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Browsing MIT Open Access Articles by Title

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  • Tsvelikhovsky, Dmitry; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2011-08)
    A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled ...
  • Han, Sunkyu; Movassaghi, Mohammad (American Chemical Society (ACS), 2011-06)
    The concise and enantioselective total syntheses of (−)-trigonoliimines A, B, and C are described. Our unified strategy to all three natural products is based on asymmetric oxidation and reorganization of a single ...
  • Kim, Justin; Movassaghi, Mohammad (American Chemical Society (ACS), 2011-08)
    Concise and enantioselective total syntheses of (+)-naseseazines A and B are described. Our regioselective and directed dimerization of diketopiperazines provides their critical C3–C[2 over sp] linkages, an assembly with ...
  • Loach, Richard Peter; Fenton, Owen S.; Movassaghi, Mohammad (American Chemical Society, 2016-01)
    The concise, enantioselective total syntheses of (+)-asperazine (1), (+)-iso-pestalazine A (2), and (+)-pestalazine A (3) have been achieved by the development of a late-stage C3–C8′ Friedel–Crafts union of polycyclic ...
  • Coste, Alexis; Kim, Justin; Adams, Timothy C.; Movassaghi, Mohammad (Royal Society of Chemistry, The, 2013-05)
    The concise and efficient total synthesis of (+)-bionectins A and C is described. Our approach to these natural products features a new and scalable method for erythro-β-hydroxytryptophan amino acid synthesis, an intramolecular ...
  • Movassaghi, Mohammad; Boyer, Nicolas Cedric (Royal Society of Chemistry, The, 2012-03)
    The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel–Crafts-based strategy to provide an efficient multigram-scale access ...
  • Adams, Timothy Cho; Payette, Joshua N.; Cheah, Jaime H; Movassaghi, Mohammad (American Chemical Society (ACS), 2015-09)
    The first total synthesis of (+)-luteoalbusins A and B is described. Highly regio- and diastereoselective chemical transformations in our syntheses include a Friedel–Crafts C3-indole addition to a cyclotryptophan-derived ...
  • Dig, Danny; Marrero, John J.; Ernst, Michael D. (Institute of Electrical and Electronics Engineers, 2009-06)
    Parallelizing existing sequential programs to run efficiently on multicores is hard. The Java 5 package java.util.concurrent (j.u.c.) supports writing concurrent programs. To use this package, programmers still need to ...
  • Harahap, Filino; Lesmana, Herry; Sambegoro, Poetro Lebdo (Springer-Verlag, 2009-11)
    Concurrent calorimetric and interferometric studies have been conducted to investigate the effect that reduction of the base-plate dimensions has on the steady-state performance of the rate of natural convection heat ...
  • Owaki, Hirofumi; Masuda, Taisuke; Kawahara, Tomohiro; Miyasaka, Kota; Ogura, Toshihiko; Arai, Fumihito (Elsevier, 2013-01)
    We propose a concurrent microvascular connection method called suction-induced vascular fixation (SVF) method for the achievement of Organ-Explant-Chip which is a biologically-designed simulator having biological materials ...
  • Hawkins, Peter; Aiken, Alex; Fisher, Kathleen; Rinard, Martin C.; Sagiv, Mooly (Association for Computing Machinery (ACM), 2012-06)
    We describe an approach for synthesizing data representations for concurrent programs. Our compiler takes as input a program written using concurrent relations and synthesizes a representation of the relations as sets of ...
  • Kaess, Michael; Williams, Stephen; Indelman, Vadim; Roberts, Richard; Leonard, John Joseph; Dellaert, Frank (Institute of Electrical and Electronics Engineers, 2012-07)
    This paper presents a novel algorithm for integrating real-time filtering of navigation data with full map/trajectory smoothing. Unlike conventional mapping strategies, the result of loop closures within the smoother serve ...
  • Williams, Stephen; Indelman, Vadim; Kaess, Michael; Roberts, Richard; Leonard, John Joseph; Dellaert, Frank (Sage Publications, 2014-07)
    We present a parallelized navigation architecture that is capable of running in real-time and incorporating long-term loop closure constraints while producing the optimal Bayesian solution. This architecture splits the ...
  • Miljkovic, Nenad; Wang, Evelyn N. (Cambridge University Press (Materials Research Society), 2013-05)
    Condensation is a phase change phenomenon often encountered in nature, as well as used in industry for applications including power generation, thermal management, desalination, and environmental control. For the past eight ...
  • Nenad, Miljkovic; Rong, Xiao; Ryan, Enright; Ian, McKay; Preston, Daniel John; Wang, Evelyn N.; Miljkovic, Nenad; Xiao, Rong; Enright, Ryan; McKay, Ian (ASME International, 2013-07)
    Color images of steady state water vapor condensing on smooth and nanostructured hydrophobic surfaces are presented. Figure 1a shows a snapshot of classical filmwise condensation on hydrophilic copper. A thin liquid film ...
  • Enright, Ryan; Miljkovic, Nenad; Nam, Youngsuk; Wang, Evelyn N.; Dou, Nicholas G. (ASME International, 2012-03)
    Condensation is an important process in both emerging and traditional power generation and water desalination technologies. Superhydrophobic nanostructures promise enhanced condensation heat transfer by reducing the ...
  • Enright, Ryan; Miljkovic, Nenad; Thompson, Carl V.; Wang, Evelyn N.; Al-Obeidi, Ahmed F. (American Chemical Society (ACS), 2012-08)
    Water condensation on surfaces is a ubiquitous phase-change process that plays a crucial role in nature and across a range of industrial applications, including energy production, desalination, and environmental control. ...
  • Wang, Xindan; Lajoie, Bryan R.; Dekker, Job; Laub, Michael T.; Rudner, David Z.; Le, Tung B. K. (Cold Spring Harbor Laboratory Press, 2015-08)
    SMC condensin complexes play a central role in compacting and resolving replicated chromosomes in virtually all organisms, yet how they accomplish this remains elusive. In Bacillus subtilis, condensin is loaded at centromeric ...
  • Shibata, Wataru; Takaishi, Shigeo; Muthupalani, Sureshkumar; Pritchard, D. Mark; Whary, Mark T.; Rogers, Arlin B.; Fox, James G.; Betz, Kelly S.; Kaestner, Klaus H.; Karin, Michael; Wang, Timothy C. (Elsevier B.V., 2009-12)
    Background & Aims: The nuclear factor κB (NF-κB)/IκB-kinase-β (IKKβ) pathway has been shown to represent a key link between inflammation and cancer, inducing pro-inflammatory cytokines in myeloid cells and anti-apoptotic ...
  • Liu, Yan; Carbonell, Jaime; Gopalakrishnan, Vanathi; Weigele, Peter (Mary Ann Liebert, Inc., 2009-05)
    Determining protein structures is crucial to understanding the mechanisms of infection and designing drugs. However, the elucidation of protein folds by crystallographic experiments can be a bottleneck in the development ...
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