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Browsing MIT Open Access Articles by Title

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  • Dubbs, Alexander Joseph; Edelman, Alan; Koev, Plamen; Venkataramana, Praveen (American Institute of Physics (AIP), 2013-08)
    We introduce a “broken-arrow” matrix model for the β-Wishart ensemble, which improves on the traditional bidiagonal model by generalizing to non-identity covariance parameters. We prove that its joint eigenvalue density ...
  • Delmore, Jake E.; Issa, Ghayas C.; Lemieux, Madeleine E.; Rahl, Peter B.; Shi, Junwei; Jacobs, Hannah M.; Kastritis, Efstathios; Gilpatrick, Timothy; Paranal, Ronald M.; Qi, Jun; Chesi, Marta; Schinzel, Anna C.; McKeown, Michael R.; Heffernan, Timothy P.; Vakoc, Christopher R.; Bergsagel, P. Leif; Ghobrial, Irene M.; Richardson, Paul G.; Young, Richard A.; Hahn, William C.; Anderson, Kenneth C.; Kung, Andrew L.; Bradner, James E.; Mitsiades, Constantine S. (Elsevier B.V., 2011-09)
    MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have targeted MYC transcription by interfering ...
  • Phillips, Damon J.; Turco, Catherine; Zuckerman Sivan, Ezra W. (University of Chicago Press, 2013-01)
    Why are some diversified market identities problematic but others are not? We examine this question in the context of high-status corporate law firms, which often diversify into one low-status area of work—family law ...
  • Backurs, Arturs; Indyk, Piotr; Schmidt, Ludwig (Society for Industrial and Applied Mathematics (SIAM), 2017-01)
    The Tree Sparsity problem is defined as follows: given a node-weighted tree of size n and an integer k, output a rooted subtree of size k with maximum weight. The best known algorithm solves this problem in time O(kn), ...
  • McDermott, James; Castelli, Mauro; Manzoni, Luca; Kronberger, Gabriel; Jaśkowski, Wojciech; Luke, Sean; White, David R.; Goldman, Brian W.; O'Reilly, Una-May (Springer US, 2012-12)
    We present the results of a community survey regarding genetic programming benchmark practices. Analysis shows broad consensus that improvement is needed in problem selection and experimental rigor. While views expressed ...
  • de Palma, André; Abdellaoui, Mohammed; Attanasi, Giuseppe; Erev, Ido; Fehr-Duda, Helga; Fok, Dennis; Fox, Craig R.; Hertwig, Ralph; Picard, Nathalie; Wakker, Peter P; Walker, Joan L; Weber, Martin; Fox, Craig R.; Wakker, Peter P.; Walker, Joan L.; Ben-Akiva, Moshe E (Springer US, 2014-07)
    Uncertainty pervades most aspects of life. From selecting a new technology to choosing a career, decision makers rarely know in advance the exact outcomes of their decisions. Whereas the consequences of decisions in standard ...
  • Keating, Steven John (O'Reilly Media, 2014-11)
    Additive fabrication, often referred to as 3D printing, is the construction of objects by adding material. This stands in contrast to subtractive methods, which involve removing material by means of milling or cutting. ...
  • Moyer, Tyson; Zmolek, Andrew Charles; Irvine, Darrell J (American Society for Clinical Investigation, 2016-03)
    The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and ...
  • Williams, Adam David (Springer US, 2015-11)
    Port security is an increasing concern given the significant role of ports in global commerce and today’s increasingly complex threat environment. Current approaches to port security mirror traditional models of accident ...
  • Piantadosi, Steven Thomas; Tenenbaum, Joshua B; Goodman, Noah Daniel (Cognitive Science Society, 2010-08)
    We study concept learning for semantically-motivated, set-theoretic concepts. We first present an experiment in which we show that subjects learn concepts which cannot be represented by a simple Boolean logic. We ...
  • Lee, Jinha; Ishii, Hiroshi (Association for Computing Machinery (ACM), 2010-04)
    Since the invention of the personal computer, digital media has remained separate from the physical world, blocked by a rigid screen. In this paper, we present Beyond, an interface for 3-D design where users can directly ...
  • Alshamsi, Aamena; Pianesi, Fabio; Lepri, Bruno; Rahwan, Iyad; Pentland, Alex Paul (Public Library of Science, 2015-08)
    Contagion, a concept from epidemiology, has long been used to characterize social influence on people’s behavior and affective (emotional) states. While it has revealed many useful insights, it is not clear whether the ...
  • Bell, Mark Stephen (MIT Press, 2015-07)
    What happens to the foreign policies of states when they acquire nuclear weapons? Despite its importance, this question has not been answered satisfactorily. Nuclear weapons can facilitate six conceptually distinct foreign ...
  • Turner, Michael S.; Neben, Abraham Richard (IOP Publishing, 2013-05)
    For decades, H [subscript 0] and q [subscript 0] were the quest of cosmology, as they promised to characterize our "world model" without reference to a specific cosmological framework. Using Monte Carlo simulations, we ...
  • Nolan, Elizabeth M.; Johnstone, Timothy (Royal Society of Chemistry, 2015-02)
    Bacteria secrete small molecules known as siderophores to acquire iron from their surroundings. For over 60 years, investigations into the bioinorganic chemistry of these molecules, including fundamental coordination ...
  • Andoni, Alexandr; Nguyen, Huy L.; Indyk, Piotr; Razenshteyn, Ilya (Association for Computing Machinery, 2014-01)
    We present a new data structure for the c-approximate near neighbor problem (ANN) in the Euclidean space. For n points in R[superscript d], our algorithm achieves O[subscript c](n[superscript ρ] + d log n) query time and ...
  • Gil, Stephanie; Williams, Brian Charles (Institute of Electrical and Electronics Engineers, 2010-01)
    Local convergence is a limitation of many optimization approaches for multimodal functions. For hybrid model learning, this can mean a compromise in accuracy. We develop an approach for learning the model parameters of ...
  • Koetter, Ralf; Effros, Michelle; Medard, Muriel (Institute of Electrical and Electronics Engineers, 2010-01)
    In earlier work, we described an equivalence result for network capacity. Roughly, that result is as follows. Given a network of noisy, memoryless, point-to-point channels, replace each channel by a noiseless, memoryless ...
  • Smilkov, Daniel; Hidalgo, Cesar A.; Kocarev, Ljupco (Nature Publishing Group, 2014-04)
    The compartmental models used to study epidemic spreading often assume the same susceptibility for all individuals, and are therefore, agnostic about the effects that differences in susceptibility can have on epidemic ...
  • DiBenigno, Julia Marie; Kellogg, Katherine C (Sage Publications, 2014-05)
    We use data from a 12-month ethnographic study of two medical-surgical units in a U.S. hospital to examine how members from different occupations can collaborate with one another in their daily work despite differences in ...
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