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Browsing MIT Open Access Articles by Title

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  • Leibensperger, Eric Michael; Mickley, L. J.; Jacob, Daniel J.; Chen, W. -T.; Seinfeld, J. H.; Seinfeld, J. H.; Adams, P. J.; Streets, D. G.; Kumar, N.; Rind, D. (Copernicus GmbH, 2012-04)
    We use the GEOS-Chem chemical transport model combined with the GISS general circulation model to calculate the aerosol direct and indirect (warm cloud) radiative forcings from US anthropogenic sources over the 1950–2050 ...
  • Leibensperger, Eric Michael; Mickley, L. J.; Chen, W. -T.; Seinfeld, J. H.; Nenes, A.; Adams, P. J.; Streets, D. G.; Kumar, N.; Rind, D. (Copernicus GmbH, 2012-04)
    We investigate the climate response to changing US anthropogenic aerosol sources over the 1950–2050 period by using the NASA GISS general circulation model (GCM) and comparing to observed US temperature trends. Time-dependent ...
  • Monier, Erwan; Weare, B. C. (European Geosciences Union, 2011-07)
    A thorough analysis of the ozone transport was carried out using the Transformed-Mean Eulerian (TEM) tracer continuity equation and the European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40). In ...
  • Weare, B. C.; Monier, Erwan (Copernicus GmbH, 2011-12)
    The momentum budget of the Transformed Eulerian-Mean (TEM) equation is calculated using the European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis (ERA-40) and the National Centers for Environmental Prediction ...
  • Stern, Scott; Furman, Jeffrey L. (American Economic Association, 2011-08)
    While cumulative knowledge production is central to growth, little empirical research investigates how institutions shape whether existing knowledge can be exploited to create new knowledge. This paper assesses the impact ...
  • Snyder, Benjamin; Barzilay, Regina (Omnipress, 2010-06)
    For centuries, scholars have explored the deep links among human languages. In this paper, we present a class of probabilistic models that use these links as a form of naturally occurring supervision. These models ...
  • Thomas, L.; Talley, L.; Silverthorne, K.; Skyllingstad, E.; Samelson, R.; Lumpkin, R.; Palter, J.; Lozier, S.; Kelly, K.; Gregg, M.; Edson, J.; Weller, R.; Toole, J.; Straneo, F.; Joyce, T.; Fratantoni, D.; Doney, Scott C.; Dewar, W.; Bates, N.; Andersson, A.; Maze, Guillaume O.; Forget, Gael; Ferrari, Raffaele; Marshall, John C. (American Meteorological Society, 2009-01)
    A major oceanographic field experiment is described, which is designed to observe, quantify, and understand the creation and dispersal of weakly stratified fluid known as “mode water” in the region of the Gulf Stream. ...
  • Purdon, Patrick L.; Sampson, Aaron; Pavone, Kara J.; Brown, Emery N. (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2015-10)
    The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different ...
  • Merchant, Faisal M.; Ikeda, Takanori; Pedretti, Roberto F.E.; Salerno-Uriarte, Jorge A.; Chow, Theodore; Chan, Paul S.; Bartone, Cheryl; Hohnloser, Stefan H.; Cohen, Richard J.; Armoundas, Antonis A. (Elsevier, 2012-03)
    Background Previous studies have demonstrated that microvolt T-wave alternans (MTWA) testing is a robust predictor of ventricular tachyarrhythmias and sudden cardiac death (SCD) in at-risk patients. However, recent studies ...
  • Khoo, Bee Luan; Warkiani, Majid Ebrahimi; Tan, Daniel Shao-Weng; Bhagat, Ali Asgar S.; Irwin, Darryl; Lau, Dawn Pingxi; Lim, Alvin S. T.; Lim, Kiat Hon; Krisna, Sai Sakktee; Lim, Wan-Teck; Yap, Yoon Sim; Lee, Soo Chin; Soo, Ross A.; Han, Jongyoon; Lim, Chwee Teck (Public Library of Science, 2014-07)
    Background: Circulating tumor cells (CTCs) are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to provide critical information for guiding cancer ...
