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Browsing MIT Open Access Articles by Title

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  • Demirbas, Umit; Sennaroglu, A.; Cankaya, H.; Cizmeciyan, N.; Kurt, A.; Somer, M. (SPIE, 2010-02)
    This paper provides an overview of the experimental work performed in our research group on the synthesis, spectroscopic investigation, and laser characterization of chromium-doped zinc selenide (Cr[superscript 2+]:ZnSe). ...
  • Teleman, Aurelio A.; Graumann, Peter L.; Lin, Daniel Chi-Hong; Grossman, Alan D.; Losick, Richard (Elsevier, 1998-09)
    Background: The contour length of the circular chromosome of bacteria is greater than a millimeter but must be accommodated within a cell that is only a few micrometers in length. Bacteria do not have nucleosomes and little ...
  • Tabuchi, Tomoko M.; Deplancke, Bart; Osato, Naoki; Zhu, Lihua J.; Barrasa, M. Inmaculada; Harrison, Melissa M.; Horvitz, H. Robert; Walhout, Albertha J. M.; Hagstrom, Kristen A. (Public Library of Science, 2011-05)
    DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we describe new aspects of DRM binding and function revealed through ...
  • Schmidt, Jens Christopher; Cheeseman, Iain McPherson (Elsevier B.V., 2011-02)
    The Ndc80 complex is a key component of the kinetochore–microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins ...
  • Whittaker, Charles A.; Housman, David E.; Charest, Alain; Acquaviva, Jaime; Jun, Hyun Jung; Lessard, Julie; Ruiz, Rolando; Zhu, Haihao; Donovan, Melissa; Woolfenden, Steve; Boskovitz, Abraham; Raval, Ami; Bronson, Roderick T.; Pfannl, Rolf (American Association for Cancer Research, 2011-10)
    Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven ...
  • Oliver, Trudy; Mercer, Kim L.; Sayles, Leanne C.; Burke, James R.; Mendus, Diana; Lovejoy, Katherine S.; Cheng, Mei-Hsin; Subramanian, Aravind; Mu, David; Powers, Scott; Crowley, Denise G.; Bronson, Roderick T.; Whittaker, Charles A.; Bhutkar, Arjun (AJ); Lippard, Stephen J.; Golub, Todd R.; Thomale, Juergen; Jacks, Tyler E.; Sweet-Cordero, E. Alejandro (Cold Spring Harbor Laboratory Press in association with The Genetics Society, 2010-03)
    Chemotherapy resistance is a major obstacle in cancer treatment, yet the mechanisms of response to specific therapies have been largely unexplored in vivo. Employing genetic, genomic, and imaging approaches, we examined ...
  • Cosgrove, Cormac; Berger, Christoph T.; Kroy, Daniela C.; Cheney, Patrick C.; Ghebremichael, Musie; Aneja, Jasneet; Tomlinson, Michelle; Kim, Arthur Y.; Lauer, Georg M.; Alter, Galit (Public Library of Science, 2014-08)
    Although epidemiological and functional studies have implicated NK cells in protection and early clearance of HCV, the mechanism by which they may contribute to viral control is poorly understood, particularly at the site ...
  • Michalon, Aubin; Sidorov, Michael; Ballard, Theresa M.; Ozmen, Laurence; Spooren, Will; Wettstein, Joseph G.; Jaeschke, Georg; Bear, Mark; Lindemann, Lothar (Elsevier B.V., 2012-04)
    Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial unanswered question is whether pharmacological ...
  • CIA Leaks 
    Gillies, Anthony S.; von Fintel, Kai (Duke University Press, 2008-01)
    Epistemic modals are standardly taken to be context-dependent quantifiers over possibilities. Thus sentences containing them get truth-values with respect to both a context and an index. But some insist that this relativization ...
  • Giuffre, Carl; Hinow, Peter; Vogel, Ryan; Ahmed, Tanvir; Stocker, Roman; Consi, Thomas R.; Strickler, J. Rudi (Public Library of Science, 2011-04)
    We study the motility behavior of the unicellular protozoan Paramecium tetraurelia in a microfluidic device that can be prepared with a landscape of attracting or repelling chemicals. We investigate the spatial distribution ...
  • Leiserson, Charles E. (Association for Computing Machinery, 2009-01)
    The availability of multicore processors across a wide range of computing platforms has created a strong demand for software frameworks that can harness these resources. This paper overviews the Cilk++ programming environment, ...
  • Efrat, Netalee; Didyk, Piotr; Levin, Anat; Foshey, Michael; Matusik, Wojciech (Association for Computing Machinery (ACM), 2016-07)
    While 3D movies are gaining popularity, viewers in a 3D cinema still need to wear cumbersome glasses in order to enjoy them. Automultiscopic displays provide a better alternative to the display of 3D content, as they present ...
  • Remondes, Armando Miguel; Wilson, Matthew A. (Elsevier, 2013-11)
    Interactions between cortex and hippocampus are believed to play a role in the acquisition and maintenance of memories. Distinct types of coordinated oscillatory activity, namely at theta frequency, are hypothesized to ...
  • Yang, Qiong; Pando, Bernardo Fabian; Dong, Guogang; Golden, Susan S.; van Oudenaarden, Alexander (American Association for the Advancement of Science, 2010-03)
    Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell ...
  • Petsakou, Afroditi; Blau, Justin; Sapsis, Themistoklis P. (Elsevier, 2015-07)
    Neuronal plasticity helps animals learn from their environment. However, it is challenging to link specific changes in defined neurons to altered behavior. Here, we focus on circadian rhythms in the structure of the principal ...
  • Brakerski, Zvika; Vaikuntanathan, Vinod (Springer, 2016-07)
    We construct an LWE-based key-policy attribute-based encryption (ABE) scheme that supports attributes of unbounded polynomial length. Namely, the size of the public parameters is a fixed polynomial in the security parameter ...
  • Namburi, Praneeth; Beyeler, Anna; Yorozu, Suzuko; Calhoon, Gwendolyn G.; Wichmann, Romy; Holden, Stephanie S.; Mertens, Kim L.; Wickersham, Ian R.; Gray, Jesse M.; Halbert, Sarah; Anahtar, Melodi N.; Felix-Ortiz, Ada Celis; Tye, Kay (Nature Publishing Group, 2015-04)
    The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral ...
  • Mandal, Soumyajit; Sarpeshkar, Rahul (Institute of Electrical and Electronics Engineers, 2009-12)
    We use analogies between chemistry and subthreshold electronics to develop fast, scalable, digitally programmable hardware models of stochastic genetic networks. We also present experimental results from a prototype 0.18 ...
  • Wilusz, Jeremy E.; Sharp, Phillip A. (American Association for the Advancement of Science (AAAS), 2013-04)
    Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered ...
  • Mahmood, Zohaib; Daniel, Luca (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    In this paper we present a highly efficient algorithm to automatically generate circuit synthesizable dynamical models for passive multiport structures. The algorithm is based on a natural convex relaxation of the original ...
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