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Browsing MIT Open Access Articles by Title

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  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2013-09)
    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...
  • Feng, Yu-Xiong; Reinhardt, Ferenc; Jin, Dexter X.; Sokol, Ethan Samuel; Miller, Daniel Handel; Gupta, Piyush (Nature Publishing Group, 2017-10)
    PERK signaling is required for cancer invasion and there is interest in targeting this pathway for therapy. Unfortunately, chemical inhibitors of PERK's kinase activity cause on-target side effects that have precluded their ...
  • Lauffenburger, Douglas A.; Kreeger, Pamela K. (Oxford University Press, 2009-10)
    Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such ...
  • Nijhawan, Deepak; Zack, Travis I.; Ren, Yin; Strickland, Matthew R.; Lamothe, Rebecca; Schumacher, Steven E.; Tsherniak, Aviad; Besche, Henrike C.; Rosenbluh, Joseph; Shehata, Shyemaa; Cowley, Glenn S.; Weir, Barbara A.; Goldberg, Alfred L.; Mesirov, Jill P.; Root, David E.; Bhatia, Sangeeta N.; Beroukhim, Rameen; Hahn, William C. (Elsevier B.V., 2012-08)
    Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...
  • Gordon, Goren; Breazeal, Cynthia Lynn; Engel, Susan (Association for Computing Machinery (ACM), 2015-03)
    Curiosity is key to learning, yet school children show wide variability in their eagerness to acquire information. Recent research suggests that other people have a strong influence on children's exploratory behavior. Would ...
  • Masoumi, Ali; Hertzberg, Mark Peter (Institute of Physics Publishing/SISSA, 2016-06)
    Recently, there have been claims in the literature that the cosmological constant problem can be dynamically solved by specific compactifications of gravity from higher-dimensional toy models. These models have the ...
  • Buongiorno, Jacopo (Elsevier, 2013-08)
    It is well known that boiling and quenching heat transfer depends strongly on the morphology and composition of the solid surface through which the heat transfer occurs. The relevant surface features are roughness, wettability ...
  • Hamblin, Michael R.; Chen, Aaron Chih-Hao; Huang, Ying-Ying; Sharma, Sulbha K. (Society of Photo-optical Instrumentation Engineers, 2010-01)
    There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field ...
  • Fink, Gerald R.; Vyas, Valmik K.; Barrasa, M. Inmaculada (American Association for the Advancement of Science (AAAS), 2015-04)
    Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis ...
  • Weinberg, David Eric; Bartel, David; Fink, Gerald R. (National Academy of Sciences, 2012-01)
    The generation of mature functional RNAs from nascent transcripts requires the precise and coordinated action of numerous RNAs and proteins. One such protein family, the ribonuclease III (RNase III) endonucleases, includes ...
  • Tang, Ruqi; Noh, Hyun Ji; Wang, Dongqing; Sigurdsson, Snaevar; Swofford, Ross; Perloski, Michele; Duxbury, Margaret; Patterson, Edward E.; Albright, Julie; Castelhano, Marta; Auton, Adam; Boyko, Adam R.; Feng, Guoping; Lindblad-Toh, Kerstin; Karlsson, Elinor K. (BioMed Central Ltd, 2014-03)
    Background: Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% of the human population. While highly heritable, complex genetics has hampered ...
  • Berlijn, Tom; Volja, Dmitri; Ku, Wei (American Physical Society, 2011-02)
    We investigate from first principles the proposed destruction of the controversial eg′ pockets in the Fermi surface of Na[subscript x]CoO[subscript 2] due to Na disorder, by calculating its k-dependent configuration-averaged ...
  • Lee, Elizabeth M.; Tisdale, William; Willard, Adam P. (American Chemical Society (ACS), 2015-06)
    Recent experiments aimed at probing the dynamics of excitons have revealed that semiconducting films composed of disordered molecular subunits, unlike expectations for their perfectly ordered counterparts, can exhibit a ...
  • Malani, Ateeque A. A. G.; Raghavanpillai, Anilkumar; Wysong, Ernest B.; Rutledge, Gregory C. (American Physical Society, 2012-10)
    A method is presented for determining the dynamic contact angle at the three-phase contact between a solid, a liquid, and a vapor under an applied force, using molecular simulation. The method is demonstrated using a ...
  • Lewis-Faupel, Sean; Neggers, Yusuf; Pande, Rohini; Olken, Benjamin (American Economic Association, 2016-08)
    This paper examines whether electronic procurement (e-procurement), which increases access to information and reduces personal interactions with potentially corrupt officials, improves procurement outcomes. We develop ...
  • Fernandez, Jose-Maria; Fagnan, David Erik; Lo, Andrew W.; Stein, Roger Mark (American Economic Association, 2013-05)
    Traditional financing sources such as private and public equity may not be ideal for investment projects with low probabilities of success, long time horizons, and large capital requirements. Nevertheless, such projects, ...
  • Burton, Lisa Janelle; Bush, John W. M. (American Institute of Physics, 2012-10)
    We consider the role of flexibility in the weight-bearing characteristics of bodies floating at an interface. Specifically, we develop a theoretical model for a two-dimensional thin floating plate that yields the maximum ...
  • Miller, Amalia R.; Tucker, Catherine Elizabeth (University of Chicago Press, 2011-04)
    Electronic medical records (EMRs) facilitate fast and accurate access to patient records, which could improve diagnosis and patient monitoring. Using a 12-year county-level panel, we find that a 10 percent increase in ...
  • Cao, Charles; Chen, Yong; Liang, Bing; Lo, Andrew W. (Elsevier, 2013-04)
    We explore a new dimension of fund managers' timing ability by examining whether they can time market liquidity through adjusting their portfolios' market exposure as aggregate liquidity conditions change. Using a large ...
  • Frisch, P.; Heerikhuisen, Jacob; Pogorelov, Nikolai V.; DeMajistre, R.; Crew, Geoffrey B.; Funsten, H. O.; Janzen, Paul H.; McComas, David J.; Mobius, Eberhard; Mueller, Hans-Reinhard; Reisenfeld, Daniel Brett; Schwadron, Nathan A.; Slavin, Jonathan D.; Zank, Gary Paul (Institute of Physics/American Astronomical Society, 2010-08)
    The Interstellar Boundary Explorer (IBEX) spacecraft is providing the first all-sky maps of the energetic neutral atoms (ENAs) produced by charge exchange between interstellar neutral Ho atoms and heliospheric solar wind ...
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