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Browsing MIT Open Access Articles by Title

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  • Gao, Qing; Steine, Eveline J.; Barrasa, M. Inmaculada; Hockemeyer, Dirk; Pawlak, Mathias; Fu, Dongdong; Reddy, Seshamma; Bell, George W.; Jaenisch, Rudolf (National Academy of Sciences, 2011-10)
    Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation is mediated by the de novo methyltransferases Dnmt3a and 3b, ...
  • Sobolevsky, Stanislav; Szell, Michael; Campari, Riccardo; Smoreda, Zbigniew; Ratti, Carlo; Couronne, Thomas (Public Library of Science, 2013-12)
    Large-scale networks of human interaction, in particular country-wide telephone call networks, can be used to redraw geographical maps by applying algorithms of topological community detection. The geographic projections ...
  • Chen, Qingfeng; Ye, Weijian; Jian Tan, Wei; Yong, Kylie Su Mei; Liu, Min; Qi Tan, Shu; Loh, Eva; TE Chang, Kenneth; Chye Tan, Thiam; Preiser, Peter R.; Chen, Jianzhu (Nature Publishing Group, 2015-10)
    Understanding of natural killer (NK) cell development in human is incomplete partly because of limited access to appropriate human tissues. We have developed a cytokine-enhanced humanized mouse model with greatly improved ...
  • Greenlee, Alison S.; Murray, Timothy; Lesniewski, Victor; Jeunnette, Mark Nathaniel; Winter, Amos (ASME International, 2014-08)
    The cylindrical filters presently used in drip irrigation systems frequently clog, increasing pressure loss and lowering the flow rate through the filters. This work investigates alternative filtration strategies that ...
  • Miller, Rachel Elizabeth; Mroszczyk, Keri A.; Lee, Richard T.; Patwari, Parth; Grodzinsky, Alan J.; Florine, Emily Marie; Liebesny, Paul Hancock (Mary Ann Liebert, Inc., 2014-10)
    Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...
  • Liao, Xiaoli; Rabideau, Amy E.; Pentelute, Bradley L. (WILEY-VCH Verlag GmbH & Co., 2014-09)
    Antibody mimics have significant scientific and therapeutic utility for the disruption of protein–protein interactions inside cells; however, their delivery to the cell cytosol remains a major challenge. Here we show that ...
  • Rabideau, Amy E.; Liao, Xiaoli; Pentelute, Bradley L. (Royal Society of Chemistry, The, 2014-09)
    Mirror image peptides have unique stability and immunogenic properties in mammals, making them attractive agents to investigate. Their properties inside cells have been mostly unexplored because biopolymers are difficult ...
  • Sollins, Karen R.; Sastry, Nishanth; Crowcroft, Jon (Institute of Electrical and Electronics Engineers, 2009-06)
    The recently proposed packet switched network paradigm takes advantage of human social contacts to opportunistically create data paths over time. Our goal is to examine the effect of the human contact process on data ...
  • Nugent, Helen M.; Ng, Yin-Shan; White, Desmond; Groothuis, Adam R.; Kanner, Glenn; Edelman, Elazer R. (Elsevier, 2009-12)
    PURPOSE: High restenosis rates are a major limitation of peripheral interventions. Endothelial cells, grown within gelatin matrices and implanted onto the adventitia of injured vessels, inhibit stenosis in experimental ...
  • Alexandrou, Constantia; Korzec, Tomasz; Koutsou, Giannis; Lorce, C.; Negele, John W.; Pascalutsa, V.; Tsapalis, A.; Vanderhaeghen, M. (American Physical Society, 2009-01)
    We develop techniques to calculate the four Δ electromagnetic form factors using lattice QCD, with particular emphasis on the subdominant electric quadrupole form factor that probes deformation of the Δ. Results are presented ...
  • Schwartz, Galina A.; Tembine, Hamidou; Amin, Saurabh; Sastry, S. Shankar (International Federation of Automatic Control, 2014-08)
    In this paper, we develop a novel mechanism for reducing volatility of residential demand for electricity. We construct a reward-based (rebate) mechanism that provides consumers with incentives to shift their demand to ...
  • Zhang, Juanjuan; Miklos-Thal, Jeanine (American Marketing Association, 2013-02)
    Savvy consumers attribute a product’s market performance to its intrinsic quality as well as the seller’s marketing push. The authors study how sellers should optimize their marketing decisions in response. They find that ...
  • Schilling, Anne; Tingley, Peter (Electronic Journal of Combinatorics, 2012-04)
    It has previously been shown that, at least for non-exceptional Kac-Moody Lie algebras, there is a close connection between Demazure crystals and tensor products of Kirillov-Reshetikhin crystals. In particular, certain ...
  • Cheung, Alvin K.; Thiagarajan, Arvind; Madden, Samuel R. (Association for Computing Machinery (ACM), 2011-11)
    This demo will showcase LifeJoin, a system that collects raw sensor data from phones and laptop computers to generate interesting events. Given the raw sensor data, LifeJoin implements a number of activity recognition ...
  • Reagans, Ray Eugene (Oxford University Press, 2012-12)
    Research documenting the influence of demopraphic diversity on informal social networks is reviewed and critiqued. I focus in particular on research describing the importance of demographic diversity in the development of ...
  • Del Pozzo, W.; Li, Tjonnie G. F.; Agathos, Michalis; Van Den Broeck, Chris; Vitale, Salvatore (American Physical Society, 2013-08)
    Fisher matrix and related studies have suggested that, with second-generation gravitational-wave detectors, it may be possible to infer the equation of state of neutron stars using tidal effects in a binary inspiral. Here, ...
  • Madsen, Miriam A.; el Kaliouby, Rana; Eckhardt, Micah Rye; Goodwin, Matthew; Hoque, Mohammed Ehasanul; Picard, Rosalind W. (Institute of Electrical and Electronics Engineers, 2009-12)
    Social communication in autism is significantly hindered by difficulties processing affective cues in realtime face-to-face interaction. The interactive Social-Emotional Toolkit (iSET) allows its users to record and annotate ...
  • Temkin, Richard J.; Sirigiri, Jagadishwar R.; Joye, Colin D.; Shapiro, Michael (Institute of Electrical and Electronics Engineers, 2009-04)
    The theory, design, and experimental results of a wideband 140-GHz 1-kW pulsed gyro-traveling-wave amplifier (gyro-TWA) are presented. The gyro-TWA operates in the HE [subscript 06] mode of an overmoded quasi-optical ...
  • Liu, Dazhi; Hussey, D.; Gubarev, M. V.; Ramsey, B. D.; Jacobson, D.; Arif, M.; Moncton, David E.; Khaykovich, Boris (American Physical Society, 2013-05)
    An achromatic cold-neutron microscope with magnification 4 is demonstrated. The image-forming optics is composed of nested coaxial mirrors of full figures of revolution, so-called Wolter optics. The spatial resolution, ...
  • Chatterjee, Rohit; Yu, Mingbin; Stein, Aaron; Kwong, Dim-Lee; Kimerling, Lionel C.; Wong, Chee Wei (Optical Society of America, 2010-01)
    We demonstrate an optical hitless bypass switch based on nanomechanical proximity perturbation for high-bitrate transparent networks. Embedded in a single-level π-imbalanced Mach-Zehnder interferometer, the two ...
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