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Browsing MIT Open Access Articles by Title

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  • Rocco, Kevin A.; Gheorghe, Ciprian P.; Sivarapatna, Amogh; Ghaedi, Mahboobe; Balestrini, Jenna L.; Raredon, Thomas L.; Calle, Elizabeth A.; Niklason, Laura E.; Raredon, Micha Sam Brickman (Mary Ann Lieber, 2016-04)
    Decellularized organs are now established as promising scaffolds for whole-organ regeneration. For this work to reach therapeutic practice, techniques and apparatus are necessary for doing human-scale clinically applicable ...
  • Staymates, Matthew E.; MacCrehan, William A.; Staymates, Jessica L.; Gillen, Greg J.; Craven, Brent A.; Kunz, Roderick R; Mendum, Thomas H.e.; Ong, Ta-Hsuan; Geurtsen, Geoffrey P. (Nature Publishing Group, 2016-12)
    Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog’s nose revealed the external aerodynamics during ...
  • Triantafyllou, Michael S; Weymouth, Gabriel D; Miao, Jianmin (Annual Reviews, 2015-07)
    The fluid mechanics employed by aquatic animals in their escape or attack maneuvers, what we call survival hydrodynamics, are fascinating because the recorded performance in animals is truly impressive. Such performance ...
  • Wu, Cheng-Yeu; Young, Lena; Martel, Jan; Young, John D.; Young, David Y. (Public Library of Science, 2013-09)
    Mineralo-organic nanoparticles form spontaneously in human body fluids when the concentrations of calcium and phosphate ions exceed saturation. We have shown previously that these mineralo-organic nanoparticles possess ...
  • Hernandez Rivera, Javier; McDuff, Daniel Jonathan; Picard, Rosalind W. (Institute of Electrical and Electronics Engineers (IEEE), 2015-08)
    The large-scale adoption of smartphones during recent years has created many opportunities to improve health monitoring and care delivery. In this work, we demonstrate that motion sensors available in off-the-shelf smartphones ...
  • Ward, Ben A.; Dutkiewicz, Stephanie; Barton, Andrew D.; Follows, Michael J. (University of Chicago Press, 2011-06)
    Mixotrophic organisms combine autotrophic and heterotrophic nutrition and are abundant in both freshwater and marine environments. Recent observations indicate that mixotrophs constitute a large fraction of the biomass, ...
  • Kim, Dong-Hwee; Wirtz, Denis; Hecht, Vivian Chaya; Sullivan, Lucas Bryan; Kimmerling, Robert John; Hosios, Aaron Marc; Stockslager, Max Andrew; Stevens, Mark M.; Kang, Joon Ho; Vander Heiden, Matthew G.; Manalis, Scott R (Rockefeller University Press, The, 2016-02)
    Cytokine regulation of lymphocyte growth and proliferation is essential for matching nutrient consumption with cell state. Here, we examine how cellular biophysical changes that occur immediately after growth factor depletion ...
  • Rachmuth, Guy; Shouval, Harel Z.; Bear, Mark; Poon, Chi-Sang (National Academy of Sciences, 2011-11)
    Current advances in neuromorphic engineering have made it possible to emulate complex neuronal ion channel and intracellular ionic dynamics in real time using highly compact and power-efficient complementary metal-oxide- ...
  • Mahadevan, L.; Wood, David K.; Bhatia, Sangeeta N.; Soriano, Alicia; HIggins, John M. (American Association for the Advancement of Science (AAAS), 2012-02)
    The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...
  • Vijayan, Sujith; Ching, ShiNung; Brown, Emery N.; Kopell, Nancy J.; Purdon, Patrick Lee (Institute of Electrical and Electronics Engineers (IEEE), 2013-11)
    During the induction of general anesthesia there is a shift in power from the posterior regions of the brain to the frontal cortices; this shift in power is called anteriorization. For many anesthetics, a prominent feature ...
  • Chandramohanadas, Rajesh; Park, YongKeun; Lui, Lena; Li, Ang; Quinn, David; Liew, Kingsley; Diez Silva, Monica; Sung, Yong-Jin; Dao, Ming; Lim, Chwee Teck; Preiser, Peter Rainer; Suresh, Subra (Public Library of Science, 2011-06)
    Upon infection and development within human erythrocytes, P. falciparum induces alterations to the infected RBC morphology and bio-mechanical properties to eventually rupture the host cells through parasitic and host derived ...
  • Yao, Lining; Ou, Jifei; Wang, Guanyun; Cheng, Chin-Yi; Wang, Wen; Steiner, Helene; Ishii, Hiroshi (Mary Ann Liebert, Inc., 2015-12)
    This article presents a digital fabrication platform for depositing solution-based natural stimuli-responsive material on a thin flat substrate to create hygromorphic biohybrid films. Bacillus subtilis bacterial spores are ...
  • Ou, Jifei; Yao, Lining; Della Silva, Clark D.; Wang, Wen; Ishii, Hiroshi (Association for Computing Machinery (ACM), 2014-10)
    We propose an automatic deposition method of bacteria spores, which deform thin soft materials under environmental humidity change. We describe the process of two-dimensional printing the spore solution as well as a design ...
  • Bak, Jin Seop (Springer US, 2015-06)
    To verify the interconnective relationship between biodegradation efficiency and microfibril structure, recalcitrant rice straw (RS) was depolymerized using water soaking-based microbiological biodegradation (WSMB). This ...
  • Neiman, Jaclyn A. Shepard; Hughes, David J.; Griffith, Linda G.; Ebrahimkhani, Mohammad Reza; Raredon, Micha Sam Brickman (Elsevier, 2014-03)
    Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and technological needs drives ...
  • Bao, Chenchen; Curtin, James; Artzi, Natalie; Tian, Furong; Cui, Daxiang; Conde, Joao (Nature Publishing Group, 2015-07)
    Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo ...
  • Singh, Neetu; Karambelkar, Amrita D.; Gu, Luo; Lin, Kevin Yu-Ming; Miller, Jordan S.; Chen, Christopher S.; Sailor, Michael J.; Bhatia, Sangeeta N. (American Chemical Society (ACS), 2011-11)
    Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we ...
  • Seager, Sara; Bains, William; Hu, Renyu (Institute of Physics Publishing, 2013-11)
    Super-Earth exoplanets are being discovered with increasing frequency and some will be able to retain stable H2-dominated atmospheres. We study biosignature gases on exoplanets with thin H2 atmospheres and habitable surface ...
  • Ravera, Enrico; Martelli, Tommaso; Fragai, Marco; Luchinat, Claudio; Michaelis, Vladimir K.; Ong, Ta-Chung; Keeler, Eric George; Griffin, Robert Guy (Wiley Blackwell, 2015-09)
    Enzymes are used as environmentally friendly catalysts in many industrial applications, and are frequently immobilized in a matrix to improve their chemical stability for long-term storage and reusability. Recently, it was ...
  • Wong, Yoke-Ming; Brigham, Christopher J.; Rha, ChoKyun; Sinskey, Anthony J.; Sudesh, Kumar (Elsevier, 2012-10)
    The potential of plant oils as sole carbon sources for production of P(3HB-co-3HHx) copolymer containing a high 3HHx monomer fraction using the recombinant Cupriavidus necator strain Re2160/pCB113 has been investigated. ...
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