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Browsing MIT Open Access Articles by Title

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  • Heider, Patrick L.; Basak, Soubir; Benyahia, Brahim; Lakerveld, Richard; Zhang, Haitao; Hogan, Rachael; Buchbinder, Louis; Wolfe, Aaron; Mascia, Salvatore; Evans, James M. B.; Jamison, Timothy F.; Jensen, Klavs F.; Born, Stephen (American Chemical Society (ACS), 2014-02)
    The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with ...
  • Teverovskiy, Georgiy; Park, Nathaniel Hamilton; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2013-11)
    A new air-stable nickel precatalyst for C–N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C–N bond formation to include both a wide range of aryl and heteroaryl ...
  • Goodell, John R.; McMullen, Jonathan P.; Zaborenko, Nikolay; Maloney, Jason R.; Ho, Chuan-Xing; Jensen, Klavs F.; Porco, John A.; Beeler, Aaron B. (American Chemical Society, 2009-08)
    An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo ...
  • Korre, Hasan; Fucetola, Corey P.; Johnson, Jeremiah A.; Berggren, Karl K. (American Vacuum Society (AVS), 2010-12)
    Interference lithography (IL) has proven itself to be an enabling technology for nanofabrication. Within IL, issues of spatial phase distortion, fringe stability, and substrate development have been explored and addressed. ...
  • Harris, Eliza; Nelson, David D.; Zahniser, Mark; McManus, Barry J.; Prinn, Ronald G.; Ono, Shuhei; Olszewski, William J.; Potter, Katherine Ellison; Whitehill, Andrew Richard (American Chemical Society (ACS), 2013-12)
    Nitrous oxide is an important greenhouse gas and ozone-depleting-substance. Its sources are diffuse and poorly characterized, complicating efforts to understand anthropogenic impacts and develop mitigation policies. Online, ...
  • Kamarei, Fahimeh; Movaghari, Farshid; Ghaffari, Alireza; Zamani, Ali; Jabbari, Ali; Soltani Bozchalooi, Iman (Elsevier, 2011-01)
    In this study an effective method was developed to assay erythromycin ethylsuccinate for an oral suspension dosage form. The chromatographic separation was achieved on an X-Terra[superscript ™] C[subscript 18] analytical ...
  • Rost, Jon C.; Porkolab, Miklos (American Institute of Physics, 2010-06)
    A “synthetic diagnostic” has been developed to calculate the expected experimental response of phase contrast imaging (PCI), a scattering diagnostic used to measure density fluctuations in laboratory plasmas, to a tokamak ...
  • Ofen, Noa; Chai, Xiaoqian; Schuil, Karen D. I.; Whitfield-Gabrieli, Susan; Gabrieli, John D. E. (Society for Neuroscience, 2012-07)
    Neuroanatomical and psychological evidence suggests prolonged maturation of declarative memory systems in the human brain from childhood into young adulthood. Here, we examine functional brain development during successful ...
  • Ryu, Kevin K.; Burke, Barry E.; Lambert, Renee D.; Suntharalingam, Vyshnavi; Ward, Christopher M.; Warner, Keith; Binzel, Richard P.; Masterson, Rebecca A.; Clark, Harry R., Jr.; O'Brien, Peter W.; Bautz, Marshall W.; Kissel, Steve E. (SPIE, 2014-06)
    The Regolith x-ray Imaging Spectrometer (REXIS) is a coded-aperture soft x-ray imaging instrument on the OSIRIS-REx spacecraft to be launched in 2016. The spacecraft will fly to and orbit the near-Earth asteroid Bennu, ...
  • Hu, Juejun; Musgraves, J. David; Carlie, Nathan; Zdyrko, Bogdan; Luzinov, Igor; Richardson, Kathleen; Agrawal, Anuradha Murthy; Kimerling, Lionel C. (Society of Photo-optical Instrumentation Engineers, 2011-01)
    In this paper, we review the design, processing, and characterization of novel planar infrared chemical sensors. Chalcogenide glasses are identified as the material of choice for sensing given their wide infrared transparency ...
