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Browsing MIT Open Access Articles by Title

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  • Kaczmarek, James Cliff; Kowalski, Piotr S; Anderson, Daniel Griffith (BioMed Central, 2017-06)
    Abstract - The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics ...
  • Nicholas, Dequina; Raval, Forum M.; Ip, Blanche C.; Habib, Chloe; Ritou, Eleni; Grammatopoulos, Tom N.; Steenkamp, Devin; Dooms, Hans; Apovian, Caroline M.; Nikolajczyk, Barbara S.; Proctor, Elizabeth A; Lauffenburger, Douglas A (Public Library of Science, 2017-02)
    Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like ...
  • Vacanti, Joseph; Langer, Robert S (Elsevier, 2015-11)
    Nearly 30 years ago, we reported on a concept now known as Tissue Engineering. Here, we report on some of the advances in this now thriving area of research. In particular, significant advances in tissue engineering of ...
  • Holland, C.; Schmitz, L.; Rhodes, T. L.; Peebles, T. L.; Hillesheim, J. C.; Wang, G.; Zeng, G.; Zeng, L.; Doyle, E. J.; Smith, S. P.; Prater, R.; Burrell, K. H.; Candy, J.; Waltz, R. E.; Kinsey, J. E.; Staebler, G. M.; DeBoo, J. C.; Petty, C. C.; McKee, G. R.; Yan, Z.; White, Anne E. (American Institute of Physics, 2011-05)
    Robust validation of predictive turbulent transport models requires quantitative comparisons to experimental measurements at multiple levels, over a range of physically relevant conditions. Toward this end, a series of ...
  • Jaillet, Patrick; Zenklusen, Rico; Soto, Jose A. (Springer-Verlag, 2013-03)
    The best-known conjecture in the context of matroid secretary problems claims the existence of an O(1)-approximation applicable to any matroid. Whereas this conjecture remains open, modified forms of it were shown to be ...
  • Malloy, Timothy F.; Zaunbrecher, Virginia M.; Batteate, Christina; Blake, Ann; Carroll, William F.; Corbett, Charles J.; Hansen, Steffen Foss; Lempert, Robert; Linkov, Igor; McFadden, Roger; Ostrom, Nancy; Romero, Michelle; Schoenung, Julie; Seager, Thomas; Sinsheimer, Peter; Thayer, Kristina; Moran, Kelly H.; Olivetti, Elsa A. (Environmental Health Perspectives, 2016-10)
    Background: Decision analysis—a systematic approach to solving complex problems —offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis ...
  • Carayon, Pascale; Hancock, Peter; Leveson, Nancy; Noy, Ian; Sznelwar, Laerte; van Hootegem, Geert; Leveson, Nancy G (Taylor & Francis, 2015-04)
    Traditional efforts to deal with the enormous problem of workplace safety have proved insufficient, as they have tended to neglect the broader sociotechnical environment that surrounds workers. Here, we advocate a ...
  • Stibe, Agnis (Springer, Cham, 2015-06)
    Persuasive technologies are commonly engineered to change behavior and attitudes of users through persuasion and social influence without using coercion and deception. While earlier research has been extensively focused ...
  • Brezinski, Mark E. (Hindawi Publishing Corporation, 2012)
    The recent paper entitled by K. C. Lee et al. (2011) establishes nonlocal macroscopic quantum correlations, which they term “entanglement”, under ambient conditions. Photon(s)-phonon entanglements are established within ...
  • Stojanovic, Vladimir Marko; Batten, Christopher; Joshi, Ajay J.; Beamer, Scott; Asanovic, Krste (Association for Computing Machinery, 2009-06)
    Future single-board multi-socket systems may be unable to deliver the needed memory bandwidth electrically due to power limitations, which will hurt their ability to drive performance improvements. Energy efficient o ...
  • Harrow, Aram W.; Lee, James R.; Peres, Yuval; Brandao, Fernando G.S.L. (Association for Computing Machinery (ACM), 2014-01)
    Recall the classical hypothesis testing setting with two convex sets of probability distributions P and Q. One receives either n i.i.d. samples from a distribution p ∈ P or from a distribution q ∈ Q and wants to decide ...
  • Kochman, Yuval; Mazumdar, Arya; Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2012-07)
    This paper introduces the problem of joint source-channel coding in the setup where channel errors are adversarial and the distortion is worst case. Unlike the situation in the case of stochastic source-channel model, the ...
  • Alemzadeh, Homa; Raman, Jaishankar; Kalbarczyk, Zbigniew; Iyer, Ravishankar K.; Leveson, Nancy G (Public Library of Science, 2016-04)
    Background Use of robotic systems for minimally invasive surgery has rapidly increased during the last decade. Understanding the causes of adverse events and their impact on patients in robot-assisted surgery will help ...
  • Goldfarb, Avi; Tucker, Catherine Elizabeth (American Marketing Association, 2011-04)
    The authors examine whether the growth of the Internet has reduced the effectiveness of government regulation of advertising. They combine nonexperimental variation in local regulation of offline alcohol advertising with ...
  • Anderson, Eric T.; Simester, Duncan (American Marketing Association, 2013-08)
    Standard models of competition predict that firms will sell less when competitors target their customers with advertising. This is particularly true in mature markets with many competitors that sell relatively undifferentiated ...
  • Aaronson, Scott; Drucker, Andrew Donald (Springer Berlin / Heidelberg, 2011-06)
    We study the power of classical and quantum algorithms equipped with nonuniform advice, in the form of a coin whose bias encodes useful information. This question takes on particular importance in the quantum case, due to ...
  • Friedel, R.; Whelan, P.; Madden, D.; Morley, S.; Su, Yi-Jiun; O’Brien, T. P.; Huston, S. L.; Johnston, W. R.; Guild, T. B.; Lindstrom, C. D.; Roth, C. J.; Quinn, R. A.; Ginet, Gregory P. (Springer Netherlands, 2013-03)
    The radiation belts and plasma in the Earth’s magnetosphere pose hazards to satellite systems which restrict design and orbit options with a resultant impact on mission performance and cost. For decades the standard space ...
  • Vander Heiden, Matthew G.; Lunt, Sophia Yunkyungkwon (Annual Reviews, 2011-11)
    Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been ...
  • Bush, John W. M. (Les Editions de l’Ecole Polytechnique, 2013)
    We consider the aerodynamics of football, specifically, the interaction between a ball in flight and the ambient air. Doing so allows one to account for the characteristic range and trajectories of balls in flight, as well ...
  • Liu, Harris; Kim, Yoojeong; Mello, Kerrianne; Lovaasen, John; Shah, Apoorva; Rice, Norman; Pappas, Daphne; Yim, Jacqueline H.; Klibanov, Alexander M (Springer US, 2013-10)
    The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, ...
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