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Browsing MIT Open Access Articles by Title

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  • Vemula, Praveen; Cruikshank, Gregory; John, George; Karp, Jeffrey Michael (Institute of Electrical and Electronics Engineers (IEEE), 2009-05)
    Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators ...
  • Chryssostomidis, Chryssostomos; Karniadakis, George E.; Yang, Xiu; Venturi, Daniele; Chen, Changsheng (American Geophysical Union (AGU), 2010-12)
    Sensor placement at the extrema of empirical orthogonal functions (EOFs) is efficient and leads to accurate reconstruction of the ocean state from a limited number of measurements. In this paper, we develop important new ...
  • Cappallo, Roger J.; Corey, Brian E.; Goeke, Robert F.; Hewitt, Jacqueline N.; Kincaid, B. B.; Kratzenberg, E.; Lonsdale, Colin John; McWhirter, Stephen R.; Morgan, Edward H.; Oberoi, D.; Remillard, Ronald Alan; Rogers, Alan E. E.; Salah, J. E.; Whitney, Alan R.; Williams, Christopher Leigh (Oxford University Press, 2012-11)
    Using the final 128 antenna locations of the Murchison Widefield Array (MWA), we calculate its sensitivity to the epoch of reionization (EoR) power spectrum of redshifted 21 cm emission for a fiducial model and provide the ...
  • Farrahi, Katayoun; Emonet, Rémi; Cebrian, Manuel (Public Library of Science, 2014-05)
    Traditional contact tracing relies on knowledge of the interpersonal network of physical interactions, where contagious outbreaks propagate. However, due to privacy constraints and noisy data assimilation, this network is ...
  • Guillebaud, Julia; Mahamadou, Aboubacar; Zamanka, Halima; Katzelma, Mariama; Arzika, Ibrahim; Ibrahim, Maman L; Duchemin, Jean-Bernard; Eltahir, Elfatih A. B.; Labbo, Rabiou; Druilhe, Pierre; Fandeur, Thierry (BioMed Central Ltd., 2013-10)
    Background: Few data are available about malaria epidemiological situation in Niger. However, implementation of new strategies such as vaccination or seasonal treatment of a target population requires the knowledge of ...
  • Hackel, Benjamin J.; Neil, Jason Robert; White, Forest M.; Wittrup, Karl Dane (Oxford University Press, 2011-12)
    No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar ...
  • Octavio, Leah M.; Gedeon, Kamil S.; Maheshri, Narendra (Public Library of Science, 2009-10)
    Epigenetic switches encode their state information either locally, often via covalent modification of DNA or histones, or globally, usually in the level of a trans-regulatory factor. Here we examine how the regulation of ...
  • Octavio, Leah M.; Gedeon, Kamil S.; Maheshri, Narendra (Public Library of Science, 2009-10)
    Epigenetic switches encode their state information either locally, often via covalent modification of DNA or histones, or globally, usually in the level of a trans-regulatory factor. Here we examine how the regulation of ...
  • Theriault, Kraig M.; Daheron, Laurence; Loring, Jeanne F.; Sheridan, Steven; Reis, Surya A.; Zhou, Fen; Madison, Jon M.; Haggarty, Stephen J. (Public Library of Science, 2011-10)
    Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other ...
  • Kim, K.; Doi, A.; Wen, B.; Ng, K.; Zhao, R.; Cahan, P.; Kim, J.; Aryee, M. J.; Ji, H.; Ehrlich, L. I. R.; Yabuuchi, A.; Takeuchi, A.; Cunniff, K. C.; Hongguang, H.; Mckinney-Freeman, S.; Naveiras, O.; Yoon, T. J.; Irizarry, R. A.; Jung, N.; Seita, J.; Hanna, Jacob; Murakami, P.; Jaenisch, Rudolf; Weissleder, R.; Orkin, S. H. (Nature Publishing Group, 2010-07)
    Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, ...
  • Piazzi, Giulia; Fini, Lucia; Selgrad, Michael; Garcia, Melissa; Daoud, Yahya; Wex, Thomas; Malfertheiner, Peter; Gasbarrini, Antonio; Romano, Marco; Meyer, Richard L.; Genta, Robert M.; Fox, James G.; Boland, C. Richard; Bazzoli, Franco; Ricciardiello, Luigi (Impact Journals, 2011-12)
    The Notch signaling pathway drives proliferation, differentiation, apoptosis, cell fate, and maintenance of stem cells in several tissues. Aberrant activation of Notch signaling has been described in several tumours and ...
  • Magklara, Angeliki; Yen, Angela; Colquitt, Bradley M.; Clowney, E. Josephine; Allen, William; Markenscoff-Papadimitriou, Eirene; Evans, Zoe A.; Kheradpour, Pouya; Mountoufaris, George; Carey, Catriona; Barnea, Gilad; Kellis, Manolis; Lomvardas, Stavros (Elsevier B.V., 2011-05)
    Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-independent manner. Here, we show that, ...
  • Kaiser, David I. (Edition Open Access, 2013-09)
    Of what use are scientific textbooks? To scientists and their students, textbooks can inspire admiration and nostalgia, but also a sense of limits, of being far from the intellectual frontier. After all, research in the ...
  • Bucciarelli, Louis (Springer Netherlands, 2009-06)
    The texts (and talk) of engineers take different forms. In this essay, I present and critique several texts written for different purposes and audiences but all intended to convey to the reader the technical details of ...
  • Gutzman, Jennifer H.; Sive, Hazel L. (Company of Biologists Ltd., 2010-03)
    We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens ...
  • Vilotijevic, Ivan; Jamison, Timothy F. (Wiley Blackwell, 2009-07)
    The structural features of polycyclic polyether natural products can, in some cases, be traced to their biosynthetic origin. However in case that are less well understood, only biosynthetic pathways that feature dramatic, ...
  • Matteoli, Michela; Scita, Giorgio; Di Fiore, Pier Paolo; Kreienkamp, Hans-Jürgen; Sawallisch, Corinna; Offenhauser, Nina; Hertzog, Maud; Frittoli, Emanuela; Gelsomino, Giuliana; Schenk, Ursula; Cagnoli, Cinzia; Disanza, Andrea; Menna, Elisabetta; Gertler, Frank (Public Library of Science, 2009-06)
    The regulation of filopodia plays a crucial role during neuronal development and synaptogenesis. Axonal filopodia, which are known to originate presynaptic specializations, are regulated in response to neurotrophic factors. ...
  • Rayside, Derek; Benjamin, Zev; Singh, Rishabh; Near, Joseph Paul; Milicevic, Aleksandar; Jackson, Daniel (Institute of Electrical and Electronics Engineers, 2009-05)
    In an object-oriented language such as Java, every class requires implementations of two special methods, one for determining equality and one for computing hash codes. Although the specification of these methods is usually ...
  • Rezakhani, A. T.; Mohseni, Masoud (American Physical Society, 2009-07)
    We develop a general approach for monitoring and controlling evolution of open quantum systems. In contrast to the master equations describing time evolution of density operators, here, we formulate a dynamical equation ...
  • Speziale, Sergio; Jeanloz, Raymond; Grocholski, Brent (American Physical Society, 2010-03)
    We have measured the pressure-induced amorphization of tin iodide (SnI[superscript 4]) as a function of temperature and found a small (<1 GPa) increase in the initiation pressure of the transition from 293 to 523 K. We ...
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