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Browsing MIT Open Access Articles by Title

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  • Ernst, Jason M.; Kellis, Manolis (Nature Publishing Group, 2010-07)
    A plethora of epigenetic modifications have been described in the human genome and shown to play diverse roles in gene regulation, cellular differentiation and the onset of disease. Although individual modifications have ...
  • Seager, Sara; Winn, Joshua Nathan; Ricker, George R.; Deming, Drake; Miller-Ricci, E.; Clampin, M.; Lindler, D.; Greene, T.; Charbonneau, David; Laughlin, G.; Latham, D.; Ennico, K. (University of Chicago Press, The, 2009-08)
    Doppler and transit surveys are finding extrasolar planets of ever smaller mass and radius, and are now sampling the domain of super Earths (1–3R⊕). Recent results from the Doppler surveys suggest that discovery of a ...
  • Andersson, Karl; Bautz, Marshall W. (IOP Publishing, 2011-03)
    Using the South Pole Telescope (SPT), we have discovered the most massive known galaxy cluster at z>1, SPT-CL J2106-5844. In addition to producing a strong Sunyaev-Zel'dovich (SZ) effect signal, this system is a luminous ...
  • Lander, Eric S. (National Academy of Sciences, 2012-02)
    To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. We ...
  • Lawrence, Michael S.; Stojanov, Petar; Mermel, Craig H.; Robinson, James T.; Garraway, Levi A.; Golub, Todd R.; Meyerson, Matthew; Gabriel, Stacey B.; Lander, Eric S.; Getz, Gad (Nature Publishing Group, 2014-01)
    Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of creating a comprehensive catalogue of ...
  • Schreiber, Stuart L.; Dockendorff, Chris; Aisiku, Omozuanvbo; VerPlank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Flaumenhaft, Robert (American Chemical Society (ACS), 2012-01)
    A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets ...
  • Liu, Qingsong; Chang, Jae Won; Wang, Jinhua; Kang, Seong A.; Thoreen, Carson C.; Markhard, Andrew; Hur, Wooyoung; Zhang, Jianming; Sim, Taebo; Sabatini, David M.; Gray, Nathanael S. (American Chemical Society (ACS), 2010-09)
    The mTOR protein is a master regulator of cell growth and proliferation, and inhibitors of its kinase activity have the potential to become new class of anticancer drugs. Starting from quinoline 1, which was identified in ...
  • Kang, Seong A.; Sabatini, David M.; Liu, Qingsong; Wang, Jinhua; Thoreen, Carson C.; Hur, Wooyoung; Ahmed, Tausif; Gray, Nathanael S. (American Chemical Society (ACS), 2011-02)
    The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry ...
  • Lin, Jinrong; Chakrabarty, Deepto; Galloway, Duncan K.; Hartman, Jacob M. (IOP Publishing, 2010-02)
    We report the detection of pulsations at 552 Hz in the rising phase of two type-I (thermonuclear) X-ray bursts observed from the accreting neutron star EXO 0748–676 in 2007 January and December, by the Rossi X-ray Timing ...
  • Wang, Zhongxiang; Chakrabarty, Deepto (IOP Publishing, 2010-03)
    The X-ray source 4U 1820-30 in the globular cluster NGC 6624 is known as the most compact binary among the identified X-ray binaries (XRBs). Having an orbital period of 685.0 s, the source consists of a neutron star (NS) ...
  • Luhman, K. L.; Bochanski, John J.; Burgasser, Adam J. (IOP Publishing, 2011-02)
    We have used multi-epoch images from the Infrared Array Camera on board the Spitzer Space Telescope to search for substellar companions to stars in the solar neighborhood based on common proper motions. Through this work, ...
  • Cenko, S. Bradley; Kulkarni, S. R.; Horesh, Assaf; Corsi, A.; Fox, Derek B.; Carpenter, John; Frail, Dale A.; Nugent, Peter E.; Perley, Daniel A.; Gruber, D.; Gal-Yam, Avishay; Groot, Paul J.; Hallinan, G.; Ofek, Eran O.; Rau, Arne; MacLeod, Chelsea L.; Miller, Adam A.; Bloom, Joshua S.; Filippenko, Alexei V.; Kasliwal, Mansi M.; Law, Nicholas M.; Morgan, Adam N.; Polishook, David; Poznanski, Dovi; Quimby, Robert M.; Sesar, Branimir; Shen, Ken J.; Silverman, Jeffrey M.; Sternberg, Assaf (Institute of Physics/American Astronomical Society, 2013-06)
    We report the discovery by the Palomar Transient Factory (PTF) of the transient source PTF11agg, which is distinguished by three primary characteristics: (1) bright (R[subscript peak] = 18.3 mag), rapidly fading (ΔR = 4 ...
