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Browsing MIT Open Access Articles by Title

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  • Desai, Salil P.; Voldman, Joel (Royal Society of Chemistry, The, 2010-10)
    Microsystems are increasingly used in the manipulation, patterning and sorting of cells. Critical to the widespread adoption of these new technologies is development of an understanding of their impact on cellular physiology. ...
  • Vasquez, Claudia G; Martin, Adam C (Springer Nature, 2015-01)
    An analysis of dying cells reveals that they play an active part in modifying tissue shape by pulling on neighbouring cells. This induces neighbouring cells to contract at their apices, which results in tissue folding. See ...
  • Xu, F.; Moon, S.; Emre, Ahmet E.; Lien, C.; Turali, E. S.; Demirci, Utkan (Institute of Electrical and Electronics Engineers (IEEE), 2010-01)
    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...
  • Domke, Lisa M.; Rickelt, Steffen; Dörflinger, Yvette; Kuhn, Caecilia; Winter-Simanowski, Stefanie; Zimbelmann, Ralf; Rosin-Arbesfeld, Rina; Heid, Hans; Franke, Werner W. (Elsevier B.V., 2014-06)
    The seminiferous tubules and the excurrent ducts of the mammalian testis are physiologically separated from the mesenchymal tissues and the blood and lymph system by a special structural barrier to paracellular translocations ...
  • Corin, Karolina A.; Gibson, Lorna (Elsevier, 2010-04)
    The contractile behavior of cells is relevant in understanding wound healing and scar formation. In tissue engineering, inhibition of the cell contractile response is critical for the regeneration of physiologically normal ...
  • Ni, Ming; Tong, Wen Hao; Choudhury, Deepak; Rahim, Nur Aida Abdul; Iliescu, Ciprian; Yu, Hanry (Molecular Diversity Preservation International, 2009-12)
    Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods ...
  • Pini, Francesco; De Nisco, Nicole J.; Ferri, Lorenzo; Penterman, Jon; Fioravanti, Antonella; Brilli, Matteo; Mengoni, Alessio; Bazzicalupo, Marco; Viollier, Patrick H.; Walker, Graham C.; Biondi, Emanuele G. (Public Library of Science, 2015-05)
    In all domains of life, proper regulation of the cell cycle is critical to coordinate genome replication, segregation and cell division. In some groups of bacteria, e.g. Alphaproteobacteria, tight regulation of the cell ...
  • Maheshri, Narendra; Zopf, Christopher John; Quinn, Katie Julia; Zeidman, Joshua A. (Public Library of Science, 2013-07)
    The large variability in mRNA and protein levels found from both static and dynamic measurements in single cells has been largely attributed to random periods of transcription, often occurring in bursts. The cell cycle has ...
  • Mazumder, Aprotim; Tummler, Katja; Bathe, Mark; Samson, Leona D. (American Society for Microbiology, 2012-11)
    The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells ...
  • Levin, Petra Anne; Grossman, Alan D. (Elsevier, 1998-01)
    Despite the power of bacterial genetics, the prokaryotic cell cycle has remained poorly understood. But recent work with three different bacterial species has shed light on how chromosomes and plasmids are oriented and ...
  • Mroz, Pawel; Yaroslavsky, Anastasia; Kharkwal, Gitika B.; Hamblin, Michael R. (MDPI AG, 2011-06)
    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...
  • Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles C.; Kho, Alvin T.; Mih, Justin; Deng, Linhong; Butler, James; Tschumperlin, Daniel; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henry (Public Library of Science, 2012-09)
    Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ...
  • Tegler, Lotta Tollstoy; Corin, Karolina A.; Hillger, Julia; Wassie, Brooke; Yu, Yanmei; Zhang, Shuguang (Nature Publishing Group, 2015-01)
    Insects transmit numerous devastating diseases, including malaria, dengue fever, and sleeping sickness. Olfactory cues guide insects to their hosts, and are thus responsible for disease transmission. Understanding the ...
  • Shelley, Brandon C.; Mandefro, Berhan; Sareen, Dhruv; Svendsen, Clive N.; Milani, Pamela; Escalante, Renan A.; Patel-Murray, Natasha Leanna; Xin, Xiaofeng; Adam, Miriam; Fraenkel, Ernest (Nature Publishing Group, 2016-05)
    In recent years, the assay for transposase-accessible chromatin using sequencing (ATAC-Seq) has become a fundamental tool of epigenomic research. However, it is difficult to perform this technique on frozen samples because ...
  • Shelley, Brandon C.; Mandefro, Berhan; Sareen, Dhruv; Svendsen, Clive N.; Milani, Pamela; Escalante, Renan A.; Patel-Murray, Natasha Leanna; Xin, Xiaofeng; Adam, Miriam; Fraenkel, Ernest (Nature Publishing Group, 2016-05)
    In recent years, the assay for transposase-accessible chromatin using sequencing (ATAC-Seq) has become a fundamental tool of epigenomic research. However, it is difficult to perform this technique on frozen samples because ...
  • Kim, Min-Cheol; Silberberg, Yaron R.; Whisler, Jordan Ari; Kamm, Roger Dale; Asada, Harry (Public Library of Science, 2015-10)
    The dynamics of filopodia interacting with the surrounding extracellular matrix (ECM) play a key role in various cell-ECM interactions, but their mechanisms of interaction with the ECM in 3D environment remain poorly ...
  • Shin, Su Ryon; Aghaei-Ghareh-Bolagh, Behnaz; Dang, Tram T.; Topkaya, Seda Nur; Gao, Xiguang; Yang, Seung Yun; Jung, Sung Mi; Oh, Jong Hyun; Dokmeci, Mehmet; Tang, Xiaowu (Shirley); Khademhosseini, Ali (John Wiley & Sons, Inc, 2013-11)
    Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts ...
  • Barthes, Julien; Ndreu-Halili, Albana; Hasan, Anwarul; Vrana, Nihal Engin; Ozcelik, Hayriye; Hindie, Mathilde (Hindawi Publishing Corporation, 2014-07)
    In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological ...
  • Terfve, Camille; Cokelaer, Thomas; Henriques, David; MacNamara, Aidan; Goncalves, Emanuel; Iersel, Martijn van; Saez-Rodriguez, Julio; Morris, Melody Kay; Lauffenburger, Douglas A. (BioMed Central Ltd, 2012-10)
    Background: Cells process signals using complex and dynamic networks. Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiological and diseased situations. ...
  • Iliescu, Ciprian; Xu, Guolin; Yu, Fang; Tresset, Guillaume; Tong, Wen Hao; Bălan, Cătălin Mihai; Yu, Hanry (Springer Berlin Heidelberg, 2015-02)
    The paper presents a dielectrophoretic method for cell patterning using dielectrophoretic–hydrodynamic trap. A distinctive characteristic of the device is that the dielectrophoretic (DEP) force is generated using a structure ...
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