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Browsing MIT Open Access Articles by Title

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  • Pritchard, Justin Robert; Bruno, Peter Michael; Gilbert, Luke Andrew; Capron, Kelsey L.; Lauffenburger, Douglas A.; Hemann, Michael (National Academy of Sciences (U.S.), 2012-12)
    Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, ...
  • Sim, Adrian Chong Nyi; Too, Chien Tei; Oo, Min Zin; Lai, Junyun; Eio, Michelle Yating; Song, Zhenying; Srinivasan, Nalini; Tan, Diane Ai Lin; Pang, Shyue Wei; Gan, Shu Uin; Lee, Kok Onn; Loh, Thomas Kwok Seng; Chen, Jianzhu; Chan, Soh Ha; MacAry, Paul Anthony (Nature Publishing Group, 2013-11)
    Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived ...
  • Cheung, Clifford; Mardon, Jeremy; Nomura, Yasunori; Thaler, Jesse (Springer / SISSA, 2010-07)
    If the lightest observable-sector supersymmetric particle (LOSP) is charged and long-lived, then it may be possible to indirectly measure the Planck mass at the LHC and provide a spectacular confirmation of supergravity ...
  • Ishii, Hiroshi; Follmer, Sean Weston; Johnson, Micah K.; Adelson, Edward H. (Association for Computing Machinery (ACM), 2011-10)
    We introduce a novel input device, deForm, that supports 2.5D touch gestures, tangible tools, and arbitrary objects through real-time structured light scanning of a malleable surface of interaction. DeForm captures ...
  • Ravela, Srinivas; Yang, Christopher M. (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    We present a new approach to deformation invariant image matching. Our matcher (a) aligns templates to targets over a broad range of nonlinear deformations, (b) factors the total deformation into spectral categories, where ...
  • Ulitsky, Igor; Shamir, Ron; Krishnamurthy, Akshay; Karp, Richard M. (Public Library of Science, 2010-10)
    Background Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have ...
  • Ramirez, David M.; Rodriguez, Alejandro W.; Hashemi, Hila; Joannopoulos, John D.; Soljacic, Marin; Johnson, Steven G. (American Physical Society, 2011-03)
    We demonstrate theoretical conditions for highly efficient degenerate four-wave mixing in triply resonant nonlinear (Kerr) cavities. We employ a general and accurate temporal coupled-mode analysis in which the interaction ...
  • Flessner, Ryan M.; Jewell, Christopher M.; Anderson, Daniel G.; Lynn, David M. (American Chemical Society (ACS), 2011-05)
    We report an approach to the design of degradable polyelectrolyte-based films for the controlled release of siRNA from surfaces. Our approach is based on stepwise, layer-by-layer assembly of multilayered polyelectrolyte ...
  • Sharma, Vivek Inder; Yildiz, Bilge (Electrochemical Society, 2010-02)
    Detailed chemical and structural analyses are presented for the degradation mechanism of La0.8Sr0.2CoO3 [La subscript 0.8 Sr subscript 0.2 CoO subscript 3]] (LSC) as the contact layer of solid oxide electrolysis cell ...
  • Sheng, Morgan Hwa-Tze; Sung, Clifford C.; Brito, Ilana Lauren; Hung, Albert Y. (Public Library of Science, 2010-03)
    Changes in neuronal activity modify the structure of dendritic spines and alter the function and protein composition of synapses. Regulated degradation of postsynaptic density (PSD) proteins by the ubiquitin-proteasome ...
  • Hover, Franz S. (Inderscience Enterprises Ltd., 2011)
    A recent asymptotic model of cascading failure in two-domain, coupled infrastructures is used to pose and solve a specific degree-distribution design problem. Low-order non-linear analysis exposes the mechanisms by which ...
  • Tsitsiklis, John N. (Institute of Electrical and Electronics Engineers (IEEE), 2011-12)
    We consider a consensus algorithm in which every node in a time-varying undirected connected graph assigns equal weight to each of its neighbors. Under the assumption that the degree of any given node is constant in time, ...
  • Sauer, Robert T.; Gur, Eyal (National Academy of Sciences (U.S.), 2009-10)
    AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally ...
  • Mani, Ali; Bazant, Martin Z. (American Physical Society (APS), 2011-12)
    Salt transport in bulk electrolytes is limited by diffusion and advection, but in microstructures with charged surfaces (e.g., microfluidic devices, porous media, soils, or biological tissues) surface conduction and ...
  • Wang, Han; Hsu, Allen; Lee, Dong Seup; Kim, Ki Kang; Kong, Jing; Palacios, Tomas (Institute of Electrical and Electronics Engineers (IEEE), 2012-02)
    In this letter, we analyze the carrier transit delay in graphene field-effect transistors (GFETs).The extraction of the intrinsic delay provides a new way to directly estimate carrier velocity from the experimental data, ...
  • Modiano, Eytan H.; Le, Long Bao; Jagannathan, Krishna Prasanna (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper studies delay properties of the well-known maximum weight scheduling algorithm in wireless ad hoc networks. We consider wireless networks with either one-hop or multihop flows. Specifically, this paper shows ...
  • Hashemi, Hila; Zhang, Baile; Joannopoulos, John D.; Johnson, Steven G. (American Physical Society, 2010-06)
    We show that the difficulty of cloaking is fundamentally limited by delay-loss and delay-bandwidth limitations that worsen as the size of the object to be cloaked increases relative to the wavelength, using a simple model ...
  • Johnson, Stephen H.; Hashemi, Hila; Zhang, Baile; Joannopoulos, John D. (American Physical Society, 2010-06)
    We show that the difficulty of cloaking is fundamentally limited by delay-loss and delay-bandwidth limitations that worsen as the size of the object to be cloaked increases relative to the wavelength, using a simple model ...
  • Johnson, Daniel W; Schmidt, Ulrich H; Bittner, Edward A; Christensen, Benjamin; Levi, Retsef; Pino, Richard M (BioMed Central Ltd, 2013-07)
    Introduction: A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit ...
  • Kochman, Yuval; Wornell, Gregory W.; Yao, Huan (Institute of Electrical and Electronics Engineers (IEEE), 2011-01)
    We focus on the problem of real-time streaming over a blockage channel with long feedback delay, as arises in real-time satellite communication from a comm-on-the-move (COTM) terminal. For this problem, we introduce a ...
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