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Browsing MIT Open Access Articles by Title

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  • Giudice, Jimena; Xia, Zheng; Scavuzzo, Marissa A.; Ward, Amanda J.; Kalsotra, Auinash; Wang, Wei; Wehrens, Xander H. T.; Burge, Christopher B.; Li, Wei; Cooper, Thomas A.; Wang, Eric Tzy-shi (2014-04)
    During postnatal development the heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). Here we perform deep ...
  • Rojas-Duran, Maria F.; Gilbert, Wendy (Cold Spring Harbor Laboratory Press, 2012-10)
    mRNA levels do not accurately predict protein levels in eukaryotic cells. To investigate contributions of 5′ untranslated regions (5′ UTRs) to mRNA-specific differences in translation, we determined the 5′ UTR boundaries ...
  • Gilbert, Wendy (American Society for Biochemistry and Molecular Biology (ASBMB), 2010-09)
    Internal ribosome entry sites (IRESs) are specialized mRNA elements that allow recruitment of eukaryotic ribosomes to naturally uncapped mRNAs or to capped mRNAs under conditions in which cap-dependent translation is ...
  • Truong, Bao H.; Hu, Lin-Wen; Buongiorno, Jacopo; McKrell, Thomas J. (American Society of Mechanical Engineers, 2009-12)
    Nanofluids are engineered colloidal dispersions of nano-sized particle in common base fluids. Previous pool boiling studies have shown that nanofluids can improve critical heat flux (CHF) up to 200% for pool boiling and ...
  • Xu, Zhiping; Paparcone, Raffaella; Buehler, Markus J.; Xu, Shiping (Elsevier, 2010-05)
    Amyloid fibrils are highly ordered protein aggregates that are associated with several pathological processes, including prion propagation and Alzheimer's disease. A key issue in amyloid science is the need to understand ...
  • Srivastava, Gyan; Lunnon, Katie; Burgess, Jeremy; Yu, Lei; Ernst, Jason; McCabe, Cristin; Tang, Anna; Raj, Towfique; Replogle, Joseph; Brodeur, Wendy; Gabriel, Stacey; Younkin, Curtis; Zou, Fanggeng; Szyf, Moshe; Meissner, Alexander; Ertekin-Taner, Nilufer; Kellis, Manolis; Mill, Jonathan; De Jager, Philip L.; Schalkwyk, Leonard C.; Eaton, Matthew Lucas; Eaton, Matthew L.; Keenan, Brendan T.; Ernst, Jason; Chai, High S.; Younkin, Steven G.; Epstein, Charles B.; Schneider, Julie A.; Bernstein, Bradley E.; Chibnik, Lori B.; Bennett, David A. (Nature Publishing Group, 2014-08)
    We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 ...
  • Chibnik, Lori B.; Yu, Lei; Srivastava, Gyan; Schneider, Julie A.; Kellis, Manolis; Bennett, David A.; De Jager, Philip L.; Eaton, Matthew Lucas (American Neurological Association, 2015-04)
    Objective We explore the role of DNA methylation in Alzheimer's disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role ...
  • Christian, Theresa M.; Beaton, Daniel A.; Mukherjee, Kunal; Alberi, Kirstin; Fitzgerald, Eugene A.; Mascarenhas, Angelo (American Institute of Physics (AIP), 2013-08)
    We demonstrate amber-green emission from Al[subscript x]In[subscript 1– x]P light-emitting diodes (LEDs) with luminescence peaked at 566 nm and 600 nm. The LEDs are metamorphically grown on GaAs substrates via a graded ...
  • Foley, Megan A.; Jamison, Timothy F. (American Chemical Society (ACS), 2010-08)
    A rapid carboxylic acid-promoted lactone aminolysis is reported. A number of carboxylic acids were found to promote this amide bond-forming transformation, with aliphatic acids being the most efficient. This reaction is ...
