Assessment of in vitro engineered microvascular networks and their application in the treatment of chronic wounds

Abstract

As the number of individuals suffering from tissue loss and end-stage organ failure continues to grow, researchers are turning to tissue engineering to provide better methods of treatment. The field, however, still faces many technical challenges that are limiting its applications. One challenge faced in engineering more complex tissues and organs is the need for inherent microvasculature to supply the tissue with nutrients and oxygen. Researchers at The Charles Stark Draper Laboratory have developed a method for engineering microvascular networks in vitro using various microfabrication techniques. This paper discusses the current state of the research and technical challenges to overcome before commercializing the technology. The feasibility of using the networks in the nearer term application of treating chronic wounds will also be assessed, and a potential business strategy will be laid out.