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Browsing MIT Open Access Articles by Title

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  • Identification and characterization of receptor-specific peptides for siRNA delivery 
    Ren, Yin; Hauert, Sabine; Lo, Justin H.; Bhatia, Sangeeta N. (American Chemical Society (ACS), 2012-08)
    Tumor-targeted delivery of siRNA remains a major barrier in fully realizing the therapeutic potential of RNA interference. While cell-penetrating peptides (CPP) are promising siRNA carrier candidates, they are universal ...
  • Identification and Estimation of a Discrete Game of Complete Information 
    Bajari, Patrick; Hong, Han; Ryan, Stephen (Econometric Society / Wiley, 2010-09)
    We discuss the identification and estimation of discrete games of complete information. Following Bresnahan and Reiss (1990, 1991), a discrete game is a generalization of a standard discrete choice model where utility ...
  • Identification and Estimation of Triangular Simultaneous Equations Models Without Additivity 
    Imbens, Guido W.; Newey, Whitney K. (Econometric Society, 2009-10)
    This paper uses control variables to identify and estimate models with nonseparable, multidimensional disturbances. Triangular simultaneous equations models are considered, with instruments and disturbances that are ...
  • Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum 
    Tyne, Daria Van; Angelino, Elaine; Barnes, Kayla G.; Rosen, David M.; Lukens, Amanda K.; Daniels, Rachel F.; Milner, Danny A., Jr.; Becker, Justin S.; Yamins, Daniel; Ndiaye, Daouda; Sarr, Ousmane; Mboup, Souleymane; Happi, Christian; Furlotte, Nicholas A.; Eskin, Eleazar; Kang, Hyun Min; Hartl, Daniel L.; Park, Daniel J.; Schaffner, Stephen F.; Neafsey, Daniel E.; Cortese, Joseph F.; Daniels, Rachel F.; Johnson, Charles A.; Shlyakhter, Ilya; Grossman, Sharon Rachel; Karlsson, Elinor K.; Birren, Bruce W.; Wiegand, Roger C.; Lander, Eric S.; Wirth, Dyann F.; Volkman, Sarah K.; Sabeti, Pardis C. (Public Library of Science, 2011-04)
    The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis ...
  • Identification and Structural Analysis of a Novel Carboxysome Shell Protein with Implications for Metabolite Transport 
    Klein, Michael G.; Zwart, Peter; Bagby, Sarah C.; Cai, Fei; Chisholm, Sallie (Penny); Heinhorst, Sabine; Cannon, Gordon C.; Kerfeld, Cheryl A. (Elsevier, 2009-09)
    Bacterial microcompartments (BMCs) are polyhedral bodies, composed entirely of proteins, that function as organelles in bacteria; they promote subcellular processes by encapsulating and co-localizing targeted enzymes with ...
  • Identification of a methylase required for 2-methylhopanoid production implications for the interpretation of sedimentary hopanes 
    Welander, Paula V.; Coleman, Maureen L.; Sessions, Alex L.; Summons, Roger Everett; Newman, Dianne K. (National Academy of Sciences, 2010-04)
    The rise of atmospheric oxygen has driven environmental change and biological evolution throughout much of Earth’s history and was enabled by the evolution of oxygenic photosynthesis in the cyanobacteria. Dating this ...
  • Identification of A Population of X-ray-emitting Massive Stars in the Galactic Plane 
    Anderson, Gemma E.; Gaensler, B. M.; Kaplan, David L.; Posselt, Bettina; Slane, Patrick O.; Murray, Stephen S.; Mauerhan, Jon C.; Benjamin, Robert A.; Brogan, Crystal L.; Chakrabarty, Deepto; Drake, Jeremy J.; Drew, Janet E.; Grindlay, Jonathan E.; Hong, Jaesub; Lazio, Joseph W.; Lee, Julia C.; Steeghs, Danny T. H.; van Kerkwijk, Marten H. (Institute of Physics Publishing, 2011-01)
    We present X-ray, infrared, optical, and radio observations of four previously unidentified Galactic plane X-ray sources: AX J163252-4746, AX J184738-0156, AX J144701-5919, and AX J144547-5931. Detection of each source ...
  • Identification of avian W-linked contigs by short-read sequencing 
    Chen, Nancy; Bellott, Daniel W.; Page, David C; Clark, Andrew G (BioMed Central Ltd, 2012-05)
    Background: The female-specific W chromosomes and male-specific Y chromosomes have proven difficult to assemble with whole-genome shotgun methods, creating a demand for new approaches to identify sequence contigs specific ...
  • Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays 
    Reinke, Aaron Wade; Grigoryan, Gevorg; Keating, Amy E. (American Chemical Society, 2010-03)
    Basic-region leucine-zipper transcription factors (bZIPs) contain a segment rich in basic amino acids that can bind DNA, followed by a leucine zipper that can interact with other leucine zippers to form coiled-coil homo- ...
  • Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping 
    Vaysse, Amaury; Ratnakumar, Abhirami; Derrien, Thomas; Axelsson, Erik; Pielberg, Gerli Rosengren; Fall, Tove; Seppälä, Eija H.; Hansen, Mark S. T.; Lawley, Cindy T.; Bannasch, Danika; Vilà, Carles; Lohi, Hannes; Galibert, Francis; Fredholm, Merete; Häggström, Jens; Hedhammar, Åke; André, Catherine; Hitte, Christophe; Webster, Matthew T.; Sigurdsson, Snaevar; Karlsson, Elinor K.; Lindblad-Toh, Kerstin (Public Library of Science, 2011-10)
    The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test ...
