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Browsing MIT Open Access Articles by Title

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  • Fujino, Tadahiro; Leslie, Jennifer H.; Eavri, Ronen; Chen, Jerry L.; Lin, Walter C.; Flanders, Genevieve H.; Borok, Erzsebet; Horvath, Tamas L.; Nedivi, Elly (Cold Spring Harbor Laboratory Press, 2011-12)
    Use-dependent selection of optimal connections is a key feature of neural circuit development and, in the mature brain, underlies functional adaptation, such as is required for learning and memory. Activity patterns guide ...
  • Orlando, David A.; Guenther, Matthew G.; Frampton, Garrett M.; Young, Richard A. (Elsevier, 2012-07)
    TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. ...
  • Metreveli, Zviad; Zeldovich, Nickolai; Kaashoek, M. Frans (Association for Computing Machinery (ACM), 2012-02)
    CPHash is a concurrent hash table for multicore processors. CPHash partitions its table across the caches of cores and uses message passing to transfer lookups/inserts to a partition. CPHash's message passing avoids the ...
  • Stahl, Mason O.; Tarek, M. H.; Yeo, Darren C. J.; Badruzzaman, A. B. M.; Harvey, Charles F. (American Geophysical Union (AGU), 2014-12)
    Groundwater recharge affects water budgets and groundwater quality on the deltas and floodplains of South and Southeast Asia. Rain and flooding rivers recharge groundwater during the monsoon; irrigated rice fields and ...
  • Morgan, Stephen P.; Johnson, Catherine A.; Einstein, Herbert H. (Springer Netherlands, 2013-02)
    This paper presents a comprehensive study of the cracking and coalescence behavior of granite specimens with pre-existing flaw pairs. Uniaxial compressions tests were conducted on Barre granite with pre-existing flaw pairs ...
  • Qi, Jie; Huang, Andrew "bunnie"; Paradiso, Joseph A. (Association for Computing Machinery (ACM), 2015-06)
    Chibitronics circuit stickers are a new toolkit for crafting with electronics. Circuit stickers are modular, flexible circuit components with conductive adhesive pads. They feel like stickers but behave like electronic ...
  • Golowich, Steven E.; Manolakis, Dimitris G. (SPIE, 2013-12)
    The central parameter in the quantification of chemical vapor plumes via remote sensing is the mean concentration-path length (CL) product, which can be combined with scene geometry information to provide estimates of the ...
  • Spence, H. E.; Case, A. W.; Golightly, M. J.; Heine, T.; Larsen, B. A.; Blake, J. B.; Caranza, P.; Crain, W. R.; George, J.; Lalic, M.; Lin, A.; Looper, M. D.; Mazur, J. E.; Salvaggio, D.; Kasper, J. C.; Stubbs, T. J.; Doucette, M.; Ford, Peter Gerald; Foster, Richard F.; Goeke, Robert F.; Gordon, Dorothy; Klatt, Brian W.; O'Connor, J.; Smith, M.; Onsager, T.; Zeitlin, C.; Townsend, L. W.; Charara, Y. (Springer Netherlands, 2010-01)
    The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter (LRO) characterizes the radiation environment to be experienced by humans during future lunar missions. CRaTER measures the ...
  • Ramirez Moreno, Steve; Liu, Xu; Lin, Pei-Ann; Suh, Junghyup; Pignatelli di Spinazzola, Mich; Ryan, Tomas John; Redondo, Roger L.; Tonegawa, Susumu (American Association for the Advancement of Science (AAAS), 2013-07)
    Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram–bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context ...
  • Kirouac, Daniel C; Saez-Rodriguez, Julio; Swantek, Jennifer; Burke, John M.; Lauffenburger, Douglas A.; Sorger, Peter K (Springer/BioMed Central Ltd, 2012-05)
    Background: Understanding the information-processing capabilities of signal transduction networks, how those networks are disrupted in disease, and rationally designing therapies to manipulate diseased states require ...
