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Browsing MIT Open Access Articles by Title

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  • Jacobson, Heather R.; Frebel, Anna L. (IOP Publishing, 2015-07)
    With [Fe/H] ~ −3.3, CD −24°17504 is a canonical metal-poor main-sequence turn-off star. Though it has appeared in numerous literature studies, the most comprehensive abundance analysis for the star based on high-resolution, ...
  • Yong, Ching-Shya; Ou Yang, Chih-Ming; Chou, Yenn-Hwei; Liao, Chao-Sheng; Lee, Chung-Wei; Lee, Chin-Cheng (BioMed Central Ltd, 2012-07)
    Background: To correlate CD44/CD24 expression with gastric cancer recurrence and prognosis. Gastric cancer is the second leading cause of cancer mortality due to the high recurrence rate, of which the molecular signature ...
  • Betancur, Paola A.; Abraham, Brian J.; Yiu, Ying Y.; Willingham, Stephen B.; Khameneh, Farnaz; Zarnegar, Mark; Kuo, Angera H.; McKenna, Kelly; Kojima, Yoko; Leeper, Nicholas J.; Ho, Po; Gip, Phung; Swigut, Tomek; Sherwood, Richard I.; Clarke, Michael F.; Somlo, George; Weissman, Irving L.; Young, Richard A (Nature Publishing Group, 2017-04)
    CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal ...
  • Davis, M. M.; Artyomov, Maxim N.; Lis, Mieszko; Chakraborty, Arup K; Devadas, Srinivas (National Academy of Sciences (U.S.), 2010-09)
    The activation of T lymphocytes (T cells) requires signaling through the T-cell receptor (TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are thought to augment TCR signaling by stabilizing ...
  • Lauffenburger, Douglas A; Arnold, Kelly Benedict; Szeto, Gregory; Alter, Galit; Irvine, Darrell J (American Association for the Advancement of Science (AAAS), 2015-10)
    A vital defect in the immune systems of HIV-infected individuals is the loss of CD4⁺ T cells, resulting in impaired immune responses. We hypothesized that there were CD4⁺ T cell–dependent and CD4⁺ T cell–independent ...
  • Wang, Chao; Yosef, Nir; Gaublomme, Jellert; Wu, Chuan; Lee, Youjin; Clish, Clary B.; Kaminski, Jim; Xiao, Sheng; Zu Horste, Gerd Meyer; Pawlak, Mathias; Kishi, Yasuhiro; Joller, Nicole; Karwacz, Katarzyna; Zhu, Chen; Ordovas-Montanes, Maria; Madi, Asaf; Wortman, Ivo; Miyazaki, Toru; Sobel, Raymond A.; Park, Hongkun; Kuchroo, Vijay K.; Regev, Aviv (Elsevier, 2015-11)
    Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis, but can induce autoimmunity. The mechanisms implicated in balancing ‘pathogenic’ and ‘non-pathogenic’ Th17 cell states ...
  • Bynoe, Margaret S.; Waickman, Adam T.; Mahamed, Deeqa A.; Mueller, Cynthia; Mills, Jeffrey H.; Czopik, Agnieszka (Hindawi Publishing Corporation, 2012-07)
    CD73 is a glycosyl-phosphatidylinositol-(GPI-) linked membrane protein that catalyzes the extracellular dephosphorylation of adenosine monophosphate (AMP) to adenosine. Adenosine is a negative regulator of inflammation and ...
  • Bak, S. Peter G.; Barnkob, Mike Stein; Wittrup, Karl Dane; Chen, Jianzhu (American Association for Cancer Research, 2013-09)
    Stimulation of patients' immune systems for the treatment of solid tumors is an emerging therapeutic paradigm. The use of enriched autologous T cells for adoptive cell therapy or vaccination with antigen-loaded dendritic ...
  • Sehrawat, Sharvan; Kirak, Oktay; Koenig, Paul-Albert; Isaacson, Marisa K.; Marques, Sofia; Bozkurt, Gunes; Simas, J. Pedro; Jaenisch, Rudolf; Ploegh, Hidde (Elsevier, 2012-04)
    To study the CD8[superscript +] T cell response against a mouse γ-herpes virus, we generated K[superscript b]-MHV-68-ORF8[superscript 604–612]RAG[superscript −/−] CD8[superscript +] T cell receptor transnuclear (TN) mice ...
