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7.341 DNA Damage Checkpoints: The Emergency Brake on the Road to Cancer, Fall 2007

Research and Teaching Output of the MIT Community

Show simple item record Reinhardt, Hans Christian van Vugt, Marcel A.
dc.coverage.temporal Fall 2007 2009-10-08T04:30:00Z 2009-10-08T04:30:00Z 2007-12
dc.identifier 7.341-Fall2007
dc.identifier.other 7.341
dc.identifier.other IMSCP-MD5-8b8dc7b46d544262998267fddace3a18
dc.description.abstract The DNA contained in human cells is under constant attack by both exogenous and endogenous agents that can damage one of its three billion base pairs. To cope with this permanent exposure to DNA-damaging agents, such as the sun's radiation or by-products of our normal metabolism, powerful DNA damage checkpoints have evolved that allow organisms to survive this constant assault on their genomes. In this class we will analyze classical and recent papers from the primary research literature to gain a profound understanding of checkpoints that act as powerful emergency brakes to prevent cancer. We will consider basic principles of cell proliferation and molecular details of the DNA damage response. We will discuss the methods and model organisms typically used in this field as well as how an understanding of checkpoint mechanisms translates into the development of treatments for human cancer. This course will not stop at discussing literature. We will take it one step further and analyze real data in an MIT Biology laboratory. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. en
dc.language.iso en-US
dc.rights This site (c) Massachusetts Institute of Technology 2003. Content within individual courses is (c) by the individual authors unless otherwise noted. The Massachusetts Institute of Technology is providing this Work (as defined below) under the terms of this Creative Commons public license ("CCPL" or "license"). The Work is protected by copyright and/or other applicable law. Any use of the work other than as authorized under this license is prohibited. By exercising any of the rights to the Work provided here, You (as defined below) accept and agree to be bound by the terms of this license. The Licensor, the Massachusetts Institute of Technology, grants You the rights contained here in consideration of Your acceptance of such terms and conditions. en
dc.subject DNA en
dc.subject damage checkpoints en
dc.subject cancer en
dc.subject cells en
dc.subject human cells en
dc.subject exogenous en
dc.subject endogenous en
dc.subject checkpoints en
dc.subject gene en
dc.subject signaling en
dc.subject cancer biology en
dc.subject cancer prevention en
dc.subject primary sources en
dc.subject discussion en
dc.subject DNA damage en
dc.subject molecular en
dc.subject enzyme en
dc.subject cell cycle en
dc.subject extracellular cues en
dc.subject growth factors en
dc.subject Cdk regulation en
dc.subject cyclin-dependent kinase en
dc.subject p53 en
dc.subject tumor suppressor en
dc.subject apoptosis en
dc.subject signaling en
dc.subject MDC1 en
dc.subject H2AX en
dc.subject Rad50 en
dc.subject Fluorescence activated cell sorter en
dc.subject Chk1 en
dc.subject mutant en
dc.title 7.341 DNA Damage Checkpoints: The Emergency Brake on the Road to Cancer, Fall 2007 en
dc.title.alternative DNA Damage Checkpoints: The Emergency Brake on the Road to Cancer en
dc.audience.educationlevel Undergraduate
dc.subject.cip 260911 en
dc.subject.cip Oncology and Cancer Biology en

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