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Browsing MIT Open Access Articles by Title

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  • Ramirez Millan, Maria; Caldara, Marina; Rusconi, Roberto; Tarasova, Yekaterina; Stocker, Roman; Ribbeck, Katharina; Billings, Amanda Nicole (Public Library of Science, 2013-08)
    Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which serves as a first line of defense against antibiotic attack. Polysaccharides constitute major elements of the biofilm matrix and ...
  • Hynes, Richard O. (American Association for the Advancement of Science (AAAS), 2009-11)
    The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has many effects beyond providing structural support. ...
  • Naba, Alexandra; Clauser, Karl R; Lamar, John Michael; Carr, Steven A.; Hynes, Richard O. (eLife Sciences Publications, Ltd., 2014-03)
    The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that ...
  • Naba, Alexandra; Clauser, Karl R; Whittaker, Charles A; Carr, Steven A; Tanabe, Kenneth K; Hynes, Richard O. (BioMed Central Ltd., 2014-07)
    Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis ...
  • Reckman, Hilke; Orkin, Jeffrey David; Roy, Deb K. (Association for Computing Machinery, 2011-01)
    We use data from a virtual world game for automated learning of words and grammatical constructions and their meanings. The language data are an integral part of the social interaction in the game and consist of chat ...
  • Li, Jinglai; Kath, William L. (Society for Industrial and Applied Mathematics, 2012-04)
    We describe an iterative method that extracts the underlying soliton from a noisy pulse. The method is formulated as a functional iteration: at each step, the soliton component of the difference between the noisy pulse and ...
  • Marshall, Lisa Faye; Cui, Jian; Brokmann, Xavier; Bawendi, Moungi G. (American Physical Society, 2010-07)
    Fluorescence spectroscopy of single chromophores immobilized on a substrate has provided much fundamental insight, yet the spectral line shapes and dynamics of single chromophores freely diffusing in solution have remained ...
  • Teherani, James T.; Chern, Winston; Antoniadis, Dimitri A.; Hoyt, Judy L.; Ruiz, Liliana; Poweleit, Christian D.; Menendez, Jose (American Physical Society, 2012-05)
    Metal-oxide-semiconductor capacitors were fabricated on type-II staggered gap strained-Si/strained-Ge heterostructures epitaxially grown on relaxed SiGe substrates of various Ge fractions. Quasistatic quantum-mechanical ...
  • Teherani, James T.; Chern, Winston; Antoniadis, Dimitri A.; Hoyt, Judy L.; Ruiz, Liliana; Poweleit, Christian D.; Menendez, Jose (American Physical Society, 2012-05)
    Metal-oxide-semiconductor capacitors were fabricated on type-II staggered gap strained-Si/strained-Ge heterostructures epitaxially grown on relaxed SiGe substrates of various Ge fractions. Quasistatic quantum-mechanical ...
  • Wu, You; Picard, Mathieu; Baelden, Camille; Slocum, Alexander H.; Chang, Le (American Nuclear Society, 2014-11)
    Uranium present in low concentration in ocean water has the potential to greatly augment the current fuel reserve for nuclear power generation, but the challenge of extracting it economically remains. Two new designs of ...
  • Brar, B.; Kim, D. H.; del Alamo, Jesus A.; Antoniadis, Dimitri A. (Institute of Electrical and Electronics Engineers, 2010-03)
    We have experimentally extracted the virtual-source electron injection velocity, vx0, of various III-V HFETs at room temperature. This is the carrier velocity that matters for logic applications of these transistors. Sub-100 ...
  • Conlon, David; Fox, Jacob; Zhao, Yufei (Elsevier, 2014-02)
    Szemeredi's regularity lemma is a fundamental tool in extremal combinatorics. However, the original version is only helpful in studying dense graphs. In the 1990s, Kohayakawa and Rodl proved an analogue of Szemeredi's ...
  • Simcoe, Robert A.; Sullivan, Peter W.; Kao, Melodie M.; Burgasser, Adam J.; Cooksey, Kathy; Matejek, Michael Scott (Nature Publishing Group, 2012-12)
    In typical astrophysical environments, the abundance of heavy elements ranges from 0.001 to 2 times the solar value. Lower abundances have been seen in selected stars in the Milky Way’s halo(1, 2, 3) and in two quasar ...
  • Yunes, Nicolas; Buonanno, Alessandra; Hughes, Scott A.; Pan, Yi; Barausse, Enrico; Miller, M. Coleman; Throwe, William T. (American Physical Society, 2011-02)
    We construct effective-one-body waveform models suitable for data analysis with the Laser Interferometer Space Antenna for extreme mass-ratio inspirals in quasicircular, equatorial orbits about a spinning supermassive black ...
  • Cai, Yang; Daskalakis, Konstantinos (Institute of Electrical and Electronics Engineers (IEEE), 2011-10)
    We provide a Polynomial Time Approximation Scheme for the multi-dimensional unit-demand pricing problem, when the buyer's values are independent (but not necessarily identically distributed.) For all ϵ >; 0, we obtain a ...
  • Wang, Jingfeng; Bras, Rafael L. (American Meteorological Society, 2010-02)
    An extremum hypothesis of turbulent transport in the atmospheric surface layer is postulated. The hypothesis has led to a unique solution of Monin–Obukhov similarity equations in terms of simple expressions linking shear ...
  • Skow, Bradford (Oxford University Press (OUP), 2010-02)
    When distinguishing absolute, true, and mathematical time from relative, apparent, and common time, Newton wrote: “absolute, true, and mathematical time, in and of itself and of its own nature, without reference to ...
  • Tambe, Prasanna; Hitt, Lorin M.; Brynjolfsson, Erik (Institute for Operations Research and the Management Sciences (INFORMS), 2012-01)
    We gather detailed data on organizational practices and information technology (IT) use at 253 firms to examine the hypothesis that external focus—the ability of a firm to detect and therefore respond to changes in its ...
  • Kim, Ki-Hean; So, Peter T. C.; Sun, Tzu-Lin; Liu, Yuan; Sung, Ming-Chin; Yang, Chun-Hui; Hovhannisyan, Vladimir; Chen, Wei-Liang; Chen, Yang-Fang; Chen, Hsiao-Ching; Chiou, Ling-Ling; Huang, Guan-Tarn; Lin, Wei-Chou; Jeng, Yung-Ming; Lee, Hsuan-Shu; Dong, Chen-Yuan (SPIE, 2010-06)
    Conventionally, liver fibrosis is diagnosed using histopathological techniques. The traditional method is time-consuming in that the specimen preparation procedure requires sample fixation, slicing, and labeling. Our goal ...
  • Bryan, Bradley; Wang, Yihong; Connolly, James L.; Zhou, Chao; Aguirre, Aaron Dominic; Tsai, Tsung-Han; Fujimoto, James G. (Society of Photo-optical Instrumentation Engineers, 2009-02)
    We report an imaging study using integrated 3D-OCT and OCM for the assessment of various human thyroid and breast pathologies. The 3D-OCT data sets enable en face projection imaging, which provides large field of view with ...
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