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Browsing MIT Open Access Articles by Title

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  • Monje-Casas, Fernando; Amon, Angelika B. (Elsevier B.V., 2009-01)
    Components of the mitotic exit network (MEN), a signaling pathway that triggers exit from mitosis, localize to the spindle pole body (SPB) that migrates into the daughter cell during anaphase but are largely absent from ...
  • Wheeler, Douglas B.; Sabatini, David M.; Kang, In Han; Golland, Polina; Papallo, Adam; Lindquist, Robert A.; Carpenter, Anne E.; Jones, Thouis R. (BioMed Central Ltd., 2008-11)
    Background: Image-based screens can produce hundreds of measured features for each of hundreds of millions of individual cells in a single experiment. Results: Here, we describe CellProfiler Analyst, open-source software ...
  • Carpenter, Anne E.; Jones, Thouis R.; Lamprecht, Michael R.; Clarke, Colin; Kang, In Han; Friman, Ola; Guertin, David A.; Chang, Joo Han; Lindquist, Robert A.; Moffat, Jason; Golland, Polina; Sabatini, David M. (BioMed Central Ltd, 2006-10)
    Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source ...
  • Choi, Sungyoung; Levy, Oren; Cabral, Joaquim M. S.; Coelho, Monica B.; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, 2013-10)
    This communication presents quantitative studies of the dynamic adhesion behavior of mesenchymal stem cells (MSCs) enabled by the combination of cell-surface receptor–ligand interactions and three-dimensional hydrodynamic ...
  • van Zon, Jeroen Sebastiaan; Kienle, Simone; Huelsz-Prince, Guizela; Barkoulas, Michalis; van Oudenaarden, Alexander (Nature Publishing Group, 2015-05)
    How cells in developing organisms interpret the quantitative information contained in morphogen gradients is an open question. Here we address this question using a novel integrative approach that combines quantitative ...
  • Peng, Zhangli; Dao, Ming; Geri, Michela; Ding, Xiaoyun; Lin, Sz-Chin Steven; Li, Sixing; Li, Peng; Chen, Yuchao; Suresh, Subra; Huang, Tony Jun (National Academy of Sciences (U.S.), 2014-08)
    Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties ...
  • Choi, Sungyoung; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, The, 2012-02)
    This communication presents the concept of “deterministic cell rolling”, which leverages transient cell-surface molecular interactions that mediate cell rolling to sort cells with high purity and efficiency in a single step.
  • Sharei, Armon Reza; Cho, Nahyun; Mao, Shirley; Jackson, Emily L.; Poceviciute, Roberta; Adamo, Andrea; Zoldan, Janet; Langer, Robert; Jensen, Klavs F. (MyJoVE Corporation, 2013-11)
    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...
  • Phillips, Sarah; Prat, Aleix; Sedic, Maja; Proia, Theresa; Wronski, Ania; Mazumdar, Sohini; Skibinski, Adam; Shirley, Stephanie H.; Perou, Charles M.; Gill, Grace; Kuperwasser, Charlotte; Gupta, Piyush (Elsevier, 2014-04)
    Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, ...
  • Karp, Jeffrey Michael; Sarkar, Debanjan; Spelke, Dawn P.; Vemula, Praveen (Institute of Electrical and Electronics Engineers, 2009-05)
    There has been significant interest in the clinical use of adult mesenchymal stem cells (MSCs), which are connective tissue progenitor cells. One of the greatest challenges in traditional stem cell therapy is to deliver a ...
  • Zhao, Weian; Schafer, Sebastian; Choi, Jonghoon; Yamanaka, Yvonne Joy; Lombardi, Maria L.; Bose, Suman; Carlson, Alicia L.; Phillips, Joseph A.; Teo, Weisuong; Droujinine, Ilia A.; Cui, Cheryl; Jain, Rakesh K.; Lammerding, Jan; Love, J. Christopher; Lin, Charles; Sarkar, Debanjan; Karnik, Rohit; Karp, Jeffrey Michael (Nature Publishing Group, 2011-07)
    The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells ...
  • Heinelt, Martina; Karp, Jeffrey Michael; Levy, Oren (Impact Journals/National Center for Biotechnology Information (U.S.), 2015-07)
    The clinical potential of cell-based therapies is limited by poor targeting of systemically infused cells to diseased tissues. In our recent study, we have developed a multi-step screening platform to identify small ...
  • Pluth, Michael D.; McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society, 2010-03)
    Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other ...
  • McQuade, Lindsey E.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-09)
    The synthesis and spectroscopic characterization of two new, cell-trappable fluorescent probes for Zn(II) are presented. These probes, 2-(4,5-bis(((6-(2-ethoxy-2-oxoethoxy)quinolin-8-yl)amino)methyl)-6-hydroxy-3-oxo-3H-8 ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Luo, Minmin; Deisseroth, Karl; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-08)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of ...
  • Kohara, Keigo; Tonegawa, Susumu; Pignatelli di Spinazzola, Mich; Rivest, Alexander J.; Jung, Hae Yoon; Kitamura, Takashi; Suh, Junghyup; Frank, Dominic; Kajikawa, Koichiro; Mise, Nathan; Obata, Yuichi; Wickersham, Ian R. (Nature Publishing Group, 2013-12)
    The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal cortex layer II (ECII)right arrowdentate ...
  • Heiman, Myriam; Kulicke, Ruth; Greengard, Paul; Heintz, Nathaniel; Fenster, Robert (Nature Publishing Group, 2014-05)
    Cellular diversity and architectural complexity create barriers to understanding the function of the mammalian CNS at a molecular level. To address this problem, we have recently developed a methodology that provides the ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Deisseroth, Karl; Luo, Minmin; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-10)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function, and dysfunction. We used a Bacterial Artificial Chromosome (BAC) transgenic strategy to express Channelrhodopsin2 ...
  • Fieblinger, Tim; Graves, Steven M.; Sebel, Luke E.; Alcacer, Cristina; Plotkin, Joshua L.; Gertler, Tracy S.; Chan, C. Savio; Heiman, Myriam; Greengard, Paul; Cenci, M. Angela; Surmeier, D. James (Nature Publishing Group, 2014-10)
    The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of striatal direct pathway spiny projection ...
  • Gora, Kasia G.; Tsokos, Christos G.; Chen, Y. Erin; Srinivasan, Balaji S.; Laub, Michael T.; Perchuk, Barrett (Elsevier, 2010-07)
    Progression through the Caulobacter cell cycle is driven by the master regulator CtrA, an essential two-component signaling protein that regulates the expression of nearly 100 genes. CtrA is abundant throughout the cell ...
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