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Browsing MIT Open Access Articles by Title

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  • Atkin, David (American Economic Association, 2016-04)
    Anthropologists have documented substantial and persistent differences in food preferences across social groups. My paper asks whether such food cultures can constrain caloric intake? I first document that interstate ...
  • Cunha-Santos, Janete; Duarte-Neves, Joana; Carmona, Vitor; Pereira de Almeida, Luís; Cavadas, Cláudia; Guarente, Leonard Pershing (Nature Publishing Group, 2016-05)
    Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available ...
  • Guarente, Leonard Pershing (Cold Spring Harbor Laboratory Press, 2013-10)
    Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was ...
  • Mercken, Evi M.; Crosby, Seth D.; Lamming, Dudley W.; JeBailey, Lellean; Krzysik-Walker, Susan; Villareal, Dennis T.; Capri, Miriam; Franceschi, Claudio; Zhang, Yongqing; Becker, Kevin; Sabatini, David M.; de Cabo, Rafael; Fontana, Luigi (Wiley Blackwell, 2013-06)
    Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by ...
  • Kotecki, Maciej; Zeiger, Adam S.; Van Vliet, Krystyn J.; Herman, Ira M. (Elsevier, 2010-08)
    Pericytes surround capillary endothelial cells and exert contractile forces modulating microvascular tone and endothelial growth. We previously described pericyte contractile phenotype to be Rho GTPase- and α-smooth muscle ...
  • Amengual, Matthew (Instituto de Desarrollo Económico y Social, 2011-07)
    Developing the capacity for states to enforce labor law is a key challenge to regulating decent work. Dominant accounts of state capacity, however, suggest that the principal components of state enforcement capacity are ...
  • Lertpiriyapong, Kvin; Gamazon, Eric R.; Feng, Yan; Park, Danny S.; Pang, Jassia; Botka, Georgina; Graffam, Michelle E.; Ge, Zhongming; Fox, James G. (Public Library of Science, 2012-08)
    The recently identified type VI secretion system (T6SS) of proteobacteria has been shown to promote pathogenicity, competitive advantage over competing microorganisms, and adaptation to environmental perturbation. By ...
  • Demaine, Erik D.; Huang, Yamming; Liao, Chung-Shou; Sadakane, Kunihiko (Springer-Verlag, 2014)
    We study online algorithms for the Canadian Traveller Problem (CTP) introduced by Papadimitriou and Yannakakis in 1991. In this problem, a traveller knows the entire road network in advance, and wishes to travel as quickly ...
  • Sabatini, David M.; Cantor, Jason R. (American Association for Cancer Research, 2012-09)
    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...
  • Chaffer, Christine L.; Weinberg, Robert A. (Elsevier B.V., 2010-09)
    Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue of Cell Stem Cell, Molyneux et al. (2010) investigate the provenance of the basal-type BRCA1 breast carcinoma and come ...
  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2013-09)
    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...
  • Lauffenburger, Douglas A.; Kreeger, Pamela K. (Oxford University Press, 2009-10)
    Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such ...
  • Nijhawan, Deepak; Zack, Travis I.; Ren, Yin; Strickland, Matthew R.; Lamothe, Rebecca; Schumacher, Steven E.; Tsherniak, Aviad; Besche, Henrike C.; Rosenbluh, Joseph; Shehata, Shyemaa; Cowley, Glenn S.; Weir, Barbara A.; Goldberg, Alfred L.; Mesirov, Jill P.; Root, David E.; Bhatia, Sangeeta N.; Beroukhim, Rameen; Hahn, William C. (Elsevier B.V., 2012-08)
    Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...
  • Gordon, Goren; Breazeal, Cynthia Lynn; Engel, Susan (Association for Computing Machinery (ACM), 2015-03)
    Curiosity is key to learning, yet school children show wide variability in their eagerness to acquire information. Recent research suggests that other people have a strong influence on children's exploratory behavior. Would ...
  • Buongiorno, Jacopo (Elsevier, 2013-08)
    It is well known that boiling and quenching heat transfer depends strongly on the morphology and composition of the solid surface through which the heat transfer occurs. The relevant surface features are roughness, wettability ...
  • Hamblin, Michael R.; Chen, Aaron Chih-Hao; Huang, Ying-Ying; Sharma, Sulbha K. (Society of Photo-optical Instrumentation Engineers, 2010-01)
    There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field ...
  • Fink, Gerald R.; Vyas, Valmik K.; Barrasa, M. Inmaculada (American Association for the Advancement of Science (AAAS), 2015-04)
    Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis ...
  • Weinberg, David Eric; Bartel, David; Fink, Gerald R. (National Academy of Sciences, 2012-01)
    The generation of mature functional RNAs from nascent transcripts requires the precise and coordinated action of numerous RNAs and proteins. One such protein family, the ribonuclease III (RNase III) endonucleases, includes ...
  • Tang, Ruqi; Noh, Hyun Ji; Wang, Dongqing; Sigurdsson, Snaevar; Swofford, Ross; Perloski, Michele; Duxbury, Margaret; Patterson, Edward E.; Albright, Julie; Castelhano, Marta; Auton, Adam; Boyko, Adam R.; Feng, Guoping; Lindblad-Toh, Kerstin; Karlsson, Elinor K. (BioMed Central Ltd, 2014-03)
    Background: Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% of the human population. While highly heritable, complex genetics has hampered ...
  • Berlijn, Tom; Volja, Dmitri; Ku, Wei (American Physical Society, 2011-02)
    We investigate from first principles the proposed destruction of the controversial eg′ pockets in the Fermi surface of Na[subscript x]CoO[subscript 2] due to Na disorder, by calculating its k-dependent configuration-averaged ...
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