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Browsing MIT Open Access Articles by Title

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  • Feingold, Joseph; Gibson, Daniel J.; DePasquale, Brian; Graybiel, Ann M. (National Academy of Sciences (U.S.), 2015-11)
    Studies of neural oscillations in the beta band (13–30 Hz) have demonstrated modulations in beta-band power associated with sensory and motor events on time scales of 1 s or more, and have shown that these are exaggerated ...
  • Chemali, Jessica J.; Ching, ShiNung; Solt, Ken; Purdon, Patrick Lee; Brown, Emery N. (IOP Publishing, 2013-09)
    Objective. Burst suppression is an electroencephalogram pattern in which bursts of electrical activity alternate with an isoelectric state. This pattern is commonly seen in states of severely reduced brain activity such ...
  • Angalakudati, Mallik; Balwani, Siddharth; Calzada, Jorge; Chatterjee, Bikram; Perakis, Georgia; Raad, Nicolas; Uichanco, Joline (Institute for Operations Research and the Management Sciences (INFORMS), 2014-04)
    In this paper, we describe both applied and analytical work in collaboration with a large multistate gas utility. The project addressed a major operational resource allocation challenge that is typical to the industry. We ...
  • Demanet, Laurent; Ferrara, Matthew; Maxwell, Nicholas; Poulson, Jack; Ying, Lexing (SPIE - International Society for Optical Engineering, 2011-05)
    It is not currently known if it is possible to accurately form a synthetic aperture radar image from N data points in provable near-linear complexity, where accuracy is defined as the ℓ₂ error between the full O(N²) ...
  • Demanet, Laurent; Ferrara, Matthew; Maxwell, Nicholas; Poulson, Jack; Ying, Lexing (Society for Industrial and Applied Mathematics, 2012-02)
    In spite of an extensive literature on fast algorithms for synthetic aperture radar (SAR) imaging, it is not currently known if it is possible to accurately form an image from N data points in provable near-linear time ...
  • Zegras, P. Christopher; Lee, Jae Seung; Ben-Joseph, Eran (Sage Publications, 2012-01)
    This article analyses the travel behaviour, residential choices and related preferences of 55+ baby boomers in suburban Boston, USA, looking specifically at age-restricted neighbourhoods. For this highly auto-dependent ...
  • Shmakov, S.; Makarova, K. S.; Semenova, E.; Minakhin, L.; Severinov, K.; Koonin, E. V.; Regev, Aviv; Abudayyeh, Omar Osama; Gootenberg, Jonathan S; Konermann, Silvana M; Joung, Julia; Slaymaker, Ian; Cox, David Benjamin Turitz; Lander, Eric Steven; Zhang, Feng (American Association for the Advancement of Science (AAAS), 2016-08)
    The clustered regularly interspaced short palindromic repeat (CRISPR)–CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference. We characterize ...
  • Tonegawa, Susumu; McHugh, Thomas J. (Wiley Blackwell, 2009-07)
    The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols ...
  • Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank (Elsevier, 2000-06)
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a ...
  • Agrawal, Kunal; Fineman, Jeremy T.; Krage, Jordan; Leiserson, Charles E.; Toledo, Sivan (Association for Computing Machinery (ACM), 2012-06)
    This paper considers the problem of scheduling streaming applications on uniprocessors in order to minimize the number of cache-misses. Streaming applications are represented as a directed graph (or multigraph), where nodes ...
  • Mao, Yandong; Kohler, Eddie; Morris, Robert Tappan (Association for Computing Machinery (ACM), 2012-04)
    We present Masstree, a fast key-value database designed for SMP machines. Masstree keeps all data in memory. Its main data structure is a trie-like concatenation of B+-trees, each of which handles a fixed-length slice of ...
  • Brodal, Gerth Stolting; Demaine, Erik D.; Fineman, Jeremy T.; Iacono, John; Langerman, Stefan; Munro, J. Ian (Society for Industrial and Applied Mathematics, 2010-01)
    Several existing cache-oblivious dynamic dictionaries achieve O(logB N) (or slightly better O(logB N over M )) memory transfers per operation, where N is the number of items stored, M is the memory size, and B is ...
  • Niesen, Urs; Shah, Devavrat; Wornell, Gregory W. (Institute of Electrical and Electronics Engineers, 2009-08)
    We consider the problem of delivering content cached in a wireless network of n nodes randomly located on a square of area n. In the most general form, this can be analyzed by considering the 2[superscript n] timesn-dimensional ...
  • Szatanek, Tomasz; Anderson-White, Brooke R.; Faugno-Fusci, David M.; White, Michael; Gubbels, Marc-Jan; Saeij, Jeroen (Wiley Blackwell, 2012-04)
    Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before ...
  • Topalidou, Irini; van Oudenaarden, Alexander; Chalfie, Martin (National Academy of Sciences (U.S.), 2011-03)
    Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis ...
  • Horvitz, H. Robert; Ma, Long; Gao, Xiaoyang; Luo, Jintao; Huang, Liange; Teng, Yanling (Public Library of Science, 2012-07)
    RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity ...
  • de la Cruz, Ignacio Perez; Ma, Long; Horvitz, H. Robert (Public Library of Science, 2014-02)
    Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore ...
  • Reddy, Kirthi C.; Hunter, Ryan C.; Bhatla, Nikhil; Newman, Dianne K.; Kim, Dennis H. (National Academy of Sciences (U.S.), 2011-08)
    Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. The presence of bacterial food influences C. elegans aerotaxis, aggregation, locomotion, and pathogen avoidance behaviors through the ...
  • Truttmann, Matthias; Cruz, Victor Emmanuel; Guo, Xuanzong; Engert, Christoph; Schwartz, Thomas; Ploegh, Hidde (Public Library of Science, 2016-05)
    Protein AMPylation by Fic domain-containing proteins (Fic proteins) is an ancient and conserved post-translational modification of mostly unexplored significance. Here we characterize the Caenorhabditis elegans Fic protein ...
  • Saffer, Adam M.; Kim, Dong hyun; van Oudenaarden, Alexander; Horvitz, H. Robert (Public Library of Science, 2011-12)
    The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 ...
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