Browsing MIT Open Access Articles by Title
Now showing items 30276-30295 of 55765
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Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy
(American Chemical Society (ACS), 2013-11)Taking a nanoparticle (NP) from discovery to clinical translation has been slow compared to small molecules, in part by the lack of systems that enable their precise engineering and rapid optimization. In this work we have ... -
A Microfluidic Platform for Evaluating Anode Substrates for Microbial Fuel Cells
(ASME International, 2012-11)Microbial fuel cell technology is a new technology for producing green energy from wastewater. While lab scale and commercial microbial fuel cells typically utilize graphite as the film substrate, it is difficult to rapidly ... -
Microfluidic platform for selective microparticle parking and paired particle isolation in droplet arrays
(AIP Publishing, 2018-03)Immobilizing microscale objects (e.g., cells, spheroids, and microparticles) in arrays for direct observation and analysis is a critical step of many biological and chemical assays; however, existing techniques are often ... -
Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension
(AIP Publishing, 2020-03)Cells in a tumor microenvironment are exposed to spatial and temporal variations in oxygen tension due to hyperproliferation and immature vascularization. Such spatiotemporal oxygen heterogeneity affects the behavior of ... -
Microfluidic platforms for mechanobiology
(Royal Society of Chemistry, The, 2013-04)Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on ... -
Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions
(Springer-Verlag/Biomedical Engineering Society, 2010-01)Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide ... -
Microfluidic preparative free-flow isoelectric focusing in a triangular channel: System development and characterization
(John Wiley & Sons, Inc., 2010-04)A preparative scale free-flow IEF device is developed and characterized with the aim of addressing needs of molecular biologists working with protein samples on the milligrams and milliliters scale. A triangular-shape ... -
Microfluidic Preparative Free-Flow Isoelectric Focusing: System Optimization for Protein Complex Separation
(American Chemical Society (ACS), 2010-01)Isoelectric focusing (IEF) is the first step for two-dimensional (2D) gel electrophoresis and plays an important role in sample purification for proteomics. However, biases in protein size and pI resolution, as well as ... -
Microfluidic probe for single-cell lysis and analysis in adherent tissue culture
(Nature Publishing Group, 2014-03)Single-cell analysis provides information critical to understanding key disease processes that are characterized by significant cellular heterogeneity. Few current methods allow single-cell measurement without removing ... -
Microfluidic Production of Perfluorocarbon-Alginate Core–Shell Microparticles for Ultrasound Therapeutic Applications
(American Chemical Society (ACS), 2014-09)The fabrication of micrometer-sized core–shell particles for ultrasound-triggered delivery offers a variety of applications in medical research. In this work, we report the design and development of a glass capillary ... -
Microfluidic rheometry
(Elsevier, 2008-09)The development and growth of microfluidics has stimulated interest in the behaviour of complex liquids in micro-scale geometries and provided a rich platform for rheometric investigations of non-Newtonian phenomena at ... -
Microfluidic Screening of Electric Fields for Electroporation
(Nature Publishing Group, 2016-02)Electroporation is commonly used to deliver molecules such as drugs, proteins, and/or DNA into cells, but the mechanism remains poorly understood. In this work a rapid microfluidic assay was developed to determine the ... -
Microfluidic separation of canine adipose-derived mesenchymal stromal cells
(Mary Ann Liebert Inc, 2021)Mesenchymal stromal cells (MSCs) are potential treatments for a variety of veterinary medical conditions. However, clinical trials have often fallen short of expectations, due in part to heterogeneity and lack of ... -
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines
(Nature Publishing Group, 2015-05)B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to utilizing B-cells as APCs is their low ... -
A Microfluidic System for the Continuous Recycling of Unmodified Homogeneous Palladium Catalysts through Liquid/Liquid Phase Separation
(Wiley Blackwell, 2013-05)A prototype microflow system for the continuous recycling of homogeneous catalysts through liquid/liquid phase separation was developed and its effectiveness demonstrated in a challenging palladium-catalyzed hydroxylation ... -
Microfluidic technologies for accelerating the clinical translation of nanoparticles
(Nature Publishing Group, 2012-10)Using nanoparticles for therapy and imaging holds tremendous promise for the treatment of major diseases such as cancer. However, their translation into the clinic has been slow because it remains difficult to produce ... -
Microfluidic vascular models of tumor cell extravasation
(Frontiers Media SA, 2022-11-11)<jats:p>Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These <jats:italic>in vitro</jats:italic> technologies recapitulate key aspects of metastatic cancer, ... -
A microfluidic “baby machine” for cell synchronization
(Royal Society of Chemistry, The, 2012-04)Common techniques used to synchronize eukaryotic cells in the cell cycle often impose metabolic stress on the cells or physically select for size rather than age. To address these deficiencies, a minimally perturbing method ... -
Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples
(eLife Sciences Publications, Ltd, 2017-07)Metagenomics and single-cell genomics have enabled genome discovery from unknown branches of life. However, extracting novel genomes from complex mixtures of metagenomic data can still be challenging and represents an ... -
A microfluidics approach towards high-throughput pathogen removal from blood using margination
(American Institute of Physics, 2012-05)Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular ...
