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Browsing MIT Open Access Articles by Title

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  • Ploegh, Hidde; Sun, Jiusong; Hartvigsen, Karsten; Chou, Meng-Yun; Zhang, Yadong; Sukhova, Galina K.; Zhang, Jie; Lopez-Ilasaca, Marco; Diehl, Cody J.; Yakov, Niva; Harats, Dror; George, Jacob; Witztum, Joseph L.; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer) -American Heart Association, 2010-08)
    Background: Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis ...
  • Buehler, Markus J. (American Society of Mechanical Engineers, 2009-11)
    Here we focus on recent advances in understanding the deformation and fracture behavior of collagen, Nature's most abundant protein material and the basis for many biological composites including bone, dentin or cornea. ...
  • Pritchard, Justin Robert; Bruno, Peter Michael; Gilbert, Luke Andrew; Capron, Kelsey L.; Lauffenburger, Douglas A.; Hemann, Michael (National Academy of Sciences (U.S.), 2012-12)
    Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, ...
  • Sim, Adrian Chong Nyi; Too, Chien Tei; Oo, Min Zin; Lai, Junyun; Eio, Michelle Yating; Song, Zhenying; Srinivasan, Nalini; Tan, Diane Ai Lin; Pang, Shyue Wei; Gan, Shu Uin; Lee, Kok Onn; Loh, Thomas Kwok Seng; Chen, Jianzhu; Chan, Soh Ha; MacAry, Paul Anthony (Nature Publishing Group, 2013-11)
    Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived ...
  • Cheung, Clifford; Mardon, Jeremy; Nomura, Yasunori; Thaler, Jesse (Springer / SISSA, 2010-07)
    If the lightest observable-sector supersymmetric particle (LOSP) is charged and long-lived, then it may be possible to indirectly measure the Planck mass at the LHC and provide a spectacular confirmation of supergravity ...
  • Ishii, Hiroshi; Follmer, Sean Weston; Johnson, Micah K.; Adelson, Edward H. (Association for Computing Machinery (ACM), 2011-10)
    We introduce a novel input device, deForm, that supports 2.5D touch gestures, tangible tools, and arbitrary objects through real-time structured light scanning of a malleable surface of interaction. DeForm captures ...
  • Ravela, Srinivas; Yang, Christopher M. (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    We present a new approach to deformation invariant image matching. Our matcher (a) aligns templates to targets over a broad range of nonlinear deformations, (b) factors the total deformation into spectral categories, where ...
  • Ulitsky, Igor; Shamir, Ron; Krishnamurthy, Akshay; Karp, Richard M. (Public Library of Science, 2010-10)
    Background Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have ...
  • Ramirez, David M.; Rodriguez, Alejandro W.; Hashemi, Hila; Joannopoulos, John D.; Soljacic, Marin; Johnson, Steven G. (American Physical Society, 2011-03)
    We demonstrate theoretical conditions for highly efficient degenerate four-wave mixing in triply resonant nonlinear (Kerr) cavities. We employ a general and accurate temporal coupled-mode analysis in which the interaction ...
  • Flessner, Ryan M.; Jewell, Christopher M.; Anderson, Daniel G.; Lynn, David M. (American Chemical Society (ACS), 2011-05)
    We report an approach to the design of degradable polyelectrolyte-based films for the controlled release of siRNA from surfaces. Our approach is based on stepwise, layer-by-layer assembly of multilayered polyelectrolyte ...
  • Sharma, Vivek Inder; Yildiz, Bilge (Electrochemical Society, 2010-02)
    Detailed chemical and structural analyses are presented for the degradation mechanism of La0.8Sr0.2CoO3 [La subscript 0.8 Sr subscript 0.2 CoO subscript 3]] (LSC) as the contact layer of solid oxide electrolysis cell ...
  • Sheng, Morgan Hwa-Tze; Sung, Clifford C.; Brito, Ilana Lauren; Hung, Albert Y. (Public Library of Science, 2010-03)
    Changes in neuronal activity modify the structure of dendritic spines and alter the function and protein composition of synapses. Regulated degradation of postsynaptic density (PSD) proteins by the ubiquitin-proteasome ...
  • Hover, Franz S. (Inderscience Enterprises Ltd., 2011)
    A recent asymptotic model of cascading failure in two-domain, coupled infrastructures is used to pose and solve a specific degree-distribution design problem. Low-order non-linear analysis exposes the mechanisms by which ...
  • Tsitsiklis, John N. (Institute of Electrical and Electronics Engineers (IEEE), 2011-12)
    We consider a consensus algorithm in which every node in a time-varying undirected connected graph assigns equal weight to each of its neighbors. Under the assumption that the degree of any given node is constant in time, ...
  • Sauer, Robert T.; Gur, Eyal (National Academy of Sciences (U.S.), 2009-10)
    AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally ...
  • Mani, Ali; Bazant, Martin Z. (American Physical Society (APS), 2011-12)
    Salt transport in bulk electrolytes is limited by diffusion and advection, but in microstructures with charged surfaces (e.g., microfluidic devices, porous media, soils, or biological tissues) surface conduction and ...
  • Wang, Han; Hsu, Allen; Lee, Dong Seup; Kim, Ki Kang; Kong, Jing; Palacios, Tomas (Institute of Electrical and Electronics Engineers (IEEE), 2012-02)
    In this letter, we analyze the carrier transit delay in graphene field-effect transistors (GFETs).The extraction of the intrinsic delay provides a new way to directly estimate carrier velocity from the experimental data, ...
  • Modiano, Eytan H.; Le, Long Bao; Jagannathan, Krishna Prasanna (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper studies delay properties of the well-known maximum weight scheduling algorithm in wireless ad hoc networks. We consider wireless networks with either one-hop or multihop flows. Specifically, this paper shows ...
  • Johnson, Stephen H.; Hashemi, Hila; Zhang, Baile; Joannopoulos, John D. (American Physical Society, 2010-06)
    We show that the difficulty of cloaking is fundamentally limited by delay-loss and delay-bandwidth limitations that worsen as the size of the object to be cloaked increases relative to the wavelength, using a simple model ...
  • Hashemi, Hila; Zhang, Baile; Joannopoulos, John D.; Johnson, Steven G. (American Physical Society, 2010-06)
    We show that the difficulty of cloaking is fundamentally limited by delay-loss and delay-bandwidth limitations that worsen as the size of the object to be cloaked increases relative to the wavelength, using a simple model ...
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