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Browsing MIT Open Access Articles by Title

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  • Wamstad, Joseph A.; Alexander, Jeffrey M.; Truty, Rebecca M.; Shrikumar, Avanti; Li, Fugen; Eilertson, Kirsten E.; Ding, Huiming; Wylie, John N.; Pico, Alexander R.; Capra, John A.; Erwin, Genevieve; Kattman, Steven J.; Keller, Gordon M.; Srivastava, Deepak; Levine, Stuart S.; Pollard, Katherine S.; Holloway, Alisha K.; Boyer, Laurie; Bruneau, Benoit G.; Wamstad, Joseph Alan; Levine, Stuart S. (Elsevier B.V., 2012-09)
    Heart development is exquisitely sensitive to the precise temporal regulation of thousands of genes that govern developmental decisions during differentiation. However, we currently lack a detailed understanding of how ...
  • Bard, Lucie; Sainlos, Matthieu; Bouchet, Delphine; Cousins, Sarah; Mikasova, Lenka; Breillat, Christelle; Stephenson, F. Anne; Imperiali, Barbara; Choquet, Daniel; Groc, Laurent (National Academy of Sciences (U.S.), 2010-10)
    The relative content of NR2 subunits in the NMDA receptor confers specific signaling properties and plasticity to synapses. However, the mechanisms that dynamically govern the retention of synaptic NMDARs, in particular ...
  • Glynn, Steven E.; Nager, Andrew Ross; Baker, Tania; Sauer, Robert T. (Nature Publishing Group, 2012-05)
    In the Escherichia coli ClpXP protease, a hexameric ClpX ring couples ATP binding and hydrolysis to mechanical protein unfolding and translocation into the ClpP degradation chamber. Rigid-body packing between the small ...
  • Onak, Krzysztof; Rubinfeld, Ronitt (Springer Berlin / Heidelberg, 2010-10)
    We consider the problem of maintaining a large matching or a small vertex cover in a dynamically changing graph. Each update to the graph is either an edge deletion or an edge insertion. We give the first randomized data ...
  • Chen, Zhe; Purdon, Patrick L.; Harrell, Grace; Pierce, Eric T.; Walsh, John; Brown, Emery N.; Barbieri, Riccardo (Springer-Verlag/Biomedical Engineering Society, 2010-10)
    In this article, we present a point process method to assess dynamic baroreflex sensitivity (BRS) by estimating the baroreflex gain as focal component of a simplified closed-loop model of the cardiovascular system. ...
  • Grossman, Alan D.; Breier, Adam M. (American Society for Microbiology, 2009-01)
    DnaA functions as both a transcription factor and the replication initiator in bacteria. We characterized the DNA binding dynamics of DnaA on a genomic level. Based on cross-linking and chromatin immunoprecipitation data, ...
  • Li, Hua; Fratini, Emiliano; Chiang, Wei-Shan; Baglioni, Piero; Mamontov, Eugene; Chen, Sow-Hsin (American Physical Society, 2012-12)
    The translational dynamics of hydration water confined in calcium-silicate-hydrate (C-S-H) gel was studied by quasielastic neutron scattering spectroscopy in the temperature range from 280 to 230 K. The stretch exponent ...
  • Li, Hongmin; Zhang, Hao; Fine, Charles H. (Institute for Operations Research and the Management Sciences (INFORMS), 2013-04)
    This paper studies a repeated game between a manufacturer and two competing suppliers with imperfect monitoring. We present a principal-agent model for managing long-term supplier relationships using a unique form of ...
  • Zhao, Qin; Koh, David F.; Raza, Syed A.; Amarasinghe, Saman P.; Bruening, Derek; Wong, Weng-Fai (Association for Computing Machinery / ACM Special Interest Group on Programming Languages./ ACM Special Interest Group in Operating Systems., 2011-03)
    In today's multi-core systems, cache contention due to true and false sharing can cause unexpected and significant performance degradation. A detailed understanding of a given multi-threaded application's behavior is ...
