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Browsing MIT Open Access Articles by Title

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  • Sharghi-Namini, Soheila; Tan, Evan; Ong, Lee-Ling Sharon; Ge, Ruowen; Asada, Harry (Nature Publishing Group, 2014-02)
    Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring ...
  • Lapan, Sylvain William; Reddien, Peter (Public Library of Science, 2011-08)
    Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation ...
  • Littleton, J. Troy; Sepp, Katharine J.; Jorquera, Ramon; Song, Yun; Schulte, Joost; Wu, Chaohong; Hong, Pengyu (Society for Neuroscience, 2010-01)
    The monopolar spindle-one-binder (Mob) family of kinase-interacting proteins regulate cell cycle and cell morphology, and their dysfunction has been linked to cancer. Models for Mob function are primarily based on studies ...
  • Arya, Kapil; Cooperman, Gene; Ansel, Jason Andrew (Institute of Electrical and Electronics Engineers, 2009-07)
    DMTCP (Distributed MultiThreaded CheckPointing) is a transparent user-level checkpointing package for distributed applications. Checkpointing and restart is demonstrated for a wide range of over 20 well known applications, ...
  • Battat, James; Ahlen, S.; Caldwell, T.; Dujmic, Denis; Dushkin, A.; Fisher, Peter H.; Golub, F.; Goyal, S.; Henderson, Shawn Wesley; Inglis, A.; Lanza, Richard C.; Lopez, J.; Kaboth, Asher Cunningham; Kohse, Gordon E.; Monroe, Jocelyn; Sciolla, Gabriella; Skvorodnev, B. N.; Tomita, H.; Vanderspek, Roland K.; Wellenstein, H.; Yamamoto, Richard K. (American Institute of Physics, 2009-12)
    By correlating nuclear recoil directions with the Earth's direction of motion through the Galaxy, a directional dark matter detector can unambiguously detect Weakly Interacting Massive Particles (WIMPs), even in the presence ...
  • Nakagawa, So; Gisselbrecht, Stephen S.; Rogers, Julia M.; Hartl, Daniel L.; Bulyk, Martha L. (National Academy of Sciences (U.S.), 2013-07)
    The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ...
  • Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy Manning (American Chemical Society (ACS), 2011-02)
    The ability to detect biological analytes in a rapid, sensitive, operationally simple, and cost-effective manner will impact human health and safety. Hybrid biocatalyzed-carbon nanotube (CNT) nanowire-based detection methods ...
  • Reinhardt, H. Christian; Hasskamp, Pia; Schmedding, Ingolf; Morandell, Sandra; van Vugt, Marcel A.T.M.; Wang, XiaoZhe; Linding, Rune; Ong, Shao-En; Weaver, David; Carr, Steven A.; Yaffe, Michael B. (Elsevier B.V., 2010-10)
    Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ...
  • Yanch, Jacquelyn C.; Engelward, Bevin P. (National Institute of Environmental Health Sciences, 2012-10)
    We thank Beyea for his comments and would like to respond, in particular, regarding the works he cites in his letter. First, the results of our study are, in fact, consistent with the findings of many human epidemiologic ...
  • Modell, Joshua Wexler; Hopkins, Alexander C.; Laub, Michael T. (Cold Spring Harbor Laboratory, 2011-05)
    Following DNA damage, cells typically delay cell cycle progression and inhibit cell division until their chromosomes have been repaired. The bacterial checkpoint systems responsible for these DNA damage responses are ...
  • Gehring, Mary; Reik, Wolf; Henikoff, Steven (Elsevier Science Publishers, 2009-02)
    Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant ...
  • Shell, Scarlet S.; Baek, Seung-Hun; Shah, Rupal R.; Sassetti, Christopher M.; Dedon, Peter C.; Fortune, Sarah M.; Prestwich, Erin (Public Library of Science, 2013-07)
    DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely ...
  • Kim, A Ra; Moon, James J.; Irvine, Darrell J.; Sunghwan Jung, Darrell J.; Um, Soong Ho (Institute of Electrical and Electronics Engineers (IEEE), 2010-08)
    DNA has been used as a new generic material due to its selectivity and intrinsic biocompatibility, to construct a variety of nano-architectures such as cubic, tetrahedral, and even complicated origami. Recently, a 3-D ...
  • Dupradeau, François-Yves; Case, David A.; Chen, Jingyang; Turner, Christopher John; Stubbe, JoAnne (Oxford University Press (OUP), 2007-11)
    Abasic sites are common DNA lesions resulting from spontaneous depurination and excision of damaged nucleobases by DNA repair enzymes. However, the influence of the local sequence context on the structure of the abasic ...
  • Wang, Lianrong; Chen, Shi; Vergin, Kevin L.; Giovannoni, Stephen J.; Chan, Simon W.; DeMott, Michael S.; Taghizadeh, Koli; Cordero, Otto Xavier; Cutler, Michael Barry.; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C.; Chan, Simon W. (National Academy of Sciences, 2011-02)
    Phosphorothioate (PT) modification of DNA, with sulfur replacing a nonbridging phosphate oxygen, was recently discovered as a product of the dnd genes found in bacteria and archaea. Given our limited understanding of the ...
  • Braithwaite, Elena K.; Kedar, Padmini S.; Stumpo, Deborah J.; Bertocci, Barbara; Freedman, Jonathan H.; Wilson, Samuel H.; Samson, Leona D. (Public Library of Science, 2010-08)
    Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol β) is known to be the main polymerase in the BER pathway, various studies have ...
  • Calvo, Jennifer; Meira, Lisiane B.; Lee, Chun-Yue I.; Moroski-Erkul, Catherine A.; Abolhassani, Nona; Taghizadeh, Koli; Eichinger, Lindsey Wood; Muthupalani, Sureshkumar; Nordstrand, Line M.; Klungland, Arne; Samson, Leona D. (American Society for Clinical Investigation, 2012-06)
    More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore understanding how inflammation contributes to cancer etiology is important for both cancer prevention ...
  • Samson, Leona D.; Kisby, G. E.; Olivas, A.; Park, T.; Churchwell, M.; Doerge, D.; Gerson, S. L.; Turker, M. S. (Elsevier Pub. Co., 2009-01)
    Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly understood. The focus of the present study is to demonstrate that DNA ...
  • Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Frieder, Jillian; Wu, Jun; Farokhzad, Omid C.; Pridgen, Eric Michael; Shi, JinJun (Wiley Blackwell, 2012-10)
    Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene ...
  • Charoensawan, Varodom; Janga, Sarath Chandra; Bulyk, Martha L.; Babu, M. Madan; Teichmann, Sarah A.; Bulyk, Martha L. (Elsevier, 2012-07)
    Transcription factors (TFs) and histone octamers are two abundant classes of DNA binding proteins that coordinate the transcriptional program in cells. Detailed studies of individual TFs have shown that TFs bind to ...
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