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Browsing MIT Open Access Articles by Title
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(Nature Publishing Group, 2012-05)Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the ...
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(Springer Berlin Heidelberg, 2009-02)The demand for plasmid DNA (pDNA) is anticipated to increase significantly as DNA vaccines and non-viral gene therapies enter phase 3 clinical trials and are approved for use. This increased demand, along with renewed ...
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(Public Library of Science, 2012-12)In recent years, microfluidic systems have been used to study fundamental aspects of angiogenesis through the patterning of single-layered, linear or geometric vascular channels. In vivo, however, capillaries exist in ...
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(National Academy of Sciences (U.S.), 2010-10)The genomic revolution has identified therapeutic targets for a plethora of diseases, creating a need to develop robust technologies for combination drug therapy. In the present work, we describe a self-assembled polymeric ...
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(SPIE, 2010-02)We present a new treatment of optical forces, revealing that the forces in virtually all optomechanically variable systems can be computed exactly and simply from only the optical phase and amplitude response of the system. ...
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(Landes Bioscience, 2010-11)Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are ...
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(Institute of Electrical and Electronics Engineers, 2009-05)Antibiotic resistance is a rapidly evolving problem that is not being adequately met by new antimicrobial drugs. Thus, there is a pressing need for effective antibacterial therapies that can be adapted against antibiotic-resistant ...
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(Wiley-Blackwell Pubishers, 2010-10)The scope and complexity of engineered systems are ever-increasing as burgeoning global markets, unprecedented technological capabilities, rising consumer expectations, and ever-changing social requirements present difficult ...
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(American Physical Society, 2011-11)We have performed systematic first-principles calculations to tailor the magnetic properties at a hybrid organic-ferromagnetic interface by adsorbing organic molecules containing π(p[subscript z]) electrons onto a magnetic ...
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(American Physical Society, 2011-02)With a goal to produce a giant magnetic moment in a Mn13 cluster that will be useful for practical applications, we have considered the structure and magnetic properties of a pure Mn13 cluster and substitutionally doped ...
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(Oxford University Press, 2009-03)The transcriptional program for a gene consists of the promoter necessary for recruiting RNA polymerase along with neighboring operator sites that bind different activators and repressors. From a synthetic biology perspective, ...
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(Elsevier B.V., 2009-12)Local immunotherapies are under investigation for the treatment of unresectable tumors and sites of solid tumor resection to prevent local recurrence. Successful local therapy could also theoretically elicit systemic immune ...
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(Optical Society of America, 2012-05)We demonstrate an in-fiber gas phase chemical detection architecture in which a chemiluminescent (CL) reaction is spatially and spectrally matched to the core modes of hollow photonic bandgap (PBG) fibers in order to enhance ...
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(Royal Society of Chemistry, The, 2012-02)Nanofluidic sensing elements have been the focus of recent experiments for numerous applications ranging from nucleic acid fragment sizing to single-molecule DNA sequencing. These applications critically rely on high ...
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(Cambridge University Press, 2009-07)We present a combined experimental and numerical investigation of a sphere settling in a linearly stratified fluid at small Reynolds numbers. Using time-lapse photography and numerical modelling, we observed and quantified ...
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(Institute of Electrical and Electronics Engineers (IEEE), 2010-06)The hole mobility characteristics of 〈110〉 /(100)-oriented asymmetrically strained-SiGe p-MOSFETs are studied. Uniaxial mechanical strain is applied to biaxial compressive strained devices and the relative change in ...
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(Institute of Electrical and Electronics Engineers, 2009-10)Hole mobility and velocity are extracted from scaled strained-Si[subscript 0.4]5Ge[subscript 0.55]channel p-MOSFETs on insulator. Devices have been fabricated with sub-100-nm gate lengths, demonstrating hole mobility and ...
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(Oxford University Press (OUP), 2012-05)Genome-scale engineering of living organisms requires precise and economical methods to efficiently modify many loci within chromosomes. One such example is the directed integration of chemically synthesized single-stranded ...
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(American Physical Society, 2011-07)We consider the problem of quantum communication mediated by a passive optical refocusing system. The model captures the basic features of all those situations in which a signal is either refocused by a repeater for ...
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(American Physical Society, 2012-07)We use multipulse dynamical decoupling to increase the coherence lifetime (T[subscript 2]) of large numbers of nitrogen-vacancy (NV) electronic spins in room temperature diamond, thus enabling scalable applications of ...
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