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dc.contributor.authorBromberg, Lev
dc.contributor.authorHatton, T. Alan
dc.date.accessioned2003-12-08T16:12:32Z
dc.date.available2003-12-08T16:12:32Z
dc.date.issued2003-01
dc.identifier.urihttp://hdl.handle.net/1721.1/3792
dc.description.abstractStudies of submillimeter gels composed of covalently cross-linked poly(acrylic acid)-g-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic-PAA) networks are reviewed in light of potential applications of the microgels as drug carriers in oral delivery. The microgels are capable of volumetric transitions in response to environmental stimulae such as pH and temperature. It is shown that the type of Pluronic used in the microgel synthesis changes the structure of the resulting microgels, with the more hydrophobic Pluronic imparting porosity. Microgels based on Pluronic L92 (L92-PAA-EGDMA) possess higher ion-exchange capacity than microgels based on Pluronic F127 (F127-PAA-EGDMA), albeit the former are more hydrophobic. Analogously, more hydrophobic but heterogeneous L92-PAA-EGDMA exhibit superior capacity for equilibrium loading of hydrophobic drugs such as taxol, camptothecin and steroid hormones, as well as higher capacity for weakly basic drugs such as doxorubicin, mitomycin C, and mitoxantrone.en
dc.description.sponsorshipSingapore-MIT Alliance (SMA)en
dc.format.extent1243665 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.relation.ispartofseriesMolecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subjectanticancer drugsen
dc.subjecthydrophobic solutesen
dc.subjectoral drug deliveryen
dc.subjectsmart microgelsen
dc.titleSmart Microgel Studies. Interaction of Polyether-Modified Poly(Acrylic Acid) Microgels with Anticancer Drugsen
dc.typeArticleen


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