.author | Choi, Hyun-Goo | |
dc.contributor.author | Laibinis, Paul E. | |
dc.date.accessioned | 2003-12-08T16:02:44Z | |
dc.date.available | 2003-12-08T16:02:44Z | |
dc.date.issued | 2003-01 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/3791 | |
dc.description.abstract | We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. | en |
dc.description.sponsorship | Singapore-MIT Alliance (SMA) | en |
dc.format.extent | 444006 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.relation.ispartofseries | Molecular Engineering of Biological and Chemical Systems (MEBCS); | |
dc.subject | polymer coatings | en |
dc.subject | protein adsorption | en |
dc.subject | surface modification | en |
dc.subject | thin films | en |
dc.title | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces | en |
dc.type | Article | en |