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Browsing MIT Open Access Articles by Title

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  • Kothapalli, Roopa; Kahn, Asif M.; Basappa, Salundi; Gopalsamy, Anupriya; Chong, Yap Seng; Annamalai, Loganath (Public Library of Science, 2010-08)
    Background: MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the ...
  • Ouyang, Tom Y.; Davis, Randall (Association for Computing Machinery (ACM), 2011)
    We describe a new sketch recognition framework for chemical structure drawings that combines multiple levels of visual features using a jointly trained conditional random field. This joint model of appearance at different ...
  • Campbell, Michael Glenn; Liu, Sophie; Swager, Timothy M; Dinca, Mircea (American Chemical Society (ACS), 2015-11)
    Applications of porous metal–organic frameworks (MOFs) in electronic devices are rare, owing in large part to a lack of MOFs that display electrical conductivity. Here, we describe the use of conductive two-dimensional ...
  • Hamaguchi, Hitoshi; Fennell, John Francis; Yoon, Bora; Swager, Timothy M (MDPI AG, 2017-04)
    Chemical warfare agents (CWA) continue to present a threat to civilian populations and military personnel in operational areas all over the world. Reliable measurements of CWAs are critical to contamination detection, ...
  • Zhao, Weian; Teo, Grace Sock Leng; Kumar, Namit; Karp, Jeffrey Michael (Elsevier, 2010-03)
    Cell surfaces are fertile ground for chemists and material scientists to manipulate or augment cell functions and phenotypes. This not only helps to answer basic biology questions but also has diagnostic and therapeutic ...
  • Mangerich, Aswin; Dedon, Peter C.; Fox, James G.; Tannenbaum, Steven Robert; Wogan, Gerald N. (Informa UK (Informa Healthcare), 2013-11)
    The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its ...
  • Tonzetich, Zachary J.; Heroguel, Florent; Do, Loi Hung; Lippard, Stephen J. (American Chemical Society, 2011-01)
    Several nitrosyl complexes of Fe and Co have been prepared using the sterically hindered Ar-nacnac ligand (Ar-nacnac = anion of [(2,6-diisopropylphenyl)NC(Me)]2CH). The dinitrosyliron complexes [Fe(NO)2(Ar-nacnac)] (1) and ...
  • Nocera, Daniel G. (American Chemical Society (ACS), 2009-09)
    Personalized energy (PE) is a transformative idea that provides a new modality for the planet’s energy future. By providing solar energy to the individual, an energy supply becomes secure and available to people of both ...
  • Casey, Andrew R.; Schlaufman, Kevin C. (IOP Publishing, 2015-08)
    Metal-poor stars in the Milky Way are local relics of the epoch of the first stars and the first galaxies. However, a low metallicity does not prove that a star formed in this ancient era, as metal-poor stars form over a ...
  • Buckley, Rachael Marie; Stubbe, JoAnne (American Chemical Society (ACS), 2015-03)
    Polyhydroxybutyrate (PHB) synthases (PhaCs) catalyze the conversion of 3-(R)-hydroxybutyryl CoA (HBCoA) to PHB, which is deposited as granules in the cytoplasm of microorganisms. The class I PhaC from Caulobacter crescentus ...
  • Maloney, John M.; Van Vliet, Krystyn J. (Royal Society of Chemistry, 2014-08)
    Biological cells can be characterized as “soft matter” with mechanical characteristics potentially modulated by external cues such as pharmaceutical dosage or fever temperature. Further, quantifying the effects of chemical ...
  • Guan, Ziqiang; Lukose, Vinita; Whitworth, Garrett; Imperiali, Barbara (American Chemical Society (ACS), 2015-09)
    The cell surfaces of bacteria are replete with diverse glycoconjugates that play pivotal roles in determining how bacteria interact with the environment and the hosts that they colonize. Studies to advance our understanding ...
  • Popp, Maximilian W.; Karssemeijer, Roos A.; Ploegh, Hidde (Public Library of Science, 2012-03)
    The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, ...
  • Chandrasekaran, Sriram; Cokol‐Cakmak, Melike; Sahin, Nil; Yilancioglu, Kaan; Kazan, Hilal; Collins, James J.; Cokol, Murat (EMBO Press, 2016-05)
    Combination antibiotic therapies are being increasingly used in the clinic to enhance potency and counter drug resistance. However, the large search space of candidate drugs and dosage regimes makes the identification of ...
  • Swallow, Jessica Gabrielle; Woodford, William Henry; Chen, Y.; Lu, Qiyang; Kim, Jae Jin; Chen, D.; Chiang, Yet-Ming; Carter, W. Craig; Yildiz, Bilge; Tuller, Harry L.; Van Vliet, Krystyn J; Van Vliet, Krystyn J. (Springer Science+Business Media, 2014-01)
    Functional materials for energy conversion and storage exhibit strong coupling between electrochemistry and mechanics. For example, ceramics developed as electrodes for both solid oxide fuel cells and batteries exhibit ...
  • Kuksenok, Olga; Dayal, Pratyush; Bhattacharya, Amitabh; Yashin, Victor V.; Deb, Debabrata; Chen, Irene C.; Van Vliet, Krystyn J.; Balazs, Anna C. (Royal Society of Chemistry, The, 2013-02)
    Species ranging from single-cell organisms to social insects can undergo auto-chemotaxis, where the entities move towards a chemo-attractant that they themselves emit. Polymer gels undergoing the self-oscillating ...
  • Movassaghi, Mohammad; Noshi Alhanafy, Mohammad N.; Tjandra, Meiliana; Miller, Scott J.; Kolundzic, Filip (American Chemical Society, 2011-05)
    Catalytic enantioselective indole oxidation is a process of particular relevance to the chemistry of complex alkaloids, as it has been implicated in their biosynthesis. In the context of synthetic methodology, catalytic ...
  • Panda, Oishika; Mahanti, Parag; Schroeder, Frank C.; Meisel, Joshua Daniel; Kim, Dennis H (Elsevier, 2014-10)
    Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa ...
  • Mitchell, James G.; Smriga, Steven; Fernandez, Vicente Ignacio; Stocker, Roman (National Academy of Sciences (U.S.), 2016-01)
    The microenvironment surrounding individual phytoplankton cells is often rich in dissolved organic matter (DOM), which can attract bacteria by chemotaxis. These “phycospheres” may be prominent sources of resource heterogeneity ...
  • Gilbert, Luke Andrew; Hemann, Michael (American Association for Cancer Research, 2011-07)
    Chemotherapeutic regimens involve the systemic administration of genotoxic compounds that induce cancer cell death via well-established DNA damage response signaling networks. Less understood is how the treatment of other ...
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