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Browsing MIT Open Access Articles by Title

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  • Braida, Louis D.; Dykstra, Andrew Richard; Koh, Christine K.; Tramo, Mark Jude (Public Library of Science, 2012-09)
    It is well known that damage to the peripheral auditory system causes deficits in tone detection as well as pitch and loudness perception across a wide range of frequencies. However, the extent to which to which the auditory ...
  • Thorsen, Todd A.; Beretta, Gian Paolo; Poesio, Pietro (American Physical Society, 2009-08)
    A droplet placed in a liquid-liquid solution is expected to grow, or shrink, in time as ∼t[superscript 1/2]. In this Letter, we report experimental evidence that when the composition in the interface is far from thermodynamic ...
  • Jansen, An; van der Zande, Elisa; Meert, Wim; Fink, Gerald R.; Verstrepen, Kevin J. (Oxford University Press (OUP), 2012-01)
    The positions of nucleosomes across the genome influence several cellular processes, including gene transcription. However, our understanding of the factors dictating where nucleosomes are located and how this affects gene ...
  • Fitzsimmons, Jessica N.; Boyle, Edward A.; Jenkins, William J. (National Academy of Sciences (U.S.), 2014-11)
    Until recently, hydrothermal vents were not considered to be an important source to the marine dissolved Fe (dFe) inventory because hydrothermal Fe was believed to precipitate quantitatively near the vent site. Based on ...
  • Borraz, Fernando; Zipitria, Leandro; Cavallo, Alberto F.; Rigobon, Roberto (John Wiley & Sons, 2015-04)
    The ‘border effects’ literature finds that political boundaries have a large impact on relative prices across locations. In this paper, we show that the standard empirical specification suffers from selection bias and ...
  • Demaine, Erik D.; Gomez-Martin, Francisco; Meijer, Henk; Rappaport, David; Taslakian, Perouz; Winograd, Terry; Wood, David R.; Toussaint, Godfried (Elsevier, 2008-12)
    We demonstrate relationships between the classic Euclidean algorithm and many other fields of study, particularly in the context of music and distance geometry. Specifically, we show how the structure of the Euclidean ...
  • McCord, Rachel P.; Zhou, Vicky W.; Yuh, Tiffany; Bulyk, Martha L. (Elsevier, 2011-08)
    Identifying gene regulatory elements and their target genes in human cells remains a significant challenge. Despite increasing evidence of physical interactions between distant regulatory elements and gene promoters in ...
  • Wang, Danhua; Turitsyn, Konstantin; Chertkov, Michael (Institute of Electrical and Electronics Engineers, 2012-12)
    We consider a linear feeder connecting multiple distributed loads and generators to the sub-station. Voltage is controlled directly at the sub-station, however, voltage down the line shifts up or down, in particular depending ...
  • Haslam, Bryan Todd; Gordhandas, Ankit; Ricciardi, Catherine; Verghese, George C.; Heldt, Thomas (2011-08)
    Medical electronic systems are generating ever larger data sets from a variety of sensors and devices. Such systems are also being packaged in wearable designs for easy and broad use. The large volume of data and the ...
  • Rajagopal, Nisha; Kellis, Manolis; Ernst, Jason; Ray, Pradipta; Wu, Jie; Zhang, Michael; Ren, Bing (Genetics Society of America, 2014-08)
    In eukaryotic cells, histone lysines are frequently acetylated. However, unlike modifications such as methylations, histone acetylation modifications are often considered redundant. As such, the functional roles of distinct ...
  • Guth, Lawrence (Springer US, 2014-12)
    We give a shorter proof of a slightly weaker version of a theorem from Guth and Katz (Ann Math 181:155–190, 2015): we prove that if L is a set of L lines in R[superscript 3] with at most L[superscript 1/2] lines in any ...
  • King, A. L.; Miller, J. M.; Cackett, E. M.; Fabian, Andrew C.; Markoff, Sera B.; Rupen, M.; Reynolds, M. T.; Nowak, Michael A.; Gultekin, K. (IOP Publishing, 2010-02)
    We report on the results of a simultaneous monitoring campaign employing eight Chandra X-ray (0.5-10 keV) and six Very Large Array/Extended Very Large Array (8.4 GHz) radio observations of NGC 4051 over seven months. ...
  • Rago, Florencia; Gascoigne, Karen E.; Cheeseman, Iain M (Elsevier, 2015-02)
    The kinetochore provides a vital connection between chromosomes and spindle microtubules [1 and 2]. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by ...
  • Shabalina, Svetlana A.; Ogurtsov, Aleksey Y.; Spiridonov, Alexey Nikolaevich; Novichkov, Pavel S.; Spiridonov, Nikolay A.; Koonin, Eugene V. (Oxford University Press on behalf of the Society for Molecular Biology and Evolution, 2010-04)
    Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve ...
  • Dragoi, George; Tonegawa, Susumu (National Academy of Sciences (U.S.), 2013-05)
    The activity of ensembles of hippocampal place cells represents a hallmark of an animal’s spatial experience. The neuronal mechanisms that enable the rapid expression of novel place cell sequences are not entirely understood. ...
  • Frederick, Kendra K.; Debelouchina, Galia Tzvetanova; Kayatekin, Can; Dorminy, Tea; Jacavone, Angela; Griffin, Robert Guy; Lindquist, Susan (Elsevier, 2014-01)
    Yeast prions are self-templating protein-based mechanisms of inheritance whose conformational changes lead to the acquisition of diverse new phenotypes. The best studied of these is the prion domain (NM) of Sup35, which ...
  • Vieux (Kloss), Ellen; Wohlever, Matthew Lee; Chen, James Z.; Sauer, Robert T.; Baker, Tania (National Academy of Sciences (U.S.), 2013-05)
    Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped ...
  • Triantafyllou, Christina; Brown, Emery N.; Whitfield-Gabrieli, Susan; Scholz, Jonathan; Saxe, Rebecca R. (Public Library of Science, 2009-03)
    In functional magnetic resonance imaging (fMRI) studies, a cortical region in the right temporo-parietal junction (RTPJ) is recruited when participants read stories about people's thoughts (‘Theory of Mind’). Both fMRI and ...
  • Gantz, Stephanie C.; Robinson, Brooks G.; Buck, David C.; Bunzow, James R.; Neve, Rachael L.; Williams, John T.; Neve, Kim A. (eLife Sciences Publications, Ltd., 2015-08)
    D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly ...
  • Kim, Seokhee; Sauer, Robert T. (Cold Spring Harbor Laboratory Press, 2014-04)
    Intracellular proteases combat proteotoxic stress by degrading damaged proteins, but their activity must be carefully controlled to maintain cellular fitness. The activity of Escherichia coli DegP, a highly conserved ...
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