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Browsing MIT Open Access Articles by Title

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  • Rahmandad, Hazhir (Wiley Blackwell, 2015-12)
    This article is based on my talk at the 2015 International System Dynamics Conference upon receiving the Jay W. Forrester Award for the article “Impact of growth opportunities and competition on firm-level capability ...
  • Runstadler, Jonathan; Keogh, Mandy; Hill, Nichola J.; Hussein, Islam; Puryear, Wendy Blay (Elsevier, 2013-03)
    Continuing outbreaks of pathogenic (H5N1) and pandemic (SOIVH1N1) influenza have underscored the need to understand the origin, characteristics, and evolution of novel influenza A virus (IAV) variants that pose a threat ...
  • Gattass, Ricardo; Soares, Juliana G. M.; Desimone, Robert; Ungerleider, Leslie G. (Frontiers Research Foundation, 2014-05)
    The claustrum is a surprisingly large, sheet-like neuronal structure hidden beneath the inner surface of the neocortex. We found that the portions of the claustrum connected with V4 appear to overlap considerably with those ...
  • Spiridonov, Alexey Nikolaevich; Shabalina, Svetlana A.; Spiridonov, Nikolay A.; Koonin, Eugene V. (Oxford University Press (OUP), 2010-10)
    The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT). Comparative analysis ...
  • Haeggman, Anders K; Tsai, Geoff; Elsen, Catherine; Honda, Tomonori; Yang, Maria (ASME International, 2015-05)
    Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user response to a product, ...
  • Daskalakis, Constantinos; Dimakis, Alexandros G.; Mossel, Elchanan (Institute of Mathematical Statistics, 2011)
    We study how the structure of the interaction graph of a game affects the existence of pure Nash equilibria. In particular, for a fixed interaction graph, we are interested in whether there are pure Nash equilibria arising ...
  • Saygin, Zeynep M.; Osher, David E.; Augustinack, Jean; Fischl, Bruce; Gabrieli, John D. E. (Elsevier, 2011-03)
    The amygdala plays an important role in emotional and social functions, and amygdala dysfunction has been associated with multiple neuropsychiatric disorders, including autism, anxiety, and depression. Although the amygdala ...
  • LaPlante, Roan A.; Douw, Linda; Tang, Wei; Stufflebeam, Steven M. (Public Library of Science, 2014-12)
    In analysis of the human connectome, the connectivity of the human brain is collected from multiple imaging modalities and analyzed using graph theoretical techniques. The dimensionality of human connectivity data is high, ...
  • Tegmark, Max Erik (Elsevier, 2015-05)
    We examine the hypothesis that consciousness can be understood as a state of matter, “perceptronium”, with distinctive information processing abilities. We explore four basic principles that may distinguish conscious matter ...
  • Choi, Han-Lim; Brunet, Luc; How, Jonathan P. (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper addresses task allocation to coordinate a fleet of autonomous vehicles by presenting two decentralized algorithms: the consensus-based auction algorithm (CBAA) and its generalization to the multi-assignment ...
  • Kellis, Manolis; Lin, Michael F. (Cold Spring Harbor Laboratory Press, 2009-04)
    Effective use of the human and mouse genomes requires reliable identification of genes and their products. Although multiple public resources provide annotation, different methods are used that can result in similar but ...
  • Todd, Ryan C.; Lippard, Stephen J. (Elsevier, 2010-12)
    The effects of cisplatin binding to DNA were explored at the nucleosome level to incorporate key features of the eukaryotic nuclear environment. An X-ray crystal structure of a site-specifically platinated nucleosome ...
  • Kerr, William R.; Lerner, Josh; Schoar, Antoinette (Oxford University Press on behalf of The Society for Financial Studies, 2011-10)
    This article documents the fact that ventures funded by two successful angel groups experience superior outcomes to rejected ventures: They have improved survival, exits, employment, patenting, Web traffic, and financing. ...
  • Acemoglu, Daron; Cantoni, Davide; Johnson, Simon; Robinson, James A. (American Economic Association, 2011-01)
    The French Revolution had a momentous impact on neighboring countries. It removed the legal and economic barriers protecting oligarchies, established the principle of equality before the law, and prepared economies for ...
  • Luo, Lingqi; Kozakov, Dima; Vajda, Sandor; Allen, Karen N.; Lukose, Vinita; Imperiali, Barbara (American Chemical Society (ACS), 2015-11)
    Phosphoglycosyltransferases (PGTs) catalyze the transfer of a C1′-phosphosugar from a soluble sugar nucleotide diphosphate to a polyprenol phosphate. These enzymes act at the membrane interface, forming the first ...
  • Shay, Tal; Jojic, Vladimir; Zuk, Or; Rothamel, Katherine; Puyraimond-Zemmour, David; Feng, Ting; Wakamatsu, Ei; Benoist, Christophe; Koller, Daphne; Regev, Aviv (National Academy of Sciences (U.S.), 2013-02)
    Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal ...
  • Wei, Shuo; Xu, Guofeng; Bridges, Lance C.; Shah, Anoop; White, Judith M.; DeSimone, Douglas W.; Whittaker, Charles A. (Springer (Biomed Central Ltd.), 2010-07)
    Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The ...
  • Saxena, Tanvi; McConnell, Ona L.; Berglund, J. Andrew; Oddo, Julia Christine; Wang, Eric T (Oxford University Press, 2016-08)
    The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that regulate alternative splicing, alternative polyadenylation, RNA stability and RNA localization. Their inactivation due to ...
  • McLaughlin, Dennis; Cohn, Stephen E.; Verlaan, Martin; Janjic, Tijana (American Meteorological Society, 2014-02)
    This paper considers the incorporation of constraints to enforce physically based conservation laws in the ensemble Kalman filter. In particular, constraints are used to ensure that the ensemble members and the ensemble ...
  • Chiu, Edmond Kwan-Yu; Wang, Qiqi; Hu, Rui; Jameson, Antony (Society for Industrial and Applied Mathematics, 2012-11)
    We present a novel mesh-free scheme for solving partial differential equations. We first derive a conservative and stable formulation of mesh-free first derivatives. We then show that this formulation is a special case of ...
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