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Browsing MIT Open Access Articles by Title

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  • Hosseini, Vahid; Ahadian, Samad; Ostrovidov, Serge; Camci-Unal, Gulden; Chen, Song; Kaji, Hirokazu; Ramalingam, Murugan; Khademhosseini, Ali (Mary Ann Liebert, Inc., 2012-09)
    To engineer tissue-like structures, cells must organize themselves into three-dimensional (3D) networks that mimic the native tissue microarchitecture. Microfabricated hydrogel substrates provide a potentially useful ...
  • Brigham, Christopher J.; Sinskey, Anthony J.; Song, Yuyang; Matsumoto, Ken’ichiro; Yamada, Miwa; Gohda, Aoi; Taguchi, Seiichi (Springer-Verlag, 2011-11)
    The first biosynthetic system for lactate (LA)-based polyesters was previously created in recombinant Escherichia coli (Taguchi et al. 2008). Here, we have begun efforts to upgrade the prototype polymer production system ...
  • Mata-Fink, Jordi; Hanson, M.; Kriegsman, Barry A.; Irvine, D.; Wittrup, Karl Dane (Biomed Central Ltd., 2012-09)
    Background: One of the great challenges for an HIV vaccine is to elicit broadly neutralizing antibodies specific for conserved epitopes from which the virus cannot easily escape. The CD4 binding site is one such epitope ...
  • Swami, Archana; Reagan, Michaela R.; Basto, Pamela; Mishima, Yuji; Kamaly, Nazila; Glavey, Siobhan; Zhang, Sufeng; Moschetta, Michele; Seevaratnam, Dushanth; Zhang, Yong; Liu, Jinhe; Memarzadeh, Masoumeh; Wu, Jun; Manier, Salomon; Shi, Jinjun; Bertrand, Nicolas; Lu, Zhi Ning; Nagano, Kenichi; Baron, Roland; Sacco, Antonio; Roccaro, Aldo M.; Farokhzad, Omid C.; Ghobrial, Irene M. (National Academy of Sciences (U.S.), 2014-06)
    Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability ...
  • Varanasi, Kripa K.; Chamarthy, Pramod; Chauhan, Shakti; de Bock, Peter; Deng, Tao; Kulkarni, Ambarish; Mandrusiak, Gary; Rush, Brian; Russ, Boris; Denault, Lauraine; Weaver, Stanton; Gerner, Frank; Leland, Quinn; Yerkes, Kirk (Nano Science and Technology Institute, 2009-05)
    In the DARPA Thermal Ground Plane (TGP) program[1],we are developing a new thermal technology that will enable a monumental thermal technological leap to an entirely new class of electronics, particularly electronics ...
  • Shi, Jiahai; Kundrat, Lenka; Pishesha, Novalia; Bilate, Angelina; Theile, Christopher S.; Maruyama, Takeshi; Dougan, Stephanie K.; Ploegh, Hidde; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2014-06)
    We developed modified RBCs to serve as carriers for systemic delivery of a wide array of payloads. These RBCs contain modified proteins on their plasma membrane, which can be labeled in a sortase-catalyzed reaction under ...
  • Barbero, Roberto Juan; Carnelli, Lino; Simon, Anna; Kao, Albert; Monforte, Alessandra d'Arminio; Riccò, Moreno; Bianchi, Daniele; Belcher, Angela M. (Royal Society of Chemistry, 2013)
    In this work, a biologically catalysed CO2 mineralization process for the capture of CO2 from point sources was designed, constructed at a laboratory scale, and, using standard chemical process scale-up protocols, was ...
  • Nielsen, David R.; Yoon, Sang-Hwal; Yuan, Clara J.; Prather, Kristala L. Jones (John Wiley & Sons, Inc., 2010-01)
    The functional reconstruction of acetoin and meso-2,3-butanediol (meso-2,3-BD) biosynthetic pathways in Escherichia coli have been explored systematically. Pathway construction involved the in vivo screening of prospective ...
