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Browsing MIT Open Access Articles by Title

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  • Hanumara, Nevan Clancy; Walsh, Conor James; Slocum, Alexander H.; Seitel, Alexander; Shepard, Jo-Anne; Maier-Hein, Lena; Gupta, Rajiv; Meinzer, Hans-Peter (The International Society for Optical Engineering, 2009-03)
    The main challenges of Computed Tomography (CT)-guided organ puncture are the mental registration of the medical imaging data with the patient anatomy, required when planning a trajectory, and the subsequent precise insertion ...
  • Levin, Joshua Z.; Adiconis, Xian; Yassour, Moran; Thompson, Dawn; Guttman, Mitchell; Berger, Michael F.; Fan, Lin; Friedman, Nir; Nusbaum, Chad; Gnirke, Andreas; Regev, Aviv (BioMed Central Ltd., 2011-10)
    RNA-seq provides insights at multiple levels into the transcription of the genome as it yields sequence, splicing and expression-level information. We have been developing and comparing a wide range of RNA-seq methods for ...
  • Verma, Rajeev; Del Vecchio, Domitilla (Institute of Electrical and Electronics Engineers, 2011-12)
    In this paper, the problem of collision avoidance between two vehicles is considered, in which one vehicle is autonomous and the other one is human-driven. This problem arises in cooperative active safety systems at traffic ...
  • Theogarajan, Luke; Wyatt, John L; Mendoza, Oscar D.; Rizzo, Joseph F.; Drohan, William A.; Cogan, Stuart F.; Gingerich, Marcus D.; Doyle, Patrick S.; Chen, Jinghua; Kelly, Shawn K.; Shire, Douglas B. (Institute of Electrical and Electronics Engineers, 2009-09)
    A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models. The implant conforms to the outer wall of the eye and drives a microfabricated ...
  • Langer, Robert; Farokhzad, Omid C.; Gadde, Suresh; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Pesic, Aleksandar; Cheung, Louis; Fayad, Zahi A.; Tabas, Ira (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Langer, Robert; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Gadde, Suresh; Pesic, Alexsandar; Cheung, Louis; Fayad, Zahi A.; Tabas, Ira; Cameron Farokhzad, Omid (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Tulliani, J.-M.; Lombardi, M.; Palmero, P.; Fornabaio, M.; Gibson, Lorna (Elsevier, 2013-03)
    Porous ceramic materials are of considerable interest for a variety of chemical and industrial applications in extremely harsh conditions, particularly at very high temperatures for long time periods. A combined ...
  • Stewart, Frank J.; Ottesen, Elizabeth; DeLong, Edward (Nature Publishing Group, 2010-03)
    Metatranscriptomes generated by pyrosequencing hold significant potential for describing functional processes in complex microbial communities. Meeting this potential requires protocols that maximize mRNA recovery by ...
  • Neal, Krista L.; Shakerdge, Naomi B.; Hou, Steven S.; Klunk, William E.; Mathis, Chester A.; McLean, Pamela J.; Bacskai, Brian J.; Nesterov, Evgueni; Swager, Timothy M (Springer US, 2013-04)
    Purpose: The goal was to identify molecular imaging probes that would enter the brain, selectively bind to Parkinson’s disease (PD) pathology, and be detectable with one or more imaging modalities. Procedure: A library ...
  • Blumenstiel, Brendan; DeFelice, Matthew; Birsoy, Ozge; Bleyer, Anthony J.; Kmoch, Stanislav; Carter, Todd A.; Gnirke, Andreas; Kidd, Kendrah; Rehm, Heidi L.; Ronco, Lucienne; Gabriel, Stacey; Lennon, Niall J.; Lander, Eric Steven (Elsevier, 2016-05)
    Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal dominant tubulointerstitial kidney disease recently shown to be caused by a single-base insertion ...
