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Browsing MIT Open Access Articles by Title

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  • Abbar, Sofiane; Amer-Yahia, Sihem; Indyk, Piotr; Mahabadi, Sepideh; Varadarajan, Kasturi R. (Association for Computing Machinery (ACM), 2013-06)
    Motivated by the recent research on diversity-aware search, we investigate the k-diverse near neighbor reporting problem. The problem is defined as follows: given a query point q, report the maximum diversity set S of k ...
  • Slattery, Matthew; Ma, Lijia; Spokony, Rebecca F.; Arthur, Robert K.; Kheradpour, Pouya; Kundaje, Anshul; Negre, Nicolas; Crofts, Alex; Ptashkin, Ryan; Zieba, Jennifer; Ostapenko, Alexander; Suchy, Sarah; Victorsen, Alec; Jameel, Nader; Grundstad, A. Jason; Gao, Wenxuan; Moran, Jennifer R.; Rehm, E. Jay; Grossman, Robert L.; Kellis, Manolis; White, Kevin P. (Nature Publishing Group, 2014-07)
    Annotation of regulatory elements and identification of the transcription-related factors (TRFs) targeting these elements are key steps in understanding how cells interpret their genetic blueprint and their environment ...
  • Modiano, Eytan H.; Lee, Hyang-Won (Institute of Electrical and Electronics Engineers, 2009-06)
    We develop diverse routing schemes for dealing with multiple, possibly correlated, failures. While disjoint path protection can effectively deal with isolated single link failures, recovering from multiple failures is not ...
  • Kong, Liangliang; Jing, Hongmei; Kataoka, Takafumi; Buchwald, Carolyn; Liu, Hongbin (Public Library of Science, 2013-10)
    Anaerobic ammonia oxidation (anammox) as an important nitrogen loss pathway has been reported in marine oxygen minimum zones (OMZs), but the community composition and spatial distribution of anammox bacteria in the eastern ...
  • Rosenhaus, Vladimir; Taylor, Washington (Springer-Verlag, 2009-06)
    Techniques are developed for exploring the complete space of intersecting brane models on an orientifold. The classification of all solutions for the widely-studied T[superscript 6]/Z[subscript 2] × Z[subscript 2] orientifold ...
  • Derda, Ratmir; Tang, Sindy; Li, S. Cory; Ng, Simon; Matochko, Wadim; Jafari, Mohammad (MDPI AG, 2011-02)
    The amplification of phage-displayed libraries is an essential step in the selection of ligands from these libraries. The amplification of libraries, however, decreases their diversity and limits the number of binding ...
  • Yang, Wei; Durisi, Giuseppe; Koch, Tobias; Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2012-09)
    We study the maximal achievable rate R*(n, ∈) for a given block-length n and block error probability o over Rayleigh block-fading channels in the noncoherent setting and in the finite block-length regime. Our results show ...
  • Wilson, Nathan R.; Runyan, Caroline A.; Wang, Forea L.; Sur, Mriganka (Nature Publishing Group, 2012-08)
    Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here ...
  • Pini, Francesco; Frage, Benjamin; Ferri, Lorenzo; De Nisco, Nicole J.; Mohapatra, Saswat S.; Taddei, Lucilla; Fioravanti, Antonella; Dewitte, Frederique; Galardini, Marco; Brilli, Matteo; Villeret, Vincent; Bazzicalupo, Marco; Mengoni, Alessio; Walker, Graham C.; Becker, Anke; Biondi, Emanuele G. (Wiley Blackwell, 2013-08)
    Sinorhizobium meliloti is a soil bacterium that invades the root nodules it induces on Medicago sativa, whereupon it undergoes an alteration of its cell cycle and differentiates into nitrogen-fixing, elongated and polyploid ...
  • Singh, Karun K.; Ge, Xuecai; Mao, Yingwei; Drane, Laurel; Meletis, Konstantinos; Samuels, Benjamin A.; Tsai, Li-Huei (Elsevier, 2010-07)
    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is ...
  • Sharghi-Namini, Soheila; Tan, Evan; Ong, Lee-Ling Sharon; Ge, Ruowen; Asada, Harry (Nature Publishing Group, 2014-02)
    Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring ...
  • Lapan, Sylvain William; Reddien, Peter (Public Library of Science, 2011-08)
    Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation ...
  • Littleton, J. Troy; Sepp, Katharine J.; Jorquera, Ramon; Song, Yun; Schulte, Joost; Wu, Chaohong; Hong, Pengyu (Society for Neuroscience, 2010-01)
    The monopolar spindle-one-binder (Mob) family of kinase-interacting proteins regulate cell cycle and cell morphology, and their dysfunction has been linked to cancer. Models for Mob function are primarily based on studies ...
  • Arya, Kapil; Cooperman, Gene; Ansel, Jason Andrew (Institute of Electrical and Electronics Engineers, 2009-07)
    DMTCP (Distributed MultiThreaded CheckPointing) is a transparent user-level checkpointing package for distributed applications. Checkpointing and restart is demonstrated for a wide range of over 20 well known applications, ...
  • Battat, James; Ahlen, S.; Caldwell, T.; Dujmic, Denis; Dushkin, A.; Fisher, Peter H.; Golub, F.; Goyal, S.; Henderson, Shawn Wesley; Inglis, A.; Lanza, Richard C.; Lopez, J.; Kaboth, Asher Cunningham; Kohse, Gordon E.; Monroe, Jocelyn; Sciolla, Gabriella; Skvorodnev, B. N.; Tomita, H.; Vanderspek, Roland K.; Wellenstein, H.; Yamamoto, Richard K. (American Institute of Physics, 2009-12)
    By correlating nuclear recoil directions with the Earth's direction of motion through the Galaxy, a directional dark matter detector can unambiguously detect Weakly Interacting Massive Particles (WIMPs), even in the presence ...
  • Nakagawa, So; Gisselbrecht, Stephen S.; Rogers, Julia M.; Hartl, Daniel L.; Bulyk, Martha L. (National Academy of Sciences (U.S.), 2013-07)
    The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ...
  • Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy Manning (American Chemical Society (ACS), 2011-02)
    The ability to detect biological analytes in a rapid, sensitive, operationally simple, and cost-effective manner will impact human health and safety. Hybrid biocatalyzed-carbon nanotube (CNT) nanowire-based detection methods ...
  • Nordman, Jared T.; Kozhevnikova, Elena N.; Verrijzer, C. Peter; Pindyurin, Alexey V.; Andreyeva, Evgeniya N.; Shloma, Victor V.; Zhimulev, Igor F.; Orr-Weaver, Terry L.; Orr-Weaver, Terry L.; Nordman, Jared T. (Elsevier, 2014-10)
    Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is ...
  • Reinhardt, H. Christian; Hasskamp, Pia; Schmedding, Ingolf; Morandell, Sandra; van Vugt, Marcel A.T.M.; Wang, XiaoZhe; Linding, Rune; Ong, Shao-En; Weaver, David; Carr, Steven A.; Yaffe, Michael B. (Elsevier B.V., 2010-10)
    Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ...
  • Yanch, Jacquelyn C.; Engelward, Bevin P. (National Institute of Environmental Health Sciences, 2012-10)
    We thank Beyea for his comments and would like to respond, in particular, regarding the works he cites in his letter. First, the results of our study are, in fact, consistent with the findings of many human epidemiologic ...
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