Browsing MIT Open Access Articles by Title
Now showing items 29666-29685 of 55765
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Mechanisms underlying simultaneous brightness contrast: Early and innate
(Elsevier BV, 2020)In the phenomenon of simultaneous brightness contrast, two patches, one on a dark background and the other on a light one, appear to have different brightness despite being physically equi-luminant. Elucidating the ... -
Mechanistic action of weak acid drugs on biofilms
(Nature Publishing Group, 2017-07)Selective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication ... -
A mechanistic approach for accurate simulation of village scale malaria transmission
(BioMed Central, 2009-10)Background: Malaria transmission models commonly incorporate spatial environmental and climate variability for making regional predictions of disease risk. However, a mismatch of these models' typical spatial resolutions ... -
Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants
(American Society for Biochemistry & Molecular Biology (ASBMB), 2018-10)Flavonoids are important polyphenolic natural products, ubiquitous in land plants, that play diverse functions in plants’ survival in their ecological niches, including UV protection, pigmentation for attracting pollinators, ... -
A mechanistic compartmental model for total antibody uptake in tumors
(Elsevier BV, 2012)Antibodies are under development to treat a variety of cancers, such as lymphomas, colon, and breast cancer. A major limitation to greater efficacy for this class of drugs is poor distribution in vivo. Localization of ... -
Mechanistic Evidence for Ligand-Centered Electrocatalytic Oxygen Reduction with the Conductive MOF Ni
(American Chemical Society, 2017-09)Establishing catalytic structure–function relationships introduces the ability to optimize the catalyst structure for enhanced activity, selectivity, and durability against reaction conditions and prolonged catalysis. Here ... -
Mechanistic framework for reduced-order models in soft materials: Application to three-dimensional granular intrusion
(Proceedings of the National Academy of Sciences, 2023-01-17)Soft materials often display complex behaviors that transition through apparent solid- and fluid-like regimes. While a growing number of microscale simulation methods exist for these materials, reduced-order models that ... -
Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes
(American Chemical Society (ACS), 2018-01-29)Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination ... -
Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3
(American Association for the Advancement of Science (AAAS), 2022-12-14)<jats:p> Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer’s disease (AD). To identify ... -
Mechanistic Insight with HBCH[subscript 2]CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases
(American Chemical Society (ACS), 2014-06)Polyhydroxybutyrate (PHB) synthases catalyze the polymerization of 3-(R)-hydroxybutyrate coenzyme A (HBCoA) to produce polyoxoesters of 1–2 MDa. A substrate analogue HBCH[subscript 2]CoA, in which the S in HBCoA is replaced ... -
Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines
(Nature Publishing Group, 2015-12)To maintain protein homeostasis, AAA+ proteolytic machines degrade damaged and unneeded proteins in bacteria, archaea and eukaryotes. This process involves the ATP-dependent unfolding of a target protein and its subsequent ... -
Mechanistic Insights into the Formation of InP Quantum Dots
(Wiley Blackwell, 2009-12)The molecular mechanism of InP colloidal quantum dot (QD) syntheses was investigated by NMR spectroscopy. Unlike methods for monodisperse PbSe and CdSe, existing InP syntheses result in total depletion of molecular phosphorous ... -
Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-terminal Fragments
(American Chemical Society (ACS), 2010-08)Oligomeric forms of amyloid β-protein (Aβ) are key neurotoxins in Alzheimer’s disease (AD). Previously, we found that C-terminal fragments (CTFs) of Aβ42 interfered with assembly of full-length Aβ42 and inhibited Aβ42-induced ... -
Mechanistic Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures
(American Chemical Society, 2011-01)A continuous-flow microreactor is applied for a kinetic study of a model β-amino alcohol formation by epoxide aminolysis. A large number of experiments are performed in a short time with minimal reagent consumption. The ... -
A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion
(John Wiley & Sons, Inc., 2015-05)Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in ... -
Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells
(Elsevier BV, 2021-06)Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we ... -
Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells
(Elsevier BV, 2021)Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we ... -
A Mechanistic Model of Macromolecular Allocation, Elemental Stoichiometry, and Growth Rate in Phytoplankton
(Frontiers Media SA, 2020-02)We present a model of the growth rate and elemental stoichiometry of phytoplankton as a function of resource allocation between and within broad macromolecular pools under a variety of resource supply conditions. The model ... -
Mechanistic modeling of viral particle production
(Wiley, 2022-12-03)Viral systems such as wild-type viruses, viral vectors, and virus-like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial-scale production of viral systems ... -
Mechanistic origins of bombardier beetle (Brachinini) explosion-induced defensive spray pulsation
(American Association for the Advancement of Science (AAAS), 2015-04)Bombardier beetles (Brachinini) use a rapid series of discrete explosions inside their pygidial gland reaction chambers to produce a hot, pulsed, quinone-based defensive spray. The mechanism of brachinines’ spray pulsation ...
