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Browsing MIT Open Access Articles by Title

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  • Demaine, Erik D.; Demaine, Martin L.; Eisenstat, Sarah Charmian; Lubiw, Anna; Winslow, Andrew (Springer Berlin / Heidelberg, 2011-08)
    The Rubik’s Cube is perhaps the world’s most famous and iconic puzzle, well-known to have a rich underlying mathematical structure (group theory). In this paper, we show that the Rubik’s Cube also has a rich underlying ...
  • Goemans, Michel X.; Soto, Jose A. (Society for Industrial and Applied Mathematics, 2013-06)
    We present an efficient algorithm to find nonempty minimizers of a symmetric submodular function f over any family of sets I closed under inclusion. Our algorithm makes O(n[superscript 3]) oracle calls to f and I, where n ...
  • Ba, Demba; Temereanca, Simona; Brown, Emery N. (Frontiers Research Foundation, 2014-02)
    Understanding how ensembles of neurons represent and transmit information in the patterns of their joint spiking activity is a fundamental question in computational neuroscience. At present, analyses of spiking activity ...
  • Herrmann, Hans J.; Schneider, Christian Michael; Araujo, Nuno (American Physical Society, 2013-04)
    Interconnected networks have been shown to be much more vulnerable to random and targeted failures than isolated ones, raising several interesting questions regarding the identification and mitigation of their risk. The ...
  • Cowan, Nicolas B.; Agol, Eric; Meadows, Victoria S.; Robinson, Tyler; Livengood, Timothy A.; Deming, Drake; Lisse, Carey M.; A'Hearn, Michael F.; Wellnitz, Dennis D.; Seager, Sara; Charbonneau, David (IOP Publishing, 2009-07)
    When Earth-mass extrasolar planets first become detectable, one challenge will be to determine which of these worlds harbor liquid water, a widely used criterion for habitability. Some of the first observations of these ...
  • Stein, Itai Y.; Wardle, Brian L.; Lewis, Diana Jean (Royal Society of Chemistry, 2015-11)
    The landmark theoretical properties of low dimensional materials have driven more than a decade of research on carbon nanotubes (CNTs) and related nanostructures. While studies on isolated CNTs report behavior that aligns ...
  • Guzman de Villoria, Roberto; Ydrefors, L.; Hallander, P.; Ishiguro, Kyoko; Nordin, P.; Wardle, Brian L. (American Institute of Aeronautics and Astronautics, 2012-04)
    Vertically aligned carbon nanotubes (VACNTs) are placed between all plies in an aerospace carbon fiber reinforced plastic laminate (unidirectional plies, [(0/90/±45)2]s) to reinforce the interlaminar region in the ...
  • Chang, Jae-Byum; Son, Jeong Gon; Hannon, Adam F.; Alexander-Katz, Alfredo; Ross, Caroline A.; Berggren, Karl K. (American Chemical Society, 2012-03)
    Self-assembly of block copolymer films can generate useful periodic nanopatterns, but the self-assembly needs to be templated to impose long-range order and to control pattern registration with other substrate features. ...
  • Ross, Adam Michael; O'Neill, Michael Gregory; Hastings, Daniel E.; Rhodes, Donna H. (American Institute of Aeronautics and Astronautics, 2010-08)
    Recent years have seen a push to use explicit consideration of “value” in order to drive design. This paper conveys the need to explicitly align perspectives on “value” with the method used to quantify “value.” Various ...
  • Daskalakis, Constantinos; Roch, Sebastien (Springer Berlin / Heidelberg, 2010-05)
    We introduce the first polynomial-time phylogenetic reconstruction algorithm under a model of sequence evolution allowing insertions and deletions (or indels). Given appropriate assumptions, our algorithm requires sequence ...
  • Roch, Sebastien; Daskalakis, Konstantinos (Institute of Mathematical Statistics, 2013-04)
    We present an efficient phylogenetic reconstruction algorithm allowing insertions and deletions which provably achieves a sequence-length requirement (or sample complexity) growing polynomially in the number of taxa. Our ...
  • Sanchis Ojeda, Roberto; Fabrycky, Daniel C.; Winn, Joshua Nathan; Barclay, Thomas; Clarke, Bruce D.; Ford, Eric B.; Fortney, Jonathan J.; Geary, John C.; Holman, Matthew J.; Howard, Andrew W.; Jenkins, Jon M.; Koch, David; Lissauer, Jack J.; Marcy, Geoffrey W.; Mullally, Fergal; Ragozzine, Darin; Seader, Shawn E.; Still, Martin; Thompson, Susan E. (Nature Publishing Group, 2012-07)
    The Sun’s equator and the planets’ orbital planes are nearly aligned, which is presumably a consequence of their formation from a single spinning gaseous disk. For exoplanetary systems this well-aligned configuration is ...
  • Fedeles, Bogdan I.; Singh, Vipender; Delaney, James C.; Li, Deyu; Essigmann, John M. (American Society for Biochemistry and Molecular Biology (ASBMB), 2015-07)
    The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation. The prototypical and ...
  • Endres, Lauren; Begley, Ulrike; Clark, Ryan; Gu, Chen; Dziergowska, Agnieszka; Małkiewicz, Andrzej; Melendez, J. Andres; Dedon, Peter C.; Begley, Thomas J. (Public Library of Science, 2015-07)
    Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, ...
  • van Loon, Barbara; Samson, Leona D. (Elsevier, 2013-01)
    Due to a harsh environment mitochondrial genomes accumulate high levels of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation adducts. While repair of alkylated bases in nuclear DNA has been explored ...
  • Lu, Zhe; Fu, Gregory C. (Wiley Blackwell, 2010-08)
    No such thing as a problem substrate! In a reaction designed specifically for the title substrates C-C coupling with alkyl boranes occurred in good yield at room temperature with commercially available catalyst components ...
  • Bugni, J. M.; Meira, Lisiane B.; Samson, Leona D. (Nature Publishing Group, 2008-11)
    O[superscript 6]-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including ...
  • Kupfer, Thomas; Schrock, Richard Royce (American Chemical Society (ACS), 2009-08)
    In this paper we explore the ethylation of dinitrogen (employing [Et[subscript 3]O][BAr[f over 4]]; Ar[superscript f] = 3,5-(CF[subscript 3])[subscript 2]C[subscript 6]H[subscript 3]) in [HIPTN[subscript 3]N]Mo (Mo) complexes ...
  • Schrock, Richard Royce (Royal Society of Chemistry, The, 2013-05)
    Alkyne metathesis by molybdenum and tungsten alkylidyne complexes is now ~45 years old. Progress in the practical aspects of alkyne metathesis reactions with well-defined complexes, as well as applications, in the last ...
  • Drego, Nigel A.; Chandrakasan, Anantha P.; Boning, Duane S. (Institute of Electrical and Electronics Engineers (IEEE), 2010-02)
    Increased variation in CMOS processes due to scaling results in greater reliance on accurate variation models in developing circuit methods to mitigate variation. This paper investigates spatial variation in digital circuit ...
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