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Browsing MIT Open Access Articles by Title

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  • Angrist, Joshua; Pischke, Jorn-Steffen (American Economic Association, 2010)
    Just over a quarter century ago, Edward Leamer (1983) reflected on the state of empirical work in economics. He urged empirical researchers to “take the con out of econometrics” and memorably observed (p. 37): “Hardly ...
  • Benmelech, Efraim; Bergman, Nittai (American Economic Association, 2012-10)
    This paper studies the limitations of monetary policy in stimulating credit and investment. We show that, under certain circumstances, unconventional monetary policies fail in that liquidity injections into the banking ...
  • Slane, P.; Lee, S.-H.; Ellison, Donald C.; Patnaude, D. J.; Hughes, John P.; Eriksen, K. A.; Nagataki, S.; Castro, Daniel (IOP Publishing, 2014-02)
    Tycho's supernova remnant (SNR) is well-established as a source of particle acceleration to very high energies. Constraints from numerous studies indicate that the observed γ-ray emission results primarily from hadronic ...
  • Blanchard, Olivier Jean (Ifo Institute for Economic Research, 2009-01)
    The purpose of this lecture is to look beyond the complex events that characterize the global financial and economic crisis, identify the basic mechanisms, and infer the policies needed to resolve the current crisis, as ...
  • Isola, Phillip; Zoran, Daniel; Krishnan, Dilip; Adelson, Edward H. (Springer-Verlag, 2014)
    Detecting boundaries between semantically meaningful objects in visual scenes is an important component of many vision algorithms. In this paper, we propose a novel method for detecting such boundaries based on a simple ...
  • Chen, Sidi; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; Dahlman, James E.; Parnas, Oren; Eisenhaure, Thomas M.; Jovanovic, Marko; Graham, Daniel B.; Jhunjhunwala, Siddharth; Heidenreich, Matthias; Xavier, Ramnik J.; Langer, Robert; Hacohen, Nir; Regev, Aviv; Feng, Guoping; Sharp, Phillip A.; Zhang, Feng; Platt, Randall; Anderson, Daniel Griffith; Yim, Michael J.; Kempton, Hannah R.; Dahlman, James E.; Sharp, Phillip A. (Elsevier, 2014-09)
    CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in ...
  • Yaung, Stephanie J.; Esvelt, Kevin M.; Church, George M. (Public Library of Science, 2014-06)
    Bacteria rely on two known DNA-level defenses against their bacteriophage predators: restriction-modification and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) systems. Certain ...
  • Xue, Wen; Chen, Sidi; Yin, Hao; Tammela, Tuomas; Papagiannakopoulos, Thales; Cai, Wenxin; Bronson, Roderick T.; Crowley, Denise G.; Zhang, Feng; Sharp, Phillip A.; Joshi, Nik; Yang, Gillian R.; Anderson, Daniel Griffith; Jacks, Tyler E. (Nature Publishing Group, 2014-08)
    The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem cells. Here we describe a new method of cancer model generation ...
  • Zhu, Lihua J.; Holmes, Benjamin Ray; Aronin, Neil; Brodsky, Michael H. (Public Library of Science, 2014-09)
    CRISPR-Cas systems are a diverse family of RNA-protein complexes in bacteria that target foreign DNA sequences for cleavage. Derivatives of these complexes have been engineered to cleave specific target sequences depending ...
  • Kiani, Samira; Beal, Jacob; Huh, Jin; Xie, Zhen; Li, Yinqing; Weiss, Ron; Ebrahimkhani, Mohammad Reza; Hall, Richard N. (Nature Publishing Group, 2014-05)
    A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device libraries. Here we present a modular transcriptional repression architecture based on clustered regularly interspaced palindromic ...
  • Oehmen, Josef; Steuber, Marc (Design Society, 2012-05)
    The success framework describes performance aspects of large-scale engineering programs. It consists of 26 metrics in 5 categories. They are: 1. Enterprise strategy alignment, 2. Performance and quality, 3. Learning and ...
  • Fardin, Marc-Antoine; Ober, Thomas Joseph; Gay, C.; Gregoire, G.; McKinley, Gareth H.; Lerouge, S. (Institute of Physics Publishing, 2011-11)
    In the past twenty years, shear-banding flows have been probed by various techniques, such as rheometry, velocimetry and flow birefringence. In micellar solutions, many of the data collected exhibit unexplained spatio-temporal ...
  • Bruin, Peter; Najman, Filip (Springer International Publishing, 2016-01)
    We present a criterion for proving that certain groups of the form \(\mathbb {Z}/m\mathbb {Z}\oplus \mathbb {Z}/n\mathbb {Z}\) do not occur as the torsion subgroup of any elliptic curve over suitable (families of) number ...
  • Min, Y.; Alig, T. F.; Lee, Dong Woog; Boggs, J. M.; Israelachvili, Jacob N.; Zasadzinski, J. A. (Elsevier B.V., 2011-03)
    Monolayers based on the composition of the cytoplasmic (CYT) or extracellular (EXT) sides of the myelin bilayer form coexisting immiscible liquid phases similar to the liquid-ordered/liquid-disordered phases in ...
  • Heilmann, Ralf K.; Davis, John E.; Dewey, Dan; Bautz, Mark W.; Foster, Richard F.; Bruccoleri, Alexander Robert; Mukherjee, Pran; Robinson, David; Huenemoerder, David P.; Marshall, Herman Lee; Schattenburg, Mark Lee; Schulz, Norbert S.; Guo, L. Jay; Kaplan, Alex F.; Schweikart, Russell B. (Institute of Electrical and Electronics Engineers, 2010-06)
    High-resolution spectroscopy at energies below 1 keV covers the lines of C, N, O, Ne and Fe ions, and is central to studies of the Interstellar Medium, the Warm Hot Intergalactic Medium, warm absorption and outflows in ...
  • Stirling, Julian; Lekkas, Ioannis; Sweetman, Adam; Djuranovic, Predrag; Guo, Quanmin; Pauw, Brian; Granwehr, Josef; Moriarty, Philip; Levy, Raphael (Public Library of Science, 2014-11)
    There is now a significant body of literature which reports that stripes form in the ligand shell of suitably functionalised Au nanoparticles. This stripe morphology has been proposed to strongly affect the physicochemical ...
  • Berggren, Karl K.; Hortensius, H. L.; Driessen, E. F. C.; Klapwijk, T. M.; Clem, John R. (American Institute of Physics (AIP), 2012-05)
    We demonstrate experimentally that the critical current in superconducting NbTiN wires is dependent on their geometrical shape, due to current-crowding effects. Geometric patterns such as 90˚ corners and sudden expansions ...
  • Crandall, W.; Kemerer, Chris F.; MacCormack, Alan D.; Cusumano, Michael A. (Institute of Electrical and Electronics Engineers, 2009-08)
    This article focuses on how to choose the "right" software development process, how to structure global software design chains, how to manage the interaction of project structure and software design, and how to balance ...
  • Mohr, Dirk; Marcadet, Stephane J. M. (Springer Netherlands, 2016-06)
    A new phenomenological framework for predicting ductile fracture after non-proportional loading paths is proposed, implemented into FE software and validated experimentally for a limited set of monotonic and reverse loading ...
  • Dhillon, Navdeep Singh; Buongiorno, Jacopo; Varanasi, Kripa K. (Nature Publishing Group, 2015-09)
    Enhancing the critical heat flux (CHF) of industrial boilers by surface texturing can lead to substantial energy savings and global reduction in greenhouse gas emissions, but fundamentally this phenomenon is not well ...
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