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Browsing MIT Open Access Articles by Title

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  • Pini, Francesco; De Nisco, Nicole J.; Ferri, Lorenzo; Penterman, Jon; Fioravanti, Antonella; Brilli, Matteo; Mengoni, Alessio; Bazzicalupo, Marco; Viollier, Patrick H.; Walker, Graham C.; Biondi, Emanuele G. (Public Library of Science, 2015-05)
    In all domains of life, proper regulation of the cell cycle is critical to coordinate genome replication, segregation and cell division. In some groups of bacteria, e.g. Alphaproteobacteria, tight regulation of the cell ...
  • Maheshri, Narendra; Zopf, Christopher John; Quinn, Katie Julia; Zeidman, Joshua A. (Public Library of Science, 2013-07)
    The large variability in mRNA and protein levels found from both static and dynamic measurements in single cells has been largely attributed to random periods of transcription, often occurring in bursts. The cell cycle has ...
  • Mazumder, Aprotim; Tummler, Katja; Bathe, Mark; Samson, Leona D. (American Society for Microbiology, 2012-11)
    The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells ...
  • Levin, Petra Anne; Grossman, Alan D. (Elsevier, 1998-01)
    Despite the power of bacterial genetics, the prokaryotic cell cycle has remained poorly understood. But recent work with three different bacterial species has shed light on how chromosomes and plasmids are oriented and ...
  • Mroz, Pawel; Yaroslavsky, Anastasia; Kharkwal, Gitika B.; Hamblin, Michael R. (MDPI AG, 2011-06)
    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...
  • Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles C.; Kho, Alvin T.; Mih, Justin; Deng, Linhong; Butler, James; Tschumperlin, Daniel; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henry (Public Library of Science, 2012-09)
    Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ...
  • Tegler, Lotta Tollstoy; Corin, Karolina A.; Hillger, Julia; Wassie, Brooke; Yu, Yanmei; Zhang, Shuguang (Nature Publishing Group, 2015-01)
    Insects transmit numerous devastating diseases, including malaria, dengue fever, and sleeping sickness. Olfactory cues guide insects to their hosts, and are thus responsible for disease transmission. Understanding the ...
  • Shelley, Brandon C.; Mandefro, Berhan; Sareen, Dhruv; Svendsen, Clive N.; Milani, Pamela; Escalante, Renan A.; Patel-Murray, Natasha Leanna; Xin, Xiaofeng; Adam, Miriam; Fraenkel, Ernest (Nature Publishing Group, 2016-05)
    In recent years, the assay for transposase-accessible chromatin using sequencing (ATAC-Seq) has become a fundamental tool of epigenomic research. However, it is difficult to perform this technique on frozen samples because ...
  • Shelley, Brandon C.; Mandefro, Berhan; Sareen, Dhruv; Svendsen, Clive N.; Milani, Pamela; Escalante, Renan A.; Patel-Murray, Natasha Leanna; Xin, Xiaofeng; Adam, Miriam; Fraenkel, Ernest (Nature Publishing Group, 2016-05)
    In recent years, the assay for transposase-accessible chromatin using sequencing (ATAC-Seq) has become a fundamental tool of epigenomic research. However, it is difficult to perform this technique on frozen samples because ...
  • Kim, Min-Cheol; Silberberg, Yaron R.; Whisler, Jordan Ari; Kamm, Roger Dale; Asada, Harry (Public Library of Science, 2015-10)
    The dynamics of filopodia interacting with the surrounding extracellular matrix (ECM) play a key role in various cell-ECM interactions, but their mechanisms of interaction with the ECM in 3D environment remain poorly ...
  • Shin, Su Ryon; Aghaei-Ghareh-Bolagh, Behnaz; Dang, Tram T.; Topkaya, Seda Nur; Gao, Xiguang; Yang, Seung Yun; Jung, Sung Mi; Oh, Jong Hyun; Dokmeci, Mehmet; Tang, Xiaowu (Shirley); Khademhosseini, Ali (John Wiley & Sons, Inc, 2013-11)
    Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts ...
  • Barthes, Julien; Ndreu-Halili, Albana; Hasan, Anwarul; Vrana, Nihal Engin; Ozcelik, Hayriye; Hindie, Mathilde (Hindawi Publishing Corporation, 2014-07)
    In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological ...
  • Terfve, Camille; Cokelaer, Thomas; Henriques, David; MacNamara, Aidan; Goncalves, Emanuel; Iersel, Martijn van; Saez-Rodriguez, Julio; Morris, Melody Kay; Lauffenburger, Douglas A. (BioMed Central Ltd, 2012-10)
    Background: Cells process signals using complex and dynamic networks. Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiological and diseased situations. ...
  • Iliescu, Ciprian; Xu, Guolin; Yu, Fang; Tresset, Guillaume; Tong, Wen Hao; Bălan, Cătălin Mihai; Yu, Hanry (Springer Berlin Heidelberg, 2015-02)
    The paper presents a dielectrophoretic method for cell patterning using dielectrophoretic–hydrodynamic trap. A distinctive characteristic of the device is that the dielectrophoretic (DEP) force is generated using a structure ...
  • Crouzier, T.; Jang, H.; Ahn, J.; Stocker, Roman; Ribbeck, Katharina (American Chemical Society (ACS), 2013-09)
    The precise spatial control of cell adhesion to surfaces is an endeavor that has enabled discoveries in cell biology and new possibilities in tissue engineering. The generation of cell-repellent surfaces currently requires ...
  • Monje-Casas, Fernando; Amon, Angelika B. (Elsevier B.V., 2009-01)
    Components of the mitotic exit network (MEN), a signaling pathway that triggers exit from mitosis, localize to the spindle pole body (SPB) that migrates into the daughter cell during anaphase but are largely absent from ...
  • Wheeler, Douglas B.; Sabatini, David M.; Kang, In Han; Golland, Polina; Papallo, Adam; Lindquist, Robert A.; Carpenter, Anne E.; Jones, Thouis R. (BioMed Central Ltd., 2008-11)
    Background: Image-based screens can produce hundreds of measured features for each of hundreds of millions of individual cells in a single experiment. Results: Here, we describe CellProfiler Analyst, open-source software ...
  • Carpenter, Anne E.; Jones, Thouis R.; Lamprecht, Michael R.; Clarke, Colin; Kang, In Han; Friman, Ola; Guertin, David A.; Chang, Joo Han; Lindquist, Robert A.; Moffat, Jason; Golland, Polina; Sabatini, David M. (BioMed Central Ltd, 2006-10)
    Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source ...
  • Choi, Sungyoung; Levy, Oren; Cabral, Joaquim M. S.; Coelho, Monica B.; Karp, Jeffrey Michael; Karnik, Rohit (Royal Society of Chemistry, 2013-10)
    This communication presents quantitative studies of the dynamic adhesion behavior of mesenchymal stem cells (MSCs) enabled by the combination of cell-surface receptor–ligand interactions and three-dimensional hydrodynamic ...
  • van Zon, Jeroen Sebastiaan; Kienle, Simone; Huelsz-Prince, Guizela; Barkoulas, Michalis; van Oudenaarden, Alexander (Nature Publishing Group, 2015-05)
    How cells in developing organisms interpret the quantitative information contained in morphogen gradients is an open question. Here we address this question using a novel integrative approach that combines quantitative ...
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