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Browsing MIT Open Access Articles by Title

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  • Fletcher, Richard Ribon; Kulkarni, Sarang (Institute of Electrical and Electronics Engineers (IEEE), 2010-08)
    We present a new type of non-contact sensor for use in ambulatory cardiac monitoring. The sensor operation is based on a microwave Doppler technique; however, instead of detecting the heart activity from a distance, the ...
  • Liao, Bolin; Zebarjadi, Mona; Esfarjani, Keivan; Chen, Gang (American Physical Society, 2012-09)
    In this Letter, we aim at making nanoparticles embedded in a host semiconductor with a size comparable to electronic wavelengths “invisible” to the electron transport. Inspired by the recent progress made in optics and ...
  • Neuenschwander, Ulrich; Negron, Arnaldo; Jensen, Klavs F. (American Chemical Society (ACS), 2013-05)
    Clock reactions are rare kinetic phenomena, so far limited mostly to systems with ionic oxoacids and oxoanions in water. We report a new clock reaction in cyclohexanol that forms molybdenum blue from a noncharged, yellow ...
  • Aye, Yimon; Stubbe, JoAnne (National Academy of Sciences (U.S.), 2011-05)
    Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of alpha- and beta-subunits that form active alpha nbeta m (n, m = 2 or 6) complexes. alpha binds NDP ...
  • Aye, Yimon; Brignole, Edward J.; Long, Marcus J.C.; Chittuluru, Johnathan; Drennan, Catherine L.; Asturias, Francisco J.; Stubbe, JoAnne (Springer Science + Business Media B.V., 2012-07)
    Clofarabine (ClF) is a drug used in the treatment of leukemia. One of its primary targets is human ribonucleotide reductase (hRNR), a dual-subunit, (α2)m(β2)n, regulatory enzyme indispensable in de novo dNTP synthesis. We ...
  • Dorans, Kimberly; Chung, Katherine Minjee; Robbins, Rebecca; Tammela, Tuomas; Gocheva, Vasilena; Jacks, Tyler E; Li, Carman Man Chung; Muzumdar, Mandar (Nature Publishing Group, 2016-07)
    Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we ...
  • Lander, Eric Steven (Nature Publishing Group, 2016-05)
    Resistance to the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ...
  • Lenz, Danielle R.; McLean, Dalton; Karp, Jeffrey M.; Edge, Albert S.B.; McLean, Will J.; Yin, Xiaolei; Lu, Lin; Langer, Robert S (Elsevier, 2017-02)
    Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a ...
  • Genovese, Giulio; Handsaker, Robert E.; Lindberg, Johan; Rose, Samuel A.; Bakhoum, Samuel F.; Chambert, Kimberly; Mick, Eran; Neale, Benjamin M.; Fromer, Menachem; Purcell, Shaun M.; Svantesson, Oscar; Gabriel, Stacey B.; Moran, Jennifer L.; Lander, Eric S.; Sullivan, Patrick F.; Sklar, Pamela; Hultman, Christina M.; McCarroll, Steven A.; Kahler, Anna K.; Landen, Mikael; Hoglund, Martin; Lehmann, Soren; Gronberg, Henrik (New England Journal of Medicine, 2014-11)
    Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. Methods We analyzed ...
  • Arbab, Mandana; Srinivasan, Sharanya; Geijsen, Niels; Sherwood, Richard I.; Hashimoto, Tatsunori Benjamin (Elsevier, 2015-10)
    We present self-cloning CRISPR/Cas9 (scCRISPR), a technology that allows for CRISPR/Cas9-mediated genomic mutation and site-specific knockin transgene creation within several hours by circumventing the need to clone a ...
  • Ching, ShiNung; Chemali, Jessica; Liberman, Max Y.; Brown, Emery N. (IOP Publishing, 2013-06)
    Objective. There is growing interest in using closed-loop anesthetic delivery (CLAD) systems to automate control of brain states (sedation, unconsciousness and antinociception) in patients receiving anesthesia care. The ...
  • Walter, Matthew R.; Karaman, Sertac; Frazzoli, Emilio; Teller, Seth (Institute of Electrical and Electronics Engineers / Robotics Society of Japan, 2010-10)
    This paper addresses the problem of autonomous manipulation of a priori unknown palletized cargo with a robotic lift truck (forklift). Specifically, we describe coupled perception and control algorithms that enable the ...
  • Paster, Eli Travis; Ruddy, Bryan P.; Pillai, Priam V.; Hunter, Ian (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    Conducting polymer actuators such as polypyrrole can generate stresses over 10 times larger than skeletal muscle and have typical repeatable strains between 1% and 12%, making them potential candidates for lightweight, ...
  • Schaeffer, Luke R.; Shallit, Jeffrey (European Mathematical Information Service (EMIS), 2016-02)
    We prove that the property of being closed (resp., palindromic, rich, privileged trapezoidal, balanced) is expressible in first-order logic for automatic (and some related) sequences. It therefore follows that the ...
  • Aaronson, Scott; Watrous, John (Royal Society of London, 2009-02)
    While closed timelike curves (CTCs) are not known to exist, studying their consequences has led to non-trivial insights into general relativity, quantum information and other areas. In this paper, we show that, if CTCs ...
  • Lloyd, Seth; Maccone, Lorenzo; Garcia-Patron Sanchez, Raul; Giovannetti, Vittorio; Shikano, Yutaka; Pirandola, Stefano; Rozema, Lee A.; Ardavan, Darabi; Soudagar, Yasaman; Shalm, Lynden K.; Steinberg, Aephraim M. (American Physical Society, 2011-01)
    Closed timelike curves (CTCs) are trajectories in spacetime that effectively travel backwards in time: a test particle following a CTC can interact with its former self in the past. A widely accepted quantum theory of CTCs ...
  • Reagans, Ray Eugene (Institute for Operations Research and the Management Sciences, 2011-07)
    Models of network formation emphasize the importance of social similarity and propinquity in producing strong interpersonal connections. The positive effect each factor can have on tie strength has been documented across ...
  • Becker, Jamie William; Berube, Paul M.; Follett, Christopher; Waterbury, John B.; Chisholm, Sallie (Penny); DeLong, Edward; Repeta, Daniel J. (Frontiers Research Foundation, 2014-03)
    Production of dissolved organic matter (DOM) by marine phytoplankton supplies the majority of organic substrate consumed by heterotrophic bacterioplankton in the sea. This production and subsequent consumption converts a ...
  • Scholvin, Jorg; Kinney, Justin; Bernstein, Jacob G.; Moore-Kochlacs, Caroline; Kopell, Nancy; Fonstad, Clifton G.; Boyden, Edward Stuart (Institute of Electrical and Electronics Engineers (IEEE), 2015-12)
    Objective: Neural recording electrodes are important tools for understanding neural codes and brain dynamics. Neural electrodes that are closely packed, such as in tetrodes, enable spatial oversampling of neural activity, ...
  • Argiroffi, C.; Maggio, A.; Montmerle, T.; Alecian, E.; Audard, M.; Bouvier, J.; Damiani, F.; Donati, J.-F.; Gregory, S. G.; Gudel, M.; Hussain, G. A. J.; Kastner, Joel H.; Sacco, G. G.; Huenemoerder, David P. (IOP Publishing, 2012-05)
    We report initial results from a quasi-simultaneous X-ray/optical observing campaign targeting V4046 Sgr, a close, synchronous-rotating classical T Tauri star (CTTS) binary in which both components are actively accreting. ...
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