  • DeFlores, Lauren P.; Ganim, Ziad; Nicodemus, Rebecca A.; Tokmakoff, Andrei (American Chemical Society, 2009-02)
    We demonstrate how multimode 2D IR spectroscopy of the protein amide I′ and II′ vibrations can be used to distinguish protein secondary structure. Polarization-dependent amide I′−II′ 2D IR experiments on poly-l-lysine in ...
  • Brander, Christian; Walker, Bruce D.; Goulder, Philip J. R.; Rolland, Morgane; Carlson, Jonathan M.; Manocheewa, Siriphan; Rousseau, Christine M.; Raugi, Dana N.; Learn, Gerald H.; Maust, Brandon S.; Coovadia, Hoosen M.; Ndung'u, Thumbi; Heckerman, David; Mullins, James I.; Swain, J. Victor; Lanxon-Cookson, Erinn; Deng, Wenjie (Public Library of Science, 2010-09)
    Background Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the ...
  • Petsche Connell, Jennifer; Camci-Unal, Gulden; Khademhosseini, Ali; Jacot, Jeffrey G. (Mary Ann Liebert, Inc., 2013-03)
    Recent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and nontumorogenic. These amniotic fluid-derived stem cells (AFSC) ...
  • Ritvo, Harriet (White Horse Press, 2014-11)
    The tendency to see humans as special and separate influences even practices like scientific taxonomy which explicitly place them among other animals. The animal-related scholarship that has emerged throughout the humanities ...
  • Zens, Timothy; Becla, Piotr; Kimerling, Lionel C.; Drehman, Alvin; Agarwal, Anuradha Murthy (SPIE, 2011-05)
    The structural, electronic, and optical properties of amorphous InSb and InAs[subscript 0.3]Sb[subscript 0.7] films deposited on Corning glass, Al[subscript 2]O[subscript 3] CdZnTe, SiO[subscript 2]-Si, and CaF2 substrates ...
  • Lee, Patrick A. (American Physical Society, 2014-07)
    The enigmatic pseudogap phase in underdoped cuprate high-T[subscript c] superconductors has long been recognized as a central puzzle of the T[subscript c] problem. Recent data show that the pseudogap is likely a distinct ...
  • Wang, Jing; Tang, Fushan; Li, Feng; Lin, Juan; Zhang, Yinghui; Du, Linfang; Zhao, Xiaojun (Hindawi Publishing Corporation, 2008)
    It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...
  • Chin, J. K.; Vogels, J. M.; Ketterle, Wolfgang (American Physical Society, 2003-04)
    We study the collapse of large homogeneous Bose-Einstein condensates due to intrinsic attractive interactions. We observe the amplification of a local instability by seeding a momentum state p and suddenly switching the ...
  • Temkin, Richard J.; Nanni, Emilio Alessandro; Shapiro, Michael; Sirigiri, Jagadishwar R.; Kim, H. J.; Woskov, Paul P. (American Physical Society, 2010-09)
    An experimental study of picosecond pulse amplification in a gyrotron-traveling wave tube (gyro-TWT) has been carried out. The gyro-TWT operates with 30 dB of small signal gain near 140 GHz in the HE06 mode of a confocal ...
  • Doyle, Patrick S.; Zhang, Ce; Hernandez-Garcia, Armando; Jiang, Kai; Gong, Zongying; Guttula, Durgarao; Ng, Siow Yee; Malar, Piravi P.; van Kan, Jeroen A.; Dai, Liang; de Vries, Renko; van der Maarel, Johan R. C. (Oxford University Press, 2013-09)
    The effect of a cationic-neutral diblock polypeptide on the conformation of single DNA molecules confined in rectangular nanochannels is investigated with fluorescence microscopy. An enhanced stretch along the channel is ...
  • Williams, M. (American Physical Society, 2013-04)
    An amplitude analysis of the final state structure in the B̅ s0→J/ψK+K- decay mode is performed using 1.0  fb-1 of data collected by the LHCb experiment in 7 TeV center-of-mass energy pp collisions produced by the LHC. A ...
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