  • Mashayekhi, Mona; Sandau, Michelle M.; Dunay, Ildiko R.; Frickel, Eva M.; Khan, Asis; Goldszmid, Romina S.; Sher, Alan; Murphy, Theresa L.; Sibley, L. David; Murphy, Kenneth M.; Ploegh, Hidde (Elsevier/Cell Press, 2011-08)
    CD8α[superscript +] dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by CD8α[superscript +] ...
  • Rock, Jeremy Michael; Amon, Angelika B. (Cold Spring Harbor Laboratory Press, 2011-02)
    In budding yeast, a Ras-like GTPase signaling cascade known as the mitotic exit network (MEN) promotes exit from mitosis. To ensure the accurate execution of mitosis, MEN activity is coordinated with other cellular events ...
  • Calvo, Fernando; Ranftl, Romana; Hooper, Steven; Farrugia, Aaron J.; Moeendarbary, Emad; Bruckbauer, Andreas; Batista, Facundo; Charras, Guillaume; Sahai, Erik (Elsevier, 2015-12)
    Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the ...
  • Maia, Ana R. R.; Garcia, Zaira; Kabeche, Lilian; Barisic, Marin; Maffini, Stefano; Macedo-Ribeiro, Sandra; Cheeseman, Iain McPherson; Compton, Duane A.; Kaverina, Irina; Maiato, Helder (Rockefeller University Press, 2012-03)
    Accurate chromosome segregation during mitosis relies on a dynamic kinetochore (KT)–microtubule (MT) interface that switches from a labile to a stable condition in response to correct MT attachments. This transition is ...
  • Zhang, Lei; Zhu, J. Julius; Clauser, Karl R.; Carr, Steven A.; Guan, Ji-Song; Su, Susan Chih-Chieh; Gao, Jun; Joseph, Nadine; Xie, Zhigang; Zhou, Ying; Durak, Omer; Tsai, Li-Huei (Public Library of Science, 2011-09)
    Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory ...
  • Buchman, Joshua J.; Tseng, Huan-Chung; Zhou, Ying; Frank, Christopher Lee; Xie, Zhigang; Tsai, Li-Huei (Elsevier B.V., 2010-05)
    Primary autosomal-recessive microcephaly (MCPH) and Majewski osteodysplastic primordial dwarfism type II (MOPDII) are both genetic diseases that result in decreased brain size at birth. MCPH is thought to arise from ...
  • Wang, Yubao; Zhang, Tinghu; Kwiatkowski, Nicholas; Abraham, Brian J.; Lee, Tong Ihn; Xie, Shaozhen; Yuzugullu, Haluk; Von, Thanh; Li, Heyuan; Lin, Ziao; Stover, Daniel G.; Lim, Elgene; Wang, Zhigang C.; Iglehart, J. Dirk; Gray, Nathanael S.; Zhao, Jean J.; Young, Richard A (Elsevier B.V., 2015-09)
    Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a relatively uniform transcriptional program. We postulate that TNBC might ...
  • Chipumuro, Edmond; Marco, Eugenio; Christensen, Camilla L.; Zhang, Tinghu; Hatheway, Clark M.; Sharma, Bandana; Yeung, Caleb; Altabef, Abigail; Perez-Atayde, Antonio; Wong, Kwok-Kin; Yuan, Guo-Cheng; Gray, Nathanael S.; George, Rani E.; Kwiatkowski, Nick; Abraham, Brian Joseph; Young, Richard A (Elsevier, 2014-11)
    The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. ...
  • Cheeseman, Iain McPherson; Gascoigne, Karen E. (Rockefeller University Press, The, 2013-03)
    Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory ...
  • Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Zon, Leonard I.; Gifford, David K. (Elsevier, 2013-11)
    Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight ...
  • Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.; Ploegh, Hidde (Nature Publishing Group, 2014-10)
    T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and ...
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