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Browsing MIT Open Access Articles by Title

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  • Das, Payel; Zhou, Ruhong; King, Jonathan Alan (Proceedings of the National Academy of Sciences (PNAS), 2011-06)
    The prevalent eye disease age-onset cataract is associated with aggregation of human γD-crystallins, one of the longest-lived proteins. Identification of the γ-crystallin precursors to aggregates is crucial for developing ...
  • Rayside, Derek; Milicevic, Aleksandar; Yessenov, Kuat T.; Jackson, Daniel (Association for Computing Machinery, 2009-10)
    Traditional formal methods and modern agile methods are separated more by limitations of current technology than by fundamental intellectual differences. A mixed interpreter that executes mixed programs, comprising both ...
  • Behan, Rachel K.; Lippard, Stephen J. (American Chemical Society, 2010-10)
    The aging-associated enzyme CLK-1 is proposed to be a member of the carboxylate-bridged diiron family of proteins. To evaluate this hypothesis and characterize the protein, we expressed soluble mouse CLK-1 (MCLK1) in ...
  • Lu, Tsai-Te; Lee, Seung Jae; Apfel, Ulf-Peter; Lippard, Stephen J. (American Chemical Society (ACS), 2013-02)
    The mitochondrial membrane-bound enzyme Clock-1 (CLK-1) extends the average longevity of mice and Caenorhabditis elegans, as demonstrated for Δclk-1 constructs for both organisms. Such an apparent impact on aging and the ...
  • Yin, Lu; Zheng, Dahai; Limmon, Gino V.; Leung, Nicola H. N.; Xu, Shuoyu; Rajapakse, Jagath C.; Yu, Hanry; Chow, Vincent T. K.; Chen, Jianzhu (BioMed Central Ltd, 2014-09)
    Background Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to ...
  • Rajbhandary, Uttam L; Koehrer, Caroline; Su, Dan; Russell, Susan P.; Krivos, Kady; Castleberry, Colette M.; Blum, Paul; Limbach, Patrick A.; Söll, Dieter; Mandal, Debabrata (National Academy of Sciences (U.S.), 2010-01)
    Modification of the cytidine in the first anticodon position of the AUA decoding tRNAIle [tRNA superscript Ile subscript 2] of bacteria and archaea is essential for this tRNA to read the isoleucine codon AUA and to ...
  • Olszewski, Marek Krystyn; Zhao, Qin; Koh, David F.; Ansel, Jason Andrew; Amarasinghe, Saman P. (Association for Computing Machinery, 2012-03)
    Despite a burgeoning demand for parallel programs, the tools available to developers working on shared-memory multicore processors have lagged behind. One reason for this is the lack of hardware support for inspecting the ...
  • Ng, Man Cheuk; Fleming, Kermin Elliott; Vutukuru, Mythili; Gross, Samuel; Mithal, Arvind; Balakrishnan, Hari (Institute of Electrical and Electronics Engineers, 2010-10)
    Over the past few years, researchers have developed many crosslayer wireless protocols to improve the performance of wireless networks. Experimental evaluations of these protocols have been carried out mostly using ...
  • Perring, A. E.; Schwarz, J. P.; Baumgardner, D.; Hernandez, M. T.; Spracklen, D. V.; Gao, R. S.; Kok, G.; McMeeking, G. R.; McQuaid, J. B.; Fahey, D. W.; Heald, Colette L. (American Geophysical Union (AGU), 2015-02)
    Airborne observations of fluorescent aerosol were made aboard an airship during CloudLab, a series of flights that took place in September and October of 2013 and covered a wideband of longitude across the continental U.S. ...
  • Lin, Pao Tai; Singh, Vivek; Cai, Yan; Kimerling, Lionel C.; Agarwal, Anuradha Murthy (Optical Society of America, 2013-03)
    Toward mid-infrared (mid-IR) silicon microphotonic circuits, we demonstrate broadband on-chip silicon structures, such as: (i) straight and bent waveguides and (ii) beam splitters, utilizing an air-clad pedestal configuration ...
  • McGrew, James S.; How, Jonathan P.; Bush, Lawrence; Williams, Brian Charles; Roy, Nicholas (American Institute of Aeronautics and Astronautics, 2010-09)
    Unmanned Aircraft Systems (UAS) have the potential to perform many of the dangerous missions currently own by manned aircraft. Yet, the complexity of some tasks, such as air combat, have precluded UAS from successfully ...
  • Chati, Yashovardhan Sushil; Balakrishnan, Hamsa (2013-10-30)
  • Giraud, Matthieu; Yoshida, Hideyuki; Abramson, Jakub; Rahl, Peter B.; Young, Richard A.; Mathis, Diane; Benoist, Christophe (National Academy of Sciences, 2012-01)
    Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its ...
  • Summers, Edward K.; Lienhard, John H.; Zubair, Syed M. (ASME International, 2011-02)
    Relative to solar water heaters, solar air heaters have received relatively little investigation and have resulted in few commercial products. However, in the context of a humidification-dehumidification (HDH) desalination ...
  • Thompson, T. M.; Saari, Rebecca Kaarina; Selin, Noelle Eckley (Copernicus GmbH, 2014-01)
    We evaluate how regional characteristics of population and background pollution might impact the selection of optimal air quality model resolution when calculating the human health impacts of changes to air quality. Using ...
  • Bell, Michael M.; Montgomery, Michael T.; Emanuel, Kerry Andrew (American Meteorological Society, 2012-11)
    Quantifying air–sea exchanges of enthalpy and momentum is important for understanding and skillfully predicting tropical cyclone intensity, but the magnitude of the corresponding wind speed–dependent bulk exchange coefficients ...
  • Histon, Jonathan; Li, Lishuai; Hansman, Robert J., Jr. (Institute of Electrical and Electronics Engineers, 2010-12)
    Airspace structure is a key factor influencing controller cognitive complexity as it forms a basis for abstractions simplifying controller mental models of air traffic situations. In evaluating the feasibility of new ...
  • Takeda, Youhei; Andrew, Trisha Lionel; Lobez, Jose M.; Mork, Anna Jolene; Swager, Timothy Manning (John Wiley & Sons, Inc., 2012-08)
    Thumbnail image of graphical abstract A thin-film transistor: An n-type polymer semiconductor, poly(2,3-bis(perfluorohexyl)thieno[3,4-b]pyrazine), was synthesized through a Pd-catalyzed polycondensation employing a ...
  • Walther, Frederick G.; Michael, Steven; Parenti, Ronald R.; Taylor, John A. (Society of Photo-optical Instrumentation Engineers, 2010-08)
    We present an overview of an air-to-ground laser communications demonstration performed at MIT Lincoln Laboratory. Error-free communication at 2.5 Gb/s was demonstrated along a 25-km slant path between a 1-in transmit ...
  • Jacks, Tyler E.; Sandy, Peter; Hoersch, Sebastian; Lander, Eric S.; Gupta, Piyush (Elsevier, 2009-07)
    Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through ...
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