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Browsing MIT Open Access Articles by Title

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  • Stern, Scott; Furman, Jeffrey L. (American Economic Association, 2011-08)
    While cumulative knowledge production is central to growth, little empirical research investigates how institutions shape whether existing knowledge can be exploited to create new knowledge. This paper assesses the impact ...
  • Snyder, Benjamin; Barzilay, Regina (Omnipress, 2010-06)
    For centuries, scholars have explored the deep links among human languages. In this paper, we present a class of probabilistic models that use these links as a form of naturally occurring supervision. These models ...
  • Thomas, L.; Talley, L.; Silverthorne, K.; Skyllingstad, E.; Samelson, R.; Lumpkin, R.; Palter, J.; Lozier, S.; Kelly, K.; Gregg, M.; Edson, J.; Weller, R.; Toole, J.; Straneo, F.; Joyce, T.; Fratantoni, D.; Doney, Scott C.; Dewar, W.; Bates, N.; Andersson, A.; Maze, Guillaume O.; Forget, Gael; Ferrari, Raffaele; Marshall, John C. (American Meteorological Society, 2009-01)
    A major oceanographic field experiment is described, which is designed to observe, quantify, and understand the creation and dispersal of weakly stratified fluid known as “mode water” in the region of the Gulf Stream. ...
  • Taleban, Sasha; Singh, Prashant; Yajnik, Vijay; Khalili, Hamed; Stewart, Kathleen O.; Li, Darrick K.; Pardi, Darrell S.; Sturgeon, Holly C.; Ananthakrishnan, Ashwin N.; Xavier, Ramnik Joseph (Springer US, 2016-05)
    Background Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according ...
  • Purdon, Patrick L.; Sampson, Aaron; Pavone, Kara J.; Brown, Emery N. (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2015-10)
    The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different ...
  • Rodan, Lance; Pelletier, Renee; Cao, Siqi; Picker, Jonathan; Tan, Wen-Hann; Brownstein, Catherine A.; Beggs, Alan H.; Towne, Meghan C.; Rosenberg, Paul A.; Urion, David K.; Agrawal, Pankaj B.; Shi, Jiahai (Springer Berlin Heidelberg, 2015-09)
    Mutations in the KCNA1 gene are known to cause episodic ataxia/myokymia syndrome type 1 (EA1). Here, we describe two families with unique presentations who were enrolled in an IRB-approved study, extensively phenotyped, ...
  • Konukoglu, Ender; Sabuncu, Mert R (Springer US, 2014-07)
    Multivariate pattern analysis (MVPA) methods have become an important tool in neuroimaging, revealing complex associations and yielding powerful prediction models. Despite methodological developments and novel application ...
  • Sealfon, Rachel Sima (Elsevier, 2015-08)
    The 2013–2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality ...
  • Merchant, Faisal M.; Ikeda, Takanori; Pedretti, Roberto F.E.; Salerno-Uriarte, Jorge A.; Chow, Theodore; Chan, Paul S.; Bartone, Cheryl; Hohnloser, Stefan H.; Cohen, Richard J.; Armoundas, Antonis A. (Elsevier, 2012-03)
    Background Previous studies have demonstrated that microvolt T-wave alternans (MTWA) testing is a robust predictor of ventricular tachyarrhythmias and sudden cardiac death (SCD) in at-risk patients. However, recent studies ...
  • Khoo, Bee Luan; Warkiani, Majid Ebrahimi; Tan, Daniel Shao-Weng; Bhagat, Ali Asgar S.; Irwin, Darryl; Lau, Dawn Pingxi; Lim, Alvin S. T.; Lim, Kiat Hon; Krisna, Sai Sakktee; Lim, Wan-Teck; Yap, Yoon Sim; Lee, Soo Chin; Soo, Ross A.; Han, Jongyoon; Lim, Chwee Teck (Public Library of Science, 2014-07)
    Background: Circulating tumor cells (CTCs) are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to provide critical information for guiding cancer ...
  • Lindquist, Susan; Matlack, Kent E. S.; Tardiff, Daniel F.; Narayan, Priyanka; Hamamichi, Shusei; Caldwell, Kim A.; Caldwell, Guy A. (National Academy of Sciences (U.S.), 2014-03)
    Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-β peptide (Aβ) is associated with AD. However, identifying new compounds ...
  • Fletcher, Richard Ribon; Kulkarni, Sarang (Institute of Electrical and Electronics Engineers (IEEE), 2010-08)
    We present a new type of non-contact sensor for use in ambulatory cardiac monitoring. The sensor operation is based on a microwave Doppler technique; however, instead of detecting the heart activity from a distance, the ...
  • Liao, Bolin; Zebarjadi, Mona; Esfarjani, Keivan; Chen, Gang (American Physical Society, 2012-09)
    In this Letter, we aim at making nanoparticles embedded in a host semiconductor with a size comparable to electronic wavelengths “invisible” to the electron transport. Inspired by the recent progress made in optics and ...
  • Neuenschwander, Ulrich; Negron, Arnaldo; Jensen, Klavs F. (American Chemical Society (ACS), 2013-05)
    Clock reactions are rare kinetic phenomena, so far limited mostly to systems with ionic oxoacids and oxoanions in water. We report a new clock reaction in cyclohexanol that forms molybdenum blue from a noncharged, yellow ...
  • Aye, Yimon; Stubbe, JoAnne (National Academy of Sciences (U.S.), 2011-05)
    Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of alpha- and beta-subunits that form active alpha nbeta m (n, m = 2 or 6) complexes. alpha binds NDP ...
  • Aye, Yimon; Brignole, Edward J.; Long, Marcus J.C.; Chittuluru, Johnathan; Drennan, Catherine L.; Asturias, Francisco J.; Stubbe, JoAnne (Springer Science + Business Media B.V., 2012-07)
    Clofarabine (ClF) is a drug used in the treatment of leukemia. One of its primary targets is human ribonucleotide reductase (hRNR), a dual-subunit, (α2)m(β2)n, regulatory enzyme indispensable in de novo dNTP synthesis. We ...
  • Dorans, Kimberly; Chung, Katherine Minjee; Robbins, Rebecca; Tammela, Tuomas; Gocheva, Vasilena; Jacks, Tyler E; Li, Carman Man Chung; Muzumdar, Mandar (Nature Publishing Group, 2016-07)
    Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we ...
  • Lander, Eric Steven (Nature Publishing Group, 2016-05)
    Resistance to the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ...
  • Lenz, Danielle R.; McLean, Dalton; Karp, Jeffrey M.; Edge, Albert S.B.; McLean, Will J.; Yin, Xiaolei; Lu, Lin; Langer, Robert S (Elsevier, 2017-02)
    Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a ...
  • Genovese, Giulio; Handsaker, Robert E.; Lindberg, Johan; Rose, Samuel A.; Bakhoum, Samuel F.; Chambert, Kimberly; Mick, Eran; Neale, Benjamin M.; Fromer, Menachem; Purcell, Shaun M.; Svantesson, Oscar; Gabriel, Stacey B.; Moran, Jennifer L.; Lander, Eric S.; Sullivan, Patrick F.; Sklar, Pamela; Hultman, Christina M.; McCarroll, Steven A.; Kahler, Anna K.; Landen, Mikael; Hoglund, Martin; Lehmann, Soren; Gronberg, Henrik (New England Journal of Medicine, 2014-11)
    Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. Methods We analyzed ...
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