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Browsing MIT Open Access Articles by Title

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  • Kolisnyk, Benjamin; Guzman, Monica S.; Raulic, Sanda; Fan, Jue; Magalhaes, Ana C.; Feng, Guoping; Gros, Robert; Prado, Vania F.; Prado, Marco A. M. (Society for Neuroscience, 2013-06)
    Acetylcholine (ACh) is an important neuromodulator in the nervous system implicated in many forms of cognitive and motor processing. Recent studies have used bacterial artificial chromosome (BAC) transgenic mice expressing ...
  • Sugathan, Aarathi; Biagioli, Marta; Golzio, Christelle; Erdin, Serkan; Blumenthal, Ian; Manavalan, Poornima; Ragavendran, Ashok; Brand, Harrison; Lucente, Diane; Miles, Judith; Sheridan, Steven D.; Stortchevoi, Alexei; Kellis, Manolis; Haggarty, Stephen J.; Katsanis, Nicholas; Gusella, James F.; Talkowski, Michael E. (National Academy of Sciences (U.S.), 2014-10)
    Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms ...
  • Poliannikov, Oleg V.; Malcolm, Alison E.; Prange, Michael; Djikpesse, Hugues (Society of Exploration Geophysicists, 2012-12)
    With high-permeability hydrocarbon reservoirs exhausting their potential, developing low-permeability reservoirs is becoming of increasing importance. In order to be produced economically, these reservoirs need to be ...
  • Haschke, Raoul; Grebel, Eva K.; Frebel, Anna L. (IOP Publishing, 2012-08)
    We present for the first time a detailed spectroscopic study of chemical element abundances of metal-poor RR Lyrae stars in the Large and Small Magellanic Cloud (LMC and SMC). Using the MagE echelle spectrograph at the 6.5 ...
  • Hollek, Julie K.; Placco, Vinicius M.; Karakas, Amanda I.; Shetrone, Matthew; Sneden, Christopher; Christlieb, Norbert; Frebel, Anna L. (IOP Publishing, 2015-11)
    We present a detailed abundance analysis of 23 elements for a newly discovered carbon-enhanced metal-poor (CEMP) star, HE 0414−0343, from the Chemical Abundances of Stars in the Halo Project. Its spectroscopic stellar ...
  • Knutson, Charles G. F.; Mangerich, Aswin; Zeng, Yu; Raczynski, Arkadiusz R.; Liberman, Rosa G.; Kang, Pilsoo; Ye, Wenjie; Prestwich, Erin; Lu, Kun; Wishnok, John S.; Korzenik, Joshua R.; Wogan, Gerald N.; Fox, James G.; Dedon, Peter C.; Tannenbaum, Steven Robert (National Academy of Sciences (U.S.), 2013-06)
    Inflammatory bowel disease (IBD) arises from inappropriate activation of the mucosal immune system resulting in a state of chronic inflammation with causal links to colon cancer. Helicobacter hepaticus-infected Rag2[superscript ...
  • Shrivastav, Nidhi; Li, Deyu; Essigmann, John M. (Oxford University Press (OUP), 2009-10)
    The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they ...
  • Filipovic, Milos R.; Miljkovic, Jan Lj.; Nauser, Thomas; Royzen, Maksim; Klos, Katharina; Shubina, Tatyana; Koppenol, Willem H.; Lippard, Stephen J.; Ivanović-Burmazović, Ivana (American Chemical Society, 2012-07)
    Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its mechanisms of action have ...
  • Sneden, Christopher; Kim, Hwihyun; Mace, Gregory N.; Kaplan, Kyle F.; Lee, Hye-In; Oh, Heeyoung; Oh, Jae Sok; Pak, Soojong; Park, Chan; Pavel, Michael D.; Yuk, In-Soo; Jaffe, Daniel T.; Afsar, Melike; Frebel, Anna L. (IOP Publishing, 2016-03)
    From high resolution (R sime 45,000), high signal-to-noise ratio (S/N > 400) spectra gathered with the Immersion Grating Infrared Spectrograph (IGRINS) in the H and K photometric bands, we have derived elemental abundances ...
  • Casey, Andrew R.; Ji, Alexander Pung; Frebel, Anna L.; Ezzeddine, Rana (IOP Publishing, 2016-11)
    We present the first detailed chemical abundance study of the ultra-faint dwarf galaxy Tucana II, based on high-resolution Magellan/MIKE spectra of four red giant stars. The metallicities of these stars range from [Fe/H] ...
