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Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces

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Show simple item record Seong, Jiehyun Lee, Seok-Won Jun, Shinae Choi, Hyun-Goo Laibinis, Paul E. 2003-12-08T16:02:44Z 2003-12-08T16:02:44Z 2003-01
dc.description.abstract We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 444006 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries Molecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subject polymer coatings en
dc.subject protein adsorption en
dc.subject surface modification en
dc.subject thin films en
dc.title Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces en
dc.type Article en

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