  • Lindquist, Susan; Matlack, Kent E. S.; Tardiff, Daniel F.; Narayan, Priyanka; Hamamichi, Shusei; Caldwell, Kim A.; Caldwell, Guy A. (National Academy of Sciences (U.S.), 2014-03)
    Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-β peptide (Aβ) is associated with AD. However, identifying new compounds ...
  • Fletcher, Richard Ribon; Kulkarni, Sarang (Institute of Electrical and Electronics Engineers (IEEE), 2010-08)
    We present a new type of non-contact sensor for use in ambulatory cardiac monitoring. The sensor operation is based on a microwave Doppler technique; however, instead of detecting the heart activity from a distance, the ...
  • Liao, Bolin; Zebarjadi, Mona; Esfarjani, Keivan; Chen, Gang (American Physical Society, 2012-09)
    In this Letter, we aim at making nanoparticles embedded in a host semiconductor with a size comparable to electronic wavelengths “invisible” to the electron transport. Inspired by the recent progress made in optics and ...
  • Neuenschwander, Ulrich; Negron, Arnaldo; Jensen, Klavs F. (American Chemical Society (ACS), 2013-05)
    Clock reactions are rare kinetic phenomena, so far limited mostly to systems with ionic oxoacids and oxoanions in water. We report a new clock reaction in cyclohexanol that forms molybdenum blue from a noncharged, yellow ...
  • Aye, Yimon; Stubbe, JoAnne (National Academy of Sciences (U.S.), 2011-05)
    Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of alpha- and beta-subunits that form active alpha nbeta m (n, m = 2 or 6) complexes. alpha binds NDP ...
  • Aye, Yimon; Brignole, Edward J.; Long, Marcus J.C.; Chittuluru, Johnathan; Drennan, Catherine L.; Asturias, Francisco J.; Stubbe, JoAnne (Springer Science + Business Media B.V., 2012-07)
    Clofarabine (ClF) is a drug used in the treatment of leukemia. One of its primary targets is human ribonucleotide reductase (hRNR), a dual-subunit, (α2)m(β2)n, regulatory enzyme indispensable in de novo dNTP synthesis. We ...
  • Genovese, Giulio; Handsaker, Robert E.; Lindberg, Johan; Rose, Samuel A.; Bakhoum, Samuel F.; Chambert, Kimberly; Mick, Eran; Neale, Benjamin M.; Fromer, Menachem; Purcell, Shaun M.; Svantesson, Oscar; Gabriel, Stacey B.; Moran, Jennifer L.; Lander, Eric S.; Sullivan, Patrick F.; Sklar, Pamela; Hultman, Christina M.; McCarroll, Steven A.; Kahler, Anna K.; Landen, Mikael; Hoglund, Martin; Lehmann, Soren; Gronberg, Henrik (New England Journal of Medicine, 2014-11)
    Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. Methods We analyzed ...
  • Arbab, Mandana; Srinivasan, Sharanya; Geijsen, Niels; Sherwood, Richard I.; Hashimoto, Tatsunori Benjamin (Elsevier, 2015-10)
    We present self-cloning CRISPR/Cas9 (scCRISPR), a technology that allows for CRISPR/Cas9-mediated genomic mutation and site-specific knockin transgene creation within several hours by circumventing the need to clone a ...
  • Ching, ShiNung; Chemali, Jessica; Liberman, Max Y.; Brown, Emery N. (IOP Publishing, 2013-06)
    Objective. There is growing interest in using closed-loop anesthetic delivery (CLAD) systems to automate control of brain states (sedation, unconsciousness and antinociception) in patients receiving anesthesia care. The ...
  • Walter, Matthew R.; Karaman, Sertac; Frazzoli, Emilio; Teller, Seth (Institute of Electrical and Electronics Engineers / Robotics Society of Japan, 2010-10)
    This paper addresses the problem of autonomous manipulation of a priori unknown palletized cargo with a robotic lift truck (forklift). Specifically, we describe coupled perception and control algorithms that enable the ...
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