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Browsing MIT Open Access Articles by Title

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  • Olvera-Gomez, Irlanda; Hamilton, Sara E.; Xiao, Zhengguo; Guimaraes, Carla P.; Ploegh, Hidde; Hogquist, Kristin A.; Wang, Liangchun; Jameson, Stephen C. (National Academy of Sciences, 2012-01)
    The ability to induce humoral and cellular immunity via antigen delivery through the unbroken skin (epicutaneous immunization, EPI) has immediate relevance for vaccine development. However, it is unclear which adjuvants ...
  • Sengupta, Poulomi; Basu, Sudipta; Soni, Shivani; Pandey, Ambarish; Roy, Bhaskar; Oh, Michael S.; Chin, Kenneth T.; Paraskar, Abhimanyu S.; Sarangi, Sasmit; Connor, Yamicia D.; Sabbisetti, Venkata; Kopparam, Jawahar; Kulkarni, Ashish; Muto, Katherine; Amarasiriwardena, Chitra; Jayawardene, Innocent; Lupoli, Nicola; Dinulescu, Daniela M.; Bonventre, Joseph V.; Mashelcar, Raghunath A.; Sengupta, Shiladitya (National Academy of Sciences (U.S.), 2012-07)
    Nanoscale drug delivery vehicles have been harnessed extensively as carriers for cancer chemotherapeutics. However, traditional pharmaceutical approaches for nanoformulation have been a challenge with molecules that exhibit ...
  • Bloem, Bernard; Poorthuis, Rogier B.; Mansvelder, Huibert D. (Frontiers Research Foundation, 2014-03)
    Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal cognitive performance. Despite the fact that many have studied how ACh affects neuronal processing in the mPFC and thereby influences ...
  • Abrahamsson, Christoffer K.; Yang, Fan; Park, Hyoungshin; Brunger, Jonathan M.; Valonen, Piia K.; Langer, Robert; Welter, Jean F.; Caplan, Arnold I.; Guilak, Farshid; Freed, Lisa E. (Mary Ann Liebert, Inc., 2010-07)
    Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium ...
  • Shu, K.; Thatte, H.; Spector, Myron (Institute of Electrical and Electronics Engineers, 2009-05)
    Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were ...
  • Imbens, Guido W.; Donald, Stephen G.; Newey, Whitney K. ()
    Properties of GMM estimators are sensitive to the choice of instruments. Using many instruments leads to high asymptotic asymptotic efficiency but can cause high bias and/or variance in small samples. In this paper we ...
  • Luo, Linjie; Baran, Ilya; Rusinkiewicz, Szymon; Matusik, Wojciech (Association for Computing Machinery (ACM), 2012-11)
    3D printing technology is rapidly maturing and becoming ubiquitous. One of the remaining obstacles to wide-scale adoption is that the object to be printed must fit into the working volume of the 3D printer. We propose a ...
  • Zinser, Erik R.; Lindell, Debbie; Johnson, Zackary I.; Futschik, Matthias; Steglich, Claudia; Coleman, Maureen L.; Wright, Matthew A.; Rector, Trent; Steen, Robert; McNulty, Nathan; Thompson, Luke Richard; Chisholm, Sallie (Penny) (Public Library of Science, 2009-04)
    The marine cyanobacterium Prochlorococcus MED4 has the smallest genome and cell size of all known photosynthetic organisms. Like all phototrophs at temperate latitudes, it experiences predictable daily variation in available ...
  • Deng, Shuo; Balakrishnan, Hari; LaCurts, Katrina Leigh; Goyal, Ameesh K. (Association for Computing Machinery (ACM), 2013-10)
    Cloud computing infrastructures are increasingly being used by network-intensive applications that transfer significant amounts of data between the nodes on which they run. This paper shows that tenants can do a better job ...
