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Browsing MIT Open Access Articles by Title

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  • Pang, Bo; McFaline, Jose Luis; Burgis, Nicholas E.; Dong, Min; Taghizadeh, Koli; Sullivan, Matthew R.; Elmquist, C. Eric; Cunningham, Richard P.; Dedon, Peter C. (National Academy of Sciences, 2012-02)
    Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. ...
  • Lee, Kwang Hong; Bao, Shuyu; Chong, Gang Yih; Tan, Yew Heng; Fitzgerald, Eugene A.; Tan, Chuan Seng (American Institute of Physics (AIP), 2015-01)
    A method to remove the misfit dislocations and reduce the threading dislocations density (TDD) in the germanium (Ge) epilayer growth on a silicon (Si) substrate is presented. The Ge epitaxial film is grown directly on the ...
  • Bowers, Kevin D.; van Dijk, Marten; Griffin, Robert; Juels, Ari; Oprea, Alina; Rivest, Ronald L.; Triandopoulos, Nikos (Springer Science+Business Media, 2012)
    Most cryptographic systems carry the basic assumption that entities are able to preserve the secrecy of their keys. With attacks today showing ever increasing sophistication, however, this tenet is eroding. “Advanced ...
  • Materassi, Donatello; Bolognani, Saverio; Roozbehani, Mardavij; Dahleh, Munther A. (Institute of Electrical and Electronics Engineers (IEEE), 2014-06)
    We consider a scenario where price-responsive energy consumers are allowed to optimize their individual utilities via mechanisms of load-shifting in a distribution network subject to capacity constraints. The uncoordinated ...
  • Poterba, James M.; Rao, Nirupama; Seidman, Jeri (National Tax Association-Tax Institute of America, 2010-02)
    A firm's deferred tax position can affect its incentives to lobby for or against tax reform, as well as how the firm is affected by a transition from one tax regime to another. We compile disaggregated deferred tax ...
  • Ploegh, Hidde; Sun, Jiusong; Hartvigsen, Karsten; Chou, Meng-Yun; Zhang, Yadong; Sukhova, Galina K.; Zhang, Jie; Lopez-Ilasaca, Marco; Diehl, Cody J.; Yakov, Niva; Harats, Dror; George, Jacob; Witztum, Joseph L.; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer) -American Heart Association, 2010-08)
    Background: Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis ...
  • Celiz, Adam D.; Rajamohan, Divya; Langer, Robert; Davies, Martyn C.; Alexander, Morgan R.; Denning, Chris; Patel, Asha; Anderson, Daniel Griffith (Elsevier, 2015-05)
    Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum ...
  • Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E.; Dekker, Job; Dunham, Ian; Elnitski, Laura L.; Farnham, Peggy J.; Feingold, Elise A.; Gerstein, Mark B.; Giddings, Morgan C.; Gilbert, David M.; Gingeras, Thomas R.; Green, Eric D.; Guigo, Roderic; Hubbard, Tim; Kent, Jim; Lieb, Jason D.; Myers, Richard M.; Pazin, Michael J.; Ren, Bing; Stamatoyannopoulos, John A.; Weng, Zhiping; White, Kevin P.; Hardison, Ross C. (National Academy of Sciences (U.S.), 2014-04)
    With the completion of the human genome sequence, attention turned to identifying and annotating its functional DNA elements. As a complement to genetic and comparative genomics approaches, the Encyclopedia of DNA Elements ...
  • Buehler, Markus J. (American Society of Mechanical Engineers, 2009-11)
    Here we focus on recent advances in understanding the deformation and fracture behavior of collagen, Nature's most abundant protein material and the basis for many biological composites including bone, dentin or cornea. ...
  • Pritchard, Justin Robert; Bruno, Peter Michael; Gilbert, Luke Andrew; Capron, Kelsey L.; Lauffenburger, Douglas A.; Hemann, Michael (National Academy of Sciences (U.S.), 2012-12)
    Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, ...
  • Sim, Adrian Chong Nyi; Too, Chien Tei; Oo, Min Zin; Lai, Junyun; Eio, Michelle Yating; Song, Zhenying; Srinivasan, Nalini; Tan, Diane Ai Lin; Pang, Shyue Wei; Gan, Shu Uin; Lee, Kok Onn; Loh, Thomas Kwok Seng; Chen, Jianzhu; Chan, Soh Ha; MacAry, Paul Anthony (Nature Publishing Group, 2013-11)
    Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived ...
  • von Fintel, Kai; Fox, Daniel; Iatridou, Sabine (MIT Working Papers in Linguistics, 2014)
    We argue that definites are interpreted as denoting the maximally informative object that falls under the relevant predicate.
  • Cheung, Clifford; Mardon, Jeremy; Nomura, Yasunori; Thaler, Jesse (Springer / SISSA, 2010-07)
    If the lightest observable-sector supersymmetric particle (LOSP) is charged and long-lived, then it may be possible to indirectly measure the Planck mass at the LHC and provide a spectacular confirmation of supergravity ...
  • Byun, Sangwon; Begum, Shahinoor; Miyamoto, David T.; Maheswaran, Shyamala; Stott, Shannon L.; Toner, Mehmet; Hynes, Richard O.; Manalis, Scott R.; Bagnall, Josephine; Hecht, Vivian Chaya (Nature Publishing Group, 2015-12)
    The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance. However, CTCs are rare in the blood, and ...
  • da Silva, Marco; Barbic, Jernej; Popovic, Jovan (Association for Computing Machinery (ACM), 2009-07)
    Keyframe animation is a common technique to generate animations of deformable characters and other soft bodies. With spline interpolation, however, it can be difficult to achieve secondary motion effects such as plausible ...
  • Ishii, Hiroshi; Follmer, Sean Weston; Johnson, Micah K.; Adelson, Edward H. (Association for Computing Machinery (ACM), 2011-10)
    We introduce a novel input device, deForm, that supports 2.5D touch gestures, tangible tools, and arbitrary objects through real-time structured light scanning of a malleable surface of interaction. DeForm captures ...
  • Whelan, Thomas; Kaess, Michael; McDonald, John; Leonard, John Joseph (Institute of Electrical and Electronics Engineers (IEEE), 2013-11)
    In this paper we present a system for capturing large scale dense maps in an online setting with a low cost RGB-D sensor. Central to this work is the use of an “as-rigid-as-possible” space deformation for efficient dense ...
  • Li, Wenbin; Rieser, Jennifer M.; Liu, Andrea J.; Durian, Douglas J.; Li, Ju (American Physical Society, 2015-06)
    We report a combined experimental and simulation study of deformation-induced diffusion in compacted quasi-two-dimensional amorphous granular pillars, in which thermal fluctuations play a negligible role. The pillars, ...
  • Ravela, Srinivas; Yang, Christopher M. (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    We present a new approach to deformation invariant image matching. Our matcher (a) aligns templates to targets over a broad range of nonlinear deformations, (b) factors the total deformation into spectral categories, where ...
  • Ulitsky, Igor; Shamir, Ron; Krishnamurthy, Akshay; Karp, Richard M. (Public Library of Science, 2010-10)
    Background Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have ...
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