  • Gabrieli, John D. E.; McRae, Kateri; Gross, James J.; Weber, Jochen; Robertson, Elaine R.; Sokol-Hessner, Peter; Ray, Rebecca D.; Ochsner, Kevin N. (Oxford University Press, 2012-01)
    The ability to use cognitive reappraisal to regulate emotions is an adaptive skill in adulthood, but little is known about its development. Because reappraisal is thought to be supported by linearly developing prefrontal ...
  • Morten, Christopher J.; Byers, Jeffery A.; Van Dyke, Aaron R.; Vilotijevic, Ivan; Jamison, Timothy F. (Royal Society of Chemistry, The, 2009-09)
    This tutorial review traces the development of endo-regioselective epoxide-opening reactions in water. Templated, water-promoted epoxide-opening cyclization reactions can offer rapid access to subunits of the ladder ...
  • Kleiman, Steven L. (American Society for Microbiology, 2008-06)
    This historical introduction is in two parts. The first is reprinted with permission from "A century of mathematics in America, Part II," Hist. Math., 2, Amer. Math. Soc., 1989, pp.543-585. Virtually no change has been ...
  • Sood, Ashok K.; Richwine, Robert A.; Puri, Yash R.; DiLello, Nicole Ann; Hoyt, Judy L.; Akinwande, Tayo I.; Horn, Stuart; Balcerak, Raymond S.; Venkatasubramanian, Rama; Bulman, Gary; D'Souza, Arvind I.; Baramhall, Thomas G. (Society of Photo-optical Instrumentation Engineers, 2009-05)
    SiGe based Focal Plane Arrays offer a low cost alternative for developing visible- NIR focal plane arrays that will cover the spectral band from 0.4 to 1.6 microns. The attractive features of SiGe based IRFPA's will take ...
  • Bower, Diana Morgan; Prather, Kristala L. Jones (BioMed Central Ltd, 2012-08)
    Background: There has been renewed interest in biopharmaceuticals based on plasmid DNA (pDNA) in recent years due to the approval of several veterinary DNA vaccines, on-going clinical trials of human pDNA-based therapies, ...
  • Kalia, Amy Ashwin; Lesmes, Luis Andres; Dorr, Michael; Gandhi, Tapan Kumar; Chatterjee, Garga; Ganesh, Suma; Bex, Peter J.; Sinha, Pawan (National Academy of Sciences (U.S.), 2014-01)
    Visual plasticity peaks during early critical periods of normal visual development. Studies in animals and humans provide converging evidence that gains in visual function are minimal and deficits are most severe when ...
  • Dragoi, George; Tonegawa, Susumu (eLife Sciences Publications, Ltd., 2013-12)
    Prior experience accelerates acquisition of novel, related information through processes like assimilation into mental schemas, but the underlying neuronal mechanisms are poorly understood. We investigated the roles that ...
  • Stubbs, Keith A.; Bacik, John-Paul; Perley-Robertson, G. Evan; Whitworth, Garrett E.; Gloster, Tracey M.; Vocadlo, David J.; Mark, Brian L. (Wiley Blackwell, 2013-09)
    The increasing incidence of inducible chromosomal AmpC β-lactamases within the clinic is a growing concern because these enzymes deactivate a broad range of even the most recently developed β-lactam antibiotics. As a result, ...
  • Sood, Ashok K.; Richwine, Robert A.; Puri, Yash R.; DiLello, Nicole Ann; Hoyt, Judy L.; Dhar, Nibir; Balcerak, Raymond S.; Bramhall, Thomas G. (SPIE, 2010-08)
    SiGe based focal plane arrays offer a low cost alternative for developing visible- near-infrared focal plane arrays that will cover the spectral band from 0.4 to 1.6 microns. The attractive features of SiGe based foal plane ...
  • Alabi, Christopher A.; Sahay, Gaurav; Langer, Robert; Anderson, Daniel Griffith (Royal Society of Chemistry, 2012-08)
    One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from ...
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