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Browsing MIT Open Access Articles by Title

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  • Lee, Kichang; Lv, Wener; Ter-Ovanesyan, Evgeny; Barley, Maya E.; Voysey, Graham E.; Galea, Anna M.; Hirschman, Gordon B.; Leroy, Kristen; Marini, Robert P.; Barrett, Conor; Armoundas, Antonis A.; Cohen, Richard J. (Wiley Blackwell, 2013-02)
    Background We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a ...
  • Arai, Tatsuya; Lee, Kichang; Cohen, Richard J. (Institute of Electrical and Electronics Engineers, 2010-08)
    Cardiac output (CO) and stroke volume (SV) are the key hemodynamic parameters to be monitored and assessed in ambulatory and critically ill patients. The purpose of this study was to introduce and validate a new algorithm ...
  • Sun, James X.; Reisner, Andrew T.; Saeed, Mohammed; Heldt, Thomas; Mark, Roger Greenwood (Wolters Kluwer, 2009-01)
    Objective: The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a ...
  • Anderson, Erik S.; Lin, Chia-Ho; Xiao, Xinshu; Stoilov, Peter; Burge, Christopher B.; Black, Douglas L. (Cold Spring Harbor Laboratory Press, 2012-03)
    Modulation of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human diseases. We investigated the mechanism by which digitoxin, a member of the cardiotonic steroid class of ...
  • Jungbluth, Sean; Burkhardt, Brian; de Leo, Fabio; Bruno, Barbara; Boiteau, Rene Maurice; Bottjer, Daniela (The Oceanography Society, 2014-06)
    The world of science continues to train and grant degrees to an abundance of eager young investigators, yet the number of tenure-track positions in oceanography and related fields is not increasing. Nevertheless, academic ...
  • Hoerner, Johannes; Bonatti, Alessandro (The Econometric Society, 2017-01)
    This paper examines the interplay between career concerns and market structure. Ability and effort are complements: effort increases the probability that a skilled agent achieves a one-time breakthrough. Wages are based ...
  • Shin, Taeho; Wolfson, Johanna W.; Kandyla, Maria; Teitelbaum, Samuel Welch; Nelson, Keith Adam (American Physical Society, 2015-11)
    Femtosecond pump-probe spectroscopy of bismuth thin films has revealed strong dependencies of reflectivity and phonon frequency on film thickness in the range of 25−40 nm. The reflectivity variations are ascribed to distinct ...
  • Sander, Michelle Yen-Ling; Kaertner, Franz X. (Institute of Electrical and Electronics Engineers, 2009-06)
    The carrier-envelope phase dynamics of octave-spanning Ti:sapphire lasers are analyzed based on a one-dimensional laser. It is found that self-steepening is the major contributor to the energy dependent carrier-envelope ...
  • Albo, Asaf; Hu, Qing (American Institute of Physics (AIP), 2015-12)
    The maximum operating temperature reported so far for THz-QCLs is ∼200 K. With the well-known degradation mechanism of thermally activated LO-phonon scattering, one straightforward strategy to improve their temperature ...
  • Hachey, Julie; Ruvkun, Gary; Mojarro, Angel; Zuber, Maria; Carr, Christopher E (BioMed Central, 2018-03)
    Background Long-read nanopore sequencing technology is of particular significance for taxonomic identification at or below the species level. For many environmental samples, the total extractable DNA is ...
  • Suresh Kumar, Swarun; Shi, Lixin; Ahmed, Nabeel; Gil, Stephanie; Katabi, Dina; Rus, Daniela L. (Association for Computing Machinery, 2012-09)
    This paper introduces CarSpeak, a communication system for autonomous driving. CarSpeak enables a car to query and access sensory information captured by other cars in a manner similar to how it accesses information from ...
  • Chen, Wenlan; Hu, Jiazhong; Duan, Yiheng; Braverman, Boris; Zhang, Hao; Vuletic, Vladan (American Physical Society, 2015-12)
    We propose a versatile and efficient method to generate a broad class of complex entangled states of many atoms via the detection of a single photon. For an atomic ensemble contained in a strongly coupled optical cavity ...
  • Shmakov, Sergey; Makarova, Kira S.; Koonin, Eugene V.; Smargon, Aaron Andrew; Cox, David Benjamin Turitz; Pyzocha, Neena; Zheng, Kaijie; Slaymaker, Ian; Gootenberg, Jonathan S; Abudayyeh, Omar Osama; Essletzbichler, Patrick; Zhang, Feng (Elsevier, 2017-01)
    CRISPR-Cas adaptive immune systems defend microbes against foreign nucleic acids via RNA-guided endonucleases. Using a computational sequence database mining approach, we identify two class 2 CRISPR-Cas systems (subtype ...
  • Barkal, Amira A.; Srinivasan, Sharanya; Gifford, David K.; Sherwood, Richard I.; Hashimoto, Tatsunori Benjamin (Public Library of Science, 2016-03)
    Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional ...
  • Chavez, Alejandro; Tuttle, Marcelle; Chari, Raj; Ter-Ovanesyan, Dmitry; Qian, Jason; Pruitt, Benjamin W; Buchthal, Joanna; Church, George; Kiani, Samira; Hall, Richard N.; Beal, Jacob S; Vora, Suhani Deepak; Kowal, Emma J.; Ebrahimkhani, Mohammad Reza; Collins, James J.; Weiss, Ron (Nature Publishing Group, 2015-09)
    We demonstrate that by altering the length of Cas9-associated guide RNA(gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 ...
  • Pfotenhauer, Sebastian Michael; Jackel, O.; Polz, J.; Steinke, S.; Schlenvoigt, H.-P.; Heymann, J.; Robinson, A. P. L.; Kaluza, M. C. (Institute of Physics Publishing, 2010-10)
    We present a novel, cascaded acceleration scheme for the generation of spectrally controlled ion beams using a laser-based accelerator in a 'double-stage' setup. An MeV proton beam produced during a relativistic laser–plasma ...
  • Ku, Mark J. H.; Mukherjee, Biswaroop; Yefsah, Tarik; Zwierlein, Martin Wolfram; Ku, Mark J. H. (American Physical Society, 2016-01)
    We follow the time evolution of a superfluid Fermi gas of resonantly interacting [superscript 6]Li atoms after a phase imprint. Via tomographic imaging, we observe the formation of a planar dark soliton, its subsequent ...
  • Jui, Nathan T.; Buchwald, Stephen Leffler (John Wiley & Sons, Inc, 2013-10)
    By choice: The palladium-catalyzed cascade reaction of 2-chloroaryl sulfonates with arylamine and amide nucleophiles provides direct access to N-arylbenzimidazoles. This strategy selectively produces the heterocycles based ...
  • Benson, Edward Oscar; Karger, David R. (Association for Computing Machinery (ACM), 2013-05)
    Cascading Style Sheets (CSS) took a valuable step towards separating web content from presentation. But HTML pages still contain large amounts of "design scaffolding" needed to hierarchically layer content for proper ...
  • Battat, James; Caldwell, T.; Fedus, William B.; Fisher, Peter H.; Henderson, Shawn Wesley; Kaboth, Asher Cunningham; Kallivayalil, Nitya; Lee, A.; Lopez, Jeremy Paul; Monroe, Jocelyn; Sanderson, Robyn Ellyn; Sciolla, Gabriella; Vanderspek, Roland K.; Yegoryan, Hayk; Yamamoto, Richard K. (World Scientific Publishing, 2010-01)
    We present the case for a dark matter detector with directional sensitivity. This document was developed at the 2009 CYGNUS workshop on directional dark matter detection, and contains contributions from theorists and ...
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