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Browsing MIT Open Access Articles by Title

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  • Lander, Eric S. (Nature Publishing Group, 2013-01)
    Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation ...
  • Strauss, Bernard S.; Strauss, Jacob A. (United States National Academy of Sciences, 2009-09)
    Both biological and social scientists have recently commented on the supposed greater variability of males in IQ tests and in mathematical achievement (1). Missing from these discussions is any consideration of possible ...
  • Proia, Theresa A.; Keller, Patricia J.; Klebba, Ina; Jones, Ainsley D.; Sedic, Maja; Gilmore, Hannah; Tung, Nadine; Naber, Stephen P.; Schnitt, Stuart; Gupta, Piyush; Lander, Eric S.; Kuperwasser, Charlotte (Elsevier, 2011-02)
    Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast ...
  • Pickrell, Joseph K.; Patterson, Nick; Barbieri, Chiara; Berthold, Falko; Gerlach, Linda; Güldemann, Tom; Kure, Blesswell; Mpoloka, Sununguko Wata; Nakagawa, Hirosi; Naumann, Christfried; Lipson, Mark; Loh, Po-Ru; Lachance, Joseph; Mountain, Joanna; Bustamante, Carlos D.; Berger, Bonnie; Tishkoff, Sarah A.; Henn, Brenna M.; Stoneking, Mark; Reich, David; Pakendorf, Brigitte (Nature Publishing Group, 2012-10)
    Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, ...
  • Moon, Tae Seok; Lou, Chunbo; Tamsir, Alvin; Stanton, Brynne Christine; Voigt, Christopher A. (Nature Publishing Group, 2012-10)
    Genetic programs function to integrate environmental sensors, implement signal processing algorithms and control expression dynamics[1]. These programs consist of integrated genetic circuits that individually implement ...
  • Soukas, Alexander A.; Carr, Christopher E.; Ruvkun, Gary (Public Library of Science, 2013-10)
    Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are important for cellular maintenance and protection against age-related ...
  • Burrage, Lindsay C.; Baskin-Hill, Annie E.; Sinasac, David S.; Singer, Jonathan B.; Croniger, Colleen M.; Kirby, Andrew; Kulbokas, E. J.; Daly, Mark J.; Lander, Eric S.; Broman, Karl W.; Nadeau, Joseph H. (Springer-Verlag, 2010-02)
    Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome ...
  • Lesch, Bluma J.; Page, David C. (Nature Publishing Group, 2012-10)
    The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, ...
  • Chen, Chi-Hua; Fiecas, Mark; Gutierrez, E. D.; Panizzon, Matthew S.; Eyler, Lisa T.; Vuoksimaa, Eero; Thompson, Wesley K.; Fennema-Notestine, Christine; Hagler, Donald J., Jr.; Jernigan, Terry L.; Neale, Michael C.; Franz, Carol E.; Lyons, Michael J.; Fischl, Bruce; Tsuang, Ming T.; Dale, Anders M.; Kremen, William S. (National Academy of Sciences (U.S.), 2013-10)
    Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an ...
  • Cesarini, David Alexander; Dawes, Christopher T.; Johannesson, Magnus; Lichtenstein, Paul; Wallace, Bjorn (MIT Press, 2009-05)
    In this paper, we use the classical twin design to provide estimates of genetic and environmental influences on experimentally elicited preferences for risk and giving. Using standardmethods from behavior genetics, we ...
  • Jiang, Xiaofang; Peery, Ashley; Hall, A B; Sharma, Atashi; Chen, Xiao-Guang; Komissarov, Aleksey; Riehle, Michelle M; Shouche, Yogesh; Sharakhova, Maria V; Lawson, Dan; Pakpour, Nazzy; Arensburger, Peter; Davidson, Victoria L M; Eiglmeier, Karin; Emrich, Scott; George, Phillip; Kennedy, Ryan C; Mane, Shrinivasrao P; Maslen, Gareth; Oringanje, Chioma; Qi, Yumin; Settlage, Robert; Tojo, Marta; Tubio, Jose M C; Unger, Maria F; Wang, Bo; Vernick, Kenneth D; Ribeiro, Jose M C; James, Anthony A; Michel, Kristin; Riehle, Michael A; Luckhart, Shirley; Sharakhov, Igor V; Tu, Zhijian; Waterhouse, Robert (BioMed Central Ltd, 2014-09)
    Background: Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of ...