  • Han, Hee-Sun; Devaraj, Neal K.; Lee, Jungmin; Hilderbrand, Scott A.; Weissleder, Ralph; Bawendi, Moungi G. (American Chemical Society, 2010-05)
    We present a bioorthogonal and modular conjugation method for efficient coupling of organic dyes and biomolecules to quantum dots (QDs) using a norbornene−tetrazine cycloaddition. The use of noncoordinating functional ...
  • Yu, Zechuan; Lau, Tak Bun Denvid (Springer Berlin Heidelberg, 2015-04)
    At nanoscale, atomistic simulation is widely used for investigating crystalline chitin fibers, the structural component for many biological materials. However, the longitudinal dimension of naturally occurring chitin fibers ...
  • Martin, Eric S.; Belmont, P. J.; Sinnamon, M. J.; Richard, L. G.; Yuan, J.; Coffee, E. M.; Roper, J.; Lee, L.; Heidari, P.; Goel, G.; Ji, X.; Xie, Z.; Xie, T.; Lamb, J.; Weinrich, S. L.; VanArsdale, T.; Bronson, Roderick T.; Xavier, R. J.; Kan, J. L. C.; Mahmood, Umar; Hung, Kenneth E.; Lunt, Sophia Yunkyungkwon; Vander Heiden, Matthew G. (American Association for Cancer Research, 2013-02)
    Purpose: Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet clinical need. Previously, we described genetically engineered mouse models (GEMM) for sporadic Kras-mutant and non-mutant CRC ...
  • Smith, Matthew; Schulz, Norbert S.; Schattenburg, Mark Lee; Mukherjee, Pran; Marshall, Herman Lee; Huenemoerder, David P.; Foster, Richard F.; Bautz, Marshall W.; Ahn, Minseung; Heilmann, Ralf K. (The International Society for Optical Engineering, 2009-08)
    We present a high-resolution soft x-ray grating spectrometer concept for the International X-Ray Observatory (IXO) that meets or exceeds the minimum requirements for effective area (> 1, 000 cm[superscript 2] for E < 1 ...
  • Ricks, Sean T.; Lewandowski, John Robert; Lim, Emmanuel; Wendell, Dawn; Winter, Amos (ASME International, 2014-08)
    When developing a first-generation product, an iterative approach often yields the shortest time-to-market. In order to optimize its performance, however, a fundamental understanding of the theory governing its operation ...
  • Cohen, Jason Blake; Prinn, Ronald G. (European Geosciences Union, 2011-08)
    A reduced form metamodel has been produced to simulate the effects of physical, chemical, and meteorological processing of highly reactive trace species in urban areas, which is capable of efficiently simulating the urban ...
  • Goguen, Brenda N.; Loving, Galen S.; Imperiali, Barbara (Elsevier, 2011-04)
    Cdc42, a member of the Rho GTPase family, is a fundamental regulator of the actin cytoskeleton during cell migration. To generate a sensor for Cdc42 activation, we employed a multi-pronged approach, utilizing cysteine ...
  • Leman, Steven W.; Damayanthi, Rathnayaka Mudiyanselage Thushara; Takahashi, Hiroyuki; Ohno, Masashi; Minamikawa, Yasuhiro; Nishimura, Kentaro; Iyomoto, Naoko (Institute of Electrical and Electronics Engineers, 2009-06)
    We have recently started to develop a high-resolution gamma-ray spectrometer for material defect analysis. Our gamma-ray detector is a microcalorimeter consisting of an iridium/gold bilayer transition edge sensor (TES) ...
  • Romano, Paul Kollath; Forget, Benoit; Newton, Thomas H., Jr. (American Nuclear Society, 2009-04)
    In the present work, a graphical user interface is developed to automate in-core fuel management using MCODE, an MCNP-ORIGEN linkage code. Data abstraction is achieved by means of five object classes that define the run, ...
  • Ljubicic, Dean M.; Anthony, Brian (SPIE, 2010-08)
    Optical digital-imaging techniques offer a fast, high-resolution, and wide-range metrology capability for measuring semi-transparent and transparent polymer-based devices during manufacture. This work presents novel ...
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