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Browsing MIT Open Access Articles by Title

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  • Johnson, Daniel W.; Schmidt, Ulrich H.; Bittner, Edward A.; Christensen, Benjamin; Levi, Retsef; Pino, Richard M. (BioMed Central Ltd, 2013-07)
    Introduction: A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit ...
  • Markakis, Mihalis G.; Tsitsiklis, John N.; Modiano, Eytan H. (Institute of Electrical and Electronics Engineers (IEEE), 2014-02)
    We study scheduling and routing problems that arise in multi-hop wireline networks with a mix of heavy-tailed and light-tailed traffic. We analyze the delay performance of the widely studied class of Back-Pressure policies, ...
  • Kochman, Yuval; Wornell, Gregory W.; Yao, Huan (Institute of Electrical and Electronics Engineers (IEEE), 2011-01)
    We focus on the problem of real-time streaming over a blockage channel with long feedback delay, as arises in real-time satellite communication from a comm-on-the-move (COTM) terminal. For this problem, we introduce a ...
  • Naous, Jad; Stutsman, Ryan; Mazieres, David; McKeown, Nick; Zeldovich, Nickolai (Association for Computing Machinery, 2009-08)
    Network security is gravitating towards more centralized control. Strong centralization places a heavy burden on the administrator who has to manage complex security policies and be able to adapt to users' requests. To be ...
  • Chow, Clement Y.; Landers, John E.; Bergren, Sarah K.; Sapp, Peter C.; Grant, Adrienne E.; Jones, Julie M.; Everett, Lesley; Lenk, Guy M.; McKenna-Yasek, Diane M.; Weisman, Lois S.; Figlewicz, Denise; Brown, Robert H.; Meisler, Miriam H. (Elsevier B.V., 2009-01)
    Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P2 are responsible for the recessive peripheral-nerve disorder CMT4J. We now describe nonsynonymous variants of FIG4 in 2% (9/473) of patients with amyotrophic ...
  • Gao, Qing; Steine, Eveline J.; Barrasa, M. Inmaculada; Hockemeyer, Dirk; Pawlak, Mathias; Fu, Dongdong; Reddy, Seshamma; Bell, George W.; Jaenisch, Rudolf (National Academy of Sciences, 2011-10)
    Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation is mediated by the de novo methyltransferases Dnmt3a and 3b, ...
  • Sobolevsky, Stanislav; Szell, Michael; Campari, Riccardo; Smoreda, Zbigniew; Ratti, Carlo; Couronne, Thomas (Public Library of Science, 2013-12)
    Large-scale networks of human interaction, in particular country-wide telephone call networks, can be used to redraw geographical maps by applying algorithms of topological community detection. The geographic projections ...
  • Chen, Qingfeng; Ye, Weijian; Jian Tan, Wei; Yong, Kylie Su Mei; Liu, Min; Qi Tan, Shu; Loh, Eva; TE Chang, Kenneth; Chye Tan, Thiam; Preiser, Peter R.; Chen, Jianzhu (Nature Publishing Group, 2015-10)
    Understanding of natural killer (NK) cell development in human is incomplete partly because of limited access to appropriate human tissues. We have developed a cytokine-enhanced humanized mouse model with greatly improved ...
  • Greenlee, Alison S.; Murray, Timothy; Lesniewski, Victor; Jeunnette, Mark Nathaniel; Winter, Amos (ASME International, 2014-08)
    The cylindrical filters presently used in drip irrigation systems frequently clog, increasing pressure loss and lowering the flow rate through the filters. This work investigates alternative filtration strategies that ...
  • Miller, Rachel Elizabeth; Mroszczyk, Keri A.; Lee, Richard T.; Patwari, Parth; Grodzinsky, Alan J.; Florine, Emily Marie; Liebesny, Paul Hancock (Mary Ann Liebert, Inc., 2014-10)
    Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...
  • Liao, Xiaoli; Rabideau, Amy E.; Pentelute, Bradley L. (WILEY-VCH Verlag GmbH & Co., 2014-09)
    Antibody mimics have significant scientific and therapeutic utility for the disruption of protein–protein interactions inside cells; however, their delivery to the cell cytosol remains a major challenge. Here we show that ...
  • Rabideau, Amy E.; Liao, Xiaoli; Pentelute, Bradley L. (Royal Society of Chemistry, The, 2014-09)
    Mirror image peptides have unique stability and immunogenic properties in mammals, making them attractive agents to investigate. Their properties inside cells have been mostly unexplored because biopolymers are difficult ...
  • Sollins, Karen R.; Sastry, Nishanth; Crowcroft, Jon (Institute of Electrical and Electronics Engineers, 2009-06)
    The recently proposed packet switched network paradigm takes advantage of human social contacts to opportunistically create data paths over time. Our goal is to examine the effect of the human contact process on data ...
  • Nugent, Helen M.; Ng, Yin-Shan; White, Desmond; Groothuis, Adam R.; Kanner, Glenn; Edelman, Elazer R. (Elsevier, 2009-12)
    PURPOSE: High restenosis rates are a major limitation of peripheral interventions. Endothelial cells, grown within gelatin matrices and implanted onto the adventitia of injured vessels, inhibit stenosis in experimental ...
  • Alexandrou, Constantia; Korzec, Tomasz; Koutsou, Giannis; Lorce, C.; Negele, John W.; Pascalutsa, V.; Tsapalis, A.; Vanderhaeghen, M. (American Physical Society, 2009-01)
    We develop techniques to calculate the four Δ electromagnetic form factors using lattice QCD, with particular emphasis on the subdominant electric quadrupole form factor that probes deformation of the Δ. Results are presented ...
  • Schwartz, Galina A.; Tembine, Hamidou; Amin, Saurabh; Sastry, S. Shankar (International Federation of Automatic Control, 2014-08)
    In this paper, we develop a novel mechanism for reducing volatility of residential demand for electricity. We construct a reward-based (rebate) mechanism that provides consumers with incentives to shift their demand to ...
  • Zhang, Juanjuan; Miklos-Thal, Jeanine (American Marketing Association, 2013-02)
    Savvy consumers attribute a product’s market performance to its intrinsic quality as well as the seller’s marketing push. The authors study how sellers should optimize their marketing decisions in response. They find that ...
  • Schilling, Anne; Tingley, Peter (Electronic Journal of Combinatorics, 2012-04)
    It has previously been shown that, at least for non-exceptional Kac-Moody Lie algebras, there is a close connection between Demazure crystals and tensor products of Kirillov-Reshetikhin crystals. In particular, certain ...
  • Cheung, Alvin K.; Thiagarajan, Arvind; Madden, Samuel R. (Association for Computing Machinery (ACM), 2011-11)
    This demo will showcase LifeJoin, a system that collects raw sensor data from phones and laptop computers to generate interesting events. Given the raw sensor data, LifeJoin implements a number of activity recognition ...
  • Reagans, Ray Eugene (Oxford University Press, 2012-12)
    Research documenting the influence of demopraphic diversity on informal social networks is reviewed and critiqued. I focus in particular on research describing the importance of demographic diversity in the development of ...
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