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Neural prosthetics for paralysis : algorithms and low-power analog architectures for decoding neural signals

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dc.contributor.advisor Rahul Sarpeshkar. en_US Rapoport, Benjamin Isaac en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Physics. en_US 2007-10-22T17:31:11Z 2007-10-22T17:31:11Z 2007 en_US 2007 en_US
dc.description Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Physics, 2007. en_US
dc.description Includes bibliographical references (leaves 119-122). en_US
dc.description.abstract This thesis develops a system for adaptively and automatically learning to interpret patterns of electrical activity in neuronal populations in a real-time, on-line fashion. The system is primarily intended to enable the long-term implantation of low-power, microchip-based recording and decoding hardware in the brains of human patients in order to treat neurologic disorders. The decoding system developed in the present work interprets neural signals from the parietal cortex encoding arm movement intention, suggesting that the system could function as the decoder in a neural prosthetic limb, potentially enabling a paralyzed person to control an artificial limb just as the natural one was controlled, through thought alone. The same decoder is also used to interpret the activity of a population of thalami neurons encoding head orientation in absolute space. The success of the decoder in that context motivates the development of a model of generalized place cells to explain how networks of neurons adapt the configurations of their receptive fields in response to new stimuli, learn to encode the structure of new parameter spaces, and ultimately retrace trajectories through such spaces in the absence of the original stimuli. en_US
dc.description.abstract (cont.) Qualitative results of this model are shown to agree with experimental observations. This combination of results suggests that the neural signal decoder is applicable to a broad scope of neural systems, and that a microchip-based implementation of the decoder based on the designs presented in this thesis could function as a useful investigational tool for experimental neuroscience and potentially as an implantable interpreter of simple thoughts and dreams. en_US
dc.description.statementofresponsibility by Benjamin Isaac Rapoport. en_US
dc.format.extent 122 leaves en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.subject Physics. en_US
dc.title Neural prosthetics for paralysis : algorithms and low-power analog architectures for decoding neural signals en_US
dc.type Thesis en_US S.M. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Physics. en_US
dc.identifier.oclc 172997874 en_US

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