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Browsing MIT Open Access Articles by Title

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  • Ryan, Katherine S.; Drennan, Catherine L. (Elsevier, 2009-04)
    Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many ...
  • Almada, Albert Ernesto; Lin, Charles; Sharp, Phillip A.; Young, Richard A.; Sigova, Alla A.; Mullen, Alan C.; Molinie, Benoit; Gupta, Sumeet; Orlando, David A.; Guenther, Matthew G.; Giallourakis, Cosmas C. (National Academy of Sciences (U.S.), 2013-02)
    Many long noncoding RNA (lncRNA) species have been identified in mammalian cells, but the genomic origin and regulation of these molecules in individual cell types is poorly understood. We have generated catalogs of lncRNA ...
  • Sabatini, David M.; Grabiner, Brian C.; Nardi, Valentina; Birsoy, Kivanc; Possemato, Richard; Shen, Kuang; Sinha, Sumi; Jordan, Alexander; Beck, Andrew H. (American Association for Cancer Research, 2014-03)
    Genes encoding components of the PI3K–AKT–mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene encoding the mTOR kinase. Using publicly available tumor genome ...
  • Pang, Yan Ling Joy; Abo, Ryan; Levine, Stuart S.; Dedon, Peter C. (Oxford University Press, 2014-10)
    Emerging evidence points to roles for tRNA modifications and tRNA abundance in cellular stress responses. While isolated instances of stress-induced tRNA degradation have been reported, we sought to assess the effects of ...
  • Swager, Timothy Manning; Wang, Fei (American Chemical Society (ACS), 2011-03)
    A diverse array of multiwalled carbon nanotube (MWCNT) sensory materials have been synthesized and used to create sensors capable of identifying volatile organic compounds (VOCs) on the basis of their functional groups. ...
  • Odendall, Charlotte; Dixit, Evelyn; Stavru, Fabrizia; Bierne, Helene; Franz, Kate M; Durbin, Ann Fiegen; Boulant, Steeve; Gehrke, Lee; Cossart, Pascale; Kagan, Jonathan C (Nature Publishing Group, 2014-08)
    Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The ...
  • Abbar, Sofiane; Amer-Yahia, Sihem; Indyk, Piotr; Mahabadi, Sepideh; Varadarajan, Kasturi R. (Association for Computing Machinery (ACM), 2013-06)
    Motivated by the recent research on diversity-aware search, we investigate the k-diverse near neighbor reporting problem. The problem is defined as follows: given a query point q, report the maximum diversity set S of k ...
  • Slattery, Matthew; Ma, Lijia; Spokony, Rebecca F.; Arthur, Robert K.; Kheradpour, Pouya; Kundaje, Anshul; Negre, Nicolas; Crofts, Alex; Ptashkin, Ryan; Zieba, Jennifer; Ostapenko, Alexander; Suchy, Sarah; Victorsen, Alec; Jameel, Nader; Grundstad, A. Jason; Gao, Wenxuan; Moran, Jennifer R.; Rehm, E. Jay; Grossman, Robert L.; Kellis, Manolis; White, Kevin P. (Nature Publishing Group, 2014-07)
    Annotation of regulatory elements and identification of the transcription-related factors (TRFs) targeting these elements are key steps in understanding how cells interpret their genetic blueprint and their environment ...
  • Modiano, Eytan H.; Lee, Hyang-Won (Institute of Electrical and Electronics Engineers, 2009-06)
    We develop diverse routing schemes for dealing with multiple, possibly correlated, failures. While disjoint path protection can effectively deal with isolated single link failures, recovering from multiple failures is not ...
  • Kong, Liangliang; Jing, Hongmei; Kataoka, Takafumi; Buchwald, Carolyn; Liu, Hongbin (Public Library of Science, 2013-10)
    Anaerobic ammonia oxidation (anammox) as an important nitrogen loss pathway has been reported in marine oxygen minimum zones (OMZs), but the community composition and spatial distribution of anammox bacteria in the eastern ...
  • Rosenhaus, Vladimir; Taylor, Washington (Springer-Verlag, 2009-06)
    Techniques are developed for exploring the complete space of intersecting brane models on an orientifold. The classification of all solutions for the widely-studied T[superscript 6]/Z[subscript 2] × Z[subscript 2] orientifold ...
  • Derda, Ratmir; Tang, Sindy; Li, S. Cory; Ng, Simon; Matochko, Wadim L.; Jafari, Mohammad (MDPI AG, 2011-02)
    The amplification of phage-displayed libraries is an essential step in the selection of ligands from these libraries. The amplification of libraries, however, decreases their diversity and limits the number of binding ...
  • Yang, Wei; Durisi, Giuseppe; Koch, Tobias; Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2012-09)
    We study the maximal achievable rate R*(n, ∈) for a given block-length n and block error probability o over Rayleigh block-fading channels in the noncoherent setting and in the finite block-length regime. Our results show ...
  • Wilson, Nathan R.; Runyan, Caroline A.; Wang, Forea L.; Sur, Mriganka (Nature Publishing Group, 2012-08)
    Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here ...
  • Pini, Francesco; Frage, Benjamin; Ferri, Lorenzo; De Nisco, Nicole J.; Mohapatra, Saswat S.; Taddei, Lucilla; Fioravanti, Antonella; Dewitte, Frederique; Galardini, Marco; Brilli, Matteo; Villeret, Vincent; Bazzicalupo, Marco; Mengoni, Alessio; Walker, Graham C.; Becker, Anke; Biondi, Emanuele G. (Wiley Blackwell, 2013-08)
    Sinorhizobium meliloti is a soil bacterium that invades the root nodules it induces on Medicago sativa, whereupon it undergoes an alteration of its cell cycle and differentiates into nitrogen-fixing, elongated and polyploid ...
  • Singh, Karun K.; Ge, Xuecai; Mao, Yingwei; Drane, Laurel; Meletis, Konstantinos; Samuels, Benjamin A.; Tsai, Li-Huei (Elsevier, 2010-07)
    The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is ...
  • Sharghi-Namini, Soheila; Tan, Evan; Ong, Lee Ling; Ge, Ruowen; Asada, Harry (Nature Publishing Group, 2014-02)
    Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring ...
  • Lapan, Sylvain William; Reddien, Peter (Public Library of Science, 2011-08)
    Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation ...
  • Littleton, J. Troy; Sepp, Katharine J.; Jorquera, Ramon; Song, Yun; Schulte, Joost; Wu, Chaohong; Hong, Pengyu (Society for Neuroscience, 2010-01)
    The monopolar spindle-one-binder (Mob) family of kinase-interacting proteins regulate cell cycle and cell morphology, and their dysfunction has been linked to cancer. Models for Mob function are primarily based on studies ...
  • Arya, Kapil; Cooperman, Gene; Ansel, Jason Andrew (Institute of Electrical and Electronics Engineers, 2009-07)
    DMTCP (Distributed MultiThreaded CheckPointing) is a transparent user-level checkpointing package for distributed applications. Checkpointing and restart is demonstrated for a wide range of over 20 well known applications, ...
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