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Browsing MIT Open Access Articles by Title

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  • White, Kevin P.; Henikoff, Steven; Stein, Lincoln; White, Robert A. H.; Russell, Steven; Ahmad, Kami; Feng, Xin; Henikoff, Jorja G.; Morrison, Carolyn A.; Shah, Parantu K.; Brown, Christopher D.; Negre, Nicolas; Kheradpour, Pouya; Kellis, Manolis (Public Library of Science, 2010-01)
    Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...
  • Zhang, Jin; Sun, Zhen; Zhang, Li; Ross, Christian A.; Huang, Yu-Chung; Asara, John M.; Li, Hu; Daley, George Q.; Chandrasekaran, Sriram; Collins, James J. (Elsevier, 2017-12)
    Metabolism is an emerging stem cell hallmark tied to cell fate, pluripotency, and self-renewal, yet systems-level understanding of stem cell metabolism has been limited by the lack of genome-scale network models. Here, we ...
  • Taylor, Frank E. (American Physical Society, 2014-12)
    This article presents measurements of the t-channel single top-quark (t) and top-antiquark ([bar over t]) total production cross sections σ(tq) and σ(t¯q), their ratio R[subscript t]=σ(tq)/σ([bar over t] q), and a measurement ...
  • Lander, Eric S. (Nature Publishing Group, 2012-07)
    To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. ...
  • Lander, Eric S. (Nature Publishing Group, 2014-07)
    Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, ...
  • Zobeiry, Navid; Gereke, Thomas; Tressou, Benjamin; Vaziri, Reza; Malekmohammadi, Sardar (Springer Berlin Heidelberg, 2014-10)
    A multi-scale modelling framework was developed for predicting the mechanical properties of strand-based wood composites. This framework is based on closed-form analytical models at three different resolution levels; micro-, ...
  • Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Pärn, Kalle; Fischer, Krista; Milani, Lili; Mägi, Reedik; Palta, Priit; Metspalu, Andres; Esko, Tõnu; Zekavat, Seyedeh M.; Gabriel, Stacey; Lander, Eric Steven; Kathiresan, Sekar; Hirschhorn, Joel N; Sankaran, Vijay G. (National Academy of Sciences (U.S.), 2016-12)
    Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based ...
  • Srivastava, Ankur; Meade, Andrew J. (Hindawi Publishing Corporation, 2015)
    Use of probabilistic techniques has been demonstrated to learn air data parameters from surface pressure measurements. Integration of numerical models with wind tunnel data and sequential experiment design of wind tunnel ...
  • Lie, Halvor; Braaten, Henning; Sequeiros, Octavio E.; Jhingran, Vikas Gopal; Vandiver, John Kim (American Society of Mechanical Engineers, 2012-07)
    Despite of considerable research activity during the last decades considerable uncertainties still remain in prediction of Vortex Induced Vibrations (VIV) of risers. Model tests of risers subjected to current have been ...
  • Abdulkhaleq, Asim; Wagner, Stefan; Leveson, Nancy G (Elsevier, 2015-12)
    Formal verification and testing are complementary approaches which are used in the development process to verify the functional correctness of software. However, the correctness of software cannot ensure the safe operation ...
  • Weisenfeld, Neil I; Yin, Shuangye; Sharpe, Ted; Lau, Bayo; Hegarty, Ryan; Holmes, Laurie; Sogoloff, Brian; Tabbaa, Diana; Williams, Louise; Russ, Carsten; Nusbaum, Chad; MacCallum, Iain; Jaffe, David B.; Lander, Eric S. (Nature Publishing Group, 2014-10)
    Complete knowledge of the genetic variation in individual human genomes is a crucial foundation for understanding the etiology of disease. Genetic variation is typically characterized by sequencing individual genomes and ...
  • Mineo, S.; Pooley, D.; Rappaport, Saul A.; Levine, Alan M.; Homan, Jeroen; Steinhorn, Benjamin S. (IOP Publishing, 2014-12)
    We present a comprehensive study of the total X-ray emission from the colliding galaxy pair NGC 2207/IC 2163, based on Chandra, Spitzer, and GALEX data. We detect 28 ultraluminous X-ray sources (ULXs), 7 of which were not ...
  • Belanger-Rioux, R.; Demanet, Laurent (Society for Industrial and Applied Mathematics, 2015-10)
    Absorbing layers are sometimes required to be impractically thick in order to offer an accurate approximation of an absorbing boundary condition for the Helmholtz equation in a heterogeneous medium. It is always possible ...
  • Choi, Jae-Hoon; Christensen, Caleb A.; Heo, Myoung-Sun; Ketterle, Wolfgang; Lee, Ye-Ryoung; Rvachov, Timur Michael; Wang, Tout T. (American Physical Society, 2012-06)
    Fermi gases with repulsive interactions are characterized by measuring their compressibility as a function of interaction strength. The compressibility is obtained from in-trap density distributions monitored by phase-contrast ...
  • Choong, Looh Tchuin; Mannarino, Matthew M.; Basu, Sandip; Rutledge, Gregory C. (Springer-Verlag, 2013-06)
    Compressive properties of electrospun fiber mats are reported for the first time. Mats of bisphenol-A polysulfone (PSU) and of poly(trimethyl hexamethylene terephthalamide) [PA 6(3)T] were electrospun and annealed over a ...
  • Stark, Cyril; Harrow, Aram W (Institute of Electrical and Electronics Engineers (IEEE), 2016-03)
    We investigate compressibility of the dimension of positive semidefinite matrices, while approximately preserving their pairwise inner products. This can either be regarded as compression of positive semidefinite factorizations ...
  • Magesan, Easwar; Cappellaro, Paola; Cooper-Roy, Alexandre (American Physical Society, 2013-12)
    We present methods that can provide an exponential savings in the resources required to perform dynamic parameter estimation using quantum systems. The key idea is to merge classical compressive sensing techniques with ...
  • Sanzeni, Alex; Whittle, Andrew; Germaine, John T.; Colleselli, Francesco (American Society of Civil Engineers (ASCE), 2012-10)
    A laboratory test program was conducted to evaluate the one-dimensional (1D) compression and creep properties of intact sand (and silty-sand) samples from a deep borehole at the Malamocco Inlet to the Venice Lagoon. The ...
  • Tang, Jing; Du, Ning; Doyle, Patrick S. (National Academy of Sciences (U.S.), 2011-09)
    We experimentally study the effects of a uniform electric field on the conformation of single DNA molecules. We demonstrate that a moderate electric field (~200 V/cm) strongly compresses isolated DNA polymer coils into ...
  • Cho, Hyesun; Flemming, Edward (National Research Foundation of Korea, 2015)
    Compression and truncation are two general strategies adopted by languages in realizing tonal melodies in the face of time pressure. Compression involves adjustment of the phonetic details of tone realization to fit a tone ...
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