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Browsing MIT Open Access Articles by Title

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  • Vaillier, Clarisse; Honegger, Thibault; Gidrol, Xavier; Peyrade, David; Kermarrec, Frederique (Public Library of Science, 2014-04)
    AC electrokinetics is a versatile tool for contact-less manipulation or characterization of cells and has been widely used for separation based on genotype translation to electrical phenotypes. Cells responses to an AC ...
  • Waters, Amanda J.; Bilinski, Paul; Eichten, Steven R.; Vaughn, Matthew W.; Ross-Ibarra, Jeffrey; Gehring, Mary; Springer, Nathan M. (National Academy of Sciences (U.S.), 2013-11)
    In plants, a subset of genes exhibit imprinting in endosperm tissue such that expression is primarily from the maternal or paternal allele. Imprinting may arise as a consequence of mechanisms for silencing of transposons ...
  • Ernst, Jason; Kellis, Manolis (Nature Publishing Group, 2010-12)
    Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin ...
  • Regev, Aviv; Levin, Joshua Z.; Yassour, Moran; Adiconis, Xian; Nusbaum, Chad; Thompson, Dawn Anne; Friedman, Nir; Gnirke, Andreas (Nature Publishing Group, 2010-08)
    Strand-specific, massively parallel cDNA sequencing (RNA-seq) is a powerful tool for transcript discovery, genome annotation and expression profiling. There are multiple published methods for strand-specific RNA-seq, but ...
  • Dimitriou, Christopher J.; McKinley, Gareth H. (Royal Society of Chemistry, 2014-06)
    Guided by a series of discriminating rheometric tests, we develop a new constitutive model that can quantitatively predict the key rheological features of waxy crude oils. We first develop a series of model crude oils, ...
  • Jimenez Zarco, Jose I.; Xulvi-Brunet, Ramon; Campbell, Gregory W.; Turk-MacLeod, Rebecca; Chen, Irene A. (National Academy of Sciences (U.S.), 2013-09)
    The origin of life is believed to have progressed through an RNA world, in which RNA acted as both genetic material and functional molecules. The structure of the evolutionary fitness landscape of RNA would determine natural ...
  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2012-09)
    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...
  • Cong, Le; Zhou, Ruhong; Kuo, Yu-chi; Cunniff, Margaret Mary; Zhang, Feng (Nature Publishing Group, 2012-07)
    Transcription activator-like effectors are sequence-specific DNA-binding proteins that harbour modular, repetitive DNA-binding domains. Transcription activator-like effectors have enabled the creation of customizable ...
  • White, Kevin P.; Henikoff, Steven; Stein, Lincoln; White, Robert A. H.; Russell, Steven; Ahmad, Kami; Feng, Xin; Henikoff, Jorja G.; Morrison, Carolyn A.; Shah, Parantu K.; Brown, Christopher D.; Negre, Nicolas; Kheradpour, Pouya; Kellis, Manolis (Public Library of Science, 2010-01)
    Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...
  • Taylor, Frank E. (American Physical Society, 2014-12)
    This article presents measurements of the t-channel single top-quark (t) and top-antiquark ([bar over t]) total production cross sections σ(tq) and σ(t¯q), their ratio R[subscript t]=σ(tq)/σ([bar over t] q), and a measurement ...
  • Lander, Eric S. (Nature Publishing Group, 2012-07)
    To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. ...
  • Lander, Eric S. (Nature Publishing Group, 2014-07)
    Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, ...
  • Srivastava, Ankur; Meade, Andrew J. (Hindawi Publishing Corporation, 2015)
    Use of probabilistic techniques has been demonstrated to learn air data parameters from surface pressure measurements. Integration of numerical models with wind tunnel data and sequential experiment design of wind tunnel ...
  • Weisenfeld, Neil I; Yin, Shuangye; Sharpe, Ted; Lau, Bayo; Hegarty, Ryan; Holmes, Laurie; Sogoloff, Brian; Tabbaa, Diana; Williams, Louise; Russ, Carsten; Nusbaum, Chad; MacCallum, Iain; Jaffe, David B.; Lander, Eric S. (Nature Publishing Group, 2014-10)
    Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and ...
  • Mineo, S.; Pooley, D.; Rappaport, Saul A.; Levine, Alan M.; Homan, Jeroen; Steinhorn, Benjamin S. (IOP Publishing, 2014-12)
    We present a comprehensive study of the total X-ray emission from the colliding galaxy pair NGC 2207/IC 2163, based on Chandra, Spitzer, and GALEX data. We detect 28 ultraluminous X-ray sources (ULXs), 7 of which were not ...
  • Belanger-Rioux, R.; Demanet, Laurent (Society for Industrial and Applied Mathematics, 2015-10)
    Absorbing layers are sometimes required to be impractically thick in order to offer an accurate approximation of an absorbing boundary condition for the Helmholtz equation in a heterogeneous medium. It is always possible ...
  • Choi, Jae-Hoon; Christensen, Caleb A.; Heo, Myoung-Sun; Ketterle, Wolfgang; Lee, Ye-Ryoung; Rvachov, Timur Michael; Wang, Tout T. (American Physical Society, 2012-06)
    Fermi gases with repulsive interactions are characterized by measuring their compressibility as a function of interaction strength. The compressibility is obtained from in-trap density distributions monitored by phase-contrast ...
  • Choong, Looh Tchuin; Mannarino, Matthew M.; Basu, Sandip; Rutledge, Gregory C. (Springer-Verlag, 2013-06)
    Compressive properties of electrospun fiber mats are reported for the first time. Mats of bisphenol-A polysulfone (PSU) and of poly(trimethyl hexamethylene terephthalamide) [PA 6(3)T] were electrospun and annealed over a ...
  • Magesan, Easwar; Cappellaro, Paola; Cooper-Roy, Alexandre (American Physical Society, 2013-12)
    We present methods that can provide an exponential savings in the resources required to perform dynamic parameter estimation using quantum systems. The key idea is to merge classical compressive sensing techniques with ...
  • Sanzeni, Alex; Whittle, Andrew; Germaine, John T.; Colleselli, Francesco (American Society of Civil Engineers (ASCE), 2012-10)
    A laboratory test program was conducted to evaluate the one-dimensional (1D) compression and creep properties of intact sand (and silty-sand) samples from a deep borehole at the Malamocco Inlet to the Venice Lagoon. The ...
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