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Browsing MIT Open Access Articles by Title

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  • Attosecond Resolution Timing Jitter Characterization of Diode Pumped Femtosecond Cr:Lisaf Lasers 
    Demirbas, Umit; Benedick, Andrew J.; Sennaroglu, Alphan; Li, Duo; Kim, Jungwon; Fujimoto, James G.; Fujimoto, James G. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    Two diode pumped Cr:LiSAF lasers are synchronized using a balanced nonlinear optical cross correlator. An integrated timing jitter of less than 156 as in the 10 kHz to 10 MHz range is measured.
  • Audience Structure and the Failure of Institutional Entrepreneurship 
    Kahl, Steven J.; Liegel, Gregory J.; Yates, JoAnne (Emerald Group Publishing Limited, 2012-01)
    Purpose – The broader aim of this research is twofold. First, we aim to better understand how the business computer was conceptualized and used within U.S. industry. Second, this research investigates the role of social ...
  • Audio classification from time-frequency texture 
    Slotine, Jean-Jacques E.; Yu, Guoshen (Institute of Electrical and Electronics Engineers (IEEE), 2009-05)
    Time-frequency representations of audio signals often resemble texture images. This paper derives a simple audio classification algorithm based on treating sound spectrograms as texture images. The algorithm is inspired ...
  • Audit fees and book-tax differences 
    Hanlon, Michelle; Krishnan, Gopal V.; Mills, Lillian F. (American Accounting Association, 2012-01)
    We investigate whether book-tax differences are associated with higher audit fees, a proxy for auditor risk assessments and auditor effort. Our evidence suggests that there is a significantly positive relation. Further, ...
  • Augmentation of post-swelling surgical sealant potential of adhesive hydrogels 
    Shazly, Tarek M.; Baker, Aaron B.; Naber, John R.; Bon, Adriana; Van Vliet, Krystyn J.; Edelman, Elazer R. (Wiley Blackwell, 2010-11)
  • Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesis 
    Fox, James G.; Xie, Meimin; Kotecha, Vijay R.; Andrade, Jon David P.; Carey, Martin C. (Wiley Blackwell (Blackwell Publishing -The Physiological Society), 2012-02)
    Cholesterol gallstones are associated with slow intestinal transit in humans as well as in animal models, but the molecular mechanism is unknown. We investigated in C57L/J mice whether the components of a lithogenic diet ...
  • Augmented Expression and Activity of Extracellular Matrix-Degrading Enzymes in Regions of Low Endothelial Shear Stress Colocalize With Coronary Atheromata With Thin Fibrous Caps in Pigs 
    Chatzizisis, Yiannis S.; Baker, Aaron B.; Sukhova, Galina K.; Koskinas, Konstantinos C.; Papafaklis, Michail I.; Beigel, Roy; Jonas, Michael; Coskun, Ahmet U.; Stone, Benjamin V.; Maynard, Charles; Shi, Guo-Ping; Libby, Peter; Feldman, Charles L.; Edelman, Elazer R.; Stone, Peter H. (Ovid Technologies (Wolters Kluwer) -American Heart Association, 2011-01)
    Background—The molecular mechanisms that determine the localized formation of thin-capped atheromata in the coronary arteries remain unknown. This study tested the hypothesis that low endothelial shear stress augments the ...
  • Augmenting sticky notes as an I/O interface 
    Maes, Patricia; Mistry, Pranav K. (Springer Berlin/Heidelberg, 2009)
    The design and implementation of systems that combine both the utilities of the digital world as well as intrinsic affordances of traditional artifacts are challenging. In this paper, we present ‘Quickies’, an attempt to ...
  • Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface 
    Welburn, Julie P. I.; Vleugel, Mathijs; Liu, Dan; Yates, John R., III; Lampson, Michael A.; Fukagawa, Tatsuo; Cheeseman, Iain McPherson (Elsevier, 2010-05)
    Accurate chromosome segregation requires carefully regulated interactions between kinetochores and microtubules, but how plasticity is achieved to correct diverse attachment defects remains unclear. Here we demonstrate ...
  • Authentic teaching and learning through synthetic biology 
    Kuldell, Natalie (BioMed Central Ltd, 2007-12)
    Synthetic biology is an emerging engineering discipline that, if successful, will allow well-characterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. ...
  • Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis 
    Ploegh, Hidde; Spooner, Eric; Ray, Arundhati; Amato, Anthony A.; Bradshaw, Elizabeth M.; Felice, Kevin J.; DiCapua, Daniel B.; Goldstein, Jonathan M.; Lundberg, Ingrid E.; Nowak, Richard J.; Wu, Qian; Willis, Simon N.; O’Connor, Kevin C. (Public Library of Science, 2012-10)
    Inclusion body myositis (IBM) belongs to a group of muscle diseases known as the inflammatory myopathies. The presence of antibody-secreting plasma cells in IBM muscle implicates the humoral immune response in this disease. ...
