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Browsing MIT Open Access Articles by Title

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  • Chen, Qingfeng; Khoury, Maroun; Chen, Jianzhu (National Academy of Sciences, 2009-12)
    Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B ...
  • Chen, Steve C.-Y.; Stern, Patrick; Guo, Zhuyan; Chen, Jianzhu (Public Library of Science, 2011-07)
    Background: The use of RNAi in both basic and translational research often requires expression of multiple siRNAs from the same vector. Methods/Principal Findings: We have developed a novel chicken miR126-based artificial ...
  • Andrus, Linda; Marukian, Svetlana; Jones, Christopher T.; Catanese, Maria Teresa; Sheahan, Timothy P.; Schoggins, John W.; Barry, Walter T.; Dustin, Lynn B.; Trehan, Kartik; Ploss, Alexander; Bhatia, Sangeeta N.; Rice, Charles M. (Wiley Blackwell, 2011-09)
    Here we demonstrate that primary cultures of human fetal liver cells (HFLC) reliably support infection with laboratory strains of hepatitis C virus (HCV), although levels of virus replication vary significantly between ...
  • DuPage, Michel J.; Mazumdar, Claire; Schmidt, Leah Marie; Cheung, Ann F.; Jacks, Tyler E. (Nature Publishing Group, 2012-02)
    Cancer immunoediting is a process by which immune cells, particularly lymphocytes of the adaptive immune system, protect the host from the development of cancer and alter tumour progression by driving the outgrowth of ...
  • Maniatis, Tom; Friedman, Brad Aaron (BioMed Central Ltd., 2011-07)
    RNA-Seq and microarray platforms have emerged as important tools for detecting changes in gene expression and RNA processing in biological samples. We present ExpressionPlot, a software package consisting of a default back ...
  • Ahn, Jin Ho; Keum, Jung-Won; Kim, Dong-Myung (Public Library of Science, 2011-11)
    While access to soluble recombinant proteins is essential for a number of proteome studies, preparation of purified functional proteins is often limited by the protein solubility. In this study, potent solubility-enhancing ...
  • Mandelblat-Cerf, Yael; Novick, Itai; Vaadia, Eilon (Public Library of Science, 2011-07)
    Previous studies support the notion that sensorimotor learning involves multiple processes. We investigated the neuronal basis of these processes by recording single-unit activity in motor cortex of non-human primates ...
  • Levine, Alan M.; Bradt, Hale V.; Chakrabarty, Deepto; Corbet, Robin H. D.; Harris, Robert J. (Institute of Physics Publishing, 2011-08)
    We present the results of a systematic search in ~14 years of Rossi X-ray Timing Explorer All-Sky Monitor (ASM) data for evidence of periodicities. Two variations of the commonly used Fourier analysis search method have ...
  • Sullivan, Joseph Timothy; Buonassisi, Tonio; Said, Aurore J.; Recht, Daniel; Warrender, Jeffrey M.; Persans, Peter D.; Aziz, Michael J. (American Institute of Physics (AIP), 2011-08)
    Highly supersaturated solid solutions of selenium or sulfur in silicon were formed by ion implantation followed by nanosecond pulsed laser melting. n[superscript +]p photodiodes fabricated from these materials exhibit gain ...
  • García-Marín, M.; Eckart, A.; Weiss, A.; Witzel, G.; Bremer, M.; Zamaninasab, M.; Morris, M. R.; Schödel, R.; Kunneriath, D.; Nishiyama, S.; Baganoff, Frederick K.; Dovciak, M.; Sabha, N.; Duschl, W. J.; Moultaka, J.; Karas, V.; Najarro, F.; Mužic, K.; Straubmeier, C.; Vogel, S. N.; Krips, M.; Wiesemeyer, H. (Institute of Physics/American Astronomical Society, 2011-09)
    The innermost tens of parsecs of our Galaxy are characterized by the presence of molecular cloud complexes surrounding Sgr A*, the radiative counterpart of the supermassive black hole (~4 × 10[superscript 6] M ☉) at the ...
  • Mandilara, A.; Karpov, E.; Cerf, Nicolas J. (American Physical Society, 2009-06)
    According to Hudson’s theorem, any pure quantum state with a positive Wigner function is necessarily a Gaussian state. Here, we make a step toward the extension of this theorem to mixed quantum states by finding upper and ...
  • Poonen, Bjorn (European Math Society, 2013)
    Using the closed point sieve, we extend to finite fields the following theorem proved by A. Bhatnagar and L. Szpiro over infinite fields: if X is a closed subscheme of P[superscript n] over a field, and φ: X → X satisfies ...
  • Goodman, Joel I.; Miller, Benjamin A.; Herman, Matthew; Vai, Mankuan Michael; Monticciolo, Paul (Institute of Electrical and Electronics Engineers, 2009-03)
    Systems currently being developed to operate across wide bandwidths with high sensitivity requirements are limited by the inherent dynamic range of a receiver's analog and mixed-signal components. To increase a receiver's ...
  • Timmerman, Chayil S.; Wright, Michael; Brick, Todd A. (Institute of Electrical and Electronics Engineers, 2009-10)
    In 2007, MIT Lincoln Laboratory began supporting the United States Air Force (USAF) MILSATCOM family of advanced beyond line of sight terminals increment 2 (FAB-T Inc 2) program. The Laboratory led the development and ...
  • Rangan, Sundeep; Fletcher, Alyson K.; Goyal, Vivek K. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    The replica method is a non-rigorous but widely-accepted technique from statistical physics used in the asymptotic analysis of large, random, nonlinear problems. This paper applies the replica method to analyze non-Gaussian ...
  • Moitra, Ankur; Leighton, Frank Thomson (Association for Computing Machinery (ACM), 2010-06)
    Suppose we are given a graph G = (V, E) and a set of terminals K ⊂ V. We consider the problem of constructing a graph H = (K, E[subscript H]) that approximately preserves the congestion of every multicommodity flow with ...
  • Megias, G. D.; Barbaro, M. B.; Caballero, J. A.; Donnelly, T. William; Gonzalez-Jimenez, R. (American Physical Society, 2014-09)
    We present a systematic analysis of the quasielastic scaling functions computed within the relativistic mean field (RMF) theory and we propose an extension of the superscaling approach (SuSA) model based on these results. ...
  • Kopparty, Swastik; Saraf, Shubhangi; Sudan, Madhu; Dvir, Zeev (Institute of Electrical and Electronics Engineers, 2009-10)
    We extend the "method of multiplicities" to get the following results, of interest in combinatorics and randomness extraction. 1) We show that every Kakeya set (a set of points that contains a line in every direction) in ...
  • Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Subtelny, Alexander Orest; Koppstein, David Neal Pira; Bell, George W.; Sive, Hazel L.; Bartel, David P. (Cold Spring Harbor Laboratory Press, 2012-06)
    The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling ...
  • Hung, Tiffany; Wang, Yulei; Lin, Michael F; Koegel, Ashley K; Kotake, Yojiro; Grant, Gavin D; Horlings, Hugo M; Shah, Nilay; Umbricht, Christopher; Wang, Pei; Wang, Yu; Kong, Benjamin; Langerød, Anita; Børresen-Dale, Anne-Lise; Kim, Seung K; van de Vijver, Marc; Sukumar, Saraswati; Whitfield, Michael L; Kellis, Manolis; Xiong, Yue; Wong, David J; Chang, Howard Y; Lin, Michael F. (Nature Publishing Group, 2011-06)
    Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known. Here we use an ...
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