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Browsing MIT Open Access Articles by Title

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  • Chan, Vincent W. S.; Chapin, John M. (Institute of Electrical and Electronics Engineers, 2010-01)
    The Transmission Control Protocol (TCP) is ubiquitous, sophisticated, and effective. It also prevents the innovation needed to improve delivery of Internet services to the wireless tactical edge of DOD operations. We argue ...
  • Cotruvo, Joseph Alfred; Stubbe, JoAnne (American Chemical Society (ACS), 2011-01)
    Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5′-diphosphates to deoxynucleoside 5′-diphosphates in iron-limited and oxidative stress conditions. We have recently demonstrated in vitro that ...
  • Cheeseman, Iain McPherson (Springer-Verlag, 2013-04)
    The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been ...
  • Chryssostomidis, Chryssostomos; Chalfant, Julie; Vargas, J. V. C.; Souza, J. A.; Hovsapian, R.; Ordonez, J. C.; Chiocchio, T. (Association for Computing Machinery (ACM), 2011)
    This work presents a fast visualization and thermal simulation tool developed as part of the Electric Ship Research and Development Consortium (ESRDC) funded by the Office of Naval Research (ONR) that is capable of providing ...
  • Barresi, Michael J. F.; Burton, Sean; Dipietrantonio, Kristina; Amsterdam, Adam; Hopkins, Nancy H.; Karlstrom, Rolf O. (Wiley Blackwell (John Wiley & Sons), 2010-08)
    The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, ...
  • Yoon, Bong-June; Smith, Gordon B.; Heynen, Arnold J.; Neve, Rachael L.; Bear, Mark (National Academy of Sciences, 2009-06)
    The classic example of experience-dependent cortical plasticity is the ocular dominance (OD) shift in visual cortex after monocular deprivation (MD). The experimental model of homosynaptic long-term depression (LTD) was ...
  • Richardson, Claire Elissa; Kooistra, Tristan G.; Kim, Dennis H. (Nature Publishing Group, 2010-02)
    The detection and compensatory response to the accumulation of unfolded proteins in the endoplasmic reticulum (ER), termed the unfolded protein response (UPR), represents a conserved cellular homeostatic mechanism with ...
  • Scobie, Kimberly N.; Damez-Werno, Diane; Sun, HaoSheng; Shao, NingYi; Gancarz, Amy; Panganiban, Clarisse H.; Dias, Caroline; Koo, JaWook; Caiafa, Paola; Kaufman, Lewis; Neve, Rachael L.; Dietz, David M.; Shen, Li; Nestler, Eric J. (National Academy of Sciences (U.S.), 2014-02)
    Many of the long-term effects of cocaine on the brain’s reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, ...
  • Ferguson, Deveroux; Koo, Ja Wook; Feng, Jian; Heller, Elizabeth; Rabkin, Jacqui; Heshmati, Mitra; Renthal, William; Neve, Rachael L.; Liu, Xiaochuan; Shao, Ningyi; Sartorelli, Vittorio; Shen, Li; Nestler, Eric J. (Society for Neuroscience, 2013-10)
    Sirtuins (SIRTs), class III histone deacetylases, are well characterized for their control of cellular physiology in peripheral tissues, but their influence in brain under normal and pathological conditions remains poorly ...
  • Pulina, Maria V.; Hou, Shuan-Yu; Mittal, Ashok; Julich, Dorthe; Whittaker, Charlie A.; Holley, Scott A.; Hynes, Richard O.; Astrof, Sophie; Whittaker, Charles A. (Elsevier, 2011-04)
    Studies in Xenopus laevis suggested that cell-extracellular matrix (ECM) interactions regulate the development of the left–right axis of asymmetry; however, the identities of ECM components and their receptors important ...
  • De Sole, Alberto; Kac, Victor (Springer-Verlag, 2012-04)
    In our recent paper “The variational Poisson cohomology” (2011) we computed the dimension of the variational Poisson cohomology H[subscript K](V) for any quasiconstant coefficient ℓ × ℓ matrix differential operator K of ...
  • Farhi, Emmanuel; Werning, Ivan (American Economic Association, 2013-05)
    We develop a theory of optimal estate taxation in a model where bequest inequality is driven by differences in parental altruism. We show that a wide range of results are possible, from positive taxes to subsidies. The ...
  • Langton, Rae (Wiley Periodicals, Inc., 2009-12)
  • Forget, Gael; Maze, Guillaume O.; Buckley, Martha Weaver; Marshall, John C. (American Meteorological Society, 2010-07)
    The seasonal cycle in the volume and formation rate of Eighteen Degree Water (EDW) in the North Atlantic is quantified over the 3-yr period from 2004 to 2006. The EDW layer is defined as all waters that have a temperature ...
  • Schmitt, Raymond W.; Schanze, Julian Johannes (American Meteorological Society, 2013-04)
    Owing to the larger thermal expansion coefficient at higher temperatures, more buoyancy is put into the ocean by heating than is removed by cooling at low temperatures. The authors show that, even with globally balanced ...
  • Tewelde, Yodit; Perron, J. Taylor; Miller, Scott; Ford, Peter Gerald; Black, Benjamin Alexander (American Geophysical Union (AGU), 2013-10)
    Titan has few impact craters, suggesting that its surface is geologically young. Titan's surface also has abundant landforms interpreted to be fluvial networks. Here we evaluate whether fluvial erosion has caused significant ...
  • Raymond, Peter A.; Bohlen, W. Frank; Howard-Strobel, Mary M.; Collins, James Robert (Springer-Verlag, 2012-10)
    Biogeochemical cycles in estuaries are regulated by a diverse set of physical and biological variables that operate over a variety of time scales. Using in situ optical sensors, we conducted a high-frequency time-series ...
  • Bhatia, Gaurav; Patterson, Nick; Sankararaman, Sriram; Price, Alkes L. (Cold Spring Harbor Laboratory Press, 2013-07)
    In a pair of seminal papers, Sewall Wright and Gustave Malécot introduced F[subscript ST] as a measure of structure in natural populations. In the decades that followed, a number of papers provided differing definitions, ...
  • Luquette, Lovelace J.; Kharchenko, Peter V.; Day, Daniel Sindt; Park, Peter J. (Springer (Biomed Central Ltd.), 2010-06)
    We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our ...
  • Perron, J. Taylor; Burr, Devon M.; Drummond, Sarah A.; Black, Benjamin Alexander (American Geophysical Union (AGU), 2012-08)
    Drainage networks on Titan, Earth, and Mars provide the only known examples of non-volcanic fluvial activity in our solar system. The drainage networks on Titan are apparently the result of a methane-ethane cycle similar ...
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