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Browsing MIT Open Access Articles by Title

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  • Shin, Su Ryon; Aghaei-Ghareh-Bolagh, Behnaz; Dang, Tram T.; Topkaya, Seda Nur; Gao, Xiguang; Yang, Seung Yun; Jung, Sung Mi; Oh, Jong Hyun; Dokmeci, Mehmet; Tang, Xiaowu (Shirley); Khademhosseini, Ali (John Wiley & Sons, Inc, 2013-11)
    Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts ...
  • Barthes, Julien; Ndreu-Halili, Albana; Hasan, Anwarul; Vrana, Nihal Engin; Ozcelik, Hayriye; Hindie, Mathilde (Hindawi Publishing Corporation, 2014-07)
    In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological ...
  • Terfve, Camille; Cokelaer, Thomas; Henriques, David; MacNamara, Aidan; Goncalves, Emanuel; Iersel, Martijn van; Saez-Rodriguez, Julio; Morris, Melody Kay; Lauffenburger, Douglas A. (BioMed Central Ltd, 2012-10)
    Background: Cells process signals using complex and dynamic networks. Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiological and diseased situations. ...
  • Crouzier, T.; Jang, H.; Ahn, J.; Stocker, Roman; Ribbeck, Katharina (American Chemical Society (ACS), 2013-09)
    The precise spatial control of cell adhesion to surfaces is an endeavor that has enabled discoveries in cell biology and new possibilities in tissue engineering. The generation of cell-repellent surfaces currently requires ...
  • Monje-Casas, Fernando; Amon, Angelika B. (Elsevier B.V., 2009-01)
    Components of the mitotic exit network (MEN), a signaling pathway that triggers exit from mitosis, localize to the spindle pole body (SPB) that migrates into the daughter cell during anaphase but are largely absent from ...
  • Wheeler, Douglas B.; Sabatini, David M.; Kang, In Han; Golland, Polina; Papallo, Adam; Lindquist, Robert A.; Carpenter, Anne E.; Jones, Thouis R. (BioMed Central Ltd., 2008-11)
    Background: Image-based screens can produce hundreds of measured features for each of hundreds of millions of individual cells in a single experiment. Results: Here, we describe CellProfiler Analyst, open-source software ...
  • Carpenter, Anne E.; Jones, Thouis R.; Lamprecht, Michael R.; Clarke, Colin; Kang, In Han; Friman, Ola; Guertin, David A.; Chang, Joo Han; Lindquist, Robert A.; Moffat, Jason; Golland, Polina; Sabatini, David M. (BioMed Central Ltd, 2006-10)
    Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source ...
  • Choi, Sungyoung; Levy, Oren; Cabral, Joaquim M. S.; Coelho, Monica B.; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, 2013-10)
    This communication presents quantitative studies of the dynamic adhesion behavior of mesenchymal stem cells (MSCs) enabled by the combination of cell-surface receptor–ligand interactions and three-dimensional hydrodynamic ...
  • van Zon, Jeroen Sebastiaan; Kienle, Simone; Huelsz-Prince, Guizela; Barkoulas, Michalis; van Oudenaarden, Alexander (Nature Publishing Group, 2015-05)
    How cells in developing organisms interpret the quantitative information contained in morphogen gradients is an open question. Here we address this question using a novel integrative approach that combines quantitative ...
  • Peng, Zhangli; Dao, Ming; Geri, Michela; Ding, Xiaoyun; Lin, Sz-Chin Steven; Li, Sixing; Li, Peng; Chen, Yuchao; Suresh, Subra; Huang, Tony Jun (National Academy of Sciences (U.S.), 2014-08)
    Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties ...
  • Choi, Sungyoung; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, The, 2012-02)
    This communication presents the concept of “deterministic cell rolling”, which leverages transient cell-surface molecular interactions that mediate cell rolling to sort cells with high purity and efficiency in a single step.
  • Sharei, Armon Reza; Cho, Nahyun; Mao, Shirley; Jackson, Emily L.; Poceviciute, Roberta; Adamo, Andrea; Zoldan, Janet; Langer, Robert; Jensen, Klavs F. (MyJoVE Corporation, 2013-11)
    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...
  • Phillips, Sarah; Prat, Aleix; Sedic, Maja; Proia, Theresa; Wronski, Ania; Mazumdar, Sohini; Skibinski, Adam; Shirley, Stephanie H.; Perou, Charles M.; Gill, Grace; Kuperwasser, Charlotte; Gupta, Piyush (Elsevier, 2014-04)
    Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, ...
  • Karp, Jeffrey Michael; Sarkar, Debanjan; Spelke, Dawn P.; Vemula, Praveen (Institute of Electrical and Electronics Engineers, 2009-05)
    There has been significant interest in the clinical use of adult mesenchymal stem cells (MSCs), which are connective tissue progenitor cells. One of the greatest challenges in traditional stem cell therapy is to deliver a ...
  • Zhao, Weian; Schafer, Sebastian; Choi, Jonghoon; Yamanaka, Yvonne Joy; Lombardi, Maria L.; Bose, Suman; Carlson, Alicia L.; Phillips, Joseph A.; Teo, Weisuong; Droujinine, Ilia A.; Cui, Cheryl; Jain, Rakesh K.; Lammerding, Jan; Love, J. Christopher; Lin, Charles; Sarkar, Debanjan; Karnik, Rohit; Karp, Jeffrey Michael (Nature Publishing Group, 2011-07)
    The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells ...
  • Heinelt, Martina; Karp, Jeffrey Michael; Levy, Oren (Impact Journals/National Center for Biotechnology Information (U.S.), 2015-07)
    The clinical potential of cell-based therapies is limited by poor targeting of systemically infused cells to diseased tissues. In our recent study, we have developed a multi-step screening platform to identify small ...
  • Pluth, Michael D.; McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society, 2010-03)
    Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other ...
  • McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-09)
    The synthesis and spectroscopic characterization of two new, cell-trappable fluorescent probes for Zn(II) are presented. These probes, 2-(4,5-bis(((6-(2-ethoxy-2-oxoethoxy)quinolin-8-yl)amino)methyl)-6-hydroxy-3-oxo-3H-8 ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Luo, Minmin; Deisseroth, Karl; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-08)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of ...
  • Kohara, Keigo; Tonegawa, Susumu; Pignatelli di Spinazzola, Mich; Rivest, Alexander J.; Jung, Hae Yoon; Kitamura, Takashi; Suh, Junghyup; Frank, Dominic; Kajikawa, Koichiro; Mise, Nathan; Obata, Yuichi; Wickersham, Ian R. (Nature Publishing Group, 2013-12)
    The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal cortex layer II (ECII)right arrowdentate ...
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