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Browsing MIT Open Access Articles by Title

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  • Tax, David Samuel; Mastovsky, Ivan; Neilson, Jeff; Shapiro, Michael; Sirigiri, Jagadishwar R.; Temkin, Richard J.; Torrezan de Sousa, Antonio Carlos (Institute of Electrical and Electronics Engineers, 2009-11)
    We report experimental results on a 1.5 MW, 110 GHz, 3 microsecond pulsed gyrotron with a single-stage depressed collector. A simplified mode converter with smooth mirror surfaces has been installed in the tube. The converter ...
  • Winter, Amos G.; Hosoi, Anette E; Slocum, Alexander H; Deits, Robin Lloyd Henderson (American Society of Mechanical Engineers, 2009-08)
    Razor clams (Ensis directus) are one of nature’s most adept burrowing organisms, able to dig to 70cm at nearly 1cm/s using only 0.21J/cm. Ensis reduces burrowing drag by using motions of its shell to fluidize a thin layer ...
  • Murphy, Jeremy; Yang, Maria; Otto, Kevin; Jensen, Dan; Wood, Kristin; Fu, Katherine K (Springer London, 2014-11)
    Design-by-analogy is a growing field of study and practice, due to its power to augment and extend traditional concept generation methods by expanding the set of generated ideas using similarity relationships from solutions ...
  • Cardin, Michel-Alexandre; Geltner, David M; de Neufville, Richard L (Elsevier, 2015-10)
    This paper proposes design catalogs as an efficient systematic process for identifying and evaluating improved designs in engineering systems by exploiting ideas of flexibility. Standard design and evaluation approaches ...
  • Choi, Hak Soo; Liu, Wenhao; Liu, Fangbing; Nasr, Khaled; Misra, Preeti; Bawendi, Moungi G.; Frangioni, John V. (Nature Publishing Group, 2009-11)
    Inorganic/organic hybrid nanoparticles are potentially useful in biomedicine, but to avoid non-specific background fluorescence and long-term toxicity, they need to be cleared from the body within a reasonable timescale1. ...
  • Davis, Joseph Harry; Rubin, Adam J.; Sauer, Robert T. (Oxford University Press, 2010-09)
    We have generated a series of variable-strength, constitutive, bacterial promoters that act predictably in different sequence contexts, span two orders of magnitude in strength and contain convenient sites for cloning and ...
  • Drela, Mark (SAE International, 2011-10)
    The fuel energy consumption of subsonic air transportation is examined. The focus is on identification and quantification of fundamental engineering design tradeoffs which drive the design of subsonic tube and wing transport ...
  • Zhou, Qinghan; Lin, Juan; Wang, Jing; Li, Feng; Tang, Fushan; Zhao, Xiaojun (Elsevier B.V., 2009-11)
    The amphiphilic peptide is becoming attractive as a potential drug carrier to improve the dissolvability of hydrophobic drugs in an aqueous system; thus, facilitating drug uptake by target cells. Here, we report a novel ...
  • Ruan, Liping; Zhang, Hangyu; Luo, Hanlin; Liu, Jingping; Tang, Fushan; Shi, Ying-Kang; Zhao, Xiaojun (National Academy of Sciences, 2009-03)
    How do you design a peptide building block to make 2-dimentional nanowebs and 3-dimensional fibrous mats? This question has not been addressed with peptide self-assembling nanomaterials. This article describes a designed ...
  • Ryan, Jeremy A.; Letai, Anthony; Foight, Glenna W.; Gulla, Stefano V.; Keating, Amy E (American Chemical Society (ACS), 2014-07)
    Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold potential for diagnosing and disrupting Mcl-1-dependent cell ...
  • Li, Xiansen; Michaelis, Vladimir K.; Ong, Ta-Chung; Smith, Stacey J.; Griffin, Robert Guy; Wang, Evelyn N. (John Wiley & Sons, Inc, 2014-05)
    The controllable synthesis of well-ordered layered materials with specific nanoarchitecture poses a grand challenge in materials chemistry. Here the solvothermal synthesis of two structurally analogous 5-coordinate ...
  • Baaske, Philipp; Wienken, Christoph J.; Jerabek-Willemsen, Moran; Duhr, Stefan; Luo, Yuan; Braun, Dieter; Corin, Karolina A.; Ravel, Deepali B.; Song, Junyao; Brown, Emily E.; Wang, Xiaoqiang; Zhang, Shuguang (Public Library of Science, 2011-11)
    A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. ...
  • Zhang, K.; Zhang, F.; Yan, H.; Chiu, W.; Veneziano, Remi; Ratanalert, Sakul; Bathe, Mark (American Association for the Advancement of Science (AAAS), 2016-05)
    Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick basepairing manually for any given target ...
  • Telenko, Cassandra; Wood, Kristin; Otto, Kevin; Rajesh Elara, Mohan; Foong, Shaohui; Leong Pey, Kin; Tan, U-Xuan; Camburn, Bradley; Moreno, Diana; Frey, Daniel (ASME International, 2015-11)
    Design and other fundamental topics in engineering are often isolated to dedicated courses. An opportunity exists to foster a culture of engineering design and multidisciplinary problem solving throughout the curriculum. ...
  • Tolley, Michael T.; Rus, Daniela L. (Nature Publishing Group, 2015-05)
    Conventionally, engineers have employed rigid materials to fabricate precise, predictable robotic systems, which are easily modelled as rigid members connected at discrete joints. Natural systems, however, often match or ...
  • Pearlman, Jonathan L.; Winter, Amos G.; Bollini, Mario A; DeLatte, Danielle M; Judge, Benjamin M; O'Hanley, Harrison F; Scolnik, Natasha (American Society of Mechanical Engineers (ASME), 2010-08)
    The Leveraged Freedom Chair (LFC) is a lever-powered, wheelchair-based mobility aid designed specifically for use in the developing world. Its drivetrain optimally converts upper body power in a wide range of terrains, ...
  • Dave, Nirav H.; Ng, Man Cheuk; Pellauer, Michael; Mithal, Arvind (Institute of Electrical and Electronics Engineers, 2010-07)
    We propose a practical methodology based on modular refinement to design complex systems. The methodology relies on modules with latency-insensitive interfaces so that the refinements can change the timing contract of a ...
  • Austin-Breneman, Jesse; Yang, Maria (2013-08)
    Product design for emerging markets in the developing world is a rapidly growing field due to a steadily increasing market and an interest in profitably transforming consumer quality of life for this population. Economic ...
  • Kimerling, Lionel C.; Sun, Xiaochen; Hu, Juejun; Agarwal, Anuradha Murthy (Optical Society of America, 2009-04)
    In this paper, we propose a design tool for dielectric optical resonator-based biochemical refractometry sensors. Analogous to the widely accepted photodetector figure of merit, the detectivity D*, we introduce a new sensor ...
  • Nechayev, Sergey; Rotschild, Carmel; Reusswig, Philip David; Baldo, Marc A (Nature Publishing Group, 2016-12)
    High-quality micro-lasers are key ingredients in non-linear optics, communication, sensing and low-threshold solar-pumped lasers. However, such micro-lasers exhibit negligible absorption of free-space broadband pump light. ...
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