Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Sehrawat, Sharvan; Kirak, Oktay; Koenig, Paul-Albert; Isaacson, Marisa K.; Marques, Sofia; Bozkurt, Gunes; Simas, J. Pedro; Jaenisch, Rudolf; Ploegh, Hidde (Elsevier, 2012-04)
    To study the CD8[superscript +] T cell response against a mouse γ-herpes virus, we generated K[superscript b]-MHV-68-ORF8[superscript 604–612]RAG[superscript −/−] CD8[superscript +] T cell receptor transnuclear (TN) mice ...
  • Mashayekhi, Mona; Sandau, Michelle M.; Dunay, Ildiko R.; Frickel, Eva M.; Khan, Asis; Goldszmid, Romina S.; Sher, Alan; Murphy, Theresa L.; Sibley, L. David; Murphy, Kenneth M.; Ploegh, Hidde (Elsevier/Cell Press, 2011-08)
    CD8α[superscript +] dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by CD8α[superscript +] ...
  • Rock, Jeremy Michael; Amon, Angelika B. (Cold Spring Harbor Laboratory Press, 2011-02)
    In budding yeast, a Ras-like GTPase signaling cascade known as the mitotic exit network (MEN) promotes exit from mitosis. To ensure the accurate execution of mitosis, MEN activity is coordinated with other cellular events ...
  • Calvo, Fernando; Ranftl, Romana; Hooper, Steven; Farrugia, Aaron J.; Moeendarbary, Emad; Bruckbauer, Andreas; Batista, Facundo; Charras, Guillaume; Sahai, Erik (Elsevier, 2015-12)
    Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the ...
  • Maia, Ana R. R.; Garcia, Zaira; Kabeche, Lilian; Barisic, Marin; Maffini, Stefano; Macedo-Ribeiro, Sandra; Cheeseman, Iain McPherson; Compton, Duane A.; Kaverina, Irina; Maiato, Helder (Rockefeller University Press, 2012-03)
    Accurate chromosome segregation during mitosis relies on a dynamic kinetochore (KT)–microtubule (MT) interface that switches from a labile to a stable condition in response to correct MT attachments. This transition is ...
  • Zhang, Lei; Zhu, J. Julius; Clauser, Karl R.; Carr, Steven A.; Guan, Ji-Song; Su, Susan Chih-Chieh; Gao, Jun; Joseph, Nadine; Xie, Zhigang; Zhou, Ying; Durak, Omer; Tsai, Li-Huei (Public Library of Science, 2011-09)
    Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory ...
  • Buchman, Joshua J.; Tseng, Huan-Chung; Zhou, Ying; Frank, Christopher Lee; Xie, Zhigang; Tsai, Li-Huei (Elsevier B.V., 2010-05)
    Primary autosomal-recessive microcephaly (MCPH) and Majewski osteodysplastic primordial dwarfism type II (MOPDII) are both genetic diseases that result in decreased brain size at birth. MCPH is thought to arise from ...
  • Wang, Yubao; Zhang, Tinghu; Kwiatkowski, Nicholas; Abraham, Brian J.; Lee, Tong Ihn; Xie, Shaozhen; Yuzugullu, Haluk; Von, Thanh; Li, Heyuan; Lin, Ziao; Stover, Daniel G.; Lim, Elgene; Wang, Zhigang C.; Iglehart, J. Dirk; Gray, Nathanael S.; Zhao, Jean J.; Young, Richard A (Elsevier B.V., 2015-09)
    Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a relatively uniform transcriptional program. We postulate that TNBC might ...
  • Chipumuro, Edmond; Marco, Eugenio; Christensen, Camilla L.; Zhang, Tinghu; Hatheway, Clark M.; Sharma, Bandana; Yeung, Caleb; Altabef, Abigail; Perez-Atayde, Antonio; Wong, Kwok-Kin; Yuan, Guo-Cheng; Gray, Nathanael S.; George, Rani E.; Kwiatkowski, Nick; Abraham, Brian Joseph; Young, Richard A (Elsevier, 2014-11)
    The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. ...
  • Cheeseman, Iain McPherson; Gascoigne, Karen E. (Rockefeller University Press, The, 2013-03)
    Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory ...
  • Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Zon, Leonard I.; Gifford, David K. (Elsevier, 2013-11)
    Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight ...
  • Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.; Ploegh, Hidde (Nature Publishing Group, 2014-10)
    T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and ...
  • Doyle, Patrick S.; Hsiao, Lilian (Royal Society of Chemistry, 2015-09)
    We report the coexistence of stress-bearing percolation with arrested phase separation in a colloidal system of thermoresponsive nanoemulsions spanning a broad range of volume fractions (0.10 ≤ ϕ ≤ 0.33) and temperatures ...
  • Sanyal, Bishwapriya (Taylor & Francis, 2014-03)
    The Royal Town Planning Institute (RTPI) should be proud that it was one of the first organizations to introduce the idea that good cities require public planning by qualified professionals. It is not that no one had ...
  • Korzelius, Jerome; The, Inge; Ruijtenberg, Suzan; Portegijs, Vincent; Xu, Huihong; Horvitz, H. Robert; van den Heuvel, Sander (Elsevier, 2010-12)
    DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic ...
  • Zaret, K. S.; Fox, I. J.; Bhatia, Sangeeta N; Underhill, Gregory (American Association for the Advancement of Science (AAAS), 2016-07)
    Despite the tremendous hurdles presented by the complexity of the liver’s structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating ...
  • Fendyur, Anna; Varma, Sarvesh; Lo, Catherine T.; Voldman, Joel (American Chemical Society (ACS), 2014-07)
    Understanding how newly engineered micro- and nanoscale materials and systems that interact with cells impact cell physiology is crucial for the development and ultimate adoption of such technologies. Reports regarding the ...
  • Desai, Salil P.; Voldman, Joel (Royal Society of Chemistry, The, 2010-10)
    Microsystems are increasingly used in the manipulation, patterning and sorting of cells. Critical to the widespread adoption of these new technologies is development of an understanding of their impact on cellular physiology. ...
  • Vasquez, Claudia G; Martin, Adam C (Springer Nature, 2015-01)
    An analysis of dying cells reveals that they play an active part in modifying tissue shape by pulling on neighbouring cells. This induces neighbouring cells to contract at their apices, which results in tissue folding. See ...
  • Xu, F.; Moon, S.; Emre, Ahmet E.; Lien, C.; Turali, E. S.; Demirci, Utkan (Institute of Electrical and Electronics Engineers (IEEE), 2010-01)
    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...
Open Access