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Browsing MIT Open Access Articles by Title

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  • Li, Xitong; Madnick, Stuart E.; Zhu, Hongwei (Association for Computing Machinery (ACM), 2013-11)
    We present a comprehensive classification of data misinterpretation problems and develop an approach to automatic detection and reconciliation of data interpretation conflicts in Web services composition. The approach uses ...
  • Steele, Andrew D.; Lindquist, Susan; Jackson, Walker S.; Auluck, Pavan K.; Zhu, Chunni; Zhou, Zhipeng; Moskowitz, Michael A.; Chesselet, Marie-Francoise (Landes Bioscience, 2009-01)
    Although it has been known for more than twenty years that an aberrant conformation of the prion protein (PrP) is the causative agent in prion diseases, the role of PrP in normal biology is undetermined. Numerous studies ...
  • Lindquist, Susan; Jasanoff, Alan Pradip; Ma, Jiyan; Wang, Xinhe; Borkowski, Andrew W.; Jackson, Walker S.; Faas, Henryk (Elsevier, 2009-10)
    We analyzed the relationship between pathogenic protein expression and perturbations to brain anatomy and physiology in a genetic model of prion disease. In this model, the mouse line 1D4, neuropathology is promoted by ...
  • Friedlander, Sharon Y. Gidekel; Chu, Gerald C.; Snyder, Eric L.; Girnius, Nomeda; Dibelius, Gregory; Crowley, Denise G.; Vasile, Eliza; DePinho, Ronald A.; Jacks, Tyler E. (Elsevier B.V., 2009-11)
    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types ...
  • Rogers, Julia M.; Reyon, Deepak; Sander, Jeffry D.; Kellis, Manolis; Joung, J. Keith; Bulyk, Martha L.; Barrera, Luis Alberto (Nature Publishing Group, 2015-06)
    Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in genome engineering technologies that require precise targeting. Although ...
  • Haslinger, Robert Heinz; Pipa, Gordon; Lima, Bruss; Singer, Wolf; Brown, Emery N.; Neuenschwander, Sergio (Public Library of Science, 2012-07)
    Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli ...
  • Choi, Myung Jin; Torralba, Antonio; Willsky, Alan S. (Elsevier, 2012-01)
    The context of an image encapsulates rich information about how natural scenes and objects are related to each other. Such contextual information has the potential to enable a coherent understanding of natural scenes and ...
  • Gilbert, Luke Andrew; Hemann, Michael (Cold Spring Harbor Laboratory Press, 2012-08)
    A basic requirement for the development of complex organ systems is that the cellular response to identical environmental cues can vary significantly between distinct cell types and developmental stages. While it is well ...
  • Raman, Rahul; Viswanathan, Karthik; Sasisekharan, Ram; Shriver, Zachary H. (Elsevier, 2009-08)
    Protein-glycan interactions are important regulators of a variety of biological processes, ranging from immune recognition to anticoagulation. An important area of active research is directed toward understanding the role ...
  • Wachinger, Christian; Navab, Nassir (Institute of Electrical and Electronics Engineers (IEEE), 2012-06)
    We introduce a novel probabilistic framework for image registration. This framework considers, in contrast to previous ones, local neighborhood information. We integrate the neighborhood information into the framework by ...
  • Eesley, Charles E.; Hsu, David H.; Roberts, Edward B. (John Wiley & Sons, Inc, 2013-09)
    How does the relationship between founding team composition and venture performance depend on the venture's strategy and business environment? Using data from a novel survey of 2,067 firms, we show that while diverse ...
  • Zhang, Zheng; Kamon, Mattan; Daniel, Luca (Institute of Electrical and Electronics Engineers (IEEE), 2014-10)
    The voltages at which microelectromechanical actuators and sensors become unstable, known as pull-in and lift-off voltages, are critical parameters in microelectromechanical systems (MEMS) design. The ...
  • Gong, Zhihao; Tang, Zhoufei; Mukamel, Shaul; Wu, Jianlan; Cao, Jianshu (American Institute of Physics (AIP), 2015-02)
    In the spin-boson model, a continued fraction form is proposed to systematically resum high-order quantum kinetic expansion (QKE) rate kernels, accounting for the bath relaxation effect beyond the second-order perturbation. ...
  • Degenaar, N.; Wijnands, R.; Brown, E. F.; Altamirano, D.; Cackett, E. M.; Fridriksson, Joel K.; Homan, Jeroen; Heinke, C. O.; Miller, J. M.; Pooley, D.; Sivakoff, G. R. (Institute of Physics/American Astronomical Society, 2013-09)
    The transient neutron star low-mass X-ray binary and 11 Hz X-ray pulsar IGR J17480-2446 in the globular cluster Terzan 5 exhibited an 11 week accretion outburst in 2010. Chandra observations performed within five months ...
  • Sessions, Alex L.; Doughty, David M.; Welander, Paula V.; Summons, Roger E.; Newman, Dianne K. (Elsevier, 2009-07)
    The rise of atmospheric O[subscript 2] was a milestone in the history of life. Although O[subscript 2] itself is not a climate-active gas, its appearance would have removed a methane greenhouse present on the early Earth ...
  • Bryan, Andrea Kristine; Engler, Alex; Gulati, Amneet; Manalis, Scott R. (Public Library of Science, 2012-01)
    We demonstrate a method to enhance the time resolution of a commercial Coulter counter and enable continuous and long-term cell size measurements for growth rate analyses essential to understanding basic cellular processes, ...
  • Patala, Srikanth; Schuh, Christopher A. (Elsevier, 2011-01)
    Grain boundaries and their networks have profound influence over properties and structure evolution in every class of polycrystalline materials. Despite recent advances in characterization techniques, there remain fundamental ...
  • Demaine, Erik D.; Demaine, Martin L.; Hart, Vi; Iacono, John; Langerman, Stefan; O'Rourke, Joseph (Springer-Verlag, 2011-05)
    We construct the first two continuous bloomings of all convex polyhedra. First, the source unfolding can be continuously bloomed. Second, any unfolding of a convex polyhedron can be refined (further cut, by a linear number ...
  • Ma, Minglin; Titievsky, Kirill; Thomas, Edwin L.; Rutledge, Gregory C. (American Chemical Society, 2009-03)
    Fibers with long-range ordered internal structures have applications in various areas such as photonic band gap fibers, optical waveguides, wearable power, sensors, and sustained drug release. Up to now, such fibers have ...
  • Hirose, Masashi; Aiello, Clarice Demarchi; Cappellaro, Paola (American Physical Society, 2012-12)
    Solid-state qubits hold the promise to achieve an unmatched combination of sensitivity and spatial resolution. To achieve their potential, the qubits need, however, to be shielded from the deleterious effects of the ...
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