  • McKenna, Aaron; Hanna, Matthew; Banks, Eric; Sivachenko, Andrey; Cibulskis, Kristian; Kernytsky, Andrew; Garimella, Kiran; Altshuler, David; Gabriel, Stacey; Daly, Mark; DePristo, Mark A. (Cold Spring Harbor Laboratory Press, 2010-07)
    Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are already revolutionizing our understanding of genetic variation among individuals. However, the massive data sets generated by NGS—the ...
  • Carvalho, Carla M.; Kropinski, Andrew M.; Lingohr, Erika J.; Santos, Silvio B.; King, Jonathan Alan; Azeredo, Joana (BioMed Central Ltd, 2012-01)
    Background Campylobacter is the leading cause of foodborne diseases worldwide. Bacteriophages (phages) are naturally occurring predators of bacteria, ubiquitous in the environment, with high host specificity and thus ...
  • Sullivan, Matthew B.; Krastins, Bryan; Hughes, Jennifer L.; Hughes, Jennifer L.; Kelly, Libusha; Chase, Michael; Sarracino, David; Chisholm, Sallie (Penny) (2009-10)
    Prochlorococcus, an abundant phototroph in the oceans, are infected by members of three families of viruses: myo-, podo- and siphoviruses. Genomes of myo- and podoviruses isolated on Prochlorococcus contain DNA replication ...
  • Lander, Eric S. (Nature Publishing Group, 2011-08)
    The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments. ...
  • Gu, Hongcang; Bock, Christoph; Mikkelsen, Tarjei S.; Jäger, Natalie; Smith, Zachary D.; Tomazou, Eleni; Gnirke, Andreas; Lander, Eric S.; Meissner, Alexander (Nature Publishing Group, 2010-01)
    Bisulfite sequencing measures absolute levels of DNA methylation at single-nucleotide resolution, providing a robust platform for molecular diagnostics. Here, we optimize bisulfite sequencing for genome-scale analysis ...
  • Lindquist, Robert A.; Ottina, Kathleen A.; Wheeler, Douglas B.; Hsu, Peggy P.; Thoreen, Carson C.; Guertin, David A.; Ali, Siraj M.; Sengupta, Shomit; Shaul, Yoav D.; Lamprecht, Michael R.; Madden, Katherine L.; Papallo, Adam R.; Jones, Thouis R.; Sabatini, David M.; Carpenter, Anne E. (Cold Spring Harbor Laboratory Press, 2011-01)
    The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling ...
  • Labrie, Simon J.; Frois-Moniz, Katya; Osburne, Marcia; Kelly, Libusha; Roggensack, Sara; Sullivan, M. B.; Gearin, G.; Zeng, Q.; Fitzgerald, M.; Henn, M. R.; Chisholm, Sallie (Wiley Blackwell, 2013-01)
    The marine cyanobacteria Prochlorococcus and Synechococcus are highly abundant in the global oceans, as are the cyanophage with which they co-evolve. While genomic analyses have been relatively extensive for cyanomyoviruses, ...
  • Karlsson, Elinor K; Sigurdsson, Snaevar; Ivansson, Emma; Thomas, Rachael; Elvers, Ingegerd; Wright, Jason; Howald, Cedric; Tonomura, Noriko; Perloski, Michele; Swofford, Ross; Biagi, Tara; Fryc, Sarah; Anderson, Nathan; Courtay-Cahen, Celine; Youell, Lisa; Ricketts, Sally L; Mandlebaum, Sarah; Rivera, Patricio; von Euler, Henrik; Kisseberth, William C; London, Cheryl A; Couto, Guillermo; Comstock, Kenine; Starkey, Mike P; Modiano, Jaime F; Breen, Matthew; Lindblad-Toh, Kerstin; Lander, Eric S. (BioMed Central Ltd, 2013-12)
    Background: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. Results: Through genome-wide association analyses in three ...
  • Runstadler, Jonathan; Vernau, Karen M.; Brown, Emily A.; Cameron, Jessie M.; Huson, Heather J.; Higgins, Robert J.; Ackerley, Cameron; Sturges, Beverly K.; Dickinson, Peter J.; Puschner, Birgit; Giulivi, Cecilia; Shelton, G. Diane; Robinson, Brian H.; DiMauro, Salvatore; Bollen, Andrew W.; Bannasch, Danika L. (Public Library of Science, 2013-03)
    Alaskan Husky Encephalopathy (AHE) has been previously proposed as a mitochondrial encephalopathy based on neuropathological similarities with human Leigh Syndrome (LS). We studied 11 Alaskan Husky dogs with AHE, but found ...
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