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Browsing MIT Open Access Articles by Title

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  • Rich, Alexander; de Rosa, Matteo; de Sanctis, Daniele; Rosario, Ana Lucia; Archer, Margarida; Athanasiadis, Alekos; Carrondo, Maria Armenia (National Academy of Sciences, 2010-05)
    The double helix of DNA, when composed of dinucleotide purine-pyrimidine repeats, can adopt a left-handed helical structure called Z-DNA. For reasons not entirely understood, such dinucleotide repeats in genomic sequences ...
  • Schmidt, Michael M.; Townson, Sharon A.; Andreucci, Amy J.; King, Bracken M.; Schirmer, Emily B.; Murillo, Alec J.; Dombrowski, Christian; Tisdale, Alison W.; Lowden, Patricia A.; Masci, Allyson L.; Kovalchin, Joseph T.; Erbe, David V.; Wittrup, Karl Dane; Furfine, Eric S.; Barnes, Thomas M. (Elsevier B.V., 2013-11)
    The long circulating half-life of serum albumin, the most abundant protein in mammalian plasma, derives from pH-dependent endosomal salvage from degradation, mediated by the neonatal Fc receptor (FcRn). Using yeast display, ...
  • Deshpande, Chandrika N.; Harrop, Stephen J.; Boucher, Yan; Hassan, Karl A.; Di Leo, Rosa; Xu, Xiaohui; Cui, Hong; Savchenko, Alexei; Chang, Changsoo; Labbate, Maurizio; Paulsen, Ian T.; Stokes, H. W.; Curmi, Paul M. G.; Mabbutt, Bridget C. (Public Library of Science, 2011-03)
    Background The direct isolation of integron gene cassettes from cultivated and environmental microbial sources allows an assessment of the impact of the integron/gene cassette system on the emergence of new phenotypes, ...
  • Schmitz, Karl R.; Carney, Daniel W.; Sello, Jason K.; Sauer, Robert T. (National Academy of Sciences (U.S.), 2014-09)
    Caseinolytic peptidase P (ClpP), a double-ring peptidase with 14 subunits, collaborates with ATPases associated with diverse activities (AAA+) partners to execute ATP-dependent protein degradation. Although many ClpP enzymes ...
  • Glynn, Steven E.; Martin, Andreas; Nager, Andrew Ross; Baker, Tania; Sauer, Robert T. (Elsevier, 2009-11)
    ClpX is a AAA+ machine that uses the energy of ATP binding and hydrolysis to unfold native proteins and translocate unfolded polypeptides into the ClpP peptidase. The crystal structures presented here reveal striking ...
  • Backer, Chelsea B.; Gutzman, Jennifer H.; Pearson, Chad G.; Cheeseman, Iain McPherson (American Society for Cell Biology, 2012-04)
    The diverse populations of microtubule polymers in cells are functionally distinguished by different posttranslational modifications, including polyglutamylation. Polyglutamylation is enriched on subsets of microtubules ...
  • Li, Yang; Wilson, Justin J.; Do, Loi H.; Apfel, Ulf-Peter; Lippard, Stephen J. (Royal Society of Chemistry, The, 2012-06)
    A triptycene-based bis(benzoxazole) diacid ligand H[subscript 2]L2[superscript Ph4] bearing sterically encumbering groups was synthesized. Treatment of H[subscript 2]L2[superscript Ph4] with Fe(OTf)[subscript 3] afforded ...
  • Beigi, Salman; Shor, Peter W. (Rinton Press, 2010-01)
    Fault-tolerant quantum computation is a basic problem in quantum computation, andteleportation is one of the main techniques in this theory. Using teleportation on stabi-lizer codes, the most well-known quantum codes, Pauli ...
  • Luna, Rafael E.; Arthanari, Haribabu; Hiraishi, Hiroyuki; Nanda, Jagpreet; Martin-Marcos, Pilar; Markus, Michelle A.; Akabayov, Barak; Milbradt, Alexander G.; Luna, Lunet E.; Seo, Hee-Chan; Hyberts, Sven G.; Fahmy, Amr; Reibarkh, Mikhail; Miles, David; Hagner, Patrick R.; O'Day, Elizabeth M.; Yi, Tingfang; Marintchev, Assen; Hinnebusch, Alan G.; Lorsch, Jon R.; Asano, Katsura; Wagner, Gerhard; Luna, Lunet E. (Elsevier, 2012-05)
    Recognition of the proper start codon on mRNAs is essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5. The carboxyl terminal domain (CTD) ...
