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Browsing MIT Open Access Articles by Title

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  • Davis, Joseph H.; Rubin, Adam J.; Sauer, Robert T. (Oxford University Press, 2010-09)
    We have generated a series of variable-strength, constitutive, bacterial promoters that act predictably in different sequence contexts, span two orders of magnitude in strength and contain convenient sites for cloning and ...
  • Drela, Mark (SAE International, 2011-10)
    The fuel energy consumption of subsonic air transportation is examined. The focus is on identification and quantification of fundamental engineering design tradeoffs which drive the design of subsonic tube and wing transport ...
  • Ruan, Liping; Zhang, Hangyu; Luo, Hanlin; Liu, Jingping; Tang, Fushan; Shi, Ying-Kang; Zhao, Xiaojun (National Academy of Sciences, 2009-03)
    How do you design a peptide building block to make 2-dimentional nanowebs and 3-dimensional fibrous mats? This question has not been addressed with peptide self-assembling nanomaterials. This article describes a designed ...
  • Li, Xiansen; Michaelis , Vladimir K.; Ong , Ta-Chung; Smith, Stacey J.; Griffin, Robert Guy; Wang, Evelyn N.; Michaelis, Vladimir K.; Ong, Ta-Chung (John Wiley & Sons, Inc, 2014-05)
    The controllable synthesis of well-ordered layered materials with specific nanoarchitecture poses a grand challenge in materials chemistry. Here the solvothermal synthesis of two structurally analogous 5-coordinate ...
  • Baaske, Philipp; Wienken, Christoph J.; Jerabek-Willemsen, Moran; Duhr, Stefan; Luo, Yuan; Braun, Dieter; Corin, Karolina A.; Ravel, Deepali B.; Song, Junyao; Brown, Emily E.; Wang, Xiaoqiang; Zhang, Shuguang (Public Library of Science, 2011-11)
    A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. ...
  • Dave, Nirav H.; Ng, Man Cheuk; Pellauer, Michael; Mithal, Arvind (Institute of Electrical and Electronics Engineers, 2010-07)
    We propose a practical methodology based on modular refinement to design complex systems. The methodology relies on modules with latency-insensitive interfaces so that the refinements can change the timing contract of a ...
  • Kimerling, Lionel C.; Sun, Xiaochen; Hu, Juejun; Agarwal, Anuradha Murthy (Optical Society of America, 2009-04)
    In this paper, we propose a design tool for dielectric optical resonator-based biochemical refractometry sensors. Analogous to the widely accepted photodetector figure of merit, the detectivity D*, we introduce a new sensor ...
  • Ryan, Jason Christopher; Cummings, M. L.; Roy, Nicholas; Banerjee, Ashis; Schulte, Axel (American Institute of Aeronautics and Astronautics, 2011-03)
    In the near future, unmanned aerial vehicles will become part of the naval aircraft carrier operating environment. This will add significant complexity to an already highly constrained and dangerous environment. The move ...
  • da Costa, David Carvalho Teixeira; de Neufville, Richard (Transportation Research Board of the National Academies, 2012-11)
    This paper provides a practical procedure for designing efficient taxi pickup operations at airports. How to do this effectively is an open question. Solutions are not available, and practices vary. They reflect different ...
  • Joshi, Ajay J.; Kim, Byungsub; Stojanovic, Vladimir Marko (Institute of Electrical and Electronics Engineers, 2009-09)
    In a power and area constrained multicore system, the on-chip communication network needs to be carefully designed to maximize the system performance and programmer productivity while minimizing energy and area. In this ...
  • Rodriguez-Wong, Alejandro; Woolf, David; Hui, Pui-Chuen; Iwase, Eiji; McCauley, Alexander Patrick; Capasso, Federico; Loncar, Marko; Johnson, Steven G. (American Institute of Physics, 2011-05)
    We propose an optomechanical structure consisting of a photonic-crystal (holey) membrane suspended above a layered silicon-on-insulator substrate in which resonant bonding/antibonding optical forces created by externally ...
  • Stojanovic, Vladimir Marko; Shamim, Imran; Batten, Christopher; Joshi, Ajay J.; Kwon, Yong-Jin; Beamer, Scott; Asanovic, Krste (Institute of Electrical and Electronics Engineers, 2009-12)
    We present a vertical integration approach for designing silicon photonic networks for communication in manycore systems. Using a top-down approach we project the photonic device requirements for a 64-tile system designed ...
  • Asatekin, Ayse; Barr, Miles C.; Baxamusa, Salmaan H.; Lau, Kenneth K.S.; Tenhaeff, Wyatt; Xu, Jingjing; Gleason, Karen K. (Elsevier, 2010-04)
    Chemical Vapor Deposition (CVD) methods significantly augment the capabilities of traditional surface modification techniques for designing polymeric surfaces. In CVD polymerization, the monomer(s) are delivered to the ...
  • Brizzolara, Stefano; Grassi, Davide; Tincani, Emilio P. (Hindawi Publishing Corporation, 2012)
    The main theoretical and numerical aspects of a design method for optimum contrar-rotating (CR) propellers for fast marine crafts are presented. We propose a reformulated version of a well-known design theory for contra-rotating ...
  • Burkhart, Justin M.; Korsunsky, Roman; Perreault, David J. (Institute of Electrical and Electronics Engineers (IEEE), 2013-04)
    This paper introduces a design methodology for a resonant boost converter topology that is suitable for operation at very high frequencies. The topology we examine features a low parts count and fast transient response, ...
  • Burkhart, Justin M.; Korsunsky, Roman; Perreault, David J. (IEEE Industry Applications Society, 2010-06)
    This document introduces a design methodology for a resonant boost converter topology that is suitable for operation at very high frequencies. The topology we examine features a low parts count and fast transient response ...
  • Parkesh, Raman; Childs-Disney, Jessica L.; Nakamori, Masayuki; Kumar, Amit; Wang, Eric; Wang, Thomas; Hoskins, Jason; Tran, Tuan; Thornton, Charles A.; Disney, Matthew D.; Housman, David E. (American Chemical Society (ACS), 2012-02)
    Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3′-untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The transcribed repeats fold into an RNA ...
  • Slocum, Alexander H.; Bosworth, William R.; Mazumdar, Anirban; Saez, Miguel A.; Culpepper, Martin Luther; Levine, Robert A. (American Society of Mechanical Engineers, 2009-06)
    This paper focuses on the design and implementation of a percutaneous catheter-based device to provide physicians with an externally controlled tool capable of manipulating and cutting specific chordae tendinae within the ...
  • Ramanujam, Rohit Sunkam; Soteriou, Vassos; Lin, Bill; Peh, Li-Shiuan (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    Router microarchitecture plays a central role in the performance of an on-chip network (NoC). Buffers are needed in routers to house incoming flits which cannot be immediately forwarded due to contention. This buffering ...
  • Castonia, Ryan; Boussemart, Yves; Cummings, M. L. (American Institute of Aeronautics and Astronautics, 2010-04)
    This paper presents the findings from the design, development, and evaluation of a hidden semi-Markov model based operator state monitoring display. This operator state monitoring display is designed to function as a ...
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