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Browsing MIT Open Access Articles by Title

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  • Derda, Ratmir; Tang, Sindy; Li, S. Cory; Ng, Simon; Matochko, Wadim L.; Jafari, Mohammad (MDPI AG, 2011-02)
    The amplification of phage-displayed libraries is an essential step in the selection of ligands from these libraries. The amplification of libraries, however, decreases their diversity and limits the number of binding ...
  • Yang, Wei; Durisi, Giuseppe; Koch, Tobias; Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2012-09)
    We study the maximal achievable rate R*(n, ∈) for a given block-length n and block error probability o over Rayleigh block-fading channels in the noncoherent setting and in the finite block-length regime. Our results show ...
  • Wilson, Nathan R.; Runyan, Caroline A.; Wang, Forea L.; Sur, Mriganka (Nature Publishing Group, 2012-08)
    Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here ...
  • Pini, Francesco; Frage, Benjamin; Ferri, Lorenzo; De Nisco, Nicole J.; Mohapatra, Saswat S.; Taddei, Lucilla; Fioravanti, Antonella; Dewitte, Frederique; Galardini, Marco; Brilli, Matteo; Villeret, Vincent; Bazzicalupo, Marco; Mengoni, Alessio; Walker, Graham C.; Becker, Anke; Biondi, Emanuele G. (Wiley Blackwell, 2013-08)
    Sinorhizobium meliloti is a soil bacterium that invades the root nodules it induces on Medicago sativa, whereupon it undergoes an alteration of its cell cycle and differentiates into nitrogen-fixing, elongated and polyploid ...
  • Singh, Karun K.; Ge, Xuecai; Mao, Yingwei; Drane, Laurel; Meletis, Konstantinos; Samuels, Benjamin A.; Tsai, Li-Huei (Elsevier, 2010-07)
    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is ...
  • Sharghi-Namini, Soheila; Tan, Evan; Ong, Lee Ling; Ge, Ruowen; Asada, Harry (Nature Publishing Group, 2014-02)
    Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring ...
  • Lapan, Sylvain William; Reddien, Peter (Public Library of Science, 2011-08)
    Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation ...
  • Littleton, J. Troy; Sepp, Katharine J.; Jorquera, Ramon; Song, Yun; Schulte, Joost; Wu, Chaohong; Hong, Pengyu (Society for Neuroscience, 2010-01)
    The monopolar spindle-one-binder (Mob) family of kinase-interacting proteins regulate cell cycle and cell morphology, and their dysfunction has been linked to cancer. Models for Mob function are primarily based on studies ...
  • Arya, Kapil; Cooperman, Gene; Ansel, Jason Andrew (Institute of Electrical and Electronics Engineers, 2009-07)
    DMTCP (Distributed MultiThreaded CheckPointing) is a transparent user-level checkpointing package for distributed applications. Checkpointing and restart is demonstrated for a wide range of over 20 well known applications, ...
  • Battat, James; Ahlen, S.; Caldwell, T.; Dujmic, Denis; Dushkin, A.; Fisher, Peter H.; Golub, F.; Goyal, S.; Henderson, Shawn Wesley; Inglis, A.; Lanza, Richard C.; Lopez, Jeremy Paul; Kaboth, Asher Cunningham; Kohse, Gordon E.; Monroe, Jocelyn; Sciolla, Gabriella; Skvorodnev, B. N.; Tomita, H.; Vanderspek, Roland K.; Wellenstein, H.; Yamamoto, Richard K. (American Institute of Physics, 2009-12)
    By correlating nuclear recoil directions with the Earth's direction of motion through the Galaxy, a directional dark matter detector can unambiguously detect Weakly Interacting Massive Particles (WIMPs), even in the presence ...
  • Patrick, William G.; Levy, Taylor J.; Wang, Che-Wei; Rivera, Jaime J.; Voigt, Christopher A.; Oxman, Neri; Kong, David S.; Nielsen, Alec Andrew; Keating, Steven John; Mondragon-Palomino, Octavio; Carr, Peter A., Sr. (Public Library of Science, 2015-12)
    The process of connecting genetic parts—DNA assembly—is a foundational technology for synthetic biology. Microfluidics present an attractive solution for minimizing use of costly reagents, enabling multiplexed reactions, ...
  • Nakagawa, So; Gisselbrecht, Stephen S.; Rogers, Julia M.; Hartl, Daniel L.; Bulyk, Martha L. (National Academy of Sciences (U.S.), 2013-07)
    The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ...
  • Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy Manning (American Chemical Society (ACS), 2011-02)
    The ability to detect biological analytes in a rapid, sensitive, operationally simple, and cost-effective manner will impact human health and safety. Hybrid biocatalyzed-carbon nanotube (CNT) nanowire-based detection methods ...
  • Nordman, Jared T.; Kozhevnikova, Elena N.; Verrijzer, C. Peter; Pindyurin, Alexey V.; Andreyeva, Evgeniya N.; Shloma, Victor V.; Zhimulev, Igor F.; Orr-Weaver, Terry L. (Elsevier, 2014-10)
    Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is ...
  • Reinhardt, H. Christian; Hasskamp, Pia; Schmedding, Ingolf; Morandell, Sandra; van Vugt, Marcel A.T.M.; Wang, XiaoZhe; Linding, Rune; Ong, Shao-En; Weaver, David; Carr, Steven A.; Yaffe, Michael B. (Elsevier B.V., 2010-10)
    Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ...
  • Yanch, Jacquelyn C.; Engelward, Bevin P. (National Institute of Environmental Health Sciences, 2012-10)
    We thank Beyea for his comments and would like to respond, in particular, regarding the works he cites in his letter. First, the results of our study are, in fact, consistent with the findings of many human epidemiologic ...
  • Modell, Joshua W.; Hopkins, Alexander C.; Laub, Michael T. (Cold Spring Harbor Laboratory, 2011-05)
    Following DNA damage, cells typically delay cell cycle progression and inhibit cell division until their chromosomes have been repaired. The bacterial checkpoint systems responsible for these DNA damage responses are ...
  • Modell, Joshua W.; Kambara, Tracy K.; Laub, Michael T.; Perchuk, Barrett (Public Library of Science, 2014-10)
    Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the ...
  • Gilbert, Luke Andrew; Hemann, Michael (Elsevier B.V., 2010-10)
    While numerous cell-intrinsic processes are known to play decisive roles in chemotherapeutic response, relatively little is known about the impact of the tumor microenvironment on therapeutic outcome. Here, we use a ...
  • Gehring, Mary; Reik, Wolf; Henikoff, Steven (Elsevier Science Publishers, 2009-02)
    Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant ...
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