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Browsing MIT Open Access Articles by Title

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  • Marsili, Francesco; Najafi, Faraz; Korre, Hasan; Anant, Vikas; Berggren, Karl K.; Dauler, Eric A.; Sunter, Kristen A. (Optical Society of America, 2012-05)
    We propose a design for cavity-integrated Superconducting Nanowire Single-Photon Detectors based on 20-nm-wide 10-nm-thick nanowires. Our simulations show that these detectors can potentially reach ~90% device detection ...
  • Jiang, Bing; Chen, Yang; Wang, Junzhi; Su, Yang; Zhou, Xin; Safi-Harb, Samar; DeLaney, Tracey (Institute of Physics/American Astronomical Society, 2010-04)
    3C 397 is a radio and X-ray bright Galactic supernova remnant (SNR) with an unusual rectangular morphology. Our CO observation obtained with the Purple Mountain Observatory at Delingha, Qinghai Province, China reveals that ...
  • Schuster, D. I.; Bishop, Lev S.; Chuang, Isaac L.; DeMille, David; Schoelkopf, Robert J. (American Physical Society, 2011-01)
    We propose a class of experiments using rotational states of dipolar molecular ions trapped near an on-chip superconducting microwave cavity. Molecular ions have several advantages over neutral molecules for such cavity ...
  • Vuletic, Vladan; Labaziewicz, Jaroslaw; Chuang, Isaac L.; Leibrandt, David Ray (American Physical Society, 2009-08)
    We report a demonstration and quantitative characterization of one-dimensional cavity cooling of a single trapped [superscript 88]Sr[superscript +] ion in the resolved-sideband regime. We measure the spectrum of cavity ...
  • Friedman, Beth; Ardon Dryer, Karin; Kroll, Jesse; Thornton, Joel; Carrasquillo, Anthony Joseph; Daumit, Kelly Elizabeth; Boulanger, Kelsey Jane; Cross, Eben Spencer; Browne, Eleanor C.; Cziczo, Daniel James (American Institute of Physics (AIP), 2013-05)
    Cloud condensation nuclei, aerosol chemical composition, and aerosol size measurements were determined at a field site subject to a variety of aerosol sources. A pumped counterflow virtual impactor was utilized to directly ...
  • Jacobson, Heather R.; Frebel, Anna L. (IOP Publishing, 2015-07)
    With [Fe/H] ~ −3.3, CD −24°17504 is a canonical metal-poor main-sequence turn-off star. Though it has appeared in numerous literature studies, the most comprehensive abundance analysis for the star based on high-resolution, ...
  • Yong, Ching-Shya; Ou Yang, Chih-Ming; Chou, Yenn-Hwei; Liao, Chao-Sheng; Lee, Chung-Wei; Lee, Chin-Cheng (BioMed Central Ltd, 2012-07)
    Background: To correlate CD44/CD24 expression with gastric cancer recurrence and prognosis. Gastric cancer is the second leading cause of cancer mortality due to the high recurrence rate, of which the molecular signature ...
  • Bynoe, Margaret S.; Waickman, Adam T.; Mahamed, Deeqa A.; Mueller, Cynthia; Mills, Jeffrey H.; Czopik, Agnieszka (Hindawi Publishing Corporation, 2012-07)
    CD73 is a glycosyl-phosphatidylinositol-(GPI-) linked membrane protein that catalyzes the extracellular dephosphorylation of adenosine monophosphate (AMP) to adenosine. Adenosine is a negative regulator of inflammation and ...
  • Bak, S. Peter G.; Barnkob, Mike Stein; Wittrup, Karl Dane; Chen, Jianzhu (American Association for Cancer Research, 2013-09)
    Stimulation of patients' immune systems for the treatment of solid tumors is an emerging therapeutic paradigm. The use of enriched autologous T cells for adoptive cell therapy or vaccination with antigen-loaded dendritic ...
  • Sehrawat, Sharvan; Kirak, Oktay; Koenig, Paul-Albert; Isaacson, Marisa K.; Marques, Sofia; Bozkurt, Gunes; Simas, J. Pedro; Jaenisch, Rudolf; Ploegh, Hidde (Elsevier, 2012-04)
    To study the CD8[superscript +] T cell response against a mouse γ-herpes virus, we generated K[superscript b]-MHV-68-ORF8[superscript 604–612]RAG[superscript −/−] CD8[superscript +] T cell receptor transnuclear (TN) mice ...
  • Mashayekhi, Mona; Sandau, Michelle M.; Dunay, Ildiko R.; Frickel, Eva M.; Khan, Asis; Goldszmid, Romina S.; Sher, Alan; Murphy, Theresa L.; Sibley, L. David; Murphy, Kenneth M.; Ploegh, Hidde (Elsevier/Cell Press, 2011-08)
    CD8α[superscript +] dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by CD8α[superscript +] ...
  • Rock, Jeremy Michael; Amon, Angelika B. (Cold Spring Harbor Laboratory Press, 2011-02)
    In budding yeast, a Ras-like GTPase signaling cascade known as the mitotic exit network (MEN) promotes exit from mitosis. To ensure the accurate execution of mitosis, MEN activity is coordinated with other cellular events ...
  • Calvo, Fernando; Ranftl, Romana; Hooper, Steven; Farrugia, Aaron J.; Moeendarbary, Emad; Bruckbauer, Andreas; Batista, Facundo; Charras, Guillaume; Sahai, Erik (Elsevier, 2015-12)
    Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the ...
  • Maia, Ana R. R.; Garcia, Zaira; Kabeche, Lilian; Barisic, Marin; Maffini, Stefano; Macedo-Ribeiro, Sandra; Cheeseman, Iain McPherson; Compton, Duane A.; Kaverina, Irina; Maiato, Helder (Rockefeller University Press, 2012-03)
    Accurate chromosome segregation during mitosis relies on a dynamic kinetochore (KT)–microtubule (MT) interface that switches from a labile to a stable condition in response to correct MT attachments. This transition is ...
  • Zhang, Lei; Zhu, J. Julius; Clauser, Karl R.; Carr, Steven A.; Guan, Ji-Song; Su, Susan Chih-Chieh; Gao, Jun; Joseph, Nadine; Xie, Zhigang; Zhou, Ying; Durak, Omer; Tsai, Li-Huei (Public Library of Science, 2011-09)
    Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory ...
  • Buchman, Joshua J.; Tseng, Huan-Chung; Zhou, Ying; Frank, Christopher Lee; Xie, Zhigang; Tsai, Li-Huei (Elsevier B.V., 2010-05)
    Primary autosomal-recessive microcephaly (MCPH) and Majewski osteodysplastic primordial dwarfism type II (MOPDII) are both genetic diseases that result in decreased brain size at birth. MCPH is thought to arise from ...
  • Cheeseman, Iain McPherson; Gascoigne, Karen E. (Rockefeller University Press, The, 2013-03)
    Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory ...
  • Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Zon, Leonard I.; Gifford, David K. (Elsevier, 2013-11)
    Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight ...
  • Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.; Ploegh, Hidde (Nature Publishing Group, 2014-10)
    T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and ...
  • Doyle, Patrick S.; Hsiao, Lilian (Royal Society of Chemistry, 2015-09)
    We report the coexistence of stress-bearing percolation with arrested phase separation in a colloidal system of thermoresponsive nanoemulsions spanning a broad range of volume fractions (0.10 ≤ ϕ ≤ 0.33) and temperatures ...
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