  • Autocrine-controlled formation and function of tissue-like aggregates by hepatocytes in micropatterned hydrogel arrays 
    Williams, Courtney M.; Mehta, Geeta; Peyton, Shelly R.; Zeiger, Adam Scott; Van Vliet, Krystyn J.; Griffith, Linda G. (Mary Ann Liebert, Inc., 2011-03)
    The liver carries out a variety of essential functions regulated in part by autocrine signaling, including hepatocyte-produced growth factors and extracellular matrix (ECM). The local concentrations of autocrine factors ...
  • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts 
    Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T.; Scheel, Christina; Ben-Porath, Ittai; Onder, Tamer; Wang, Zhigang C.; Richardson, Andrea L.; Weinberg, Robert A.; Orimo, Akira (National Academy of Sciences (U.S.), 2010-11)
    Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast ...
  • Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance 
    Iftimia, Nicusor V.; Bressner, Jason E.; Pitman, Martha B.; Halpern, Elkan; Tearney, Guillermo J.; Goldberg, Brian D.; Bouma, Brett E. (SPIE - International Society for Optical Engineering, 2008-02)
    Fine needle aspiration biopsy (FNAB) is a rapid and cost-effective method for obtaining a first-line diagnosis of a palpable mass of the breast. However, because it can be difficult to manually discriminate between adipose ...
  • Automated and Adaptable Quantification of Cellular Alignment from Microscopic Images for Tissue Engineering Applications 
    Feng, Xu; Beyazoglu, Turker; Hefner, Evan; Gurkan, Umut Atakan; Demirci, Utkan (Mary Ann Liebert, 2011-06)
    Cellular alignment plays a critical role in functional, physical, and biological characteristics of many tissue types, such as muscle, tendon, nerve, and cornea. Current efforts toward regeneration of these tissues include ...
  • Automated compact dynamical modeling: An enabling tool for analog designers 
    Bond, Bradley N.; Daniel, Luca (Association for Computing Machinery (ACM), 2010-06)
    In this paper we summarize recent developments in compact dynamical modeling for both linear and nonlinear systems arising in analog applications. These techniques include methods based on the projection framework, rational ...
  • Automated de-identification of free-text medical records 
    Neamatullah, Ishna; Douglass, Margaret M.; Long, William J.; Szolovits, Peter; Moody, George B.; Clifford, Gari D.; Lehman, Li-Wei H.; Reisner, Andrew T.; Villarroel Montoya, Mauricio Christian; Mark, Roger Greenwood (BioMed Central Ltd, 2008-07)
    Background: Text-based patient medical records are a vital resource in medical research. In order to preserve patient confidentiality, however, the U.S. Health Insurance Portability and Accountability Act (HIPAA) requires ...
  • Automated Formal Verification of the DHCP Failover Protocol Using Timeout Order Abstraction 
    Umeno, Shinya; Lynch, Nancy Ann (Institute of Electrical and Electronics Engineers (IEEE), 2010-11)
    In this paper, we present automated formal verification of the DHCP Failover protocol. We conduct bounded model-checking for the protocol using Timeout Order Abstraction (TO-Abstraction), a technique to abstract a given ...
  • Automated high-dimensional flow cytometric data analysis 
    Pyne, Saumyadipta; Hu, Xinli; Wang, Kui; Rossin, Elizabeth; Lin, Tsung-I; Maier, Lisa M.; Baecher-Allan, Clare; McLachlan, Geoffrey J.; Tamayo, Pablo; Hafler, David A.; De Jager, Philip L.; Mesirov, Jill P. (National Academy of Sciences, 2009-05)
    Flow cytometric analysis allows rapid single cell interrogation of surface and intracellular determinants by measuring fluorescence intensity of fluorophore-conjugated reagents. The availability of new platforms, allowing ...
  • Automated Home-Cage Behavioural Phenotyping of Mice 
    Jhuang, Huei-Han; Garrote, Estibaliz; Yu, Xinlin; Khilnani, Vinita; Poggio, Tomaso A.; Steele, Andrew D.; Serre, Thomas R. (Nature Publishing Group, 2010-01)
    Neurobehavioral analysis of mouse phenotypes requires the monitoring of mouse behavior over long periods of time. Here, we describe a trainable computer vision system enabling the automated analysis of complex mouse ...
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