  • Boghossian, Ardemis A.; Zhang, Jingqing; Le Floch-Yin, Francois T.; Ulissi, Zachary Ward; Bojo, Peter; Han, Jae-Hee; Kim, Jong-Ho; Arkalgud, Jyoti R.; Reuel, Nigel Forest; Braatz, Richard D.; Strano, Michael S. (American Institute of Physics (AIP), 2011-08)
    Recent advances in nanotechnology have produced the first sensor transducers capable of resolving the adsorption and desorption of single molecules. Examples include near infrared fluorescent single-walled carbon nanotubes ...
  • Chen, Yan; Jung, Woo Chul; Kuru, Yener; Tuller, Harry L.; Yildiz, Bilge (Electrochemical Society, 2011-05)
    The surface structure, chemical composition and electronic structure of Sr(Ti1-xFex)O3 under different temperatures and oxygen pressures were studied by Scanning Tunneling Microscopy / Spectroscopy (STM/S) and X-ray ...
  • Jacobson, Heather; Thanathibodee, Thanawuth; Roederer, Ian U.; Cescutti, Gabriele; Matteucci, Francesca; Frebel, Anna L. (IOP Publishing, 2014-11)
    Phosphorus is one of the few remaining light elements for which little is known about its nucleosynthetic origin and chemical evolution, given the lack of optical absorption lines in the spectra of long-lived FGK-type ...
  • Kuru, Yener; Bishop, Sean; Kim, Jae-Jin; Yildiz, Bilge; Tuller, Harry L. (Electrochemical Society, 2011)
    Doped CeO2 is a promising candidate for solid oxide fuel cell electrolyte and electrode applications because of its high ionic conductivity and reduction/oxidation behavior at intermediate temperatures. Its electronic and ...
  • Fedeles, Bogdan I.; Zhu, Angela W.; Young, Kellie S.; Hillier, Shawn M.; Proffitt, Kyle D.; Essigmann, John M.; Croy, Robert G. (American Society for Biochemistry and Molecular Biology (ASBMB), 2011-08)
    The antitumor agent 11β (CAS 865070-37-7), consisting of a DNA-damaging aniline mustard linked to an androgen receptor (AR) ligand, is known to form covalent DNA adducts and to induce apoptosis potently in AR-positive ...
  • Shrivastav, Nidhi; Fedeles, Bogdan I.; Li, Deyu; Delaney, James C.; Frick, Lauren E.; Foti, James J.; Walker, Graham C.; Essigmann, John M. (Public Library of Science, 2014-04)
    DinB, the E. coli translesion synthesis polymerase, has been shown to bypass several N[superscript 2]-alkylguanine adducts in vitro, including N[superscript 2]-furfurylguanine, the structural analog of the DNA adduct formed ...
  • Banko, Max R.; Allen, Jasmina J.; Schaffer, Bethany E.; Wilker, Erik W.; Tsou, Peiling; White, Jamie L.; Villen, Judit; Wang, Beatrice; Kim, Sara R.; Sakamoto, Kei; Gygi, Steven P.; Cantley, Lewis C.; Yaffe, Michael B.; Shokat, Kevan M.; Brunet, Anne (Elsevier, 2011-12)
    The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use a chemical genetics screen ...
  • Mann, Paul A.; Koseoglu, Sandra; Si, Qian; Kuzmin, Elena; Flattery, Amy; Harris, Guy; Sher, Xinwei; Murgolo, Nicholas; Wang, Hao; Devito, Kristine; de Pedro, Nuria; Genilloud, Olga; Kahn, Jennifer Nielsen; Jiang, Bo; Costanzo, Michael; Boone, Charlie; Garlisi, Charles G.; Roemer, Terry; McLellan, Catherine; Lindquist, Susan (American Chemical Society (ACS), 2014-12)
    Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the ...
  • Cai, Zhuhua; Kubicek, Markus; Yildiz, Bilge; Fleig, Jurgen (American Chemical Society (ACS), 2012-02)
    La[subscript 0.6]Sr[subscript 0.4]CoO[subscript 3−δ](LSC) thin film cathodes synthesized by pulsed laser deposition at 450°C (LSC_450°C) and 650°C (LSC_650°C) exhibit different electrochemical performance. The origin of ...
  • Bromm, Volker; Ji, Alexander Pung; Frebel, Anna L. (IOP Publishing, 2014-02)
    We investigate the impact of dust-induced gas fragmentation on the formation of the first low-mass, metal-poor stars (<1 M[subscript ☉]) in the early universe. Previous work has shown the existence of a critical dust-to-gas ...
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