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Browsing MIT Open Access Articles by Title

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  • Gattass, Ricardo; Soares, Juliana G. M.; Desimone, Robert; Ungerleider, Leslie G. (Frontiers Research Foundation, 2014-05)
    The claustrum is a surprisingly large, sheet-like neuronal structure hidden beneath the inner surface of the neocortex. We found that the portions of the claustrum connected with V4 appear to overlap considerably with those ...
  • Spiridonov, Alexey Nikolaevich; Shabalina, Svetlana A.; Spiridonov, Nikolay A.; Koonin, Eugene V. (Oxford University Press (OUP), 2010-10)
    The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT). Comparative analysis ...
  • Daskalakis, Constantinos; Dimakis, Alexandros G.; Mossel, Elchanan (Institute of Mathematical Statistics, 2011)
    We study how the structure of the interaction graph of a game affects the existence of pure Nash equilibria. In particular, for a fixed interaction graph, we are interested in whether there are pure Nash equilibria arising ...
  • Choi, Han-Lim; Brunet, Luc; How, Jonathan P. (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper addresses task allocation to coordinate a fleet of autonomous vehicles by presenting two decentralized algorithms: the consensus-based auction algorithm (CBAA) and its generalization to the multi-assignment ...
  • Kellis, Manolis; Lin, Michael F. (Cold Spring Harbor Laboratory Press, 2009-04)
    Effective use of the human and mouse genomes requires reliable identification of genes and their products. Although multiple public resources provide annotation, different methods are used that can result in similar but ...
  • Kerr, William R.; Lerner, Josh; Schoar, Antoinette (Oxford University Press on behalf of The Society for Financial Studies, 2011-10)
    This article documents the fact that ventures funded by two successful angel groups experience superior outcomes to rejected ventures: They have improved survival, exits, employment, patenting, Web traffic, and financing. ...
  • Acemoglu, Daron; Cantoni, Davide; Johnson, Simon; Robinson, James A. (American Economic Association, 2011-01)
    The French Revolution had a momentous impact on neighboring countries. It removed the legal and economic barriers protecting oligarchies, established the principle of equality before the law, and prepared economies for ...
  • Shay, Tal; Jojic, Vladimir; Zuk, Or; Rothamel, Katherine; Puyraimond-Zemmour, David; Feng, Ting; Wakamatsu, Ei; Benoist, Cristophe; Koller, Daphne; Regev, Aviv (National Academy of Sciences (U.S.), 2013-02)
    Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal ...
  • Wei, Shuo; Xu, Guofeng; Bridges, Lance C.; Shah, Anoop; White, Judith M.; DeSimone, Douglas W.; Whittaker, Charles A. (Springer (Biomed Central Ltd.), 2010-07)
    Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The ...
  • Chiu, Edmond Kwan-Yu; Wang, Qiqi; Hu, Rui; Jameson, Antony (Society for Industrial and Applied Mathematics, 2012-11)
    We present a novel mesh-free scheme for solving partial differential equations. We first derive a conservative and stable formulation of mesh-free first derivatives. We then show that this formulation is a special case of ...
  • Davies, Bryan William; Jacob, Asha I.; Koehrer, Caroline; Rajbhandary, Uttam L.; Walker, Graham C. (Elsevier, 2012-12)
    Quality control of ribosomes is critical for cellular function since protein mistranslation leads to severe physiological consequences. We report evidence of a previously unrecognized ribosome quality control system in ...
  • Airoldi, Edoardo; Slavov, Nikolai G.; van Oudenaarden, Alexander; Botstein, David (American Society for Cell Biology, 2012-03)
    The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is ...
  • Krishnan, Rajaraman; Goodman, Jessica L.; Mukhopadhyay, Samrat; Pacheco, Chris D.; Lemke, Edward A.; Deniz, Ashok A.; Lindquist, Susan (National Academy of Sciences, 2012-07)
    Some amyloid-forming polypeptides are associated with devastating human diseases and others provide important biological functions. For both, oligomeric intermediates appear during amyloid assembly. Currently we have few ...
  • Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Sive, Hazel L.; Bartel, David; Jan, Calvin H. (Elsevier B.V., 2011-12)
    Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq ...
  • Thomas, Jacob; Lee, Catherine Ann; Grossman, Alan D. (Public Library of Science, 2013-01)
    Integrative and conjugative elements (ICEs) are agents of horizontal gene transfer and have major roles in evolution and acquisition of new traits, including antibiotic resistances. ICEs are found integrated in a host ...
  • Schnall-Levin, Michael; Berger, Bonnie; Zhao, Yong; Perrimon, Norbert (National Academy of Sciences (U.S.), 2010-08)
    MicroRNAs (miRNAs) are a class of short noncoding RNAs that regulate protein-coding genes posttranscriptionally. In animals, most known miRNA targeting occurs within the 3′UTR of mRNAs, but the extent of biologically ...
  • Hoersch, Sebastian; Mansisidor, Andres R.; Cecere, Germano; Jensen, Morten B.; Kawli, Trupti; Kennedy, Lisa M.; Chavez, Violeta; Tan, Man-Wah; Lieb, Jason D.; Grishok, Alla (Public Library of Science, 2011-09)
    Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased ...
  • Le, Minh T. N.; Shyh-Chang, Ng; Khaw, Swea Ling; Chin, Lingzi; Teh, Cathleen; Tay, Junliang; O'Day, Elizabeth; Korzh, Vladimir; Yang, Henry; Lal, Ashish; Lieberman, Judy; Lim, Bing; Lodish, Harvey F. (Public Library of Science, 2011-09)
    MicroRNAs regulate networks of genes to orchestrate cellular functions. MiR-125b, the vertebrate homologue of the Caenorhabditis elegans microRNA lin-4, has been implicated in the regulation of neural and hematopoietic ...
  • Choi, Myung Jin; Tan, Vincent Yan Fu; Anandkumar, Animashree; Willsky, Alan S. (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    We study the problem of learning a latent tree graphical model where samples are available only from a subset of variables. We propose two consistent and computationally efficient algorithms for learning minimal latent ...
  • Vasudevan, Ramanarayan; Gonzalez, Humberto; Bajcsy, Ruzena; Sastry, S. Shankar; Vasudevan, Ram (Society for Industrial and Applied Mathematics, 2013-12)
    Switched systems, or systems whose control parameters include a continuous-valued input and a discrete-valued input which corresponds to the mode of the system that is active at a particular instance in time, have shown ...
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