  • Brown, Emery N.; Barbieri, Riccardo; Napadow, V.; LaCount, L. T.; Kuo, B.; Park, K.; Kim, J. (Institute of Electrical and Electronics Engineers, 2010-09)
    A visual display of stripes was used to examine cardiovagal response to motion sickness. Heart rate variability (HRV) was investigated using dynamic methods to discern instantaneous fluctuations in reaction to stimulus and ...
  • Schneider, Toby Edwin; Schmidt, Henrik (Institute of Electrical and Electronics Engineers, 2010-05)
    The Dynamic Compact Control Language (DCCL) extends the ubiquitous Extensible Markup Language (XML) to provide a structure for defining very short messages comprised of bounded basic variable types, suitable for transmission ...
  • Tsokos, Christos G.; Laub, Michael T.; Perchuk, Barrett; Laub, Michael T.; Tsokos, Christos G. (Elsevier, 2011-03)
    Cellular asymmetry is critical to metazoan development and the life cycle of many microbes. In Caulobacter, cell cycle progression and the formation of asymmetric daughter cells depend on the polarly-localized histidine ...
  • Kisiday, John D.; Frisbie, David D.; McIlwraith, C. Wayne; Grodzinsky, Alan J (Mary Ann Liebert, 2009-04)
    The objective of this study was to evaluate the effect of dynamic compression on mesenchymal stem cell (MSC) chondrogenesis. Dynamic compression was applied to agarose hydrogels seeded with bone marrow-derived adult ...
  • Dawson, Matthew A.; McKinley, Gareth H.; Gibson, Lorna (American Society of Mechanical Engineers, 2009-11)
    The response of a reticulated, elastomeric foam filled with colloidal silica under dynamic compression is studied. Under compression beyond local strain rates on the order of 1 s[superscript −1], the non-Newtonian, colloidal ...
  • Effinger, Robert Temple; Williams, Brian Charles; Kelly, Gerard; Sheehy, Michael (AAAI Publicaitons, 2009-10)
    In this paper we extend dynamic controllability of temporally-flexible plans to temporally-flexible reactive programs. We consider three reactive programming language constructs whose behavior depends on runtime observations; ...
  • Simaiakis, Ioannis; Balakrishnan, Hamsa (Institute of Electrical and Electronics Engineers (IEEE), 2012-06)
    Surface congestion leads to significant increases in taxi times and fuel burn at major airports. In this paper, we formulate the airport surface congestion management problem as a dynamic control problem. We address two ...
  • Evans, Jeremy S.; Van Voorhis, Troy (American Chemical Society, 2009-07)
    We critically re-examine conductance in benzenedithiol (BDT)/gold junctions using real-time DFT simulations. Our results indicate a powerful influence of the BDT molecular charge on current, with negative charge suppressing ...
  • Biros, G.; Chambers, J.; Ghattas, O.; Kordonowy, D.; Allaire, Douglas L.; Willcox, Karen E. (Elsevier, 2012-06)
    A self-aware aerospace vehicle can dynamically adapt the way it performs missions by gathering information about itself and its surroundings and responding intelligently. Achieving this DDDAS paradigm enables a revolutionary ...
  • Huang, Sha, Ph. D. Massachusetts Institute of Technology; Undisz, Andreas; Diez-Silva, Monica; Bow, Hansen; Dao, Ming; Han, Jongyoon (Royal Society of Chemistry, 2012-11)
    Artesunate (ART) is widely used for the treatment of malaria, but the mechanisms of its effects on parasitized red blood cells (RBCs) are not fully understood. We investigated ART's influence on the dynamic deformability ...
  • Shwartz, A.; Prabhu, B.J.; Miller, G.; Avrachenkov, K.; Altman, E.; Menache, Ishai (Institute of Electrical and Electronics Engineers, 2009-10)
    We consider an uplink power control problem where each mobile wishes to maximize its throughput (which depends on the transmission powers of all mobiles) but has a constraint on the average power consumption. A finite ...
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