  • Liu, Hui; Ong, Shao-En; Badu-Nkansah, Kwabena; Schindler, Jeffrey W.; White, Forest M.; Hynes, Richard O. (National Academy of Sciences (U.S.), 2011-01)
    We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino ...
  • Cahoy, Kerri; Cheng, Kezi; Jamil, Sara; Marinan, Anne D.; Kerr, Caitlin E. (2012-08)
    The goal of the CubeSat Deformable Mirror Demonstration (DeMi) is to characterize the performance of a small deformable mirror over a year in low-Earth orbit. Small form factor deformable mirrors are a key technology needed ...
  • Maiti, Debabrata; Buchwald, Stephen Leffler (American Chemical Society, 2010-02)
    Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K3PO4 with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional ...
  • Jones, Stephanie R.; Kerr, Catherine E.; Hämäläinen, Matti; Wan, Qian; Pritchett, Dominique Leon; Moore, Christopher I. (Society for Neuroscience, 2010-10)
    Cued spatial attention modulates functionally relevant alpha rhythms in visual cortices in humans. Here, we present evidence for analogous phenomena in primary somatosensory neocortex (SI). Using magnetoencephalography, ...
  • Yoon, Jennifer M. D.; Witthoft, Nathan; Winawer, Jonathan; Frank, Michael C.; Everett, Daniel L.; Gibson, Edward A. (Public Library of Science, 2014-11)
    Visual illusions and other perceptual phenomena can be used as tools to uncover the otherwise hidden constructive processes that give rise to perception. Although many perceptual processes are assumed to be universal, ...
  • Filipsson, H. L.; Bernhard, J. M.; Lincoln, Sara Ann; McCorkle, D. C. (Copernicus Publications on behalf of the European Geophysical Society, 2010-04)
    Benthic foraminifera were cultured for five months at four temperatures (4, 7, 14 and 21 °C) to establish the temperature dependence of foraminiferal calcite δ18O and Mg/Ca. Two Bulimina species (B. aculeata and B. marginata) ...
  • Lam, Raymond H. W.; Thorsen, Todd A.; Kim, Min-Cheol (American Chemical Society, 2009-07)
    In this manuscript, we report on the culture of anaerobic and aerobic species within a disposable multilayer polydimethylsiloxane (PDMS) microfluidic device with an integrated differential oxygenator. A gas-filled microchannel ...
  • Gordan, Raluca; Zhu, Cong; Vedenko, Anastasia; Bulyk, Martha L.; Murphy, Kevin F.; McCord, Rachel P. (BioMed Central Ltd, 2011-12)
    Background: Transcription factors (TFs) play a central role in regulating gene expression by interacting with cis-regulatory DNA elements associated with their target genes. Recent surveys have examined the DNA binding ...
  • Qin, B.; Chong, Z. J.; Ang, M. H.; Frazzoli, Emilio; Rus, Daniela L.; Bandyopadhyay, Tirthankar (Institute of Electrical and Electronics Engineers (IEEE), 2012-05)
    One of the most prominent features on an urban road is the curb, which defines the boundary of a road surface. An intersection is a junction of two or more roads, appearing where no curb exists. The combination of curb and ...
  • Mitrovic, Nikola; Asif, Muhammad Tayyab; Rasheed, Umer; Dauwels, Justin; Jaillet, Patrick (Institute of Electrical and Electronics Engineers (IEEE), 2013-10)
    Intelligent Transportation Systems (ITS) often operate on large road networks, and typically collect traffic data with high temporal resolution. Consequently, ITS need to handle massive volumes of data, and methods to ...
  • Hauck, Steven A.; Margot, Jean-Luc; Solomon, Sean C.; Phillips, Roger J.; Johnson, Catherine L.; Lemoine, Frank G.; Mazarico, Erwan M.; McCoy, Timothy J.; Padovan, Sebastiano; Peale, Stanton J.; Perry, Mark E.; Smith, David Edmund; Zuber, Maria (American Geophysical Union, 2013-06)
    The recent determination of the gravity field of Mercury and new Earth-based radar observations of the planet's spin state afford the opportunity to explore Mercury's internal structure. These observations provide estimates ...
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