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Browsing MIT Open Access Articles by Title

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  • Attner, Michelle Andrea; Amon, Angelika B. (American Society for Cell Biology, 2012-06)
    The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to ...
  • Merrikh, Houra (John Wiley & Sons, Inc., 2011-09)
    Proper coordination of DNA replication with cell growth and division is critical for production of viable progeny. In bacteria, coordination of DNA replication with cell growth is generally achieved by controlling activity ...
  • Wu, Chia-Yung; Rolfe, Philip Alexander; Gifford, David K.; Fink, Gerald R. (Public Library of Science, 2010-11)
    Cell size increases significantly with increasing ploidy. Differences in cell size and ploidy are associated with alterations in gene expression, although no direct connection has been made between cell size and transcription. ...
  • Landsman, Alexandra S.; Slotine, Jean-Jacques E. (American Physical Society, 2012-10)
    Understanding synchronous and traveling-wave oscillations, particularly as they relate to transitions between different types of behavior, is a central problem in modeling biological systems. Here, we address this problem ...
  • Carroll, Bernadette; Maetzel, Dorothea; Otten, Gisela; Ratcliff, Matthew; Jaenisch, Rudolf; Sarkar, Sovan; Maddocks, Oliver D. K.; Smith, Graham R.; Dunlop, Elaine A.; Passos, Joao F.; Davies, Owen R.; Tee, Andrew R.; Korolchuk, Viktor I. (eLife Sciences Publications, Ltd., 2016-01)
    The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by ...
  • Andalman, Aaron S.; Foerster, Jakob N.; Fee, Michale S. (Public Library of Science, 2011-09)
    Learned motor behaviors require descending forebrain control to be coordinated with midbrain and brainstem motor systems. In songbirds, such as the zebra finch, regular breathing is controlled by brainstem centers, but ...
  • Kiani, Amirreza; Nicaise, Sam; Cheng, Jian Wei Jayce; Gradecak, Silvija; Berggren, Karl K. (IOP Publishing, 2015-02)
    Hydrothermally synthesized zinc oxide nanowire arrays have been used as nanostructured acceptors in emerging photovoltaic (PV) devices. The nanoscale dimensions of such arrays allow for enhanced charge extraction from PV ...
  • McIver, James; Hsieh, David; Steinberg, Hadar; Jarillo-Herrero, Pablo; Gedik, Nuh (Nature Publishing Group, 2011-12)
    Three-dimensional topological insulators (1-3) represent a new quantum phase of matter with spin-polarized surface states (4,5) that are protected from backscattering. The static electronic properties of these surface ...
  • Mandler, Ben; Grove, Timothy L (Springer Berlin Heidelberg, 2016-08)
    Presented here is a suite of new experiments aimed at quantifying the effects of pressure, temperature, bulk composition, and H[subscript 2]O content on the stability and composition of amphibole in the Earth’s mantle. ...
  • Mandler, Ben; Grove, Timothy L (Springer Berlin Heidelberg, 2016-08)
    Presented here is a suite of new experiments aimed at quantifying the effects of pressure, temperature, bulk composition, and H[subscript 2]O content on the stability and composition of amphibole in the Earth’s mantle. ...
  • Del Vecchio, Domitilla (Elsevier, 2013-10)
    Control theory has been instrumental for the analysis and design of a number of engineering systems, including aerospace and transportation systems, robotics and intelligent machines, manufacturing chains, electrical, ...
  • Prabhat, Naveen; Buongiorno, Jacopo; Hu, Lin-Wen (American Scientific Publishers, 2012-06)
    The nanofluid literature contains many claims of anomalous convective heat transfer enhancement in both turbulent and laminar flow. To put such claims to the test, we have performed a critical detailed analysis of the ...
  • Forrest, Eric C.; Buongiorno, Jacopo; Hu, Lin-Wen; McKrell, Thomas J (ASME International, 2015-10)
    Experimental results are presented for single-phase heat transfer in a narrow rectangular minichannel heated on one side. The aspect ratio and gap thickness of the test channel were 29:1 and 1.96 mm, respectively. Friction ...
  • Goluskin, David; Johnston, Hans; Spiegel, Edward A.; Flierl, Glenn Richard (Cambridge University Press, 2014-10)
    We report on direct numerical simulations of two-dimensional, horizontally periodic Rayleigh–Bénard convection between free-slip boundaries. We focus on the ability of the convection to drive large-scale horizontal flow ...
  • Lobel, Ilan; Ozdaglar, Asuman E. (Institute of Electrical and Electronics Engineers, 2009-03)
    We consider the problem of cooperatively minimizing the sum of convex functions, where the functions represent local objective functions of the agents. We assume that each agent has information about his local function, ...
  • Babadi, Behtash; Brown, Emery N.; Ba, Demba E.; Purdon, Patrick Lee (Institute of Electrical and Electronics Engineers (IEEE), 2013-10)
    In this paper, we study the theoretical properties of iteratively re-weighted least squares (IRLS) algorithms and their utility in sparse signal recovery in the presence of noise. We demonstrate a one-to-one correspondence ...
  • Marzouk, Youssef M.; Schlegel, Fabrice; Ghoniem, Ahmed F. (Society for Industrial and Applied Mathematics, 2009-06)
    We study the convergence characteristics of two algebraic kernels used in vortex calculations: the Rosenhead–Moore kernel, which is a low-order kernel, and the Winckelmans–Leonard kernel, which is a high-order kernel. To ...
  • Hnisz, Denes; Schuijers, Jurian; Lin, Charles Y.; Abraham, Brian J.; Lee, Tong Ihn; Bradner, James E.; Weintraub, Abraham Selby; Young, Richard A (Elsevier, 2015-03)
    Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of these clustered enhancer elements is poorly understood, so it ...
  • Barnes, S. A.; Wijetunge, L. S.; Jackson, A. D.; Katsanevaki, D.; Osterweil, E. K.; Komiyama, N. H.; Grant, S. G. N.; Nagerl, U. V.; Kind, P. C.; Wyllie, D. J. A.; Bear, Mark (Society for Neuroscience, 2015-11)
    Previous studies have hypothesized that diverse genetic causes of intellectual disability (ID) and autism spectrum disorders (ASDs) converge on common cellular pathways. Testing this hypothesis requires detailed phenotypic ...
  • Wang, Qiqi (Society for Industrial and Applied Mathematics, 2014-01)
    For a parameterized hyperbolic system $u_{i+1} = f(u_i,s)$, the derivative of an ergodic average $\langle J\rangle = \lim_{n\rightarrow\infty} \frac1n \sum_1^n J(u_i,s)$ to the parameter $s$ can be computed via the least ...
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