  • Ryu, Min-Hyung; Kang, In-Hye; Nelson, Mathew D.; Jensen, Tricia M.; Lyuksyutova, Anna I.; Siltberg-Liberles, Jessica; Raizen, David M.; Gomelsky, Mark (National Academy of Sciences (U.S.), 2014-06)
    Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties ...
  • Belmont, Brian Joshua; Niles, Jacquin (American Chemical Society, 2010-06)
    The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common mechanism uses inducible protein−RNA interactions to shape diverse aspects of cellular ...
  • Nielsen, David R.; Leonard, Effendi; Yoon, Sang-Hwal; Tseng, Hsien-chung; Yuan, Clara J.; Prather, Kristala L. Jones (Elsevier B.V., 2009-05)
    Alternative microbial hosts have been engineered as biocatalysts for butanol biosynthesis. The butanol synthetic pathway of Clostridium acetobutylicum was first re-constructed in Escherichia coli to establish a baseline ...
  • Potter, Andrew Cole; Lee, Patrick A. (American Physical Society, 2011-05)
    We compare topological insulator materials and Rashba-coupled surfaces as candidates for engineering p+ip superconductivity. Specifically, in each type of material we examine (1) the limitations to inducing superconductivity ...
  • Renugopalakrishnan, Venkatesan; Barbiellini, Bernardo; King, Chris; Molinari, Michael; Mochalov, Konstantin; Sukhanova, Alyona; Nabiev, Igor; Fojan, Peter; Tuller, Harry L.; Chin, Michael; Somasundaran, Ponisseril; Ramakrishna, Seeram; Padros, Esteve (American Chemical Society (ACS), 2014-05)
    We present a route toward a radical improvement in solar cell efficiency using resonant energy transfer and sensitization of semiconductor metal oxides with a light-harvesting quantum dot (QD)/bacteriorhodopsin (bR) layer ...
  • Vanhoutte, Michiel; Singh, Vivek; Hu, Juejun; Cai, Yan; Michel, Jurgen; Kimerling, Lionel C.; Lin, Pao Tai; Patel, Neil Sunil; Camacho-Aguilera, Rodolfo Ernesto; Agarwal, Anuradha Murthy (Optical Society of America, 2012-01)
    Broadband and anisotropic light emission from rare-earth doped tellurite thin films is demonstrated using Er[superscript 3+]-TeO[subscript 2] photonic crystals (PhCs). By adjusting the PhC parameters, photoluminescent light ...
  • Bowring, J. F.; McLean, Noah Morgan; Bowring, Samuel A. (American Geophysical Union (AGU), 2011-06)
    In the past decade, major advancements in precision and accuracy of U-Pb geochronology, which stem from improved sample pretreatment and refined measurement techniques, have revealed previously unresolvable discrepancies ...
  • Barthelmes, Katja; Reynolds, Anne M.; Peisach, Ezra; Jonker, Hendrik R. A.; DeNunzio, Nicholas J.; Allen, Karen N.; Imperiali, Barbara; Schwalbe, Harald (American Chemical Society, 2010-12)
    Lanthanide-binding tags (LBTs) are valuable tools for investigation of protein structure, function, and dynamics by NMR spectroscopy, X-ray crystallography, and luminescence studies. We have inserted LBTs into three different ...
  • Jeng, Lily; Olsen, Bjorn R.; Spector, Myron (Mary Ann Liebert, 2010-06)
    Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...
  • Lippow, Shaun M.; Moon, Tae Seok; Basu, Subhayu; Yoon, Sang-Hwal; Li, Xiazhen; Chapman, Brad A.; Robison, Keith; Lipovšek, Daša; Prather, Kristala L. Jones (Elsevier, 2010-12)
    Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we ...
  • Drake, Adam; Chen, Jianzhu; Chen, Qingfeng (Nature Publishing Group, 2012-05)
    Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the ...
  • Moon, James J.; Huang, Bonnie; Irvine, Darrell J. (Wiley Blackwell, 2012-05)
    The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders. Thus, therapies aimed to amplify or ...
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