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Browsing MIT Open Access Articles by Title

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  • Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands 
    Das, Payel; Zhou, Ruhong; King, Jonathan Alan (Proceedings of the National Academy of Sciences (PNAS), 2011-06)
    The prevalent eye disease age-onset cataract is associated with aggregation of human γD-crystallins, one of the longest-lived proteins. Identification of the γ-crystallin precursors to aggregates is crucial for developing ...
  • Aggressive flight of fixed-wing and quadrotor aircraft in dense indoor environments 
    Richter, Charles Andrew; Roy, Nicholas; Bry, Adam P.; Bachrach, Abraham Galton (Sage Publications, 2015-03)
    In this paper, we describe trajectory planning and state estimation algorithms for aggressive flight of micro aerial vehicles in known, obstacle-dense environments. Finding aggressive but dynamically feasible and collision-free ...
  • Agile specifications 
    Rayside, Derek; Milicevic, Aleksandar; Yessenov, Kuat T.; Jackson, Daniel (Association for Computing Machinery, 2009-10)
    Traditional formal methods and modern agile methods are separated more by limitations of current technology than by fundamental intellectual differences. A mixed interpreter that executes mixed programs, comprising both ...
  • The Aging-Associated Enzyme CLK-1 is a Member of the Carboxylate-Bridged Diiron Family of Proteins 
    Behan, Rachel K.; Lippard, Stephen J. (American Chemical Society, 2010-10)
    The aging-associated enzyme CLK-1 is proposed to be a member of the carboxylate-bridged diiron family of proteins. To evaluate this hypothesis and characterize the protein, we expressed soluble mouse CLK-1 (MCLK1) in ...
  • Aging-Associated Enzyme Human Clock-1: Substrate-Mediated Reduction of the Diiron Center for 5-Demethoxyubiquinone Hydroxylation 
    Lu, Tsai-Te; Lee, Seung Jae; Apfel, Ulf-Peter; Lippard, Stephen J. (American Chemical Society (ACS), 2013-02)
    The mitochondrial membrane-bound enzyme Clock-1 (CLK-1) extends the average longevity of mice and Caenorhabditis elegans, as demonstrated for Δclk-1 constructs for both organisms. Such an apparent impact on aging and the ...
  • Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia 
    Yin, Lu; Zheng, Dahai; Limmon, Gino V.; Leung, Nicola H. N.; Xu, Shuoyu; Rajapakse, Jagath C.; Yu, Hanry; Chow, Vincent T. K.; Chen, Jianzhu (BioMed Central Ltd, 2014-09)
    Background Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to ...
  • Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine 
    Rajbhandary, Uttam L; Koehrer, Caroline; Su, Dan; Russell, Susan P.; Krivos, Kady; Castleberry, Colette M.; Blum, Paul; Limbach, Patrick A.; Söll, Dieter; Mandal, Debabrata (National Academy of Sciences (U.S.), 2010-01)
    Modification of the cytidine in the first anticodon position of the AUA decoding tRNAIle [tRNA superscript Ile subscript 2] of bacteria and archaea is essential for this tRNA to read the isoleucine codon AUA and to ...
  • Aikido: Accelerating shared data dynamic analyses 
    Olszewski, Marek Krystyn; Zhao, Qin; Koh, David F.; Ansel, Jason Andrew; Amarasinghe, Saman P. (Association for Computing Machinery, 2012-03)
    Despite a burgeoning demand for parallel programs, the tools available to developers working on shared-memory multicore processors have lagged behind. One reason for this is the lack of hardware support for inspecting the ...
  • Airblue: A System for Cross-Layer Wireless Protocol Development 
    Ng, Man Cheuk; Fleming, Kermin Elliott; Vutukuru, Mythili; Gross, Samuel; Mithal, Arvind; Balakrishnan, Hari (Institute of Electrical and Electronics Engineers, 2010-10)
    Over the past few years, researchers have developed many crosslayer wireless protocols to improve the performance of wireless networks. Experimental evaluations of these protocols have been carried out mostly using ...
  • Airborne observations of regional variation in fluorescent aerosol across the United States 
    Perring, A. E.; Schwarz, J. P.; Baumgardner, D.; Hernandez, M. T.; Spracklen, D. V.; Gao, R. S.; Kok, G.; McMeeking, G. R.; McQuaid, J. B.; Fahey, D. W.; Heald, Colette L. (American Geophysical Union (AGU), 2015-02)
    Airborne observations of fluorescent aerosol were made aboard an airship during CloudLab, a series of flights that took place in September and October of 2013 and covered a wideband of longitude across the continental U.S. ...