  • Zhao, Y.; Wyrick, J.; Natterer, F. D.; Lewandowski, C.; Watanabe, K.; Taniguchi, T.; Zhitenev, N. B.; Stroscio, J. A.; Rodriguez Nieva, Joaquin Fran; Levitov, Leonid (American Association for the Advancement of Science (AAAS), 2015-05)
    The design of high-finesse resonant cavities for electronic waves faces challenges due to short electron coherence lengths in solids. Complementing previous approaches to confine electronic waves by carefully positioned ...
  • Taylor, Elizabeth Vogel; Mitchell, Rudolph; Drennan, Catherine L. (American Chemical Society, 2009-12)
    Cutting edge scientific research increasingly occurs at the interface of disciplines, and equipping students to recognize interdisciplinary connections is essential for preparing the next generation of researchers, health ...
  • Bashir, Rashid; Kamm, Roger Dale (Springer-Verlag, 2013-09)
    Development of increasingly complex integrated cellular systems will be a major challenge for the next decade and beyond, as we apply the knowledge gained from the sub-disciplines of regenerative medicine, synthetic biology, ...
  • Brennand, Kristen J.; Marchetto, M. Carol; Benvenisty, Nissim; Ebert, Allison; Izpisua Belmonte, Juan Carlos; Kaykas, Ajamete; Lancaster, Madeline A.; Livesey, Frederick J.; McConnell, Michael J.; McKay, Ronald D.; Morrow, Eric M.; Muotri, Alysson R.; Panchision, David M.; Rubin, Lee L.; Sawa, Akira; Soldner, Frank; Song, Hongjun; Studer, Lorenz; Temple, Sally; Vaccarino, Flora M.; Wu, Jun; Vanderhaeghen, Pierre; Gage, Fred H.; Jaenisch, Rudolf; Brustle, Oliver (Elsevier, 2015-11)
    As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided ...
  • Wei, Xi; Syed, Abeer; Mao, Pan; Han, Jongyoon; Song, Yong-Ak (MyJoVE Corporation, 2016-03)
    Polydimethylsiloxane (PDMS) is the prevailing building material to make microfluidic devices due to its ease of molding and bonding as well as its transparency. Due to the softness of the PDMS material, however, it is ...
  • Hammond, Tracy A.; Davis, Randall (Association for Computing Machinery (ACM), 2010-08)
    Sketch recognition is automated understanding of hand-drawn diagrams. Current sketch recognition systems exist for only a handful of domains, which contain on the order of 10--20 shapes. Our goal was to create a generalized ...
  • Summy, G. S.; Ramareddy, V.; Behinaein, G.; Ahmadi, Peyman (American Physical Society, 2009-11)
    We investigate the creation mechanism of quantum accelerator modes which are attributed to the existence of the stability islands in an underlying pseudoclassical phase space of the quantum delta-kicked accelerator. Quantum ...
  • Reiling, Jan H.; Olive, Andrew J.; Sanyal, Sumana; Carette, Jan E.; Brummelkamp, Thijn R.; Starnbach, Michael N.; Sabatini, David M.; Ploegh, Hidde (Nature Publishing Group, 2013-11)
    Treatment of cells with brefeldin A (BFA) blocks secretory vesicle transport and causes a collapse of the Golgi apparatus. To gain more insight into the cellular mechanisms mediating BFA toxicity, we conducted a genome-wide ...
  • Fass, Daniel M.; Reis, Surya A.; Ghosh, Balaram; Hennig, Krista M.; Joseph, Nadine F.; Zhao, Wen-Ning; Nieland, Thomas J.F.; Guan, Ji-Song; Groves Kuhnle, Chelsea E.; Tang, Weiping; Barker, Douglas D.; Mazitschek, Ralph; Schreiber, Stuart L.; Tsai, Li-Huei; Haggarty, Stephen J. (Elsevier, 2012-07)
    Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation ...
  • Neve, Rachael L.; Zhou, Yu; Won, Jaejoon; Karlsson, Mikael Guzman; Zhou, Miou; Rogerson, Thomas; J., Balaji; Poirazi, Panayiota; Silva, Alcino J. (Nature Publishing Group, 2009-09)
    The mechanisms that determine how information is allocated to specific regions and cells in the brain are fundamentally important for memory capacity, storage and retrieval, but are poorly understood. Here, we manipulated ...
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