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Browsing MIT Open Access Articles by Title

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  • Michalon, Aubin; Sidorov, Michael; Ballard, Theresa M.; Ozmen, Laurence; Spooren, Will; Wettstein, Joseph G.; Jaeschke, Georg; Bear, Mark; Lindemann, Lothar (Elsevier B.V., 2012-04)
    Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial unanswered question is whether pharmacological ...
  • CIA Leaks 
    Gillies, Anthony S.; von Fintel, Kai (Duke University Press, 2008-01)
    Epistemic modals are standardly taken to be context-dependent quantifiers over possibilities. Thus sentences containing them get truth-values with respect to both a context and an index. But some insist that this relativization ...
  • Giuffre, Carl; Hinow, Peter; Vogel, Ryan; Ahmed, Tanvir; Stocker, Roman; Consi, Thomas R.; Strickler, J. Rudi (Public Library of Science, 2011-04)
    We study the motility behavior of the unicellular protozoan Paramecium tetraurelia in a microfluidic device that can be prepared with a landscape of attracting or repelling chemicals. We investigate the spatial distribution ...
  • Leiserson, Charles E. (Association for Computing Machinery, 2009-01)
    The availability of multicore processors across a wide range of computing platforms has created a strong demand for software frameworks that can harness these resources. This paper overviews the Cilk++ programming environment, ...
  • Remondes, Armando Miguel; Wilson, Matthew A. (Elsevier, 2013-11)
    Interactions between cortex and hippocampus are believed to play a role in the acquisition and maintenance of memories. Distinct types of coordinated oscillatory activity, namely at theta frequency, are hypothesized to ...
  • Yang, Qiong; Pando, Bernardo Fabian; Dong, Guogang; Golden, Susan S.; van Oudenaarden, Alexander (American Association for the Advancement of Science, 2010-03)
    Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell ...
  • Petsakou, Afroditi; Blau, Justin; Sapsis, Themistoklis P. (Elsevier, 2015-07)
    Neuronal plasticity helps animals learn from their environment. However, it is challenging to link specific changes in defined neurons to altered behavior. Here, we focus on circadian rhythms in the structure of the principal ...
  • Namburi, Praneeth; Beyeler, Anna; Yorozu, Suzuko; Calhoon, Gwendolyn G.; Wichmann, Romy; Holden, Stephanie S.; Mertens, Kim L.; Wickersham, Ian R.; Gray, Jesse M.; Halbert, Sarah; Anahtar, Melodi N.; Felix-Ortiz, Ada Celis; Tye, Kay (Nature Publishing Group, 2015-04)
    The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral ...
  • Mandal, Soumyajit; Sarpeshkar, Rahul (Institute of Electrical and Electronics Engineers, 2009-12)
    We use analogies between chemistry and subthreshold electronics to develop fast, scalable, digitally programmable hardware models of stochastic genetic networks. We also present experimental results from a prototype 0.18 ...
  • Wilusz, Jeremy E.; Sharp, Phillip A. (American Association for the Advancement of Science (AAAS), 2013-04)
    Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered ...
  • Mahmood, Zohaib; Daniel, Luca (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    In this paper we present a highly efficient algorithm to automatically generate circuit synthesizable dynamical models for passive multiport structures. The algorithm is based on a natural convex relaxation of the original ...
  • Brakerski, Zvika; Goldwasser, Shafi (Springer Berlin / Heidelberg, 2010-08)
    The main results of this work are new public-key encryption schemes that, under the quadratic residuosity (QR) assumption (or Paillier’s decisional composite residuosity (DCR) assumption), achieve key-dependent message ...
  • Wang, Yihua; Gedik, Nuh (John Wiley & Sons, Inc, 2013-02)
    Topological insulators are a new phase of matter that exhibits exotic surface electronic properties. Determining the spin texture of this class of material is of paramount importance for both fundamental understanding of ...
  • Gawarkiewicz, Glen; Jan, Sen; Lermusiaux, Pierre F. J.; McClean, Julie L.; Centurioni, Luca; Taylor, Kevin; Cornuelle, Bruce D.; Duda, Timothy F.; Wang, Joe; Yiing, Jiang Yang; Sanford, Thomas; Lien, Ren-Chieh; Lee, Craig M.; Lee, Ming-An; Leslie, Wayne G.; Haley, Patrick; Niiler, Pearn P.; Gopalakrishnan, Ganesh; Velez-Belchi, Pedro; Lee, Dong-Kyu; Kim, Yoo Yin (Oceanography Society, 2011-12)
    An important element of present oceanographic research is the assessment and quantification of uncertainty. These studies are challenging in the coastal ocean due to the wide variety of physical processes occurring on a ...
  • Lermusiaux, Pierre F. J.; Gawarkiewicz, Glen; Jan, Sen; McClean, Julie L.; Centurioni, Luca; Taylor, Kevin; Cornuelle, Bruce D.; Duda, Timothy F.; Wang, Joe; Yang, Yiing Jiang; Sanford, Thomas; Lien, Ren-Chieh; Lee, Craig M.; Lee, Ming-An; Leslie, Wayne G.; Haley, Patrick; Niiler, Pearn P.; Gopalakrishnan, Ganesh; Velez-Belchi, Pedro; Lee, Dong-Kyu; Kim, Yoo Yin (The Oceanography Society, 2011-12)
    An important element of present oceanographic research is the assessment and quantification of uncertainty. These studies are challenging in the coastal ocean due to the wide variety of physical processes occurring on a ...
  • Drumond, Betania Paiva; Mondini, Adriano; Schmidt, Diane J.; Bronzoni, Roberta Vieira de Morais; Bosch, Irene; Nogueira, Mauricio Lacerda (Public Library of Science, 2013-03)
    The American/Asian genotype of Dengue virus type 2 (DENV-2) was introduced into the Americas in the 80′s. Although there is no data showing when this genotype was first introduced into Brazil, it was first detected in ...
  • Froyd, Karl D.; Cziczo, Daniel James; Hoose, Corinna; Jensen, Eric J.; Diao, Minghui; Zondlo, Mark A.; Smith, Jessica B.; Twohy, Cynthia H.; Murphy, Daniel M. (American Institute of Physics (AIP), 2013)
    Composition, size, and phase are key properties that define the ability of an aerosol particle to initiate ice in cirrus clouds. Properties of cirrus ice nuclei (IN) have not been well constrained due to a lack of systematic ...
  • Kim, Minlee; Kogan, Nicole E.; Slack, Frank J. (Impact Journals/National Center for Biotechnology Information (U.S.), 2016-02)
    Multiple RNA-binding proteins and non-coding RNAs, such as microRNAs (miRNAs), are involved in post-transcriptional gene regulation through recognition motifs in the 3′ untranslated region (UTR) of their target genes. The ...
  • Zhu, Lei; Flook, Margaret M.; Lee, Shern-Long; Chan, Li-Wei; Huang, Shou-Ling; Chiu, Ching-Wen; Chen, Chun-Hsien; Luh, Tien-Yau; Schrock, Richard Royce (American Chemical Society (ACS), 2012-10)
    Upon treatment with a molybdenum-carbene with bidentate substituted biaryl-o,o′-diphenoxide ligand 12, norbornene fused with N-aryl-endo-pyrrolidine 9a undergoes ROMP to give exclusively polynorbornene with cis, ...
  • Chowanadisai, Winyoo; Messerli, Shanta M.; Miller, Daniel Handel; Medina, Jamie E.; Hamilton, Joshua W.; Messerli, Mark A.; Brodsky, Alexander S. (Public Library of Science, 2016-03)
    The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and ...
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