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Browsing MIT Open Access Articles by Title

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  • Kohara, Keigo; Tonegawa, Susumu; Pignatelli di Spinazzola, Mich; Rivest, Alexander J.; Jung, Hae Yoon; Kitamura, Takashi; Suh, Junghyup; Frank, Dominic; Kajikawa, Koichiro; Mise, Nathan; Obata, Yuichi; Wickersham, Ian R. (Nature Publishing Group, 2013-12)
    The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal cortex layer II (ECII)right arrowdentate ...
  • Heiman, Myriam; Kulicke, Ruth; Greengard, Paul; Heintz, Nathaniel; Fenster, Robert (Nature Publishing Group, 2014-05)
    Cellular diversity and architectural complexity create barriers to understanding the function of the mammalian CNS at a molecular level. To address this problem, we have recently developed a methodology that provides the ...
  • Zhao, Shengli; Ting, Jonathan Thomas; Atallah, Hicham; Qiu, Li; Tan, Jie; Gloss, Bernd; Augustine, George J.; Deisseroth, Karl; Luo, Minmin; Graybiel, Ann M.; Feng, Guoping (Nature Publishing Group, 2011-10)
    Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function, and dysfunction. We used a Bacterial Artificial Chromosome (BAC) transgenic strategy to express Channelrhodopsin2 ...
  • Fieblinger, Tim; Graves, Steven M.; Sebel, Luke E.; Alcacer, Cristina; Plotkin, Joshua L.; Gertler, Tracy S.; Chan, C. Savio; Heiman, Myriam; Greengard, Paul; Cenci, M. Angela; Surmeier, D. James (Nature Publishing Group, 2014-10)
    The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of striatal direct pathway spiny projection ...
  • Gora, Kasia G.; Tsokos, Christos G.; Chen, Y. Erin; Srinivasan, Balaji S.; Laub, Michael T.; Perchuk, Barrett (Elsevier, 2010-07)
    Progression through the Caulobacter cell cycle is driven by the master regulator CtrA, an essential two-component signaling protein that regulates the expression of nearly 100 genes. CtrA is abundant throughout the cell ...
  • Gregoriou, Georgia G.; Gotts, Stephen J.; Desimone, Robert (Elsevier, 2012-02)
    Shifts of gaze and shifts of attention are closely linked and it is debated whether they result from the same neural mechanisms. Both processes involve the frontal eye fields (FEF), an area which is also a source of top-down ...
  • Feng, Guoping; Peca, Joao (Elsevier, 2012-03)
    Many candidate genes are now thought to confer susceptibility to autism spectrum disorders (ASDs). Here we review four interrelated complexes, each composed of multiple families of genes that functionally coalesce on common ...
  • Yamanaka, Yvonne Joy; Szeto, Gregory Lee; Gierahn, Todd Michael; Forcier, Talitha L.; Benedict, Kelly; Brefo, Mavis S.; Lauffenburger, Douglas A.; Irvine, Darrell J.; Love, J. Christopher (American Chemical Society, 2012-12)
    We present a method that uses fluorescent cellular barcodes to increase the number of unique samples that can be analyzed simultaneously by microengraving, a nanowell array-based technique for quantifying the secretory ...
  • Tanaka, Elly M.; Reddien, Peter (Elsevier, 2011-07)
    The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving ...
  • Balazsi, Gabor; van Oudenaarden, Alexander; Collins, James J.; van Oudenaarden, Alexander (Elsevier, 2011-03)
    Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate ...
  • Wu, Rongcong; Goldsipe, Arthur C.; Schauer, David B.; Lauffenburger, Douglas A. (SPIE, 2011-04)
    Vertebrates are constantly threatened by the invasion of microorganisms and have evolved systems of immunity to eliminate infectious pathogens in the body. Initial sensing of microbial agents is mediated by the recognition ...
  • Zheng, Dahai; Limmon, Gino V.; Yin, Lu; Leung, Nicola H. N.; Yu, Hanry; Chow, Vincent T. K.; Chen, Jianzhu (Public Library of Science, 2013-08)
    Regeneration of alveolar epithelia following severe pulmonary damage is critical for lung function. We and others have previously shown that Scgb1a1-expressing cells, most likely Clara cells, can give rise to newly generated ...
  • Fujimoto, James G.; Aguirre, Aaron Dominic; Chen, Yu; Bryan, Bradley; Mashimo, Hiroshi; Huang, Qin; Connolly, James L. (Society of Photo-optical Instrumentation Engineers, 2010-03)
    Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex ...
  • Rambhatla, Lakshmi; Bohn, Shirley A.; Stadler, Patrizia B.; Boyd, Jonathan T.; Coss, Ronald A.; Sherley, James L. (Hindawi Publishing Corporation, 2001)
    Although senescence is a defining property of euploid mammalian cells, its physiologic basis remains obscure. Previously, cell kinetics properties of normal tissue cells have not been considered in models for senescence. ...
  • Amano, Miho; Suzuki, Aussie; Backer, Chelsea B.; Okawa, Katsuya; Cheeseman, Iain McPherson; Fukagawa, Tatsuo (Rockefeller University Press, 2009-07)
    The constitutive centromere-associated network (CCAN) proteins are central to kinetochore assembly. To define the molecular architecture of this critical kinetochore network, we sought to determine the full complement of ...
  • Nishino, Tatsuya; Takeuchi, Kozo; Gascoigne, Karen E.; Suzuki, Aussie; Hori, Tetsuya; Oyama, Takuji; Morikawa, Kosuke; Fukagawa, Tatsuo; Cheeseman, Iain McPherson (Elsevier, 2012-02)
    The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specify the position of the ...
  • Cowling, James Alexander; Ports, Dan R. K.; Liskov, Barbara H.; Popa, Raluca Ada; Gaikwad, Abhijeet (USENIX Association, 2009-06)
    We present Census, a platform for building large-scale distributed applications. Census provides a membership service and a multicast mechanism. The membership service provides every node with a consistent view of the ...
  • Humphrey, Philip J.; Buote, David A.; Canizares, Claude R.; Fabian, Andrew C.; Miller, Jon M. (IOP Publishing, 2011-03)
    We present a study of the dark and luminous matter in the isolated elliptical galaxy NGC 720, based on deep X-ray observations made with the Chandra and Suzaku observatories. The gas properties are reliably measured almost ...
  • Ruangsri, Uchupol; Hughes, Scott A. (American Physical Society, 2014-04)
    Transient orbital resonances have recently been identified as potentially important to the inspiral of small bodies into large black holes. These resonances occur as the inspiral evolves through moments in which two ...
  • Kallman, T. R.; Evans, Daniel A.; Longinotti, Anna Lia; Marshall, Herman Lee; Canizares, Claude R.; Nowak, Michael A.; Schulz, Norbert S. (IOP Publishing, 2013-12)
    We present models for the X-ray spectrum of the Seyfert 2 galaxy NGC 1068. These are fitted to data obtained using the High Energy Transmission Grating on Chandra. The data show line and radiative recombination continuum ...
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