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Browsing MIT Open Access Articles by Title

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  • Regev, Aviv; Chen, Ying-Lien; Konieczka, Jay H.; Springer, Deborah J.; Bowen, Samantha E.; Zhang, Jing; Silao, Fitz Gerald S.; Bungay, Alice Alma C.; Bigol, Ursela G.; Nicolas, Marilou G.; Abraham, Soman N.; Thompson, Dawn A.; Heitman, Joseph (Genetics Society of America, The, 2012-06)
    Candida glabrata is an emerging human fungal pathogen that is frequently drug tolerant, resulting in difficulties in treatment and a higher mortality in immunocompromised patients. The calcium-activated protein phosphatase ...
  • Bellott, Daniel W.; Skaletsky, Helen; Pyntikova, Tatyana; Mardis, Elaine R.; Grave, Tina; Kremitzki, Colin; Brown, Laura G.; Rozen, Steve; Warren, Wesley C.; Wilson, Richard K.; Page, David C. (Nature Publishing Group, 2010-07)
    In birds, as in mammals, one pair of chromosomes differs between the sexes. In birds, males are ZZ and females ZW. In mammals, males are XY and females XX. Like the mammalian XY pair, the avian ZW pair is believed to have ...
  • Hanson, Robert N.; Hua, Edward; Labaree, David; Hochberg, Richard B.; Proffitt, Kyle; Essigmann, John M.; Croy, Robert G. (Royal Society of Chemistry, 2012-09)
    A convergent synthesis of a novel estrogen receptor-targeted drug hybrid was developed based on structures of the potent anti-proliferative mitomycin C and the steroidal anti-estrogen RU 39411. The steroidal antiestrogen ...
  • Ahmadi, Amir Ali; Parrilo, Pablo A. (Institute of Electrical and Electronics Engineers (IEEE), 2012-03)
    Despite the pervasiveness of sum of squares (sos) techniques in Lyapunov analysis of dynamical systems, the converse question of whether sos Lyapunov functions exist whenever polynomial Lyapunov functions exist has remained ...
  • Falcao-Filho, Edilson L.; Gordon, Ariel; Kartner, Franz X.; Gkortsas, Vasileios-Marios (Institute of Electrical and Electronics Engineers, 2009-08)
    Closed form expressions for the high harmonic generation (HHG) conversion efficiency in the plateau and cut-off region are derived showing agreement with previous observations. Application of these results to optimal ...
  • Lindquist, Susan; Dong, Jijun; Garrity, Sean J.; Sivanathan, Viknesh; Hochschild, Ann (National Academy of Sciences (U.S.), 2010-05)
    Prions are infectious, self-propagating protein aggregates that have been identified in evolutionarily divergent members of the eukaryotic domain of life. Nevertheless, it is not yet known whether prokaryotes can support ...
  • Chandrasekaran, Venkat; Recht, Benjamin; Parrilo, Pablo A.; Willsky, Alan S. (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    We study a class of ill-posed linear inverse problems in which the underlying model of interest has simple algebraic structure. We consider the setting in which we have access to a limited number of linear measurements of ...
  • Chandrasekaran, Venkat; Parrilo, Pablo A.; Willsky, Alan S. (Society for Industrial and Applied Mathematics, 2012-08)
    The structural properties of graphs are usually characterized in terms of invariants, which are functions of graphs that do not depend on the labeling of the nodes. In this paper we study convex graph invariants, which are ...
  • Taylor, Joshua A.; Hover, Franz S. (Institute of Electrical and Electronics Engineers (IEEE), 2012-08)
    We derive new mixed-integer quadratic, quadratically constrained, and second-order cone programming models of distribution system reconfiguration, which are to date the first formulations of the ac problem that have convex, ...
  • Tobenkin, Mark M.; Manchester, Ian R.; Wang, Jennifer; Megretski, Alexandre; Tedrake, Russell Louis (Institute of Electrical and Electronics Engineers (IEEE), 2010-12)
    A new framework for nonlinear system identification is presented in terms of optimal fitting of stable nonlinear state space equations to input/output/state data, with a performance objective defined as a measure of ...
  • Majumdar, Anirudha; Vasudevan, Ram; Tobenkin, Mark M.; Tedrake, Russell Louis (2013-06)
    In this paper, we present an approach for designing feedback controllers for polynomial systems that maximize the size of the time-limited backwards reachable set (BRS). We rely on the notion of occupation measures to pose ...
  • Turaga, Srinivas C.; Murray, Joseph F.; Jain, Viren; Roth, Fabian; Helmstaedter, Moritz; Briggman, Kevin; Denk, Winfried; Seung, H. Sebastian (MIT Press, 2010-01)
    Many image segmentation algorithms first generate an affinity graph and then partition it. We present a machine learning approach to computing an affinity graph using a convolutional network (CN) trained using ground truth ...
  • Wang, Yana; Irvine, Darrell J. (Royal Society of Chemistry, 2013)
    Chemoattractants regulate diverse immunological, developmental, and pathological processes, but how cell migration patterns are shaped by attractant production in tissues remains incompletely understood. Using computational ...
  • Di Modugno, Francesca; Mottolese, Marcella; DeMonte, Lucia; Trono, Paola; Terrenato, Irene; Belleudi, Francesca; Torrisi, Maria Rosaria; Alessio, Massimo; Santoni, Angela; Nistico, Paola (Public Library of Science, 2010-12)
    hMena and the epithelial specific isoform hMena11a are actin cytoskeleton regulatory proteins belonging to the Ena/VASP family. EGF treatment of breast cancer cell lines upregulates hMena/hMena11a expression and phosphorylates ...
  • Ambrus, Attila; Pathak, Parag (Elsevier B.V., 2010-09)
    This paper shows that the presence of different types of players { those who only care about their own material payoffs and those who reciprocate others' contributions { can explain the robust features of observed ...
  • Schmidt, Henrik; Pastore, Thomas; Benjamin, Michael; Schneider, Toby Edwin (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    Autonomous surface and underwater vehicles present a safe and low-cost solution for various contact investigation tasks, such as harbor surveillance for potentially threatening small craft or submarines. Since such a task ...
  • Fallon, Maurice Francis; Papadopoulos, Georgios; Leonard, John Joseph; Patrikalakis, Nicholas M. (Sage Publications, 2010-08)
    In this paper we describe the experimental implementation of an online algorithm for cooperative localization of submerged autonomous underwater vehicles (AUVs) supported by an autonomous surface craft. Maintaining accurate ...
  • Ackerman, Joshua; Kenrick, Douglas T. (Sage Publications, 2009-10)
    Do people help each other form romantic relationships? Research on the role of the social environment in relationship formation has traditionally focused on competition, but this article investigates novel patterns of ...
  • Qin, Zhao; Buehler, Markus J. (American Physical Society, 2010-12)
    Beta-sheet protein domains are stabilized by weak hydrogen bonds, yet materials such as silk—whose ultimate tensile strength is controlled primarily by this secondary structure—can exceed the ultimate tensile strength of ...
  • Bahr, Alexander; Leonard, John Joseph; Fallon, Maurice Francis (Sage Publications, 2009-06)
    This paper describes an algorithm for distributed acoustic navigation for Autonomous Underwater Vehicles (AUVs). Whereas typical AUV navigation systems utilize pre-calibrated arrays of static transponders, our work seeks ...
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