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Browsing MIT Open Access Articles by Title

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  • Green, Todd; Guiducci, Candace; Segre, Ayellet V.; Daly, Mark J.; Altshuler, David; Korn, Joshua M. (Public Library of Science, 2010-10)
    The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors.1 To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we ...
  • Lee, M. N.; Ye, C.; Villani, A.-C.; Raj, T.; Li, W.; Eisenhaure, Thomas; Imboywa, S. H.; Chipendo, P. I.; Slowikowski, K.; Raddassi, K.; McCabe, C.; Lee, M. H.; Frohlich, I. Y.; Raychaudhuri, S.; Stranger, B. E.; Benoist, Christophe; De Jager, Philip L.; Hacohen, Nir; Ran, F. Ann; Zhang, Feng; Regev, Aviv; Hafler, David A.; Ward, Lucas D.; Kellis, Manolis (American Association for the Advancement of Science (AAAS), 2014-03)
    Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic ...
  • Skerry, Amy E.; Saxe, Rebecca R. (Society for Neuroscience, 2014-11)
    Although the emotions of other people can often be perceived from overt reactions (e.g., facial or vocal expressions), they can also be inferred from situational information in the absence of observable expressions. How ...
  • Heineman, Richard H.; Chantranupong, Lynne (Springer (Biomed Central Ltd.), 2012-03)
    Background: Optimality models of evolution, which ignore genetic details and focus on natural selection, are widely used but sometimes criticized as oversimplifications. Their utility for quantitatively predicting phenotypic ...
  • Nandkishore, Rahul Mahajan; Levitov, Leonid (National Academy of Sciences (U.S.), 2011-08)
    Interference and tunneling are two signature quantum effects that are often perceived as the yin and yang of quantum mechanics: a particle simultaneously propagating along several distinct classical paths versus a particle ...
  • Fridriksson, Joel K.; Homan, Jeroen; Remillard, Ronald Alan (IOP Publishing, 2015-08)
    The X-ray transient XTE J1701–462 was the first source observed to evolve through all known subclasses of low-magnetic-field neutron star low-mass X-ray binaries (NS-LMXBs), as a result of large changes in its mass accretion ...
  • Roussano, Nikolai; Lustig, Hanno (Oxford University Press on behalf of The Society for Financial Studies, 2011-08)
    We identify a “slope” factor in exchange rates. High interest rate currencies load more on this slope factor than low interest rate currencies. This factor accounts for most of the cross-sectional variation in average ...
  • Dinakar, Karthik; Jones, Birago; Havasi, Catherine; Lieberman, Henry A.; Picard, Rosalind W. (Association for Computing Machinery (ACM), 2012-09)
    Cyberbullying (harassment on social networks) is widely recognized as a serious social problem, especially for adolescents. It is as much a threat to the viability of online social networks for youth today as spam once was ...
  • Forney, David C.; Rothman, Daniel H. (Royal Society, 2012-04)
    Carbon removed from the atmosphere by photosynthesis is released back by respiration. Although some organic carbon is degraded quickly, older carbon persists; consequently carbon stocks are much larger than predicted by ...
  • Aloupis, Greg; Bose, Prosenjit; Collette, Sebastien; Demaine, Erik D.; Demaine, Martin L.; Douieb, Karim; Dujmovic, Vida; Iacono, John; Langerman, Stefan; Morin, Pat (Springer Berlin / Heidelberg, 2011-11)
    This paper studies common unfoldings of various classes of polycubes, as well as a new type of unfolding of polyominoes. Previously, Knuth and Miller found a common unfolding of all tree-like tetracubes. By contrast, we ...
  • Ernst, Jason; Kellis, Manolis (Public Library of Science, 2012-04)
    Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve ...
  • Peltonen, Leena; Timpson, Nicholas J.; Tobias, Jon H.; Richards, J. Brent; Soranzo, Nicole; Duncan, Emma L.; Sims, Anne-Marie; Whittaker, Pamela; Kumanduri, Vasudev; Zhai, Guangju; Glaser, Beate; Eisman, John; Jones, Graeme; Nicholson, Geoff; Prince, Richard; Seeman, Ego; Spector, Tim D.; Brown, Matthew A.; Davey-Smith, George; Deloukas, Panos; Evans, David M. (Oxford University Press (OUP), 2009-01)
    Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related ...
  • Sterman, John (Springer-Verlag, 2011-08)
    The Intergovernmental Panel on Climate Change (IPCC) has been extraordinarily successful in the task of knowledge synthesis and risk assessment. However, the strong scientific consensus on the detection, attribution, and ...
  • Kelly, Shawn K.; Shire, Douglas B.; Chen, Jinghua; Gingerich, Marcus D.; Cogan, Stuart F.; Drohan, William A.; Theogarajan, Luke S.; Wyatt, John L.; Rizzo, Joseph F.; Doyle, Patrick S. (Elsevier, 2011-06)
    A small, hermetic, wirelessly-controlled retinal prosthesis has been developed for pre-clinical studies in Yucatan minipigs. The device was attached conformally to the outside of the eye in the socket and received both ...
  • Blader, Ira J.; Saeij, Jeroen (Wiley Blackwell, 2009-04)
    Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although ...
  • Wohr, Markus; Roullet, Florence I.; Hung, Albert Y.; Sheng, Morgan Hwa-Tze; Crawley, Jacqueline N. (Public Library of Science, 2011-06)
    Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of ...
  • Pinto, Pedro C.; Win, Moe Z. (Institute of Electrical and Electronics Engineers, 2010-07)
    In Part I of this paper, we presented a mathematical model for communication subject to both network interference and noise, where the interferers are scattered according to a spatial Poisson process, and are operating ...
  • Pinto, Pedro C.; Win, Moe Z. (Institute of Electrical and Electronics Engineers / IEEE Communications Society / IEEE signal Processing Society, 2010-07)
    We present a mathematical model for communication subject to both network interference and noise. We introduce a framework where the interferers are scattered according to a spatial Poisson process, and are operating ...
  • Van Lehn, Reid C.; Alexander-Katz, Alfredo (American Institute of Physics, 2011-10)
    Here, we present a new method to model lateral phase separation in mixed polymer brushes physisorbed to a planar surface with mobile grafting points. The model is based on a local mean field theory that combines a Flory-Huggins ...
  • Ruff, Susan; Carter, Michael (Institute of Electrical and Electronics Engineers, 2009-10)
    It is widely acknowledged that employers tend to be dissatisfied with the communication skills of new engineering graduates, yet research into employers' expectations has not provided a sufficient foundation for incorporating ...
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