Nanoparticles for Targeted Drug Delivery

dc.contributor.author	Chow, Gan-Moog
dc.date.accessioned	2003-12-16T14:00:17Z
dc.date.available	2003-12-16T14:00:17Z
dc.date.issued	2004-01
dc.identifier.uri	http://hdl.handle.net/1721.1/3936
dc.description.abstract	Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) was subsequently adsorbed onto the Au-Au<sub>2</sub>S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au<sub>2</sub>S nanoparticles was controlled by the pH value of solution, and the rate of drug release was sensitive to NIR irradiation. The results of the synthesis, drug-release properties and nanoparticle-cell interactions will be discussed.	en
dc.description.sponsorship	Singapore-MIT Alliance (SMA)	en
dc.format.extent	12186 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en_US
dc.relation.ispartofseries	Molecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subject	nanoparticles	en
dc.subject	targeted drug delivery	en
dc.subject	near infrared sensitive Au-Au<sub>2</sub>S nanoparticles	en
dc.subject	anti-cancer drugs	en
dc.subject	NIR irradiation	en
dc.subject	adsorption of cis-platin	en
dc.title	Nanoparticles for Targeted Drug Delivery	en
dc.type	Article	en