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Browsing MIT Open Access Articles by Title

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  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2012-09)
    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...
  • Cong, Le; Zhou, Ruhong; Kuo, Yu-chi; Cunniff, Margaret Mary; Zhang, Feng (Nature Publishing Group, 2012-07)
    Transcription activator-like effectors are sequence-specific DNA-binding proteins that harbour modular, repetitive DNA-binding domains. Transcription activator-like effectors have enabled the creation of customizable ...
  • White, Kevin P.; Henikoff, Steven; Stein, Lincoln; White, Robert A. H.; Russell, Steven; Ahmad, Kami; Feng, Xin; Henikoff, Jorja G.; Morrison, Carolyn A.; Shah, Parantu K.; Brown, Christopher D.; Negre, Nicolas; Kheradpour, Pouya; Kellis, Manolis (Public Library of Science, 2010-01)
    Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...
  • Taylor, Frank E. (American Physical Society, 2014-12)
    This article presents measurements of the t-channel single top-quark (t) and top-antiquark ([bar over t]) total production cross sections σ(tq) and σ(t¯q), their ratio R[subscript t]=σ(tq)/σ([bar over t] q), and a measurement ...
  • Lander, Eric S. (Nature Publishing Group, 2012-07)
    To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. ...
  • Lander, Eric S. (Nature Publishing Group, 2014-07)
    Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, ...
  • Srivastava, Ankur; Meade, Andrew J. (Hindawi Publishing Corporation, 2015)
    Use of probabilistic techniques has been demonstrated to learn air data parameters from surface pressure measurements. Integration of numerical models with wind tunnel data and sequential experiment design of wind tunnel ...
  • Weisenfeld, Neil I; Yin, Shuangye; Sharpe, Ted; Lau, Bayo; Hegarty, Ryan; Holmes, Laurie; Sogoloff, Brian; Tabbaa, Diana; Williams, Louise; Russ, Carsten; Nusbaum, Chad; MacCallum, Iain; Jaffe, David B.; Lander, Eric S. (Nature Publishing Group, 2014-10)
    Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and ...
  • Mineo, S.; Pooley, D.; Rappaport, Saul A.; Levine, Alan M.; Homan, Jeroen; Steinhorn, Benjamin S. (IOP Publishing, 2014-12)
    We present a comprehensive study of the total X-ray emission from the colliding galaxy pair NGC 2207/IC 2163, based on Chandra, Spitzer, and GALEX data. We detect 28 ultraluminous X-ray sources (ULXs), 7 of which were not ...
  • Belanger-Rioux, R.; Demanet, Laurent (Society for Industrial and Applied Mathematics, 2015-10)
    Absorbing layers are sometimes required to be impractically thick in order to offer an accurate approximation of an absorbing boundary condition for the Helmholtz equation in a heterogeneous medium. It is always possible ...
  • Choi, Jae-Hoon; Christensen, Caleb A.; Heo, Myoung-Sun; Ketterle, Wolfgang; Lee, Ye-Ryoung; Rvachov, Timur Michael; Wang, Tout T. (American Physical Society, 2012-06)
    Fermi gases with repulsive interactions are characterized by measuring their compressibility as a function of interaction strength. The compressibility is obtained from in-trap density distributions monitored by phase-contrast ...
  • Choong, Looh Tchuin; Mannarino, Matthew M.; Basu, Sandip; Rutledge, Gregory C. (Springer-Verlag, 2013-06)
    Compressive properties of electrospun fiber mats are reported for the first time. Mats of bisphenol-A polysulfone (PSU) and of poly(trimethyl hexamethylene terephthalamide) [PA 6(3)T] were electrospun and annealed over a ...
  • Magesan, Easwar; Cappellaro, Paola; Cooper-Roy, Alexandre (American Physical Society, 2013-12)
    We present methods that can provide an exponential savings in the resources required to perform dynamic parameter estimation using quantum systems. The key idea is to merge classical compressive sensing techniques with ...
  • Sanzeni, Alex; Whittle, Andrew; Germaine, John T.; Colleselli, Francesco (American Society of Civil Engineers (ASCE), 2012-10)
    A laboratory test program was conducted to evaluate the one-dimensional (1D) compression and creep properties of intact sand (and silty-sand) samples from a deep borehole at the Malamocco Inlet to the Venice Lagoon. The ...
  • Tang, Jing; Du, Ning; Doyle, Patrick S. (National Academy of Sciences (U.S.), 2011-09)
    We experimentally study the effects of a uniform electric field on the conformation of single DNA molecules. We demonstrate that a moderate electric field (~200 V/cm) strongly compresses isolated DNA polymer coils into ...
  • Campagne, Fabien; Dorff, Kevin C.; Chambwe, Nyasha; Robinson, James T.; Mesirov, Jill P. (Public Library of Science, 2013-11)
    Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS). Most approaches currently used to store HTS data are ...
  • Juba, Brendan Andrew; Kalai, Adam Tauman; Khanna, Sanjeev; Sudan, Madhu (Institute for Theoretical Computer Science, 2011-01)
    Compression is a fundamental goal of both human language and digital communication, yet natural language is very different from compression schemes employed by modern computers. We partly explain this difference using ...
  • Marwah, Kshitij; Wetzstein, Gordon; Bando, Yosuke; Raskar, Ramesh (Association for Computing Machinery, 2013-07)
    Light field photography has gained a significant research interest in the last two decades; today, commercial light field cameras are widely available. Nevertheless, most existing acquisition approaches either multiplex a ...
  • Hirsch, Matthew Waggener; Wetzstein, Gordon; Raskar, Ramesh (Association for Computing Machinery, 2014-07)
    For about a century, researchers and experimentalists have strived to bring glasses-free 3D experiences to the big screen. Much progress has been made and light field projection systems are now commercially available. ...
  • Heide, Felix; Gregson, James; Wetzstein, Gordon; Raskar, Ramesh; Heidrich, Wolfgang (Optical Society of America, 2014-06)
    Compressive displays are an emerging technology exploring the co-design of new optical device configurations and compressive computation. Previously, research has shown how to improve the dynamic range of displays and ...
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