  • Identification of host cell factors required for intoxication through use of modified cholera toxin 
    Guimaraes, Carla P.; Carette, Jan E.; Varadarajan, Malini; Antos, John; Popp, Maximilian W.; Spooner, Eric; Brummelkamp, Thijn R.; Ploegh, Hidde (Rockefeller University Press, 2011-10)
    We describe a novel labeling strategy to site-specifically attach fluorophores, biotin, and proteins to the C terminus of the A1 subunit (CTA1) of cholera toxin (CTx) in an otherwise correctly assembled and active CTx ...
  • Identification of Multichannel Cardiovascular Dynamics Using Dual Laguerre Basis Functions for Noninvasive Cardiovascular Monitoring 
    McCombie, D. B.; Asada, Harry; Reisner, Andrew T.; Hahn, Jin-Oh; Hojman, H. M. (Institute of Electrical and Electronics Engineers, 2009-12)
    This paper presents a novel method to identify the cardiovascular (CV) system using two distinct peripheral blood pressure (BP) signals. The method can characterize the distinct arterial path dynamics that shape each of ...
  • Identification of Multiple Hypoxia Signatures in Neuroblastoma Cell Lines by l(1)-l(2) Regularization and Data Reduction 
    Rosasco, Lorenzo Andrea; Fardin, Paolo; Cornero, Andrea; Barla, Annalisa; Mosci, Sofia; Acquaviva, Massimo; Gambini, Claudio; Verri, Alessandro; Varesio, Luigi (Hindawi, 2010-04)
    Hypoxia is a condition of low oxygen tension occurring in the tumor and negatively correlated with the progression of the disease. We studied the gene expression profiles of nine neuroblastoma cell lines grown under hypoxic ...
  • Identification of Novel Human Damage Response Proteins Targeted through Yeast Orthology 
    Svensson, J. Peter; Fry, Rebecca C.; Wang, Emma; Somoza, Luis A.; Samson, Leona D. (Public Library of Science, 2012-05)
    Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S. cerevisiae proteins would also be required for ...
  • Identification of Potent EGFR Inhibitors from TCM Database@Taiwan 
    Yang, Shun-Chieh; Chang, Su-Sen; Chen, Hsin-Yi; Chen, Yu-Chian (Public Library of Science, 2011-10)
    Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. Hence, we employed Traditional ...
  • Identification of Protein-Bound Dinitrosyl Iron Complexes by Nuclear Resonance Vibrational Spectroscopy 
    Wang, Hongxin; Mitra, Devrani; Tinberg, Christine E.; Do, Loi Hung; Jenney, Francis E., Jr.; Adams, Michael W. W.; Cramer, Stephen P.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-04)
    We have applied [superscript 57]Fe nuclear resonance vibrational spectroscopy (NRVS) to identify protein-bound dinitrosyl iron complexes. Intense NRVS peaks due to vibrations of the N−Fe−N unit can be observed between 500 ...
  • Identification of Robust Routes using Convective Weather Forcasts 
    Michalek, Diana; Balakrishnan, Hamsa (Eurocontrol, 2009-06)
    Convective weather is responsible for large delays and widespread disruptions in the U.S. National Airspace System (NAS), especially during summer months when travel demand is high. This has been the motivation for Air ...
  • Identified Hadron Compositions in p+p and Au+Au Collisions at High Transverse Momenta at √sNN=200  GeV 
    Balewski, Jan T.; Betancourt, M. J.; Corliss, Ross; Hays-Wehle, James Prewitt; Leight, William Axel; Milner, Richard G.; Redwine, Robert P; Seele, J.; Steadman, Stephen G.; Surrow, Bernd; van Nieuwenhuizen, G.; Walker, M. (American Physical Society, 2012-02)
    We report transverse momentum (pT≤15  GeV/c) spectra of π[superscript ±], K[superscript ±], p, p̅ , K[subscript S][superscript 0], and ρ[superscript 0] at midrapidity in p+p and Au+Au collisions at √sNN=200  GeV. Perturbative ...
  • Identified particle production, azimuthal anisotropy, and interferometry measurements in Au+Au collisions at [sqrt]sNN=9.2 GeV 
    Surrow, Bernd; Balewski, Jan T.; Betancourt, Michael Joseph; Hays-Wehle, James Prewitt; Hoffman, A. M.; Jones, Christopher LaDon; Kocoloski, Adam Philip; Leight, William Axel; Milner, Richard G.; Redwine, Robert P.; Sakuma, Tai; Seele, Joseph Patrick; Stephans, George S. F.; van Nieuwenhuizen, Gerrit Jan; Walker, M.; Corliss, Ross Cameron (American Physical Society, 2010-02)
    We present the first measurements of identified hadron production, azimuthal anisotropy, and pion interferometry from Au+Au collisions below the nominal injection energy at the BNL Relativistic Heavy-Ion Collider (RHIC) ...
  • Identifying Agglomeration Spillovers: Evidence from Winners and Losers of Large Plant Openings 
    Greenstone, Michael; Hornbeck, Richard; Moretti, Enrico (University of Chicago Press, 2010-06)
    We quantify agglomeration spillovers by comparing changes in total factor productivity (TFP) among incumbent plants in “winning” counties that attracted a large manufacturing plant and “losing” counties that were the new ...
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