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Browsing MIT Open Access Articles by Title

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  • Choi, Sungyoung; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, The, 2012-02)
    This communication presents the concept of “deterministic cell rolling”, which leverages transient cell-surface molecular interactions that mediate cell rolling to sort cells with high purity and efficiency in a single step.
  • Sharei, Armon Reza; Cho, Nahyun; Mao, Shirley; Jackson, Emily L.; Poceviciute, Roberta; Adamo, Andrea; Zoldan, Janet; Langer, Robert; Jensen, Klavs F. (MyJoVE Corporation, 2013-11)
    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...
  • Phillips, Sarah; Prat, Aleix; Sedic, Maja; Proia, Theresa; Wronski, Ania; Mazumdar, Sohini; Skibinski, Adam; Shirley, Stephanie H.; Perou, Charles M.; Gill, Grace; Kuperwasser, Charlotte; Gupta, Piyush (Elsevier, 2014-04)
    Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, ...
  • Karp, Jeffrey Michael; Sarkar, Debanjan; Spelke, Dawn P.; Vemula, Praveen (Institute of Electrical and Electronics Engineers, 2009-05)
    There has been significant interest in the clinical use of adult mesenchymal stem cells (MSCs), which are connective tissue progenitor cells. One of the greatest challenges in traditional stem cell therapy is to deliver a ...
  • Zhao, Weian; Schafer, Sebastian; Choi, Jonghoon; Yamanaka, Yvonne Joy; Lombardi, Maria L.; Bose, Suman; Carlson, Alicia L.; Phillips, Joseph A.; Teo, Weisuong; Droujinine, Ilia A.; Cui, Cheryl; Jain, Rakesh K.; Lammerding, Jan; Love, J. Christopher; Lin, Charles; Sarkar, Debanjan; Karnik, Rohit; Karp, Jeffrey Michael (Nature Publishing Group, 2011-07)
    The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells ...
  • Heinelt, Martina; Karp, Jeffrey Michael; Levy, Oren (Impact Journals/National Center for Biotechnology Information (U.S.), 2015-07)
    The clinical potential of cell-based therapies is limited by poor targeting of systemically infused cells to diseased tissues. In our recent study, we have developed a multi-step screening platform to identify small ...
  • Pluth, Michael D.; McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society, 2010-03)
    Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other ...
  • McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-09)
    The synthesis and spectroscopic characterization of two new, cell-trappable fluorescent probes for Zn(II) are presented. These probes, 2-(4,5-bis(((6-(2-ethoxy-2-oxoethoxy)quinolin-8-yl)amino)methyl)-6-hydroxy-3-oxo-3H-8 ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Luo, Minmin; Deisseroth, Karl; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-08)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of ...
  • Kohara, Keigo; Tonegawa, Susumu; Pignatelli di Spinazzola, Mich; Rivest, Alexander J.; Jung, Hae Yoon; Kitamura, Takashi; Suh, Junghyup; Frank, Dominic; Kajikawa, Koichiro; Mise, Nathan; Obata, Yuichi; Wickersham, Ian R. (Nature Publishing Group, 2013-12)
    The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal cortex layer II (ECII)right arrowdentate ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Deisseroth, Karl; Luo, Minmin; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-10)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function, and dysfunction. We used a Bacterial Artificial Chromosome (BAC) transgenic strategy to express Channelrhodopsin2 ...
  • Gora, Kasia G.; Tsokos, Christos G.; Chen, Y. Erin; Srinivasan, Balaji S.; Laub, Michael T.; Perchuk, Barrett (Elsevier, 2010-07)
    Progression through the Caulobacter cell cycle is driven by the master regulator CtrA, an essential two-component signaling protein that regulates the expression of nearly 100 genes. CtrA is abundant throughout the cell ...
  • Gregoriou, Georgia G.; Gotts, Stephen J.; Desimone, Robert (Elsevier, 2012-02)
    Shifts of gaze and shifts of attention are closely linked and it is debated whether they result from the same neural mechanisms. Both processes involve the frontal eye fields (FEF), an area which is also a source of top-down ...
  • Feng, Guoping; Peca, Joao (Elsevier, 2012-03)
    Many candidate genes are now thought to confer susceptibility to autism spectrum disorders (ASDs). Here we review four interrelated complexes, each composed of multiple families of genes that functionally coalesce on common ...
  • Yamanaka, Yvonne Joy; Szeto, Gregory Lee; Gierahn, Todd Michael; Forcier, Talitha L.; Benedict, Kelly; Brefo, Mavis S.; Lauffenburger, Douglas A.; Irvine, Darrell J.; Love, J. Christopher (American Chemical Society, 2012-12)
    We present a method that uses fluorescent cellular barcodes to increase the number of unique samples that can be analyzed simultaneously by microengraving, a nanowell array-based technique for quantifying the secretory ...
  • Tanaka, Elly M.; Reddien, Peter (Elsevier, 2011-07)
    The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving ...
  • Balazsi, Gabor; van Oudenaarden, Alexander; Collins, James J.; van Oudenaarden, Alexander (Elsevier, 2011-03)
    Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate ...
  • Wu, Rongcong; Goldsipe, Arthur C.; Schauer, David B.; Lauffenburger, Douglas A. (SPIE, 2011-04)
    Vertebrates are constantly threatened by the invasion of microorganisms and have evolved systems of immunity to eliminate infectious pathogens in the body. Initial sensing of microbial agents is mediated by the recognition ...
  • Zheng, Dahai; Limmon, Gino V.; Yin, Lu; Leung, Nicola H. N.; Yu, Hanry; Chow, Vincent T. K.; Chen, Jianzhu (Public Library of Science, 2013-08)
    Regeneration of alveolar epithelia following severe pulmonary damage is critical for lung function. We and others have previously shown that Scgb1a1-expressing cells, most likely Clara cells, can give rise to newly generated ...
  • Fujimoto, James G.; Aguirre, Aaron Dominic; Chen, Yu; Bryan, Bradley; Mashimo, Hiroshi; Huang, Qin; Connolly, James L. (Society of Photo-optical Instrumentation Engineers, 2010-03)
    Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex ...
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