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Browsing MIT Open Access Articles by Title

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  • Ng, Christopher W.; Yildirim, Ferah; Yap, Soon Ming Micha; Dalin, Simona Sara; Matthews, Bryan; Velez, Patricio J.; Labadorf, Adam; Housman, David E.; Fraenkel, Ernest (National Academy of Sciences (U.S.), 2013-01)
    The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the ...
  • Wong, Daniel; Teixeira, Ana; Oikonomopoulos, Spyros; Humburg, Peter; Lone, Imtiaz N.; Saliba, David; Siggers, Trevor; Bulyk, Martha L.; Angelov, Dimitar; Dimitrov, Stefan; Udalova, Irina A.; Ragoussis, Jiannis (BioMed Central Ltd., 2011-07)
    Background Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays ...
  • Gehring, Mary; Bubb, Kerry L.; Henikoff, Steven (American Association for the Advancement of Science (AAAS), 2009-06)
    DNA methylation is an epigenetic mark associated with transposable element silencing and gene imprinting in flowering plants and mammals. In plants, imprinting occurs in the endosperm, which nourishes the embryo during ...
  • Badertscher, Brad; Shroff, Nemit; White, Hal D. (Elsevier, 2013-04)
    Public firms provide a large amount of information through their disclosures. In addition, information intermediaries publicly analyze, discuss, and disseminate these disclosures. Thus, greater public firm presence in an ...
  • Andoni, Alexandr; Indyk, Piotr; Onak, Krzysztof; Rubinfeld, Ronitt (Springer Berlin / Heidelberg, 2009-07)
    We initiate the study of sublinear-time algorithms in the external memory model [1]. In this model, the data is stored in blocks of a certain size B, and the algorithm is charged a unit cost for each block access. This ...
  • Kasahara, Shunichi; Niiyama, Ryuma; Ishii, Hiroshi; Heun, Valentin Markus Josef (Association for Computing Machinery (ACM), 2013-02)
    As domestic robots and smart appliances become increasingly common, they require a simple, universal interface to control their motion. Such an interface must support a simple selection of a connected device, highlight its ...
  • Jagielska, Anna; Wilhite, Kristen D.; Van Vliet, Krystyn J. (Public Library of Science, 2013-09)
    Axon remyelination in the central nervous system requires oligodendrocytes that produce myelin. Failure of this repair process is characteristic of neurodegeneration in demyelinating diseases such as multiple sclerosis, ...
  • Ramirez Millan, Maria; Caldara, Marina; Rusconi, Roberto; Tarasova, Yekaterina; Stocker, Roman; Ribbeck, Katharina; Billings, Amanda Nicole (Public Library of Science, 2013-08)
    Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which serves as a first line of defense against antibiotic attack. Polysaccharides constitute major elements of the biofilm matrix and ...
  • Hynes, Richard O. (American Association for the Advancement of Science (AAAS), 2009-11)
    The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has many effects beyond providing structural support. ...
  • Reckman, Hilke; Orkin, Jeffrey David; Roy, Deb K. (Association for Computing Machinery, 2011-01)
    We use data from a virtual world game for automated learning of words and grammatical constructions and their meanings. The language data are an integral part of the social interaction in the game and consist of chat ...
  • Li, Jinglai; Kath, William L. (Society for Industrial and Applied Mathematics, 2012-04)
    We describe an iterative method that extracts the underlying soliton from a noisy pulse. The method is formulated as a functional iteration: at each step, the soliton component of the difference between the noisy pulse and ...
  • Marshall, Lisa Faye; Cui, Jian; Brokmann, Xavier; Bawendi, Moungi G. (American Physical Society, 2010-07)
    Fluorescence spectroscopy of single chromophores immobilized on a substrate has provided much fundamental insight, yet the spectral line shapes and dynamics of single chromophores freely diffusing in solution have remained ...
  • Teherani, James T.; Chern, Winston; Antoniadis, Dimitri A.; Hoyt, Judy L.; Ruiz, Liliana; Poweleit, Christian D.; Menendez, Jose (American Physical Society, 2012-05)
    Metal-oxide-semiconductor capacitors were fabricated on type-II staggered gap strained-Si/strained-Ge heterostructures epitaxially grown on relaxed SiGe substrates of various Ge fractions. Quasistatic quantum-mechanical ...
  • Teherani, James T.; Chern, Winston; Antoniadis, Dimitri A.; Hoyt, Judy L.; Ruiz, Liliana; Poweleit, Christian D.; Menendez, Jose (American Physical Society, 2012-05)
    Metal-oxide-semiconductor capacitors were fabricated on type-II staggered gap strained-Si/strained-Ge heterostructures epitaxially grown on relaxed SiGe substrates of various Ge fractions. Quasistatic quantum-mechanical ...
  • Brar, B.; Kim, D. H.; del Alamo, Jesus A.; Antoniadis, Dimitri A. (Institute of Electrical and Electronics Engineers, 2010-03)
    We have experimentally extracted the virtual-source electron injection velocity, vx0, of various III-V HFETs at room temperature. This is the carrier velocity that matters for logic applications of these transistors. Sub-100 ...
  • Simcoe, Robert A.; Sullivan, Peter W.; Kao, Melodie M.; Burgasser, Adam J.; Cooksey, Kathy; Matejek, Michael Scott (Nature Publishing Group, 2012-12)
    In typical astrophysical environments, the abundance of heavy elements ranges from 0.001 to 2 times the solar value. Lower abundances have been seen in selected stars in the Milky Way’s halo(1, 2, 3) and in two quasar ...
  • Yunes, Nicolas; Buonanno, Alessandra; Hughes, Scott A.; Pan, Yi; Barausse, Enrico; Miller, M. Coleman; Throwe, William T. (American Physical Society, 2011-02)
    We construct effective-one-body waveform models suitable for data analysis with the Laser Interferometer Space Antenna for extreme mass-ratio inspirals in quasicircular, equatorial orbits about a spinning supermassive black ...
  • Cai, Yang; Daskalakis, Konstantinos (Institute of Electrical and Electronics Engineers (IEEE), 2011-10)
    We provide a Polynomial Time Approximation Scheme for the multi-dimensional unit-demand pricing problem, when the buyer's values are independent (but not necessarily identically distributed.) For all ϵ >; 0, we obtain a ...
  • Wang, Jingfeng; Bras, Rafael L. (American Meteorological Society, 2010-02)
    An extremum hypothesis of turbulent transport in the atmospheric surface layer is postulated. The hypothesis has led to a unique solution of Monin–Obukhov similarity equations in terms of simple expressions linking shear ...
  • Skow, Bradford (Oxford University Press (OUP), 2010-02)
    When distinguishing absolute, true, and mathematical time from relative, apparent, and common time, Newton wrote: “absolute, true, and mathematical time, in and of itself and of its own nature, without reference to ...
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