  • Lin, Dacheng; Irwin, Jimmy A.; Webb, Natalie A.; Barret, Didier; Remillard, Ronald Alan (Institute of Physics/American Astronomical Society, 2013-12)
    We report the discovery of a new ultraluminous X-ray source (ULX) 2XMM J125048.6+410743 within the spiral galaxy M94. The source has been observed by ROSAT, Chandra, and XMM-Newton on several occasions, exhibiting as a ...
  • Altamirano, D.; Cavecchi, Y.; Patruno, A.; Watts, A.; Linares, Manuel; Degenaar, N.; Kalamkar, M.; van der Klis, M.; Rea, N.; Casella, P.; Armas Padilla, M.; Kaur, R.; Yang, Y. J.; Soleri, P.; Wijnands, R. (Institute of Physics/American Astronomical Society, 2011-01)
    We report on the discovery and the timing analysis of the first eclipsing accretion-powered millisecond X-ray pulsar (AMXP): SWIFT J1749.4-2807. The neutron star rotates at a frequency of ~517.9 Hz and is in a binary system ...
  • Burgasser, Adam J.; West, Andrew A.; Bochanski, John J.; Schmidt, Sarah J.; Hawley, Suzanne L. (American Astronomical Society, 2010-02)
    We report the discovery of an unusually blue L5 dwarf within 10 pc of the Sun from a search of Sloan Digital Sky Survey (SDSS) spectra. A spectrophotometric distance estimate of 8.0±1.6 pc places SDSS J141624.08+134826.7 among ...
  • Heinke, C. O.; Altamirano, D.; Cohn, H. N.; Lugger, P. M.; Budac, S. A.; Servillat, M.; Linares, Manuel; Strohmayer, T. E.; Markwardt, C. B.; Wijnands, R.; Swank, J. H.; Knigge, C.; Bailyn, Charles D.; Grindlay, J. E. (Institute of Physics/American Astronomical Society, 2010-05)
    We have discovered a new transient low-mass X-ray binary, NGC 6440 X-2, with Chandra/ACIS, RXTE/PCA, and Swift/XRT observations of the globular cluster NGC 6440. The discovery outburst (2009 July 28-31) peaked at LX ~ 1.5 ...
  • Banados, E.; Venemans, B. P.; Morganson, E.; Decarli, R.; Walter, F.; Chambers, K. C.; Rix, H.-W.; Farina, E. P.; Fan, X.; Jiang, L.; McGreer, I.; De Rosa, G.; Weiss, A.; Price, P. A.; Morgan, J. S.; Burgett, William S.; Greiner, J.; Kaiser, N.; Kudritzki, R.-P.; Magnier, E. A.; Metcalfe, N.; Stubbs, C. W.; Sweeney, W.; Tonry, J. L.; Wainscoat, R. J.; Waters, C.; Simcoe, Robert A. (IOP Publishing, 2014-06)
    High-redshift quasars are currently the only probes of the growth of supermassive black holes and potential tracers of structure evolution at early cosmic time. Here we present our candidate selection criteria from the ...
  • Seager, Sara; Welsh, William F.; Orosz, Jerome A.; Fortney, Jonathan J.; Jenkins, Jon; Rowe, Jason F.; Koch, David; Borucki, William J. (IOP Publishing, 2010-03)
    We present an analysis of the early Kepler observations of the previously discovered transiting planet HAT-P-7b. The light curve shows the transit of the star, the occultation of the planet, and the orbit phase-dependent ...
  • Ma, Jiao; Ward, Carl C.; Jungreis, Irwin; Slavoff, Sarah A.; Schwaid, Adam G.; Neveu, John; Budnik, Bogdan A.; Kellis, Manolis; Saghatelian, Alan (American Chemical Society (ACS), 2014-03)
    The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) products. The discovery of novel SEPs increases ...
  • Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Atkinson, Steve; Langer, Robert; Davies, Martyn C.; Williams, Paul; Alexander, Morgan R.; Anderson, Daniel Griffith (Wiley Blackwell, 2013-02)
    A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available ...
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