  • Jayaraman, Vijaysekhar; Cable, Alex E.; Duker, Jay S.; Huber, Robert; Fujimoto, James G.; Choi, Woo Jhon; Mohler, Kathrin Juliane; Potsaid, Benjamin M.; Lu, Chen David; Liu, Jonathan Jaoshin (Public Library of Science, 2013-12)
    We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a ...
  • Esmaeelpour, Marieh; Kajic, Vedran; Zabihian, Behrooz; Othara, Richu; Ansari-Shahrezaei, Siamak; Kellner, Lukas; Krebs, Ilse; Nemetz, Susanne; Kraus, Martin F.; Hornegger, Joachim; Fujimoto, James G.; Drexler, Wolfgang; Binder, Susanne (Public Library of Science, 2014-06)
    Objectives: To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness ...
  • Regatieri, Caio V.; Branchini, Lauren; Fujimoto, James G.; Duker, Jay S. (Lippincott Williams & Wilkins, 2012-05)
    Background: A structurally and functionally normal choroidal vasculature is essential for retinal function. Therefore, a precise clinical understanding of choroidal morphology should be important for understanding many ...
  • Manjunath, Varsha; Taha, Mohammad; Fujimoto, James G.; Duker, Jay S. (Elsevier, 2010-09)
    Purpose: To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). Design: Retrospective, observational case series. Methods: Thirty-four eyes (34 ...
  • Regatieri, Caio V.; Branchini, Lauren; Carmody, Jill; Fujimoto, James G.; Duker, Jay S. (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2012-03)
    Purpose: This study was designed to examine choroidal thickness in patients with diabetes using spectral-domain optical coherence tomography. Methods: Forty-nine patients (49 eyes) with diabetes and 24 age-matched normal ...
  • Fox, Jacob; Lee, Choongbum; Sudakov, Benny (Springer-Verlag, )
    For a graph G, let (G) denote its chromatic number and (G) denote the order of the largest clique subdivision in G. Let H(n) be the maximum of (G)= (G) over all n-vertex graphs G. A famous conjecture of Haj os from ...
  • Fudenberg, Geoffrey; Mirny, Leonid A.; Doyle, Boryana G.; Imakaev, Maksim Viktorovich (Public Library of Science, 2014-10)
    The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are ...
  • Onder, Tamer T.; Kara, Nergis; Cherry, Anne; Sinha, Amit U.; Zhu, Nan; Bernt, Kathrin M.; Cahan, Patrick; Marcarci, B. Ogan; Unternaehrer, Juli; Lander, Eric S.; Armstrong, Scott A.; Daley, George Q.; Gupta, Piyush (Nature Publishing Group, 2012-03)
    Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic ...
  • Vastenhouw, Nadine L.; Zhang, Yong; Woods, Ian G.; Imam, Farhad; Regev, Aviv; Liu, X. Shirley; Rinn, John; Schier, Alexander F. (Nature Publishing Group, 2010-03)
    After fertilization the embryonic genome is inactive until transcription is initiated during the maternal–zygotic transition. This transition coincides with the formation of pluripotent cells, which in mammals can be used ...
  • Guttman, Mitchell; Amit, Ido; Garber, Manuel; French, Courtney; Lin, Michael F.; Feldser, David M.; Huarte, Maite; Zuk, Or; Carey, Bryce W.; Cassady, John P.; Cabili, Moran N.; Jaenisch, Rudolf; Mikkelsen, Tarjei S.; Jacks, Tyler E.; Hacohen, Nir; Bernstein, Bradley E.; Kellis, Manolis; Lander, Eric S. (Nature Publishing Group, 2009-02)
    There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts [1, 2, 3, 4]. However, the functional significance of these transcripts has been particularly controversial. Although ...
  • Guenther, Matthew G.; Frampton, Garrett M.; Soldner, Frank; Hockemeyer, Dirk; Mitalipova, Maya; Jaenisch, Rudolf; Young, Richard A. (Elsevier, 2010-08)
    Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes ...
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