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Browsing MIT Open Access Articles by Title

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  • Cheeseman, Iain McPherson; Gascoigne, Karen E. (Rockefeller University Press, The, 2013-03)
    Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory ...
  • Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Zon, Leonard I.; Gifford, David K. (Elsevier, 2013-11)
    Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight ...
  • Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.; Ploegh, Hidde (Nature Publishing Group, 2014-10)
    T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and ...
  • Doyle, Patrick S.; Hsiao, Lilian (Royal Society of Chemistry, 2015-09)
    We report the coexistence of stress-bearing percolation with arrested phase separation in a colloidal system of thermoresponsive nanoemulsions spanning a broad range of volume fractions (0.10 ≤ ϕ ≤ 0.33) and temperatures ...
  • Sanyal, Bishwapriya (Taylor & Francis, 2014-03)
    The Royal Town Planning Institute (RTPI) should be proud that it was one of the first organizations to introduce the idea that good cities require public planning by qualified professionals. It is not that no one had ...
  • Korzelius, Jerome; The, Inge; Ruijtenberg, Suzan; Portegijs, Vincent; Xu, Huihong; Horvitz, H. Robert; van den Heuvel, Sander (Elsevier, 2010-12)
    DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic ...
  • Fendyur, Anna; Varma, Sarvesh; Lo, Catherine T.; Voldman, Joel (American Chemical Society (ACS), 2014-07)
    Understanding how newly engineered micro- and nanoscale materials and systems that interact with cells impact cell physiology is crucial for the development and ultimate adoption of such technologies. Reports regarding the ...
  • Desai, Salil P.; Voldman, Joel (Royal Society of Chemistry, The, 2010-10)
    Microsystems are increasingly used in the manipulation, patterning and sorting of cells. Critical to the widespread adoption of these new technologies is development of an understanding of their impact on cellular physiology. ...
  • Xu, F.; Moon, S.; Emre, Ahmet E.; Lien, C.; Turali, E. S.; Demirci, Utkan (Institute of Electrical and Electronics Engineers (IEEE), 2010-01)
    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...
  • Domke, Lisa M.; Rickelt, Steffen; Dörflinger, Yvette; Kuhn, Caecilia; Winter-Simanowski, Stefanie; Zimbelmann, Ralf; Rosin-Arbesfeld, Rina; Heid, Hans; Franke, Werner W. (Elsevier B.V., 2014-06)
    The seminiferous tubules and the excurrent ducts of the mammalian testis are physiologically separated from the mesenchymal tissues and the blood and lymph system by a special structural barrier to paracellular translocations ...
  • Corin, Karolina A.; Gibson, Lorna (Elsevier, 2010-04)
    The contractile behavior of cells is relevant in understanding wound healing and scar formation. In tissue engineering, inhibition of the cell contractile response is critical for the regeneration of physiologically normal ...
  • Ni, Ming; Tong, Wen Hao; Choudhury, Deepak; Rahim, Nur Aida Abdul; Iliescu, Ciprian; Yu, Hanry (Molecular Diversity Preservation International, 2009-12)
    Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods ...
  • Pini, Francesco; De Nisco, Nicole J.; Ferri, Lorenzo; Penterman, Jon; Fioravanti, Antonella; Brilli, Matteo; Mengoni, Alessio; Bazzicalupo, Marco; Viollier, Patrick H.; Walker, Graham C.; Biondi, Emanuele G. (Public Library of Science, 2015-05)
    In all domains of life, proper regulation of the cell cycle is critical to coordinate genome replication, segregation and cell division. In some groups of bacteria, e.g. Alphaproteobacteria, tight regulation of the cell ...
  • Maheshri, Narendra; Zopf, Christopher John; Quinn, Katie Julia; Zeidman, Joshua A. (Public Library of Science, 2013-07)
    The large variability in mRNA and protein levels found from both static and dynamic measurements in single cells has been largely attributed to random periods of transcription, often occurring in bursts. The cell cycle has ...
  • Mazumder, Aprotim; Tummler, Katja; Bathe, Mark; Samson, Leona D. (American Society for Microbiology, 2012-11)
    The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells ...
  • Levin, Petra Anne; Grossman, Alan D. (Elsevier, 1998-01)
    Despite the power of bacterial genetics, the prokaryotic cell cycle has remained poorly understood. But recent work with three different bacterial species has shed light on how chromosomes and plasmids are oriented and ...
  • Mroz, Pawel; Yaroslavsky, Anastasia; Kharkwal, Gitika B.; Hamblin, Michael R. (MDPI AG, 2011-06)
    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...
  • Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles C.; Kho, Alvin T.; Mih, Justin; Deng, Linhong; Butler, James; Tschumperlin, Daniel; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henry (Public Library of Science, 2012-09)
    Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ...
  • Tegler, Lotta Tollstoy; Corin, Karolina A.; Hillger, Julia; Wassie, Brooke; Yu, Yanmei; Zhang, Shuguang (Nature Publishing Group, 2015-01)
    Insects transmit numerous devastating diseases, including malaria, dengue fever, and sleeping sickness. Olfactory cues guide insects to their hosts, and are thus responsible for disease transmission. Understanding the ...
  • Kim, Min-Cheol; Silberberg, Yaron R.; Whisler, Jordan Ari; Kamm, Roger Dale; Asada, Harry (Public Library of Science, 2015-10)
    The dynamics of filopodia interacting with the surrounding extracellular matrix (ECM) play a key role in various cell-ECM interactions, but their mechanisms of interaction with the ECM in 3D environment remain poorly ...
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