  • Air-clad silicon pedestal structures for broadband mid-infrared microphotonics 
    Lin, Pao Tai; Singh, Vivek; Cai, Yan; Kimerling, Lionel C.; Agarwal, Anuradha Murthy (Optical Society of America, 2013-03)
    Toward mid-infrared (mid-IR) silicon microphotonic circuits, we demonstrate broadband on-chip silicon structures, such as: (i) straight and bent waveguides and (ii) beam splitters, utilizing an air-clad pedestal configuration ...
  • Air-Combat Strategy Using Approximate Dynamic Programming 
    McGrew, James S.; How, Jonathan P.; Bush, Lawrence; Williams, Brian Charles; Roy, Nicholas (American Institute of Aeronautics and Astronautics, 2010-09)
    Unmanned Aircraft Systems (UAS) have the potential to perform many of the dangerous missions currently own by manned aircraft. Yet, the complexity of some tasks, such as air combat, have precluded UAS from successfully ...
  • Aircraft Engine Performance Study Using Flight Data Recorder Archives 
    Chati, Yashovardhan Sushil; Balakrishnan, Hamsa (2013-10-30)
  • Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells 
    Giraud, Matthieu; Yoshida, Hideyuki; Abramson, Jakub; Rahl, Peter B.; Young, Richard A.; Mathis, Diane; Benoist, Christophe (National Academy of Sciences, 2012-01)
    Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its ...
  • Air-Heating Solar Collectors for Humidification-Dehumidification Desalination Systems 
    Summers, Edward K.; Lienhard, John H.; Zubair, Syed M. (ASME International, 2011-02)
    Relative to solar water heaters, solar air heaters have received relatively little investigation and have resulted in few commercial products. However, in the context of a humidification-dehumidification (HDH) desalination ...
  • Air quality resolution for health impact assessment: influence of regional characteristics 
    Thompson, T. M.; Saari, Rebecca Kaarina; Selin, Noelle Eckley (Copernicus GmbH, 2014-01)
    We evaluate how regional characteristics of population and background pollution might impact the selection of optimal air quality model resolution when calculating the human health impacts of changes to air quality. Using ...
  • Air–Sea Enthalpy and Momentum Exchange at Major Hurricane Wind Speeds Observed during CBLAST 
    Bell, Michael M.; Montgomery, Michael T.; Emanuel, Kerry Andrew (American Meteorological Society, 2012-11)
    Quantifying air–sea exchanges of enthalpy and momentum is important for understanding and skillfully predicting tropical cyclone intensity, but the magnitude of the corresponding wind speed–dependent bulk exchange coefficients ...
  • Airspace structure, future ATC systems, and controller complexity reduction 
    Histon, Jonathan; Li, Lishuai; Hansman, Robert J., Jr. (Institute of Electrical and Electronics Engineers, 2010-12)
    Airspace structure is a key factor influencing controller cognitive complexity as it forms a basis for abstractions simplifying controller mental models of air traffic situations. In evaluating the feasibility of new ...
  • An Air-Stable Low-Bandgap n-Type Organic Polymer Semiconductor Exhibiting Selective Solubility in Perfluorinated Solvents 
    Takeda, Youhei; Andrew, Trisha Lionel; Lobez, Jose M.; Mork, Anna Jolene; Swager, Timothy Manning (John Wiley & Sons, Inc., 2012-08)
    Thumbnail image of graphical abstract A thin-film transistor: An n-type polymer semiconductor, poly(2,3-bis(perfluorohexyl)thieno[3,4-b]pyrazine), was synthesized through a Pd-catalyzed polycondensation employing a ...
  • Air-to-ground lasercom system demonstration design overview and results summary 
    Walther, Frederick G.; Michael, Steven; Parenti, Ronald R.; Taylor, John A. (Society of Photo-optical Instrumentation Engineers, 2010-08)
    We present an overview of an air-to-ground laser communications demonstration performed at MIT Lincoln Laboratory. Error-free communication at 2.5 Gb/s was demonstrated along a 25-km slant path between a 1-in transmit ...
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