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Browsing MIT Open Access Articles by Title

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  • Barthelmes, Katja; Reynolds, Anne M.; Peisach, Ezra; Jonker, Hendrik R. A.; DeNunzio, Nicholas J.; Allen, Karen N.; Imperiali, Barbara; Schwalbe, Harald (American Chemical Society, 2010-12)
    Lanthanide-binding tags (LBTs) are valuable tools for investigation of protein structure, function, and dynamics by NMR spectroscopy, X-ray crystallography, and luminescence studies. We have inserted LBTs into three different ...
  • Jeng, Lily; Olsen, Bjorn R.; Spector, Myron (Mary Ann Liebert, 2010-06)
    Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...
  • Lippow, Shaun M.; Moon, Tae Seok; Basu, Subhayu; Yoon, Sang-Hwal; Li, Xiazhen; Chapman, Brad A.; Robison, Keith; Lipovšek, Daša; Prather, Kristala L. Jones (Elsevier, 2010-12)
    Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we ...
  • Drake, Adam; Chen, Jianzhu; Chen, Qingfeng (Nature Publishing Group, 2012-05)
    Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the ...
  • Moon, James J.; Huang, Bonnie; Irvine, Darrell J. (Wiley Blackwell, 2012-05)
    The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders. Thus, therapies aimed to amplify or ...
  • Prather, Kristala L. Jones; Bower, Diana Morgan (Springer Berlin Heidelberg, 2009-02)
    The demand for plasmid DNA (pDNA) is anticipated to increase significantly as DNA vaccines and non-viral gene therapies enter phase 3 clinical trials and are approved for use. This increased demand, along with renewed ...
  • Chan, Juliana Maria; Zervantonakis, Ioannis K.; Rimchala, Tharathorn; Polacheck, William Joseph; Whisler, Jordan; Kamm, Roger Dale (Public Library of Science, 2012-12)
    In recent years, microfluidic systems have been used to study fundamental aspects of angiogenesis through the patterning of single-layered, linear or geometric vascular channels. In vivo, however, capillaries exist in ...
  • Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert; Farokhzad, Omid C.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry, 2012-05)
    Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...
  • Kolishetti, Nagesh; Dhar, Shanta; Valencia, Pedro Miguel; Lin, Lucy Q.; Karnik, Rohit N.; Lippard, Stephen J.; Langer, Robert; Farokhzad, Omid C. (National Academy of Sciences (U.S.), 2010-10)
    The genomic revolution has identified therapeutic targets for a plethora of diseases, creating a need to develop robust technologies for combination drug therapy. In the present work, we describe a self-assembled polymeric ...
  • Xiao, Zeyu; Levy-Nissenbaum, Etgar; Alexis, Frank; Luptak, Andrej; Teply, Benjamin A.; Chan, Juliana Maria; Shi, Jinjun; Digga, Elise; Cheng, Judy; Langer, Robert; Farokhzad, Omid C. (American Chemical Society, 2012-01)
    One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential binding and uptake by the target cancer cells. Using prostate ...
  • Rakich, Peter T.; Wang, Zheng; Popovic, Milos (SPIE, 2010-02)
    We present a new treatment of optical forces, revealing that the forces in virtually all optomechanically variable systems can be computed exactly and simply from only the optical phase and amplitude response of the system. ...
  • Uspal, William E.; Doyle, Patrick S.; Eral, Huseyin Burak (Nature Publishing Group, 2013-11)
    Recent advances in microfluidic technologies have created a demand for techniques to control the motion of flowing microparticles. Here we consider how the shape and geometric confinement of a rigid microparticle can be ...
  • Lu, Timothy K. (Landes Bioscience, 2010-11)
    Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are ...
  • Lu, Timothy Kuan-Ta; Collins, J. J. (Institute of Electrical and Electronics Engineers, 2009-05)
    Antibiotic resistance is a rapidly evolving problem that is not being adequately met by new antimicrobial drugs. Thus, there is a pressing need for effective antibacterial therapies that can be adapted against antibiotic-resistant ...
  • Irvine, Darrell J.; Swartz, Melody A.; Szeto, Gregory Lee (Nature Publishing Group, 2013-10)
    Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against ...
  • Bartolomei, Jason E.; Hastings, Daniel E.; de Neufville, Richard; Rhodes, Donna H. (Wiley-Blackwell Pubishers, 2010-10)
    The scope and complexity of engineered systems are ever-increasing as burgeoning global markets, unprecedented technological capabilities, rising consumer expectations, and ever-changing social requirements present difficult ...
  • Lazic, Predrag; Atodiresei, Nicolae; Caciuc, Vasile; Blügel, Stefan (American Physical Society, 2011-11)
    We have performed systematic first-principles calculations to tailor the magnetic properties at a hybrid organic-ferromagnetic interface by adsorbing organic molecules containing π(p[subscript z]) electrons onto a magnetic ...
  • Datta, Soumendu; Kabir, Mohammad Mukul; Mookerjee, Abhijit; Saha-Dasgupta, Tanusri (American Physical Society, 2011-02)
    With a goal to produce a giant magnetic moment in a Mn13 cluster that will be useful for practical applications, we have considered the structure and magnetic properties of a pure Mn13 cluster and substitutionally doped ...
  • Cho, Yigil; Shin, Joong-Ho; Costa, Avelino; Kim, Tae Ann; Kunin, Valentin; Li, Ju; Lee, Su Yeon; Yang, Shu; Han, Heung Nam; Choi, In-Suk; Srolovitz, David J. (National Academy of Sciences (U.S.), 2014-12)
    In this paper we discuss the transformation of a sheet of material into a wide range of desired shapes and patterns by introducing a set of simple cuts in a multilevel hierarchy with different motifs. Each choice of ...
  • Wu, Jiang; Griffeth, Nancy; Newport, Calvin; Lynch, Nancy (2011-08)
    The VNLayer approach simplifies software development for MANET by providing the developers an abstraction of a network divided into fixed geographical regions, each containing a virtual server for network services. In this ...
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